scholarly journals Features of the Retina Light Sensitivity in Patients with Chronic Cerebral Ischemia, Depending on the Stage of Discirculatory Encephalopathy with the Use of a Neuropeptide

2020 ◽  
Vol 17 (4) ◽  
pp. 784-788
Author(s):  
M. A. Frolov ◽  
A. M. Gasankhanova
Keyword(s):  
Cerebral Ischemia ◽  
Visual Fields ◽  
Light Sensitivity ◽  
Cellular Structures ◽  
Visual Field Defects ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Partial Restoration ◽  
Before And After ◽  
Transfer Of Information

Objective. Our study was to examine the degree of the light sensitivity impairment of the retina in patients with chronic cerebral ischemia, as well as to reveal the dynamics of these disorders on the background of the neuropeptide, depending on the stage of vascular encephalopathy.Patients and methods. Comparative analysis of visual function was conducted in 70 persons (140 eyes). Patients were divided into 2 groups, each group is divided into two subgroups. To study the light sensitivity of the retina used automatic computer perimeter Hamphrey Field Analyzer HFA II — I Series (model 610, ZEISS, Germany).Results. As a result of quantifying visual field defects in patients with chronic cerebral ischemia at 2 and 3 tbsp. vascular encephalopathy before treatment received preferential reduction of the light sensitivity of the retina in the temporal halves When comparing manual data with chronic cerebral ischemia patients 2 and 3 stadies vascular encephalopathy control group no significant differences before and after treatment have been identified. However, it is important to note that after 6 months treatment in the same group showed a slight increase in absolute numbers of cattle. In the control group using Cortexin observed reduction in the amount of absolute cattle.Conclusions. The light sensitivity of the retina in patients with chronic cerebral ischemia decreases as the disease progresses, with a primary lesion of the temporal halves of the visual fields. The improvement in the computer perimetry during the treatment, especially in combination with cortexin can be attributed to the normalization of the retina cellular structures, improving the transfer of information and the partial restoration of the disturbed functions, which indicates the relative ischemia is reversible processes, which is effective in patients with stage 2 or 3 vascular encephalopathy. 

scholarly journals Chronic cerebrovascular disease: the role of venous disorders and the possibility of pathogenetic correction

2020 ◽  
Vol 4 (9) ◽  
pp. 544-551
Author(s):  
I.A. Schukin ◽  
◽  
M.S. Fidler ◽  
I.A. Koltsov ◽  
◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cerebrovascular Disease ◽  
Venous Insufficiency ◽  
Main Group ◽  
Duplex Scanning ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Venous Disorders ◽  
Tinetti Test

Aim: to evaluate the efficacy and safety of the L-lysine escinate venotropic drug in the treatment of cephalgic, atactic and asthenic syndromes in patients with chronic cerebral ischemia, mainly caused by venous disorders. Patients and Methods: the study involved 60 patients with a diagnosis of chronic cerebral ischemia with signs of chronic venous insufficiency. All patients were randomly divided into two groups consisting of 30 people. Patients in the main group received L-lysine escinate, and the control group received Vinpocetine. The drugs were administered by intravenous drip for 10 days. A dynamic assessment was performed using a modified subjective scale of asthenia evaluation (MFI-20), 100 mm long visual analogue scale (VAS) for headache, subjective neurological impairment scale (SNIS), and Tinetti test. An ophthalmic examination with an assessment of the fundus vessels and an ultrasound duplex scanning of head vessels (veins) were also conducted. Results: it was shown that L-lysine escinate therapy showed a statistically more significant reduction in the severity of headache (according to VAS) and an improved stability measured by Tinetti test versus during Vinpocetine treatment. There were no significant differences in the level of asthenia (MFI-20), the severity of emotional disorders, and the SNIS score. Also, the number of patients with dilated fundus veins significantly decreased during treatment in the main group (p<0.05), which was not the case in the control group. According to ultrasound duplex scanning data, the venous flow velocity through the veins of Rosenthal and angular veins during L-lysine escinate therapy was significantly higher (p<0.05) than in patients receiving Vinpocetine. Conclusion: the inclusion of vasotropic drugs (in particular, the L-lysine escinate venotonic drug) in the treatment regimen of patients with chronic brain ischemia seems appropriate, especially if there are signs of venous insufficiency. KEYWORDS: systemic venous insufficiency, chronic cerebrovascular disease, venous dyscirculation, glymphatic system, L-lysine escinate, Vinpocetine. FOR CITATION: Schukin I.A., Fidler M.S., Koltsov I.A. Chronic cerebrovascular disease: the role of venous disorders and the possibility of pathogenetic correction. Russian Medical Inquiry. 2020;4(9):544–551. DOI: 10.32364/2587-6821-2020-4-9-544-551.

scholarly journals Psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris

2017 ◽  
pp. 36-41
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Angina Pectoris ◽  
Autonomic Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Depression And Anxiety ◽  
Chronic Cerebral Ischemia ◽  
Stable Angina Pectoris ◽  
Personal Anxiety ◽  
High Level

The article presents the results of the study of the state of the autonomic nervous system and the psychoemotional state in patients with chronic cerebral ischemia (CCI) against the background of stable angina pectoris II and III FС. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.27 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted research and conclusions are given. Based on the findings, it was found that a high level of anxiety causes an imbalance between sympathetic and parasympathetic activity. In the group of patients with CCI against the background of stable angina pectoris III FС revealed a high level of depression and anxiety, reactive and personal anxiety, which causes a pronounced autonomic dysfunction, which was manifested in insufficient vegetative provision and the predominance of sympathicotonia in these patients. We can assume that autonomic dysfunction is one of the mechanisms for the progression of stable angina pectoris in patients with CCI.

Intermediate results 2016 of a search study of translational diagnostic methods Mitochondrial dysfunction in patients with chronic myocardial ischemia and/or head Brain

2017 ◽  
Author(s):  
Виктория Киреева ◽  
Viktoriya Kireeva ◽  
Ю. Усольцев ◽  
Yu. Usolcev ◽  
Ж. Капустенская ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Heart Disease ◽  
Cerebral Ischemia ◽  
Cell Damage ◽  
Diagnostic Methods ◽  
Cellular Damage ◽  
Rank Test ◽  
Clinical Test ◽  
Chronic Cerebral Ischemia ◽  
Before And After

Purpose of the study. To rate prognostic properties of changes in mitochondrial DNA concentration in the blood plasma of patients with chronic cerebral ischemia and ischemic heart disease in relation to the disease and the effectiveness of the therapy. Materials and methods. The study involved patients suffering from coronary heart disease (CHD) and chronic cerebral ischemia (CCI) with stable and unstable atherosclerotic plaques, who have signed informed consent to the data processing within the framework of scientific research. The patients were admitted to the hospital for examination and treatment of CHD and CCI in Cardiology and Neurology Unit of the Hospital of ISC SB RAS. The subjects underwent laboratory and instrumental examination and analysis of the level of free circulating serum mitochondrial DNA by real-time PCR (copies/ml). The examination results considered as satisfactory were compared with the mtDNA levels before and after the treatment. Results. The average value of the mtDNA levels before and after the treatment in patients of neurological and cardiological profile were significantly different: 1 093 686 copies/ml vs 418 046 copies/ml, respectively (p = 0.02). Unlike women, men mtDNA levels statistically significantly (p = 0.03) decreased after the treatment. We revealed statistically significant differences in mtDNA level indicators before and after the treatment, depending on the definition of the series (p = 0.0010) for rank test Kruskal – Wallis test. The results of the proposed research will help to identify prognostic factors of destabilization of cell damage and plaques in endothelial dysfunction, atherosclerosis and its complications, to conduct clinical test of the method for predicting and diagnostics of cellular damage in chronic ischemia on a background of atherosclerosis.

Effects and Comparison of Curcumin on Morphology Changes of Chronic Cerebral Hypoperfusion in Young and Aged Rats

2015 ◽  
Vol 1120-1121 ◽  
pp. 842-846
Author(s):  
Dan Li ◽  
Yue Xiang ◽  
Xiong Zhang ◽  
Yu Li
Keyword(s):  
Cerebral Ischemia ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Control Group ◽  
Age Difference ◽  
Dependent Manner ◽  
Aged Rats ◽  
Pathological Changes ◽  
Chronic Cerebral Ischemia ◽  
Ca1 Region

To observe the effect of curcumin on the morphology of the hippocampus in young and aged rats with vascular dementia (VD) induced by chronic cerebral hypoperfusion, then further investigate whether the effect of curcumin have any differences in age. Both young and aged Male Sprague-Dawley rats were randomly divided into normal control group, sham-operated group, 2VO group, 2VO+curcumin 50mg/Kg group and 2VO+curcumin 100mg/Kg goup. Permanent occlusion of bilateral common carotid arteries ligation (2VO) method was used to establish chronic cerebral ischemia model. The rats were injected intraperitoneally with curcumin or DMSO once daily for 30d. The pathological changes of CA1 region of the hippocampus were measured by HE staining and Nissl staining. Chronic cerebral ischemia led to pathological changes of young and aged rats, but no significant differences were found between the two ages of rats (t=0.658，P=0.523). Furthermore, curcumin could reduce the pathological injury of CA1 region of the hippocampus in young and aged VD rats, no significant differences were found between the two ages of rats (P=0.384，P=0.380). Curcumin can reduce the brain damage in young and aged VD rats in dose-dependent manner but without age difference. Our study suggests that the pathological injury of the hippocampus might be one of the mechanisms of curcumin’s protection effect of VD rats.

scholarly journals Features of neuroimaging data in patients with chronic cerebral ischemia on the background of angina pectoris

2018 ◽  
pp. 38-42
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Stable Angina ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Resonance Imaging ◽  
Bioelectric Activity ◽  
Acute Cerebrovascular Accident ◽  
Neuroimaging Data ◽  
The Brain ◽  
Neuroimaging Techniques

In the article the features of bioelectric activity and magnetic resonance imaging of the brain in patients with chronic cerebral ischemia (CCI) are exposed on the background of stable angina of the voltage ІІ and ІІІ ФК. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.2.6 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted complex neuroimaging examination of patients with ССI on the background of stable angina was collected and provided. Based on the data obtained using neuroimaging techniques, it has been established that in patients with CCI, against the background of stable angina, the course of the disease is associated with the risk of development of the acute cerebrovascular accident.

scholarly journals Training of Respiratory Muscles in Motion in the Physical Rehabilitation of Patients with Chronic Cerebral Ischem

2020 ◽  
Vol 100 (6) ◽  
pp. 19-24
Author(s):  
V.V. Ezhov ◽  
V.I. Mizin ◽  
A.Yu. Tsarev ◽  
T.E. Platunova
Keyword(s):  
Cerebral Ischemia ◽  
Respiratory Muscles ◽  
Physical Rehabilitation ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Physical Endurance ◽  
External Respiration ◽  
Chronic Cerebral Ischemia ◽  
State Reduction ◽  
Therapeutic Exercises

The aim of the study was to evaluate the effectiveness of respiratory muscles training in patients with chronic cerebral ischemia at thehealth resort stage of medical rehabilitation. Materials and methods. An open randomized controlled clinical trial was conducted in 60 patients with chronic cerebral ischemia,who underwent a course of sanatorium-resort rehabilitation treatment on the southern coast of Crimea (Yalta, Republic of Crimea). Men - 11.0%, women - 89.0%, age - 62.3 ± 2.3 years, disease duration - 4.5 ± 1.2 years. In control group 1 (n = 30), climatotherapy, physical training (morning exercises, remedial gymnastics, health path), massage, hardware physiotherapy and medications were carried out. In the main group 2 (n = 30), a similar basic complex was used, but therapeutic exercises were carried out with a breathing simulator and included walking, exercises for diaphragm training, general motor skills, coordination, dexterity, mobility, and joint flexibility. Number 10–12. Before and after the treatment, clinical, laboratory, biochemical, functional (spirography, electrocardiography, fitness test), psychological (Reeder and Back tests) studies were carried out; the indicators of the quality of life were studied; the state of 23 selected domains of the “International classification of functioning, disabilities and health”, included in the section “Body functions”, was assessed. Results. During the sanatorium-resort stage of medical rehabilitation, significant systemic effects were noted in the form of a decrease in clinical manifestations of the disease, an improvement in physical performance indicators and an increase in reserves for overcoming psychological stress. In patients, there was an improvement in static-coordination and psycho emotional state, reduction of dizziness and cephalgia, fatigue, increase in exercise tolerance, general physical endurance, normalization of carbohydrate metabolism indicators and blood lipids.Conclusion. A method of physical rehabilitation based on the principle of external respiration modification by using a breathing trainer with vibration function has been developed. The study allows us to recommend the inclusion in the complex of medical rehabilitation of patients with chronic cerebral ischemia, physical exercises with a breathing simulator, focused on increasing the functional body reserves.

scholarly journals Structural and functional properties of erythrocytes in patients with chronic cerebral ischemia.

2018 ◽  
Vol 96 (5) ◽  
pp. 427-432
Author(s):  
A. A. Shulginova ◽  
A. I. Konoplya ◽  
N. A. Bystrova ◽  
V. P. Gavriliouk
Keyword(s):  
Cerebral Ischemia ◽  
Clinical Manifestations ◽  
Cognitive Disorders ◽  
Stage I ◽  
Disease Stage ◽  
Chronic Cerebral Ischemia ◽  
Laboratory Parameters ◽  
Structural And Functional Properties ◽  
Before And After ◽  
Normal Metabolism

Treatment of chronic cerebral ischemia is still an important problem, because in most cases you cannot influence the constantly progressive character of the disease. Particularly relevant is the search for relationships between laboratory parameters and clinical manifestations of chronic cerebral ischemia with a subsequent search of the most informative indicators for timely assessment of disease severity and prediction of outcome. The aim of the study was to determine the relationships between neurological and cognitive disorders with representativeness in the membrane of red blood cells proteins and lipids in patients with chronic cerebral ischemia stage I and II treatment. Under constant observation there were 44 patients with a diagnosis of chronic cerebral ischemia stage I or II on the background of hypertensive disease stage II. Already in the early stages of the development of chronic cerebral ischemia are significant changes in the content of proteins that form the structure of erythrocyte membrane, shape and flexibility of the membrane, provide intracellular metabolism. Revealed violations in the content and ratio of lipids in the membrane. Primarily, this refers to the content of membrane glycerophospholipids and sphingomyelins, which are the basis of the double lipid layer of cell membrane and play a major role in regulating protein macromolecules and to the normal metabolism of erythrocytes. There is a relatively large number of significant relationships between laboratory parameters and parameters of the neuropsychiatric status in patients with chronic cerebral ischemia stage I or II before and after treatment.

scholarly journals ALGORITHM OF PSYCHOLOGICAL AND PSYCHOTHERAPEUTIC SUPPORT OF PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA

2018 ◽  
Vol 25 (2) ◽  
pp. 52-56
Author(s):  
I. V. Khianikiainen ◽  
V. A. Mikhailov
Keyword(s):  
Cerebral Ischemia ◽  
Middle Age ◽  
Early Stage ◽  
Psychological Adaptation ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Gender And Age ◽  
Sf 36 ◽  
The Individual ◽  
Express Methods

Introduction. Nowadays, it is important to study the mechanisms of psychological adaptation in patients with early stage of chronic cerebral ischemia (ES CCI) from the standpoint of biopsychosocial approach. The objective of the study was to develop the algorithm for identifying psychosocial characteristics of patients with ES CCI and providing them with psychotherapeutic care. Material and methods. 280 patients with ES CCI developed against a background of arterial hypertension and/or cerebral atherosclerosis (middle age 53.9±8.1 years (from 30 to 72 years) gender index 1:1) were selected for the study. The control group included healthy individuals comparable to those in the main group according to gender and age characteristics (n=32, middle age 52.4±6.5 years (31–65 years), gender index 1:1, p>0.05 ). The panel of psychological methods was used to identify the individual psychological and socio-environmental factors in patients with ES CCI.Results and conclusions. A three-stage algorithm of psychological and psychotherapeutic support of patients with early stage of chronic cerebral ischemia (ES CCI) was developed and tested by the multidisciplinary team of specialists. At the stage of opportunistic screening, the neurologist used express methods for diagnosing cognitive (Mini-test of mental state), emotional (Hospital scale of anxiety and depression), vegetative disorders (the Wayne test) among the studied persons. At the stage of selective screening, the medical psychologist performed systemic psychodiagnostics of the ES CCI. At the stage of treatment, a correction was made: psychovegetative disorders by progressive muscular relaxation; anxiety-depressive manifestations – cognitive re-attribution according to A. Beck; obsessive-phobic disorders – direct motivated suggestion in reality with elements of clarification and persuasion. The indicators of the effectiveness of psychological and psychotherapeutic correction in patients with ES CCI were: positive dynamics of the Scale of quality of life SF-36 and regression of integrative indicators of the Scale of psychopathological manifestations of SCL-90-R – «Index of overall severity of symptoms» and «Total number of affirmative answers». Thus, the algorithm described above is suitable for use in practical healthcare for optimizing individual therapeutic strategies.  

Is the Blind Spot Enlarged in Early Glaucoma?

1998 ◽  
Vol 8 (1) ◽  
pp. 28-32 ◽  
Author(s):  
J.H. Meyer ◽  
M. Guhlmann ◽  
J. Funk
Keyword(s):  
Optic Disc ◽  
Visual Fields ◽  
Stimulus Presentation ◽  
Light Sensitivity ◽  
Blind Spot ◽  
Control Group ◽  
Horizontal Meridian ◽  
Early Glaucoma ◽  
Disc Center ◽  
Optic Discs

Purpose We investigated whether the blind spot is larger in early “preperimetric” glaucoma with already deeply excavated optic discs than in normal persons. Methods We examined eight eyes of five patients with definite glaucomatous optic disc cupping but normal visual fields. Ten eyes of five normal healthy volunteers, with normal central excavation, served as controls. With SLO-perimetry we measured the differential light sensitivity 0.5-1.0° outside the disc margins, “within” the center (Goldmann V stimulus) and along the horizontal meridian of the optic discs. Optic disc topography was documented with the Heidelberg Retina Tomograph (HRT). Results Differential light sensitivities adjacent to the optic discs did not differ in the two groups (normal 8.3dB, early glaucoma 8.4dB). Goldmann IV stimuli presented on the horizontal meridian of optic discs with glaucomatous cupping were seen up to 0.7° centrally (i.e., towards the center) of the disc margin. In the control group this distance was significantly greater (1.3°). The light differential thresholds with stimulus presentation in the disc center (Goldmann V) were significantly higher in the glaucoma group (0±2.8dB) than in the normal controls (6.6±1.3dB), though disc size was the same in both groups. Conclusions Blind spots of normal discs seem to be smaller than those of deeply excavated discs in eyes with early glaucoma, possibly because there is more light scattering by the normal disc surface towards the adjacent functioning retina.

scholarly journals The experience of using iodine-bromine baths and ozone therapy at the stage of health resort treatment of patients with chronic cerebral ischemia

2020 ◽  
Vol 17 (5) ◽  
pp. 263-271
Author(s):  
Lyubov A. Cherevaschenko ◽  
L. YU. Dadova ◽  
Nikolay N. Kulikov ◽  
Anatolii T. Tereshin ◽  
Igor A. Cherevashchenko
Keyword(s):  
Cerebral Ischemia ◽  
Comparison Group ◽  
Main Group ◽  
Control Group ◽  
High Plasticity ◽  
Chronic Cerebral Ischemia ◽  
Ozone Therapy ◽  
Health Resort ◽  
Treatment Groups ◽  
The Brain

Background. Treatment of chronic cerebral ischemia should be aimed both to the main etiological factor and to the pathogenetic mechanisms of cerebral ischemia and hypoxia. The action of ozone therapy is characterized with a multilateral positive effect on the main aspects of chronic cerebral ischemia pathogenesis, such as chronic cerebral hypoxia, impaired microcirculation, rheological disorders, and activation of lipid peroxidation. The use of iodine-bromine baths in chronic cerebral ischemia has been proved to be accompanied by an improvement in cerebral circulation, normalization of the brain bioelectric processes, an initially impaired condition of the autonomic nervous system, and an increase in the level of adaptive capabilities of the body. Aim: to develop effective pathogenetically substantiated methods for the combined use of iodine-bromine baths and ozone therapy in patients with chronic cerebral ischemia to increase the effectiveness of health resort treatment. Methods. In accordance with the tasks set in the work, 90 patients with chronic cerebral ischemia of the degree 1, who were randomized into three treatment groups, were examined and treated. Patients of the control group (n = 30) received iodine-bromine baths, patients of the comparison group (n = 30) received ozone therapy, patients of the main group (n = 30) received iodine-bromine baths and ozone therapy. Examination of patients included Doppler ultrasound, electroencephalography, rheoencephalography, сardiointervalography, lipid metabolism studies, fibrinogen content studies. Results. As a result of treatment, the improvement of clinical symptoms and the normalization of biochemical and neurophysiological parameters were noted in patients of all treatment groups. Overall efficiency (improvement and significant improvement) was 53.3% in the control group, in the comparison group it was 63.3%, and 73.3% in the main group. Conclusion. The authors proved the practicability of rehabilitative treatment of early forms of vascular diseases of the brain at the stage of sanatorium and resort rehabilitation, which is due to significant compensatory reserves and high plasticity of the structural and functional formations of the brain with preserved ability to develop nonspecific elements of the nervous tissue and restore reversibly damaged structures.

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