scholarly journals Metabolomic blood test: purpose, implementation and interpretation of data

2017 ◽  
Vol 63 (3) ◽  
pp. 232-240 ◽  
Author(s):  
P.G. Lokhov ◽  
A.V. Lisitsa ◽  
A.I. Archakov
Keyword(s):  
Human Body ◽  
Blood Test ◽  
The Body ◽  
Toxic Substances ◽  
Average Life Expectancy ◽  
Biochemical Processes ◽  
Human Lifespan ◽  
Lump Sum ◽  
Chemical Purity ◽  
Sum Scores

The human body is an open system that receives a variety of xenobiotics in the course of dietary route or respiration and in the form of the drugs. As a lump sum scores of toxic and potentially toxic substances are detected in a human body that significantly affect health and human lifespan. There are also thousands of diseases, dozens of which latently occur in the body of each person. Traditional diagnosis is not able to screen all the variety of xenobiotics and potential human diseases. For this purpose metabolomic blood test is available which is of non-targeted (review) nature. The test can reveal all the diversity of low molecular weight substances in blood, including tens of thousands of xenobiotics and markers of different diseases. Detection of xenobiotics in the blood, directional detoxification and subsequent monitoring of “body's chemical purity” together with the control of “normality” of all biochemical processes in the organism, using metabolomics blood tests is a necessary and presumably a sufficient condition in the implementation of inherent human genotype longevity. This article describes the purpose, implementation and interpretation of metabolomic blood test facilitating the implementation of this method in the Russian Federation, in order to significantly increase the average life expectancy.

scholarly journals ON THE POSSIBILITY OF THE RAPID ASSISTANCE TO PEOPLE AFTER A SINGLE EXPOSURE TO URANIUM HEXAFLUORIDE

2018 ◽  
Vol 97 (3) ◽  
pp. 213-219 ◽  
Author(s):  
S. P. Babenko ◽  
Andrey V. Badyin ◽  
A. V. Ovchinnikov
Keyword(s):  
Human Body ◽  
Aerosol Particles ◽  
Toxic Substance ◽  
Theoretical Method ◽  
Uranium Hexafluoride ◽  
The Body ◽  
Toxic Substances ◽  
Functional Changes ◽  
Working Space ◽  
Hydrolysis Products

Introduction. The accidental release of uranium hexafluoride (UHF) is associated with the pollution of the air of the working premises with its hydrolysis products, containing toxic substances (uranium and fluorine). The intake of UHF hydrolysis products by is related to a negative impact on the human body. The magnitude and the rate of the exposure are determined by the amount of deposited toxic substances. Known methods for the determination of these amounts are based on the study of involved biological media (urine, blood, postmortem examination of all organs), requiring time-consuming, sometimes are critical for the preservation of the human life. In this paper, we propose a theoretical method for the detecting the amount of the deposited toxic substances. The calculation is based on models constructed by authors of this article. They describe successively: pollution of the working premises with UHF hydrolysis products, the input of toxic substances in the human body, uranium and passing fluorine through the body. The first model includes the following processes: hydrolysis, the formation of aerosol particles as on the deposition gas molecules and the wall of working space as on the human skin, deposition of the aerosol particles on the floor of the working space. With continuity equations written for the concentrations of molecules of substances of interest to us, the analytical expressions for n(z,t) - the concentration of atoms of a toxic substance at the height z at the time t; j(t) - flux density of toxic substance atoms on the surface of the skin at the time t. The second and third models describe percutaneous intake and inhalation of uranium and fluorine consisting of UHF hydrolysis products entering the human body, as well as toxic substances passed through the body. Results. There are presented results of calculating the amounts deposited in the body of uranium fluoride at various time points. There is given a comparison of these values with the experimental data in the literature on the quantity of uranium and fluorine, which enters the body to cause various organic and functional changes. Conclusion. The theoretical method of determining a person’s level of the destruction was concluded to allow extending the prediction of the development of adverse effects of uranium and fluorine without its prior survey, and choose the most effective methods of healthcare provision.

scholarly journals Structural problems of water metabolism in the human body

2021 ◽  
pp. 17-21
Author(s):  
R. O. Sabadishin
Keyword(s):  
Chemical Composition ◽  
Human Body ◽  
The Body ◽  
Water Metabolism ◽  
Normal Functioning ◽  
Biochemical Processes ◽  
Structural Problems ◽  
Chemical Composition Of Water

The article highlights the main biochemical processes that determine the normal functioning of the body and depend on the chemical composition of water consumed by humans. The lack and excess of water, as well as certain features of its composition affect the human body.

scholarly journals ABOUT CALCULATION OF THE DETERMINISTIC EFFECT OF PROTEINURIA IN EMPLOYEES OF ENRICHMENT PLANTS OF NUCLEAR INDUSTRY

2018 ◽  
Vol 97 (4) ◽  
pp. 315-321 ◽  
Author(s):  
S. P. Babenko ◽  
Andrey V. Badin
Keyword(s):  
Working Conditions ◽  
Human Body ◽  
Occupational Diseases ◽  
Theoretical Method ◽  
Uranium Hexafluoride ◽  
Nuclear Industry ◽  
The Body ◽  
Toxic Substances ◽  
Urologic Diseases ◽  
Deterministic Effect

In this paper, we consider the impacts of gaseous uranium hexafluoride used at concentrating plants of the nuclear industry on the human body. The appearance of uranium hexafluoride in the air of the working premises is accompanied by hydrolysis and the formation of substances that can enter the human body and bring atoms of uranium and fluorine. The article describes the method of the determination of the working conditions preventing the development of occupational diseases in employees. The method is based both on the calculation of the number of toxic substances entering the human body in routine working conditions and comparison of this number with the threshold values for different deterministic effects. The proteinuria (protein content in urine) is selected as the considered deterministic effect. We used the published statistics on the threshold of the daily release from the human body toxic substances, long-entering the body in small doses and seem to be responsible for the occurrence of urologic diseases. The calculation was performed in the framework of a complex model describing the air pollution with products of hydrolysis of uranium hexafluoride entering of toxic substances in the human body, in working premises, as well as the passing of uranium and fluorine through the body. This model constructed by the authors of this article was described in previous publications. To ensure that the theoretical methods give the same results as the experimental, the results obtained by the standard method for employees of one of the enterprises of nuclear industry were compared with the data obtained using the theoretical method under the same working conditions. The considered theoretical method can complement and enrich the existing experimental methods for the identification of the onset of occupational diseases based on the sampling of different biomaterials from the employees working at enterprises.

scholarly journals On the calculated method for assessing the impact of hydrolysis products from uranium hexafluoride on the human body

2021 ◽  
Vol 100 (1) ◽  
pp. 13-18
Author(s):  
Svetlana P. Babenko ◽  
Andrey V. Bad’in
Keyword(s):  
Human Body ◽  
Calculation Method ◽  
Uranium Hexafluoride ◽  
The Body ◽  
Similar Process ◽  
Toxic Substances ◽  
Chemical Transformations ◽  
Gaseous State ◽  
Advantages And Disadvantages ◽  
The Impact

Introduction. This article refers to the authors’ calculation method for studying the effects UF6 (uranium hexafluoride, UHF) on the human body. A review of this method’s main ideas and the features of the approach to solving the problem at certain stages of the movement of UHF from being released into the air before entering the body is offered. The possibilities of the proposed method and its place in many well-known studies in this direction are described. Material and methods. The research material is UHF. It serves as the primary working substance in technologies for enriching natural uranium with the 235U isotope. UHF, due to various circumstances, appears in the production room in a gaseous state. A method for studying the effects of UHF on humans is to describe the distribution processes of UHF molecules in the volume of the working room, chemical transformations of UHF, physical transformations of the resulting products, i.e., all processes accompanied by the delivery of toxic substances and their transfer from the source to the person and before excretion from the body in a natural way. The description of these processes is carried out analytically. Results. Lists the results that can be obtained by calculation. Discussion. A discussion of the results is carried out in the following areas. The issue of the possibility of using the described calculation method to solve the problems of ensuring labor safety at work is considered. The question of trust in the calculated values characterizing the effect of UHF on the human body is being studied. To solve this problem, we compared the calculated results obtained for a particular process and the experimental ones implemented in a similar process. Conclusion. A conclusion is made regarding the advantages and disadvantages of the method under investigation for studying the effects of UHF on humans and determining their place among existing methods.

scholarly journals Recommendations for Choosing a Model Describing the Human Exposure to Uranium Hexafluoride

2020 ◽  
pp. 31-42
Author(s):  
S. P. Babenko ◽  
A. V. Bad'in
Keyword(s):  
Human Body ◽  
Radiation Effect ◽  
Quantitative Description ◽  
Uranium Hexafluoride ◽  
Natural Uranium ◽  
Nuclear Industry ◽  
The Body ◽  
Radiological Protection ◽  
Toxic Substances ◽  
Gaseous State

The article notes the fact that uranium hexafluoride (UHF) is the only uranium compound in a gaseous state under conditions close to normal to be used in the enrichment of natural uranium with an isotope. It is noted that during the hydrolysis of UHF in the air of a working room, this room is polluted with gases and aerosols that are carriers of uranium and fluorine atoms, which have a negative chemical and radiation effect on the human body. This, of course, poses problems when using uranium hexafluoride at the enterprises of the nuclear industry both in everyday work and, especially, in possible emergency situations. The problems lie with a need for protective measures, development of the quantitative assessment methods for the intake of toxic substances, and establishment of relationships between the amount of incorporated (ingested) substance and the measure of its effect on the body. A review of certain publications on the quantitative description of the uranium and fluorine intake in the body of employees is given. The paper notes an involvement of this article’s authors in solving this issue in their previous works too. Their calculation methods are described. The conditions under which they were carried out and the experimental results that they used were described. The article presents the calculation results both of the uranium mass intake in the body (by the time t) that characterizes the toxic effect of uranium and of the number Q of decays accumulated in the body that characterize the radiation effect. The uranium penetration through the skin (percutaneous intake) in an emergency and under normal production conditions is considered. There is given a description of two models suitable for calculations, which are distinguished by various accounting for metabolism when uranium moves from the UHF source to the exit from the human body in the natural way. It is indicated that one of the models was partially borrowed from publications of the International Commission on Radiological Protection (ICRP). The results obtained using two different models are compared and recommendations are made regarding their use depending on the tasks assigned to the researcher.

Immunological mechanisms of chronic liver lesions under the influence of chemicals

2020 ◽  
pp. 536-537
Author(s):  
G. S. Agzamova ◽  
M. M. Abdullaeva
Keyword(s):  
The Body ◽  
Chronic Liver ◽  
Toxic Substances ◽  
Liver Lesions ◽  
Industrial Chemicals ◽  
Toxic Agent ◽  
Chronic Poisoning ◽  
Immunological Mechanisms ◽  
T System

The immunological profile of chronic liver lesions depending on the toxic agent was studied. It was revealed that chronic poisoning by industrial toxic substances causes changes in the functional state of the T-system of immunity, long-term contact with industrial chemicals leads to increased sensitization to autoantigens of the body.

Correction of Posture Deviations in the Sagittal Plane Using the Pilates Method

2019 ◽  
pp. 3-13
Author(s):  
Alexandru Cîtea ◽  
George-Sebastian Iacob
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Postural Control ◽  
Human Body ◽  
Sagittal Plane ◽  
The Body ◽  
Lower Limbs ◽  
Low Back ◽  
Pilates Method ◽  
The Relationship

Posture is commonly perceived as the relationship between the segments of the human body upright. Certain parts of the body such as the cephalic extremity, neck, torso, upper and lower limbs are involved in the final posture of the body. Musculoskeletal instabilities and reduced postural control lead to the installation of nonstructural posture deviations in all 3 anatomical planes. When we talk about the sagittal plane, it was concluded that there are 4 main types of posture deviation: hyperlordotic posture, kyphotic posture, rectitude and "sway-back" posture.Pilates method has become in the last decade a much more popular formof exercise used in rehabilitation. The Pilates method is frequently prescribed to people with low back pain due to their orientation on the stabilizing muscles of the pelvis. Pilates exercise is thus theorized to help reactivate the muscles and, by doingso, increases lumbar support, reduces pain, and improves body alignment.

Representation of a Human Body: A Comparison Study between Balinese and Javanese Traditional House

Humaniora ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 83-90
Author(s):  
Anak Agung Ayu Wulandari ◽  
Ade Ariyani Sari Fajarwati
Keyword(s):  
Comparative Study ◽  
Human Body ◽  
Qualitative Method ◽  
Descriptive Analysis ◽  
The Body ◽  
Comparison Study ◽  
Architectural Drawing ◽  
Study Approach ◽  
The Comparative Study ◽  
Head Area

The research would look further at the representation of the human body in both Balinese and Javanese traditional houses and compared the function and meaning of each part. To achieve the research aim, which was to evaluate and compare the representation of the human body in Javanese and Balinese traditional houses, a qualitative method through literature and descriptive analysis study was conducted. A comparative study approach would be used with an in-depth comparative study. It would revealed not only the similarities but also the differences between both subjects. The research shows that both traditional houses represent the human body in their way. From the architectural drawing top to bottom, both houses show the same structure that is identical to the human body; head at the top, followed by the body, and feet at the bottom. However, the comparative study shows that each area represents a different meaning. The circulation of the house is also different, while the Balinese house is started with feet and continued to body and head area. Simultaneously, the Javanese house is started with the head, then continued to body, and feet area.

A Comprehensive Review on Nanotechnology-Based Innovations in Topical Drug Delivery for the Treatment of Skin Cancer

2020 ◽  
Vol 26 (44) ◽  
pp. 5720-5731 ◽  
Author(s):  
Arun Singh Lalotra ◽  
Vishesh Singh ◽  
Bharat Khurana ◽  
Shelly Agrawal ◽  
Shubham Shrestha ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Systemic Exposure ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Toxic Substances ◽  
Abnormal Growth ◽  
Dermal Layer ◽  
Therapeutic Benefits ◽  
Carrier Systems

Background: Skin is the largest organ of the body and helps to regulate several physiological functions. It acts as a barrier that protects the body against UV-radiation, toxic substances, infections, etc. The abnormal growth of the skin cells is called skin cancer. Different types of skin cancer can be classified as Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC); which mainly occur due to chronic exposure to UV- sunlight and pollution. Methods: The conventional topical treatments of skin cancer such as cream, gel, ointment, etc., are more occlusive and thus they do not penetrate deep into the skin (dermal layer) and remain at the upper part of the skin (epidermal layer). The stratum corneum acts as a physiological barrier for the drug-loaded in the conventional formulation. The novel carrier systems have the potential to facilitate the penetration of the drug deep into the skin (dermal layer) because these have less size and higher flexibility than conventional treatment. Conclusion: In the present review, we have discussed various novel carrier systems being investigated for the topical application of chemotherapeutic agents for efficient skin targeting and better dermatological as well as therapeutic benefits with minimal systemic exposure and toxicity.

Toxicology

2017 ◽  
Author(s):  
Robert Laumbach ◽  
Michael Gochfeld
Keyword(s):  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Toxicity Testing ◽  
The Body ◽  
Toxic Substances ◽  
Basic Principles ◽  
Practical Applications ◽  
Mechanisms Of Toxicity ◽  
Body Distribution ◽  
Threshold Doses

This chapter describes the basic principles of toxicology and their application to occupational and environmental health. Topics covered include pathways that toxic substances may take from sources in the environment to molecular targets in the cells of the body where toxic effects occur. These pathways include routes of exposure, absorption into the body, distribution to organs and tissues, metabolism, storage, and excretion. The various types of toxicological endpoints are discussed, along with the concepts of dose-response relationships, threshold doses, and the basis of interindividual differences and interspecies differences in response to exposure to toxic substances. The diversity of cellular and molecular mechanisms of toxicity, including enzyme induction and inhibition, oxidative stress, mutagenesis, carcinogenesis, and teratogenesis, are discussed and the chapter concludes with examples of practical applications in clinical evaluation and in toxicity testing.

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