A Comprehensive Review on Nanotechnology-Based Innovations in Topical Drug Delivery for the Treatment of Skin Cancer

2020 ◽  
Vol 26 (44) ◽  
pp. 5720-5731 ◽  
Author(s):  
Arun Singh Lalotra ◽  
Vishesh Singh ◽  
Bharat Khurana ◽  
Shelly Agrawal ◽  
Shubham Shrestha ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Systemic Exposure ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Toxic Substances ◽  
Abnormal Growth ◽  
Dermal Layer ◽  
Therapeutic Benefits ◽  
Carrier Systems

Background: Skin is the largest organ of the body and helps to regulate several physiological functions. It acts as a barrier that protects the body against UV-radiation, toxic substances, infections, etc. The abnormal growth of the skin cells is called skin cancer. Different types of skin cancer can be classified as Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC); which mainly occur due to chronic exposure to UV- sunlight and pollution. Methods: The conventional topical treatments of skin cancer such as cream, gel, ointment, etc., are more occlusive and thus they do not penetrate deep into the skin (dermal layer) and remain at the upper part of the skin (epidermal layer). The stratum corneum acts as a physiological barrier for the drug-loaded in the conventional formulation. The novel carrier systems have the potential to facilitate the penetration of the drug deep into the skin (dermal layer) because these have less size and higher flexibility than conventional treatment. Conclusion: In the present review, we have discussed various novel carrier systems being investigated for the topical application of chemotherapeutic agents for efficient skin targeting and better dermatological as well as therapeutic benefits with minimal systemic exposure and toxicity.

scholarly journals Understanding Melanoma in Kids and Adults

2021 ◽  
Vol 9 ◽  
Author(s):  
Holly Neale ◽  
Jillian M. Richmond
Keyword(s):  
Skin Cancer ◽  
Young People ◽  
Early Diagnosis ◽  
Protective Clothing ◽  
Sun Exposure ◽  
The Body ◽  
The Sun ◽  
Abnormal Growth ◽  
Protective Actions

Did you know the reason behind wearing sunscreen is more than just preventing a sunburn? Sun damage to the skin over a lifetime can lead to the most dangerous type of skin cancer, called melanoma. Melanoma is abnormal growth of the pigment-producing cells of the skin, the same types of cells that make up moles. Though rare in young people, the risk for melanoma increases with age. Melanoma in kids looks and acts differently than it does in adults, often making the diagnosis challenging for doctors. Early diagnosis is important so that the melanoma can be removed and treated before it spreads to other parts of the body. Protective actions done in childhood, such as wearing sunscreen, avoiding excessive sun exposure, and wearing protective clothing when out in the sun, will help to prevent melanoma later in life.

scholarly journals Skin Cancer Diagnostic using Machine Learning Techniques - Stationary Wavelet Transform and Random Forest Classifier

2019 ◽  
Vol 9 (2) ◽  
pp. 4705-4708
Keyword(s):  
Wavelet Transform ◽  
Skin Cancer ◽  
Random Forest ◽  
Sensitivity And Specificity ◽  
Image Features ◽  
The Body ◽  
Machine Learning Techniques ◽  
Stationary Wavelet Transform ◽  
Abnormal Growth ◽  
Learning Techniques

The abnormal growth of skin cells in the skin is known as skin cancer. It develops in skin due to exposure of the sun. Skin cancer spreads into other parts of the body easily. The death rate of skin cancer is increasing day by day, so, early diagnosis of skin cancer is necessary. In this paper, an efficient method for skin image classification using Stationary Wavelet Transform (SWT) based entropy features and Random Forest (RF) classifier is presented. The input skin images are decomposed by SWT. The skin image features are extracted by the entropy of decomposed skin images and classified using RF classifier. The performance of the system is evaluated in terms of accuracy, sensitivity and specificity. The results show the better classification accuracy of 91.5% at the 3rd level of SWT decomposition based on entropy features and RF classifier, and also their sensitivity and specificity are 90 % and 93 %..

scholarly journals Behavioral factors associated with the development of skin cancer in patients of arsenicosis

2018 ◽  
Vol 11 (2) ◽  
pp. 103
Author(s):  
Towhida Noor ◽  
Md. Shahidullah Sikder ◽  
Lubna Khondker ◽  
Mohammed Saiful Islam Bhuiyan ◽  
Tanvir Rahman
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Sun Exposure ◽  
The Body ◽  
Case Group ◽  
Skin Carcinoma ◽  
Bowen’S Disease ◽  
Behavioral Factors ◽  
Bowen's Disease ◽  
Factors Associated

<p>The study was conducted to evaluate the behavioral factors associated with the development of skin cancer in arsenicosis patients. Arsenicosis patients without skin cancer were taken as control. In the sun-exposed area of the body, 57.2% of skin carcinoma was Bowen’s disease. In the covered area of the body, 56.0% was Bowen’s disease, 36% was squamous cell carcinoma and 8% was basal cell carcinoma. Again, 53.1% of case and 59.4% of control never used fertilizer and pesticide. The majorities were non-smoker (case 53.1%, control 59.3%). Mean cumulative sun exposure was more in the case group (5853.9 ± 2219.7 hours) than in the control group (2219 ± 392.4 hours) and the rate of sun exposure was also higher in the case group. In conclusion, sun exposure was significantly higher in carcinoma patients and since most of the lesions were in the covered areas of the body, it can be said that these carcinomas were due to arsenicosis and not due to sun exposure and smoking status, use of fertilizer and pesticides were not associated with the development of skin carcinoma.</p>

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

Immunological mechanisms of chronic liver lesions under the influence of chemicals

2020 ◽  
pp. 536-537
Author(s):  
G. S. Agzamova ◽  
M. M. Abdullaeva
Keyword(s):  
The Body ◽  
Chronic Liver ◽  
Toxic Substances ◽  
Liver Lesions ◽  
Industrial Chemicals ◽  
Toxic Agent ◽  
Chronic Poisoning ◽  
Immunological Mechanisms ◽  
T System

The immunological profile of chronic liver lesions depending on the toxic agent was studied. It was revealed that chronic poisoning by industrial toxic substances causes changes in the functional state of the T-system of immunity, long-term contact with industrial chemicals leads to increased sensitization to autoantigens of the body.

ANDROID APPLICATION FOR DETECTION OF SKIN CANCER USING EXPERT SYSTEM

2018 ◽  
Vol 2 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Yogi Udjaja
Keyword(s):  
Risk Factor ◽  
Expert System ◽  
Skin Cancer ◽  
Cancer Cells ◽  
System Application ◽  
Ultraviolet Rays ◽  
The Sun ◽  
Android Application ◽  
Abnormal Growth ◽  
Skin Cells

Skin cancer is an abnormal growth of human skin that can damage skin cells. By knowing the symptoms of skin cancer as early as posssible, it is helpful in preventing the spread of cancer cells and treatment. There are many factors that cause skin cancer, but in general the cause is exposure to ultraviolet rays from the sun.  Therefore, an expert system application is required to detect skin cancer.  By using backward chining and probalility methode; which data is in form of someone’s risk factor and clinical sympthoms, then the application will provide temporary diagnosis.  This application is built in an android platfrom because in its development android is more used than other platforms. The accuracy obtained from this application is 96.67%.

Determination of Lead Content in Red Colored Lipsticks from Mandalay Market by Flame Atomic Absorption Spectrophotometer

2018 ◽  
Vol 30 (3) ◽  
pp. 167-173
Keyword(s):  
Sampling Procedure ◽  
The Body ◽  
Lead Content ◽  
Social Psychological ◽  
Allowable Limit ◽  
Flame Atomic Absorption ◽  
Therapeutic Benefits ◽  
Flame Atomic Absorption Spectrophotometer ◽  
Exposure Levels

Red colored lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because some lipsticks contain a considerable amount of heavy metal especially lead. Lead is being used in lipstick mainly for the pigments required to obtain needed colors. Lead accumulates in the body over time and lead-containing lipstick applied several times a day, every day, combined with lead in water and other sources, could add up to significant exposure levels. Therefore, this study was aimed to determine lead content in red colored lipsticks from market. This study was laboratorybased, analytical study by using 25 lipstick samples. Red colored lipsticks were bought from Mandalay Market by random sampling procedure and they were completely coded to avoid the bias. Then, lead content in coded samples was determined by Flame AAS according to International Conference on Harmonization (ICH) guideline. Lead contents of 88% of the lipsticks samples were more than specified limit (20 ppm) of Food and Drug Administration, United States. All of them, lead content was highest in counterfeit lipsticks group. Among the tested lipstick samples, lipstick with lowest lead content was LE-RL 01 (15.74 ppm) and the lipstick with highest lead content was CF-RL 01(60.09 ppm). In conclusion, lead contents of red colored lipsticks (22 out of 25) from market samples were higher than allowable limit (20 ppm).

Study of 5-Fluorouracil Loaded Chitosan Nanoparticles for Treatment of Skin Cancer

2020 ◽  
Vol 14 (3) ◽  
pp. 210-224
Author(s):  
Gayatri Patel ◽  
Bindu K.N. Yadav
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Chitosan Nanoparticles ◽  
Entrapment Efficiency ◽  
Fractional Factorial ◽  
Spherical Particles

Background: The purpose of this study was to formulate, characterize and in-vitro cytotoxicity of 5-Fluorouracil loaded controlled release nanoparticles for the treatment of skin cancer. The patents on nanoparticles (US8414926B1), (US61654404A), (WO2007150075A3) etc. helped in the selection polymers and method for the preparation of nanoparticles. Methods: In the present study nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and sodium tripolyphosphate (TPP). Several process and formulation parameters were screened and optimized using 25-2 fractional factorial design. The prepared nanoparticles were evaluated for particle size, shape, charge, entrapment efficiency, crosslinking mechanism and drug release study. Results: The optimized 5-Fluorouracil loaded nanoparticle were found with particle size of of 320±2.1 nm, entrapment efficiency of 85.12%± 1.1% and Zeta potential of 29mv±1mv. Scanning electron microscopy and dynamic light scattering technique revealed spherical particles with uniform size. The invitro release profile showed controlled release up to 24 hr. Further study was carried using A375 basal cell carcinoma cell-line to elucidate the mechanism of its cytotoxicity by MTT assay. Conclusion: These results demonstrate that the possibility of delivering 5-Fluorouracil to skin with enhanced encapsulation efficiency indicating effectiveness of the formulation for treatment of basal cell carcinoma type of skin cancer.

Formulation, Characterization and In vitro Cytotoxicity of 5-Fluorouracil Loaded Polymeric Electrospun Nanofibers for the Treatment of Skin Cancer

2019 ◽  
Vol 13 (2) ◽  
pp. 114-128 ◽  
Author(s):  
Gayatri Patel ◽  
Bindu K.N. Yadav
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Viability ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Fiber Diameter ◽  
Electrospun Nanofibers ◽  
In Vitro Cytotoxicity ◽  
Fractional Factorial

Background: The purpose of this study was to formulate, characterize and conduct in vitro cytotoxicity of 5-fluorouracil loaded polymeric electrospun nanofibers for the treatment of skin cancer. The patents on electrospun nanofibers (US9393216B2), (US14146252), (WO2015003155A1) etc. helped in the selection of polymers and method for the preparation of nanofibers. Methods: In the present study, the fabrication of nanofibers was done using a blend of chitosan with polyvinyl alcohol and processed using the electrospinning technique. 5-fluorouracil with known chemotherapeutic potential in the treatment of skin cancer was used as a drug carrier. 24-1 fractional factorial screening design was employed to study the effect of independent variables like the concentration of the polymeric solution, applied voltage (kV), distance (cm), flow rate (ml / hr) on dependent variables like % entrapment efficiency and fiber diameter. Results: Scanning electron microscopy was used to characterize fiber diameter and morphology. Results showed that the fiber diameter of all batches was found in the range of 100-200 nm. The optimized batch results showed the fiber diameter of 162.7 nm with uniform fibers. The tensile strength obtained was 190±37 Mpa. Further in vitro and ex vivo drug release profile suggested a controlled release mechanism for an extended period of 24 hr. The 5-fluorouracil loaded electrospun nanofibers were found to decrease cell viability up to ≥50% over 24 hr, with the number of cells dropping by ~ 10% over 48 hr. As the cell viability was affected by the release of 5-fluorouracil, we believe that electrospun nanofibers are a promising drug delivery system for the treatment of Basal Cell Carcinoma (BCC) skin cancer. Conclusion: These results demonstrate the possibility of delivering 5-Fluorouracil loaded electrospun nanofiber to skin with enhanced encapsulation efficiency indicating the effectiveness of the formulation for the treatment of basal cell carcinoma type of skin cancer.

Novel Nanolipoidal Systems for the Management of Skin Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 108-125
Author(s):  
Apoorva Singh ◽  
Nimisha
Keyword(s):  
Skin Cancer ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
The Body ◽  
Surgical Removal ◽  
The Novel ◽  
Skin Cancers ◽  
Recent Developments ◽  
Abnormal Cells ◽  
The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

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