scholarly journals Activity of Tulsi leaves (Ocimum sanctum linn) in protecting gastric ulcer in rats by cold restrain method

2017 ◽  
Vol 6 (10) ◽  
pp. 2343
Author(s):  
Ayesha Vaseem ◽  
Mazher Ali ◽  
Khuteja Afshan
Keyword(s):  
Leaf Extract ◽  
Mucosal Injury ◽  
Gastric Ulcers ◽  
Ocimum Sanctum ◽  
Control Group ◽  
Albino Rats ◽  
Dependent Manner ◽  
Standard Drug ◽  
Aqueous Leaf Extract ◽  
Pre Treatment

Background: Tulsi (Ocimum sanctum L.) common household plant, a potent adaptogen has been used for its medicinal property for many years. It is known in Ayurveda as Incomparable one, Mother of medicine of Nature and The Queen of Herbs. The present study evaluated the stress induced anti-ulcer effect of tulsi leaves in albino rats.Methods: Albino rats were randomly, allocated to different experimental groups and aqueous leaf extract of Tulsi (Ocimum sanctum) is given for 7 days. Gastric ulcers were induced by cold restrain methods and results were compared with control using distilled water and standard drug Ranitidine.Results: The Anti-ulcer effect of aqueous extract of Tulsi was significant in a dose dependent manner with cold restraint model. The percentage of ulcer protection of Tulsi leaf extract at dose 100mg/kg is 68.85% and at dose of 200mg/kg showed 65.66% and the standard drug Ranitidine showed 78.23% ulcer protection which is significant (p <0.05).Conclusions: The study showed that when Tulsi (Ocimum sanctum) is given at dose 100-200mg/kg for 7 days i.e., pre-treatment in rats for anti-ulcer effect, it caused a significant reduction in the ulcer scores and ulcer index when compared with control group, as evidenced by the gross appearance and histological findings of gastric mucosa in rats. There were few signs of mucosal injury and the percentage of damage was less compared to control group. Serosal surface revealed very few dilated blood vessels and petechial hemorrhages and mucosal surface had few ulcers of varying sizes.

scholarly journals Pre-treatment effects against the diclofenac-induced toxicity by the aqueous leaf extract of Madhuca longifolia on female Wistar albino rats for 10 and 15 days

2020 ◽  
pp. 132-143
Author(s):  
Jerine Peter Simon ◽  
Sibi Karthik Saravanan ◽  
Jayashree Sathiyaranayanan ◽  
Radhakrishnan Vidya ◽  
Usha Kumari ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Group I ◽  
Madhuca Longifolia ◽  
Aqueous Leaf Extract ◽  
Pre Treatment ◽  
Wistar Albino Rats ◽  
Enzyme Markers

Diclofenac is used to treat rheumatism disorders, which are associated with the damages of renal, gastric and hepatic organs. Diclofenac is a pharmaceutical drug that is known to induce toxicity on its overdosage and long-term usage. Madhuca longifolia is known to have antioxidant, anti-inflammatory and anti-ulcer activity. It is an evergreen tree that is reported to have many ethnomedicinal uses. The other properties of Madhuca longifolia include anti-diabetic, analgesic and anti-microbial activities. Our study aims to evaluate the pre-treatment activity against the diclofenac-induced toxicity by the Madhuca longifolia aqueous leaf extract in Wistar albino rats for 10 and 15 days. Rats were divided as Group-I: Normal control, Group-II: Diclofenac on the last two days, Group-III and group-IIIa: Diclofenac + Aqueous Leaf Extract of Madhuca longifolia, Group-IV and group-IVb: Diclofenac + Silymarin, Group -V and group-Va: Aqueous Madhuca longifolia leaf extract. After the sacrifice, the rats were studied for antioxidant assay, renal enzyme markers, liver enzyme markers, and histopathological analysis of the kidney, stomach, intestine, and liver. As a result, we could identify that Madhuca longifolia has reduced the toxic changes in rats caused by diclofenac.

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

Antihypertensive and Cardio-Protective Potentials of Ethanolic Leaf Extract of Mucuna Pruriens in Male Albino Rats

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Joseph Minari ◽  
G.E Nwosu ◽  
E.E Agho ◽  
B.O Sholaja
Keyword(s):  
Leaf Extract ◽  
Treatment Options ◽  
Mucuna Pruriens ◽  
White Blood Count ◽  
Control Group ◽  
Albino Rats ◽  
Protective Effects ◽  
Standard Drug ◽  
Hematological Indices ◽  
Ethanolic Leaf Extract

Hypertension is a risk factor for a variety of morbidities, especially stroke, myocardial infarction, and the development of congestive heart failure, as well as death. Several treatment options are used for treatment of hypertension; however, a lot of short comings have been associated with them. In order to proffer a possibly better and cheaper means of preventing hypertension, this study aims at investigating the antihypertensive and cardio-protective effects of the ethanolic leaf extract of Mucuna pruriens. Thirty-six male albino rats were used for the study. Oral administration of 8% salt diet was used to induce hypertension which significantly increased blood pressure and oxidative stress in the hypertensive animals compared to the control group. The phytochemical screening of the extract was carried out, the weight of the experimental animals was monitored, hematological indices was assessed, and systolic and diastolic rates were evaluated at different concentrations of the extract. The screening indicated the presence of tannin, saponins, flavonoids, terpenoids, and phenols while reducing sugars, cardiac glycosides, glycoside, alkaloids and steroids were absent. The weight of the liver of rats given standard drug, 150 mg/ml of the extract, 250 mg/ml of the extract and untreated groups were significant lower (p<0.05) when compared with the control group while the group administered with 100 mg/ml was higher. The white blood count

scholarly journals Phytochemical screening and diuretic activity of Euphorbia granulata

2015 ◽  
Vol 10 (3) ◽  
pp. 584 ◽  
Author(s):  
Hammad Saleem ◽  
Irshad Ahmad ◽  
M. Shoaib Ali Gill
Keyword(s):  
Reference Group ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
Dependent Manner ◽  
Diuretic Activity ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Diuretic Agent

<p>The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of <em>Euphorbia granulate</em> in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The three doses of extract (30, 50 and 100 mg/kg) were given to rats (i.p) in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. The extract induced diuretic effects and induced electrolytes excretion in a dose-dependent manner when compared with control. The extract (100 and 50 mg/kg) significantly (p&lt;0.01) increased the volume of urine in comparison to control group. Similarly, the excretion of potassium and sodium were also significantly (p&lt;0.05) increased following extract administration. However, there was no significant change in the pH of urine samples of the extract-treated group compared with control. The result of this study thus offers support to the traditional folker use of this plant as a diuretic agent.</p><p> </p>

scholarly journals Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

2014 ◽  
Vol 2 (2) ◽  
pp. 217-221 ◽  
Author(s):  
J. M. Jacob ◽  
M. T. Olaleye ◽  
J. A. O. Olugbuyiro
Keyword(s):  
Vitamin E ◽  
Liver Damage ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Albino Rats ◽  
Dependent Manner ◽  
Antioxidant Agents

Ethnopharmacological relevance: The dry leaf of Alchornea cordifolia (AC) is used, in traditional medicine in the S Nigeria, for the preparation of blood tonic, remedies for urinary, respiratory, liver and gas intestinal disorders. Aim of the study: This study investigated the protective property of AC leaf against liver damage in animals with a view to exploring its use for the treatment of hepatotoxicity in humans. Material and methods:  Ethanol extract of A. cordifolia was used to study the hepatoprotective activity in acetaminophen-induced Albino rats (150-200g). Animals in Group 1 served as vehicle control, Group 2 served as hepatotoxin (Acetaminophen 2g/kg treated) group, Groups 3 and 4 served as positive control (Vitamin E and Curcumin 100 mg/kg bw respectively) groups, and Groups 5-8 served as (200-500mg/kg bw) AC leaf extract treated groups while Group 9 served as normal group (AC extract only 300 mg/kg bw). Results: The hepatotoxic group showed hepatocytic necrosis, cellular infiltration and inflammation in the liver. The treatment group restored the liver cells to their normal lobular architecture in a dose dependent manner. The protection offered by the plant extract compared well with the standard antioxidant agents (Curcumin and Vitamin E). Tannins, flavonoids, alkaloids and saponins were detected in the phytochemical screening. Conclusion: Our findings suggest Alchornea cordifolia ethanol leaf extract as promising herpatoprotective herb and give credence to the folkloric use of this plant for the treatment of liver problems.DOI: http://dx.doi.org/10.3126/ijasbt.v2i2.10473Int J Appl Sci Biotechnol, Vol. 2(2): 217-221 

scholarly journals Evaluation of antiulcerogenic activity of combination of Aloe vera and Aegle marmelos in indomethacin induced gastric ulcers

2019 ◽  
Vol 8 (3) ◽  
pp. 453
Author(s):  
Leela Hugar ◽  
Ramesh H.
Keyword(s):  
Side Effects ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Test Group ◽  
Peptic Ulceration ◽  
Gastric Ulcers ◽  
Control Group ◽  
Albino Rats ◽  
Aegle Marmelos ◽  
Ulcer Index

Background: Most important adverse effect of NSAID is peptic ulceration. Even though H2 blockers and proton pump inhibitors are effective in preventing NSAID associated peptic ulceration, they are not without side effects. Hence there is a need for drugs which are effective in preventing NSAID induced peptic ulcer without producing side effects. Two plant products Aloe vera leaf extract and Aegle marmalos leaves are commonly used in Indian traditional medicine for treatment of peptic ulcers. Hence this study is undertaken to assess the antiulcerogenic potential of combination of these two drugs in comparison with ranitidine in preventing NSAID induced peptic ulcers.Methods: 18 albino rats were divided into 3 groups of 6 rats each. Group A: received ulcerogen only. Group B: pretreated with ranitidine before exposing to ulcerogen. Group C: pretreated with combination of Aloe vera and Aegle marmelos before exposing to ulcerogen. Two doses of indomethacin were administered at an interval of 15 hrs. Animals were sacrificed 6 hrs after the second dose of Indomethacin. Number of ulcers was noted, and ulcer index was calculated.Results: There was significant reduction in total score, mean score and ulcer index in ranitidine pretreated group and test compound group as compared to control group. Even though the total score and ulcer index in test group were lesser as compared to standard control group, it was not statistically significant.Conclusions: Combination of Aloe vera leaf extract and Aegle marmelos leaf extract produced very significant protection against indomethacin induced gastric ulcer.

scholarly journals Evaluation of Antiulcer Activity of Laghusoothshekhar (an Ayurvedic Formula) in Pyloric Ligature Induced Gastric Ulcers in Albino Rats

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Nilofer Sayed ◽  
Vandana Barve
Keyword(s):  
Basolateral Membrane ◽  
Gastric Ulcers ◽  
Control Group ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Standard Drug ◽  
Group A ◽  
Group B ◽  
Pyloric Ligation

Laghusoothshekhar is an ayurvedic formula widely used for gastritis and peptic ulcers that has been described in various ayurvedic texts such as Bharat Bhaishajya Ratnakar, Ayurved saar sangraha and Nav samhita with slight variations in their ingredients. Marketed formulas from the first two references are available but the study of this formula from nav samhita is not yet carried out nor is it available commercially. It is a simple formula of few ingredients and is widely prepared and used by ayurvedic practitioners for treating gastritis (both acute and chronic) and peptic ulcers. Hence, efforts were taken to evaluate its antiulcer activity. Four groups comprising of six animals each were studied. Control Group: vehicle (2% w/v gum acacia), Group A: (50 mg/kg), Group B: (100 mg/kg), Group C: ranitidine (25 mg/kg). One hour after the last dose, pyloric ligation was done and animals were deprived of food and water for 4 hours, thereafter sacrificed and the number of ulcers and their severity was calculated. Both the doses of Laghusoothshekhar showed significant anti-ulcer activity and the histopathological findings of the gastric tissues confirmed the same. The results proved that the drug is as efficient as the standard drug ranitidine used in the treatment of gastritis and peptic ulcers. Ranitidine inhibits acid production by reversibly blocking H2 receptors on the basolateral membrane of parietal cells in the stomach. KEYWORDS: Laghusoothshekhar; Pyloric Ligation; Ranitidine; Nav Samhita; Ayurveda; Amlapitta; Peptic Ulcers; Gastritis; Naagvel Patra; Ginger; Suvarna Gairik

scholarly journals Effects of aqueous leaf extract of Tithonia diversifolia (Mexican Sunflower) on semen characteristic and morphology in male Wistar albino rats

2015 ◽  
Vol 42 (2) ◽  
pp. 263-270
Author(s):  
J. O. Olukunle ◽  
E. B. Jacobs ◽  
J. A. Oyewusi ◽  
L. A. Durotoye ◽  
E. O. Adeleye
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Albino Rats ◽  
Tithonia Diversifolia ◽  
Aqueous Leaf Extract ◽  
Dose Dependent Decrease ◽  
Dose Dependent

The objective of the present study was to investigate the effects of the aqueous extract of Tithonia diversifolia leaves on semen characteristics and spermatozoa morphology Wistar rats. The rats were divided into three groups (A, B and C) and treated daily with 400, 800 and 1600 mg/kg of the aqueous extract of Tithonia diversifolia leaves respectively for 28 days while 5ml/kg of distilled water was given to the control group D. At the end of the experimental period, animals were sacrificed and sperm characteristics, histology of the testes and epididymis were assessed. Aqueous extract of Tithonia diversifolia leaves caused a dose-dependent decrease in the progressive sperm motility of the Wistar rats with a significant decrease (p<0.05) in the group dosed with 1600mg/kg (62.50±7.5) when compared with the control (93.75±1.3). It also cause a dose-dependent decrease in the sperm count with a significant (p<0.05) decrease in the group dosed with 1600mg (69.75±0.5) when compared with the control (129.0±5.0). Some sperm abnormalities vise headless tail (321.5±0.3), tailless head (171.00±50.0) and bent tail (3766.0±320.5) were significantly increased in the group dosed with 1,600mg/kg while histopathological evaluation of the festis and epididymis revealed varying degrees of degeneration and necrosis of the germinal epithelia cell of the seminiferous tubules. Spermiostasis and complete epididymal aspermia were also observed. Tithonia diversifolia aqueous leaf extract has significant anti-spermatogenic effects on adult male Wistar rats which could impair reproductive activities in these rats.

scholarly journals The Impact of Aqueous Leaf Extract of Soursop on Glucose and Lipid Profile in Alloxan Induced Diabetic Albino Rats

2021 ◽  
pp. 13-19
Author(s):  
P. E. Ejembi ◽  
J. I. Oche ◽  
J. O. Ejembi ◽  
L. S. Zaccheaus
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Diabetes Management ◽  
Diabetic Rats ◽  
Total Serum ◽  
Albino Rats ◽  
Total Serum Cholesterol ◽  
Standard Drug ◽  
Aqueous Leaf Extract ◽  
The Impact

The blood glucose, total serum cholesterol, High Density Lipoprotein (HDL) and Triglyceride (TRIG) levels of all rats in each group were determined before induction, post-induction with alloxan and post treatment with various concentrations of extract and standard drug. The alloxan diabetic rats treated with gliberclamide and aqueous leaf extract of Annona muricata showed average means of body weights as; (235.73±3.14a, 263.94±2.25a and 236.5±1.74a) respectively after 4 weeks of treatment. The Glucose level revealed; 168.43±5.06e, 65.29±4.57f and 57.86±3.93e respectively. Lipid profile raised significantly post exposure of diabetic rats to both standard drug and extract after 4 weeks of treatment. Therefore, A. muricata compared favorably with the standard drug in the context of diabetes management.

scholarly journals Antidiabetic activity of Manomani chooranam aqueous extract on female wistar albino rats

2019 ◽  
Vol 8 (9) ◽  
pp. 2153
Author(s):  
Sabari Anandh J. V. ◽  
Manimekalai Kumarappan ◽  
Padmavathi Shanmuganathan ◽  
Subha Vinayagam ◽  
Iyyankannu . ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Aqueous Extract ◽  
Blood Sugar Level ◽  
Control Group ◽  
Albino Rats ◽  
Dependent Manner ◽  
Standard Drug ◽  
The Mean ◽  
Group 2 ◽  
Wistar Albino Rats

Background: The aim of the present study was to evaluate the antidiabetic potential of Manomani chooranam (MMC), an indigenous polyherbal siddha formulation in Streptozotocin (STZ) induced diabetic female Wistar albino rats.Methods: Aqueous extract of MMC was prepared. Wistar albino rats were divided into six groups (n=6). Group 1 was kept as normal control, Group 2, 3, 4, 5 and 6 were induced diabetes. After induction, the group 2 was kept as diabetes control; Group 3 received the standard drug metformin (100 mg/kg), whereas Groups 4, 5 and 6 were treated with the aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg doses, respectively for the 21 days. Blood sugar was estimated at the end of each week. At the end of the study, rats were sacrificed and the pancreas was analyzed for histopathological changes. Data expressed as mean±standard error of the mean. Statistical analysis was done using one-way ANOVA followed by post hoc Tukey's test. p<0.05 considered statistically significant.Results: The groups which received aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg showed a significant decrease in the mean blood sugar level when compared to normal level. The groups which received MMC shows significant reduction in blood sugar level in comparison with standard drug metformin 100 mg/kg.Conclusions: The aqueous extract of MMC was able to decrease the elevated blood sugar levels in dose dependent manner.

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