Prevalence of metabolic syndrome among postmenopausal women in South India

Background: As the average life expectancy of women extends 20-30 years after menopause, the medical impacts of changes leading to metabolic syndrome on postmenopausal women are significant. The menopausal state has been noted to be an independent risk factor for the occurrence of metabolic syndrome. This study was conducted to look at the prevalence of metabolic syndrome in postmenopausal women.Methods: A prospective cross sectional study was done and postmenopausal women were assessed for metabolic syndrome using the International Diabetes Federation Criteria.Results: The prevalence of metabolic syndrome was found to be 64%. Women with metabolic syndrome had a higher systolic blood pressure and larger waist circumference, however did not differ in terms of diabetes and dyslipidemia. There was no significant difference with regards to frequency and severity of menopausal symptoms between women with and without metabolic syndrome.Conclusions: The increased prevalence of metabolic syndrome in postmenopausal women may be directly due to ovarian insufficiency and indirectly due to metabolic consequences of central fat redistribution with estrogen deficiency.

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Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C

LaboratoriumsMedizin ◽

10.1515/labmed-2018-0042 ◽

2018 ◽

Vol 0 (0) ◽

Author(s):

Aleksandra Klisic ◽

Nebojsa Kavaric ◽

Ivan Soldatovic ◽

Ana Ninic ◽

Jelena Kotur-Stevuljevic

Keyword(s):

Metabolic Syndrome ◽

Postmenopausal Women ◽

Cystatin C ◽

Significant Relationship ◽

Binding Protein ◽

International Diabetes Federation ◽

Retinol Binding Protein ◽

Cross Sectional ◽

Retinol Binding Protein 4 ◽

Significant Difference

Abstract Background Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p=0.011 vs. p<0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (χ2=5.1, p=0.025, and χ2=11.1, p=0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p=0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p=0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p=0.009), but also even after adjustment for age, inflammation level and duration of menopause (p=0.006). Conclusions RBP4 better correlates with MetS than cystatin C in postmenopausal women.

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Influence of 5-HTR2C Polymorphisms on Metabolic Syndromes in Thai Schizophrenia Patients

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.2057 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S168-S168

Author(s):

A. Puangpetch ◽

C. Na Nakorn ◽

W. Unaharassamee ◽

C. Sukasem

Keyword(s):

Metabolic Syndrome ◽

International Diabetes Federation ◽

Cross Sectional Study ◽

Nucleotide Polymorphisms ◽

Cross Sectional ◽

Female Patients ◽

The Metabolic Syndrome ◽

Significant Difference ◽

Male Patients ◽

Competing Interest

IntroductionMetabolic syndrome is a significant problem in the schizophrenia patients. Previous research demonstrated that single nucleotide polymorphisms in the serotonin 2C receptor (5HTR2C) genes are associated with metabolic syndrome related to schizophrenia patients taking atypical anti-psychotic drugs. This study aimed to investigate whether the effect of 3 SNPs in 5HTR2C gene on the presence of the metabolic syndrome in Thai schizophrenia patients.MethodWe conducted a cross-sectional study and 154 patients were recruited. The schizophrenia patients were identified from a diagnostic and statistical manual of mental disorders, 4th edition, (DSM-IV) and criterion and determined the metabolic syndrome according to the 2005 international diabetes federation (IDF) Asia criteria. Patients were genotyped for the 5HTR2C rs51,8147, rs126,881,02, rs128,367,71 polymorphisms.ResultsThe preliminary analysis from 154 patients showed the metabolic syndrome prevalence was 38.73%, with 46.50% in male and 53.48% in female patients. The results showed that the patients who have heterozygous and homozygous variant on 5HTR2C gene (rs518,147 and rs126,881,02) showed a significant difference in the presence of metabolic syndrome when compare with patients who carry homozygous wild type (P = 0.007), especially in male patients (P = 0.002). The association between 5HTR2C polymorphisms and metabolic syndrome was found in male patients but not found in female patients.ConclusionThese findings suggest that 5HTR2C genotypes are associated with the metabolic syndrome in patients taking atypical anti-psychotics. However, the metabolic syndrome results from the multigenetic effects. The further studies should focus on the other genes, which were involved in metabolic syndrome.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C

Journal of Laboratory Medicine ◽

10.1515/labmed-2018-0325 ◽

2019 ◽

Vol 43 (1) ◽

pp. 29-34

Author(s):

Aleksandra Klisic ◽

Nebojsa Kavaric ◽

Ivan Soldatovic ◽

Ana Ninic ◽

Jelena Kotur-Stevuljevic

Keyword(s):

Metabolic Syndrome ◽

Postmenopausal Women ◽

Cystatin C ◽

Significant Relationship ◽

Binding Protein ◽

International Diabetes Federation ◽

Retinol Binding Protein ◽

Cross Sectional ◽

Retinol Binding Protein 4 ◽

Significant Difference

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Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

Metabolites ◽

10.3390/metabo12010073 ◽

2022 ◽

Vol 12 (1) ◽

pp. 73

Author(s):

Renata Vargas Sinatora ◽

Eduardo Federighi Baisi Chagas ◽

Fernando Otavio Pires Mattera ◽

Luciano Junqueira Mellem ◽

Ana Rita de Oliveira dos Santos ◽

...

Keyword(s):

Metabolic Syndrome ◽

Postmenopausal Women ◽

Diagnostic Criteria ◽

Body Fat ◽

International Diabetes Federation ◽

Body Fat Percentage ◽

Fat Percentage ◽

Cross Sectional ◽

Tnf Α ◽

Significant Difference

The increased deposition of visceral fat in the postmenopause period increases the production of inflammatory cytokines and the release of tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), and decrease in IL-10. This study investigated the relationship between inflammatory biomarkers and metabolic syndrome (MS) in postmenopausal women considering different diagnostic criteria. We conducted a cross-sectional observational study based on STROBE. Data were collected regarding the diagnostic criteria for MS (International Diabetes Federation; NCEP (International Diabetes Federation (IDF), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III), and Harmonized criteria), body composition, comorbidities, time without menstruation, values of IL-6, IL-10, and TNF-α. ANOVA, Kruskal–Wallis, Levene tests, ROC, and odds ratio were performed to analyze the data. The results showed no significant difference between the methods and no interaction between the method and the presence of MS. However, for the values of WC, body fat percentage, TNF-α, and IL-10/TNF-α ratio, a significant effect of MS was observed. In subjects with MS, lower values of body fat percentage and TNF-α and higher values of the IL-10/TNF-α ratio were also observed. The higher IL-10/TNF-α ratio in the MS group is related to the greater anti-inflationary action of IL-10. The IL-10/TNF-α ratio showed significant accuracy to discriminate patients with MS according to the NCEP-ATP III criteria.

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Metabolic Syndrome in HIV-patients in Antiretroviral Therapy

Current HIV Research ◽

10.2174/1570162x18666200609115615 ◽

2020 ◽

Vol 18 (6) ◽

pp. 388-395

Author(s):

Daniel Vargas-Pacherrez ◽

Helma P. Cotrim ◽

Leonardo Pires ◽

Vitor Cunha ◽

Vitor Coelho ◽

...

Keyword(s):

Metabolic Syndrome ◽

Antiretroviral Therapy ◽

International Diabetes Federation ◽

Cross Sectional Study ◽

People Living With Hiv ◽

Anthropometric Data ◽

Cross Sectional ◽

History Of ◽

Family History Of Hypertension ◽

Living With Hiv

Introduction: The global prevalence of metabolic syndrome (MS) among people living with HIV/AIDS varies from 20% to 33%. Objective: to estimate the prevalence of metabolic syndrome and associated factors in a group of HIV-infected patients on antiretroviral therapy. Methods: This is a cross-sectional study with HIV-infected patients from a reference center in Bahia, Brazil. We evaluated clinical, socio-demographic and anthropometric data. MS was defined according to the guidelines of International Diabetes Federation. Results: We evaluated 152 patients with mean age of 47.3±11.6 years, 59.2% male. The main comorbidities detected were diabetes (3.3%) hypertriglyceridemia (9.3%) and metabolic syndrome (MS,38.2%). Patients with MS were predominantly women (55.2% vs 31.9%; p=0.005), older [52.1 (10.4) vs 44.3 (11.3); p<0.001], and had overweight (74.1% vs 23.4%; p<0.001). After multivariate analysis MS remained associated with age (OR = 1.076; 95% CI: 1.030 – 1.125), female sex (OR = 2.452; 95% CI: 1.114 – 5.374) and family history of hypertension (OR = 3.678; 95% CI: 1.431 – 9.395). Conclusion: Almost half of the HIV-infected patients in Bahia presents with MS which seems to be driven by classical risk factors.

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Association of Dietary Patterns with Metabolic Syndrome: Results from the Kardiovize Brno 2030 Study

Nutrients ◽

10.3390/nu10070898 ◽

2018 ◽

Vol 10 (7) ◽

pp. 898 ◽

Cited By ~ 29

Author(s):

Antonella Agodi ◽

Andrea Maugeri ◽

Sarka Kunzova ◽

Ondrej Sochor ◽

Hana Bauerova ◽

...

Keyword(s):

Metabolic Syndrome ◽

Dietary Patterns ◽

Dietary Pattern ◽

International Diabetes Federation ◽

Principal Component ◽

Cross Sectional Study ◽

Cross Sectional ◽

Logistic Regression Models ◽

Western Dietary Pattern ◽

High Adherence

Although metabolic syndrome (MetS) could be handled by lifestyle interventions, its relationship with dietary patterns remains unclear in populations from Central Europe. Using data from the Kardiovize Brno cohort, the present study aims to identify the main dietary patterns and to evaluate their association with MetS risk in a random urban sample from Brno, Czech Republic. In a cross-sectional study of 1934 subjects aged 25–65 years (44.3% male), dietary patterns were derived by food frequency questionnaire (FFQ) administration and principal component analysis. Metabolic syndrome was defined according to the International Diabetes Federation statement. Logistic regression models were applied. High adherence to the prudent dietary pattern was associated with lower odds of abdominal obesity, abnormal glucose concentration, and MetS. By contrast, high adherence to the western dietary pattern was associated with higher odds of abnormal glucose, triglycerides and blood pressure levels. Whilst our results confirm the deleterious effect of a western dietary pattern on several metabolic risk factors, they also indicate that the consumption of a diet rich in cereals, fish, fruit and vegetables is associated with a healthier metabolic profile. However, further prospective research is warranted to develop and validate novel potential preventive strategies against MetS and its complications.

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Prevalence of Metabolic Syndrome among Border Guard Bangladesh Personnel

Journal of Armed Forces Medical College Bangladesh ◽

10.3329/jafmc.v14i2.45883 ◽

2020 ◽

Vol 14 (2) ◽

pp. 97-100

Author(s):

Md Abdul Wahab ◽

Md Mustafizur Rahman ◽

Md Abdur Razzak ◽

Md Habibur Rahman ◽

Mimi Parvin ◽

...

Keyword(s):

Metabolic Syndrome ◽

International Diabetes Federation ◽

Armed Forces ◽

Cross Sectional Study ◽

Age Group ◽

Metabolic Abnormalities ◽

Sectional Study ◽

Ethnic Population ◽

Cross Sectional ◽

Medical College

Introduction: Metabolic syndrome (MetS) is a multifaceted syndrome comprises a cluster of metabolic abnormalities including hypertension, central obesity, insulin resistance, dyslipidemia, and is strongly associated with developing diabetes mellitus and cardiovascular diseases. Prevalence of MetS differs in different ethnic population by using different definition. Objectives: To determine the prevalence of the MetS and its component risk factors among Border Guard Bangladesh (BGB) personnel working in Chattagram Hill Tract (CHT). Materials & Methods: This descriptive cross-sectional study was conducted from October 2016 to February 2018 among 1455 male BGB personnel aged between 40 to 59 years and working in CHT of Bangladesh. Study subjects were selected at BGB hospital, Guimara, Khagrachari. The new International Diabetes Federation (IDF) guidelines were used to identify MetS. Detail history, clinical examination, anthropometry and blood pressure (BP) were measured and fasting plasma glucose (FPG) and lipid profile were assessed. Results: Among the 1455 respondents’ BMI, waist circumference, systolic and diastolic BP were found more than normal in 34.1, 37.7, 16.4% and 12.3% respectively. Biochemical parameters including FPG, TC, TG, and LDL-C was raised in 28.7%, 49.8%, 52.2% and 37.7% of respondents respectively. HDL-C was found decreased in 26.9% respondents. Age wise prevalence of MetS for age group 40-44, 45-49, 50-54 and 55- 59 years were found 21.3%, 21.7%, 24.1% and 26.1% of the respondents respectively. The overall prevalence of MetS was found 22.4%. Conclusion: The prevalence of the MetS in BGB personnel was found 22.4%. Appropriate measure should be taken to lower the MetS cases. Journal of Armed Forces Medical College Bangladesh Vol.14 (2) 2018: 97-100

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Comparison of Urinary Adiponectin in the Presence of Metabolic Syndrome in Peri- and Postmenopausal Women

10.21203/rs.3.rs-950874/v1 ◽

2021 ◽

Author(s):

Patsama Vichinsartvichai ◽

Rattana Teeramara ◽

Titima Jirasawas ◽

Prirayapak Sakoonwatanyoo

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Postmenopausal Women ◽

Demographic Data ◽

Diagnostic Value ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Screening And Diagnosis ◽

Baseline Demographic

Abstract Objectives To find the association between urinary adiponectin and metabolic syndrome (MetS) in peri- and postmenopausal women and its potential application as a noninvasive screening for MetS. Methods A cross-sectional study was conducted in healthy peri- and postmenopausal women (defined by STRAW+10 staging) age at least 40 years who attended annual checkup or menopause clinic were recruited. Baseline demographic data, MENQOL, anthropometric measurements, blood pressure, laboratory (FBS, total cholesterol, HDL-C, LDL-C, TG) and urinary adiponectin were collected. The MetS was diagnosed according to JIS 2009. Results 290 peri- and postmenopausal women had participated. The prevalence of Mets among our participants was 18%. Urinary adiponectin levels were similar in peri- and postmenopausal women with and without MetS (2.6±2.2 vs 2.3±1.9 ng/mL, respectively, P = 0.55). Urinary adiponectin provides no diagnostic value for MetS (AUC = 0.516). Conclusions Urinary adiponectin has no role in screening and diagnosis of MetS in peri- and postmenopausal women. The quest toward noninvasive screening for MetS is still going on.

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Diet dan Sindrom Metabolik pada Remaja Obesitas

Amerta Nutrition ◽

10.20473/amnt.v4i3.2020.191-197 ◽

2020 ◽

Vol 4 (3) ◽

pp. 191

Author(s):

Rendi Aji Prihaningtyas ◽

Nur Aisiyah Widjaja ◽

Meta Herdiana Hanindita ◽

Roedi Irawan

Keyword(s):

Metabolic Syndrome ◽

Food Consumption ◽

Fruits And Vegetables ◽

International Diabetes Federation ◽

Hdl Cholesterol ◽

Dietary Factors ◽

Chi Square ◽

Cross Sectional ◽

Obese Adolescents ◽

Significant Difference

ABSTRACTBackground : The prevalence of obesity in adolescents is increasing and causes metabolic syndrome at a young age. Metabolic syndrome results from the interaction of environmental, genetic, and dietary factors. The purpose of this study was to determine the diet profile of obese adolescents suffering from metabolic syndrome.Methods: This study was a cross-sectional study of obese adolescents who visited the Pediatric Nutrition and Metabolic Disease in Dr. Soetomo General Hospital, Surabaya. The anthropometry examination (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol, triglycerides and blood glucose levels) were measured. The diagnosis of metabolic syndrome was based on the International Diabetes Federation. Food consumption data was obtained through direct interviews using data collection sheets. Analysis of dietary differences in obese adolescents suffering from metabolic syndrome was performed by chi square using SPSS.Results and Discussions: A total of 59 obese adolescents aged 13-16 years were involved in this study. A total of 27 subjects (45.8%) suffered from metabolic syndrome and 32 subjects (54.2%) did not suffer from metabolic syndrome. The level of the consumption of fish, vegetables, and fruit in obese adolescents were still low. There was no significant difference in the diet profile between obese adolescents who suffer from metabolic syndrome or not.Conclusion: Prevention strategies through food consumption patterns are needed in obese adolescents to control metabolic stress processes and prevent metabolic syndrome in the future. Diet knowledge in obese adolescents needs to be given early to prevent further complications. Increasing foods that contain anti-oxidants, such as fruits and vegetables, is one of the strategies to prevent metabolic syndrome in obese adolescents.ABSTRAKLatar Belakang : Prevalensi obesitas pada remaja semakin meningkat dan menyebabkan sindrom metabolik di usia muda. Sindrom metabolik terjadi akibat interaksi faktor lingkungan, genetik, dan diet. Tujuan dari penelitian ini adalah mengetahui profil diet pada remaja obesitas yang menderita sindrom metabolik.Metode : Penelitian ini merupakan penelitian potong lintang pada remaja obesitas yang berkunjung di Poli Nutrisi dan Penyakit Metabolik Anak di RSUD Dr. Soetomo, Surabaya. Pada subyek dilakukan pemeriksaan antropometri (berat badan, tinggi badan, dan lingkar pinggang), pemeriksaan tekanan darah, dan pemeriksaan darah (kolesterol HDL, trigliserida, dan kadar glukosa darah). Diagnosis sindrom metabolik ditegakkan berdasarkan International Diabetes Federation. Data konsumsi makanan didapatkan melalui wawancara langsung dengan menggunakan lembar pengumpul data. Analisis perbedaan diet pada remaja obesitas yang menderita sindrom metabolik dilakukan dengan chi square menggunakan SPSS.Hasil dan Pembahasan : Sebanyak 59 remaja obesitas yang berusia 13-16 tahun terlibat dalam penelitian ini. Sebanyak 27 subyek (45,8%) menderita sindrom metabolik dan sebanyak 32 subyek (54,2%) tidak menderita sindrom metabolik. Tingkat konsumsi ikan, sayur, dan buah pada remaja obesitas masih rendah. Tidak ada perbedaan yang bermakna pada profil diet antara remaja obesitas yang menderita sindrom metabolik maupun tidak.Kesimpulan : Strategi pencegahan melalui pola konsumsi makanan diperlukan pada remaja obesitas untuk mengontrol proses stres metabolik sehingga dapat mencegah sindrom metabolik di masa datang. Pengetahuan diet pada remaja obesitas perlu diberikan sejak dini untuk mencegah komplikasi lebih lanjut. Memperbanyak makanan yang mengandung anti-oksidan, seperti buah dan sayur merupakan salah satu strategi mencegah sindrom metabolik pada remaja obesitas.

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Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400007 ◽

2010 ◽

Vol 128 (4) ◽

pp. 211-214 ◽

Cited By ~ 9

Author(s):

Patrícia Magda Soares ◽

César Cabello ◽

Luis Alberto Magna ◽

Eduardo Tinois ◽

Cristina Laguna Benetti-Pinto

Keyword(s):

Hormone Therapy ◽

Postmenopausal Women ◽

Breast Density ◽

Premature Ovarian Failure ◽

Cross Sectional Study ◽

Ovarian Failure ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference ◽

The Impact

CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF.

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