scholarly journals Study to assess sub-foveal choroidal thickness in patients of preeclampsia through spectral domain optical coherence tomography

Author(s):  
Astha Lalwani ◽  
Priye Suman Rastogi ◽  
Rehana Najam ◽  
Ashish Chander

Background: Aim of the study was to assess sub-foveal choroidal thickness (SFCT) in preeclamptic patients by SD ocular coherence tomography (SD-OCT) and correlate its changes with severity of preeclampsia.Method: This case control, observational study, conducted in department of ophthalmology in association with department of obstetrics and gynaecology. The subjects were split into two groups: study and control. Study group was further divided in to 2 groups i.e., group A (Patients with preeclampsia) and group B (Pregnant females without preeclampsia). Control group (Group C) of non-pregnant females of similar age group. Total 100 patients were taken in each group. Subjects from both study and control groups were subjected to SD-OCT and mean choroidal thickness of both eyes was noted. Data was noted and comparison of 3 groups was done.Results: Baseline characters viz, age, period of gestation, and parity was comparable among all the groups as p>0.05. Mean arterial pressure (MAP) was 102.72±9.81 and 84.56±7.83 in group A and B respectively with statistically significant difference as p<0.01. Following a post hoc analysis, it was discovered that the SFCT of the healthy pregnancy group did not differ substantially from that of the control group, however the SFCT of the pre-eclampsia group was significantly higher than that of the control and healthy pregnancy groups.Conclusions: Pre-eclampsia causes a greater increase in sub-foveal choroidal thickness than normal pregnancy or non-pregnant women. It has the potential to be used as a predictor or marker of pre-eclampsia severity.

2015 ◽  
Vol 3 (2) ◽  
pp. 38 ◽  
Author(s):  
Randhir S. Ranta ◽  
Vijay Kumar Sharma ◽  
Pankaj Gupta

The study pertains to the parenting stress, which is believed to be the resultant of child disability and further assesses the needs of the families across selected pockets of Himachal Himalaya. Perceived Stress Questionnaire (PSQ) and Need Assessment Scale were used for the purpose. For assessing the stress level among the parents, PQS was administered among two hundred parents having disabled children, herein called experimental group and two hundred parents with normal children, herein called control group. A three point Need assessment scale was used to measure the needs of 200 families on five different parameters. The result of t-test shows the significant difference between experimental and control groups indicating that the parents of disabled children experience more stress than their control counterpart. The study indicates that people need proper guidance and information regarding a child’s disability, nutritional requirements of a child, vocational training and child management. There is a need for proper counselling for parents suffering from stress and creating consciousness among parents of children with disabilities and in the society.


2021 ◽  
Vol 45 (5) ◽  
pp. 312-316
Author(s):  
Mishra Neha Sanjeev ◽  
Harsimran Kaur ◽  
Sandeep Singh Mayall ◽  
Rishika ◽  
Ramakrishna Yeluri

Objective: To evaluate the effectiveness of placing a resorbable collagen barrier in impeding the extrusion of obturation material in primary molars undergoing resorption. Study design: All the 94 canals in 47 mandibular molars were allocated to 2 groups- Group ‘A’- 47 canals with collagen barrier (Test group) and Group ‘B’- 47 canals without collagen barrier (Control group) based on randomization protocol. Pulpectomy was performed and obturation of both test and control canals were radiographically assessed. Pearson’s chi – square test was applied to analyze the results. The significance level was predetermined at p &lt; 0.05. Results: Among the test group, 93.6% of the canals showed no extrusion while, 6.4% showed visible extrusion of the material outside the apex. In the control group, 83% showed no extrusion whereas 17% of the canals showed visible extrusion outside the apex. But no significant difference was noted (p&gt;0.05). Conclusion: The placement of resorbable collagen barrier in the apical third of the canal prevented the extrusion of obturating material beyond the apex in resorbing primary molars.


Author(s):  
Fei Ha Chiew ◽  
Clotilda Petrus ◽  
Siti Zaidah Othman ◽  
Joe Davylyn Nyuin ◽  
Ung Hua Lau

This study investigated the effectiveness of a peer tutoring program that was implemented for Basic Solid Mechanics course, as an intervention program to improve students’ performance in the course. Ten tutors were chosen to provide tutoring services to an experimental group of 36 tutees. Tutees were required to answer an entry test before the intervention program, and another exit test after the program. A control group which shared the same instructor in their lecture classes was included in the study. Comparison between the performances for entry and exit tests of both experimental and control groups were made. Analyses showed an increase in the percentage of students that passed the exit test from the experimental group. The average marks for the experimental group in the exit test also increased, compared to their marks in the entry test. A Mann- Whitney U test conducted indicated a significant difference between the gain scores of the experimental group and control group. A further metaanalysis revealed a large effect size, signaling the practical significance of the results. The findings demonstrated the effectiveness of the peer tutoring intervention program on students’ performance of the course.


2021 ◽  
Vol 71 (2) ◽  
pp. 433-37
Author(s):  
Amash Aqil ◽  
Muhammad Moin ◽  
Khadijah Abid ◽  
Ahsan Mehmood

Objective: To evaluate central macular thickness and choroidal thickness in patients with macular edema due to diabetic retinopathy versus controls. Study Design: Cross-sectional comparative study. Place and Duration of Study: Department of Ophthalmology, Lahore General Hospital, Lahore, from Jan to Jul 2018. Methodology: A retrospective data of 100 eyes from 50 patients having with diabetic macular edema associated with diabetic retinopathy was extracted from hospital registry. Additionally, 100 eyes of 50 individuals without any preexisting ocular conditions, comprising a control group was included in the study. Choroidal thickness measurements were made from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at subfoveal level using optical coherence tomography. Central macular thickness was also measured for all the enrolled patients. Results: One hundred patients fulfilling the inclusion criteria were enrolled in our study. The mean age was 56.27 ± 14.41 years. The mean Central macular thickness of all the patients were reported as 270.49 ± 72.38 μm, while the choroidal thickness was 284.89 ± 96.51 μm. There was statistically significant difference in central macular thickness between both healthy and diabetic retinopathy with diabetic macular edema groups (p=0.001), whereas insignificant difference existed between the two groups forchoroidal thickness (p=0.735). Conclusion: In patients with diabetic macular edema no significant change in choroidal thickness was observed compared with healthy controls, while the thickness of the retina was high in patients with macular edema due to diabetes.


2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Zahra Saberi Louyeh ◽  
Mahin Naderifar ◽  
Hamed Faghihi ◽  
Brenda S. Lessen Knoll ◽  
Nasrin Mahmoodi

Background: Premature babies face nutritional problems caused by underdevelopment and lack of coordination between sucking, swallowing, and breathing. Appropriate early interventions are needed to promote the nutritional adequacy of these infants. Objectives: This study was designed to compare the effect of breast milk odor and incubator cover on the nutritional adequacy of premature infants. Methods: A quasi-experimental study was conducted on 105 preterm infants aged 28 - 33 weeks who were admitted to the Neonatal Intensive Care Unit (NICU) of Ali Ibn Abi Taleb Hospital in Zahedan in 2018. The subjects were selected via convenience sampling and randomized into three groups: breast milk odor (BMO), incubator cover (IC), and control. Infants in the IC group were placed in an incubator for two hours before feeding. In the BMO group, a gauze soaked with breast milk was placed 1.5 cm away from the infant’s nose in the incubator, and a prescribed amount of milk was given by a syringe to the infant through the mouth. The amount of milk that the baby orally received in the first 10 min (nutritional adequacy) was recorded by a camera, and the results were compared in the three groups. Results: One-way analysis of variance showed a statistically significant difference between the control group and the two groups of incubator cover and breast milk odor (P < 0.001) such that nutritional adequacy was lower in the control group than in the two other groups. Conclusions: Both the smell of breast milk and incubator cover improved the nutritional adequacy of premature infants and enabled them to orally receive more breast milk.


Author(s):  
MUARA P. LUBIS

Objective: Preeclampsia characterized systematically by extensive vascular endothelial dysfunction and microangiopathy on mother, dNK is very important for the success of placentation. They are the key mediator of maternal immune system interactions with fetal cells. dNK cells are also involved in the modulation of EVT and the remodeling of spiral arteries. Methods: Analytic research with cross-sectional study, with samples of pregnant women who suffer from severe PE and aterm pregnancy which came to H. Adam Malik Hospital and Networking Hospital, November 2015-April 2016. The samples are 46 women, who met the inclusion criteria. Results: Immunohistochemistry examination dNK cell in the severe PE case group and control group, statistically found p<0,05. dNK placenta expression in the severe preeclampsia case group gives an overview of expression with a mean of 2.55±2.31, while the control group of normal pregnancy had higher mean is 8.66±3.16. Conclusion: The examination of immunohistochemistry of dNK cells showed there is a significant difference in the expression of Immuno-histochemistry dNK cells between severe PE case group and non severe PE.


Author(s):  
Lata G. ◽  
Rana N. ◽  
Mittal R. ◽  
Kumar S.

Background: The study was aimed to evaluate the efficacy of Mifepristone for induction of labour and in improving the Bishop score at term. The study also aimed to assess induction delivery interval and maternal and fetal outcomes with Mifepristone.Methods: The study was carried out on 200 pregnant females with 2 study groups of 100 each. Group A females received tablet Mifepristone 400mg and   Group B females received placebo. Results: Time interval between induction to onset of labour was 28 hours 54 min and 42 hours 18 min respectively in cases and control group. Mean induction delivery interval was 35 hours 38 min and 49 hours 52 minutes respectively in cases and control group. LSCS rate was less with Mifepristone group.Conclusions: This study showed that treatment with Mifepristone is a simple and effective method of inducing labour in women with term pregnancy with unripe cervix. The use of Mifepristone provides an interesting new alternative to classic uterotonic agents when induction is necessary. The potential advantage of Mifepristone over PGs or oxytocin requires further evaluation in scarred uterus.


2015 ◽  
Vol 1 (2) ◽  
pp. 178
Author(s):  
Indras Kurnia Setiawati ◽  
Senam Senam

Penelitian ini bertujuan untuk menghasilkan produk berupa perangkat pembelajaran IPA berbasis Science, Environment, Technology, and Society (SETS) dan mengetahui (1) kelayakan produk, (2) keefektifan produk untuk meningkatkan scientific literacy, serta (3) keefektifan produk untuk meningkatkan foundational knowledge peserta didik kelas VII SMP Muhammadiyah 8 Wedi Klaten. Penelitian ini merupakan penelitian dan pengembangan dengan 3 tahap prosedur pengembangan yaitu need assesment, development dan reasearch dengan desain nonequivalent control group. Perangkat pembelajaran IPA berbasis SETS terdiri atas silabus, RPP, Lembar Kegiatan Peserta Didik (LKPD), dan instrumen penilaian otentik. Hasil penelitian menunjukkan kelayakan produk dinyatakan sangat baik dengan rerata skor 4,59 dari rentang 0-5. Semua peserta didik di kelas eksperimen mengalami peningkatan nilai scientific literacy dan foundational knowledge dengan kategori peningkatan tinggi, sedang, dan rendah. Implementasi produk berpengaruh positif terhadap kemampuan scientific literacy dan foundational knowledge yang menunjukkan perbedaan signifikan antara kelas eksperimen dan kontrol dengan kemampuan awal yang sama. Dengan demikian, perangkat pembelajaran IPA berbasis SETS terbukti efektif untuk meningkatkan scientific literacy dan foundational knowledge peserta didik kelas VII SMP Muhammadiyah 8 Wedi Klaten. Kata kunci: perangkat pembelajaran IPA, SETS, scientific literacy, foundational knowledge   DEVELOPING A SETS-BASED SCIENCE TEACHING KIT TO IMPROVE SCIENTIFIC LITERACY AND FOUNDATIONAL KNOWLEDGE Abstract This study aims to produce products such as a Science, Environment, Tecnology, and Society-based science teaching kit and to determine (1) the feasibility of the product, (2) the effectiveness of the product to improve scientific literacy, and (3) the effectiveness of the product to improve foundational knowledge for 7th grade students in SMP Muhammadiyah 8 Wedi Klaten.. This study is a Research and Development (R & D) with three phases procedure. They are need assesment, development dan reasearch with noneequivalent control using the control group. A SETS-based science teaching kit covering the syllabus, lesson plans, students worksheet, and authentic assessment instruments. The results showed the feasibility of the products avowed excellent with a mean score of 4,59 out of range 0-5. All students in the experimental class have increased the value of scientific literacy and foundational knowledge with increase category of high, medium, and low. Products implementation have a positive effect on the ability of scientific literacy and foundational knowledge which showed a significant difference between the experimental and control classes with the same initial ability. Thus, SETS-based science teaching kit is proven effective to increase scientific literacy and foundational knowledge for 7th grade students in SMP Muhammadiyah 8 Wedi Klaten. Keywords: science teaching kit, SETS, scientific literacy, foundational knowledge


2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Wei Chen ◽  
Yubo Guan ◽  
Guanghui He ◽  
Zhiwei Li ◽  
Hui Song ◽  
...  

Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV).Methods. Serum and aqueous levels of PEDF were measured by enzyme-linked immunosorbent assay in 36 high myopia patients (36 eyes) with no CNV (non-CNV group), 14 high myopia patients (14 eyes) with CNV (CNV group), and 42 nonmyopia patients (42 eyes) (control group). Macular choroidal thickness was measured by enhanced-depth imaging optical coherence tomography.Results. Aqueous levels of PEDF were significantly higher in CNV group compared with non-CNV (P<0.001) and control (P<0.001) groups. Macular choroidal thicknesses were significantly decreased in the non-CNV and CNV groups compared with the control (P<0.001) group. A statistically significant difference (P=0.012) was found between the CNV and non-CNV groups. There was a positive correlation between aqueous PEDF and macular choroidal thickness in the non-CNV group (P=0.005), but no correlation with the CNV group. No correlation between serum PEDF and macular choroidal thickness was detected in the three groups.Conclusion. Variations in aqueous PEDF levels coincide with changes in macular choroidal thickness in high myopia patients with no CNV, while no such relationship exists in high myopia patients with CNV.


2019 ◽  
Author(s):  
Tingting Hong ◽  
Xin Meng ◽  
Xinxiao Gao ◽  
Jun Wang

Abstract Background: Using spectral-domain optical coherence tomography (SD-OCT) to investigate choroidal vascular sublayers in Chinese pre-eclampsia (PE) and healthy pregnancy. Methods: This was an observational, cross-sectional study, including 20 normal subjects, 23 healthy pregnancy and 37 patients with PE. Using SD-OCT, subfoveal choroidal thickness (SFCT), 750μm nasal and temporal to the fovea, 1500μm nasal and temporal to the fovea(T1500, T750, SFCT, N750, N1500)and sublayers (choriocapillaris/Sattler layer and Haller layer) were measured. Results: There was no significant difference in mean age, spherical equivalent among the three groups (P=0.532). Additionally, no significant difference in the gestational age between the healthy pregnancy and PE group was found (P=0.783). Significant differences were seen in large choroid vessel thickness(LCVT), medium choroidal vessel thickness (MCVT) and choroidal thickness (CT) at 5 locations among three groups (P<0.05). There was significant increase in healthy pregnancy group than in normal subjects at N1500-CT, N750-CT, SFCT, T750-CT and MCVT (P<0.05), while no significant difference was observed at T1500CT and LCVT (P>0.05). Meanwhile, significant increase was detected in PE group than in healthy pregnancy group at N1500-CT, N750-CT, SFCT, T750-CT, T1500CT and LCVT (P<0.05), whereas no significant difference was observed at MCVT(P=0.709). Conclusion: Our study revealed the variation of choroidal vascular sublayers during pregnancy and PE. Key words: Pre-eclampsia, subfoveal choroidal thickness, choroidal sublayers, optical coherence tomography


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