Effect of cissus quadrangularis linn and zingiber officinale rosc in osteoarthritis patients

Background: To evaluate the efficacy of Cissus quadrangularis Linn. or Zingiber officinalis Rosc. or in combination treatment of osteoarthritis which reduces joint pain, joint swelling and tenderness without risk of side effects.Methods: Total 60 patients were selected and divided into 3 groups (each group consist of 20 patients); data were collected before and after treatment of following groups: Group A-Cissus quadrangularis linn-5gm; Group B- Zingiber officinale rosc-5gm; Group C-Treatment of Cissus quadrangularis linn combined with Zingiber officinale rosc-5 gm/dose twice a day with luke warm water.Results: 60 % cases of joint pain were relieved at the end of the treatment in group B & C, in group A 50%, reduction in joint pain extremely significant in all groups A, B, C (p<0.0001). ‘C’ 80%, ‘A’ 15% and ‘B’5% reduction in symptom of Joint swelling and which is very significant in group A, and group B (p<0.001) and extremely significant in group C (p<0.0001). Symptom of tenderness ‘C’ 90%, ‘A’ 85%, and ‘B’ 10% cases were relived from the complaint. The difference in tenderness is statistically extremely significant when compared between groups (p<0.0001).Conclusions: Present study reveals that, significant reduction of joint pain, joint swelling and tenderness after treatment of Cissus quadrangularis Linn. or Zingiber officinalis Rosc. and extremely significant reduction of joint swelling and tenderness in combination therapy.

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Anal sphincter dysfunction in multiple sclerosis: an observation manometric study

Open Medicine ◽

10.1515/med-2016-0088 ◽

2016 ◽

Vol 11 (1) ◽

pp. 509-517 ◽

Cited By ~ 3

Author(s):

Silvia Marola ◽

Alessia Ferrarese ◽

Enrico Gibin ◽

Marco Capobianco ◽

Antonio Bertolotto ◽

...

Keyword(s):

Multiple Sclerosis ◽

Fecal Incontinence ◽

Anal Pressure ◽

Before And After ◽

Group A ◽

The Difference ◽

Resting Anal Pressure ◽

Group B ◽

Multiple Sclerosis Patients ◽

Group D

AbstractConstipation, obstructed defecation, and fecal incontinence are frequent complaints in multiple sclerosis. The literature on the pathophysiological mechanisms underlying these disorders is scant. Using anorectal manometry, we compared the anorectal function in patients with and without multiple sclerosis.136 patients referred from our Center for Multiple Sclerosis to the Coloproctology Outpatient Clinic, between January 2005 and December 2011, were enrolled. The patients were divided into four groups: multiple sclerosis patients with constipation (group A); multiple sclerosis patients with fecal incontinence (group B); non-multiple sclerosis patients with constipation (group C); non-multiple sclerosis patients with fecal incontinence (group D). Anorectal manometry was performed to measure: resting anal pressure; maximum squeeze pressure; rectoanal inhibitory reflex; filling pressure and urge pressure. The difference between resting anal pressure before and after maximum squeeze maneuvers was defined as the change in resting anal pressure calculated for each patient.ResultsGroup A patients were noted to have greater sphincter hypotonia at rest and during contraction compared with those in group C (p=0.02); the rectal sensitivity threshold was lower in group B than in group D patients (p=0.02). No voluntary postcontraction sphincter relaxation was observed in either group A or group B patients (p=0.891 and p=0.939, respectively).ConclusionsThe decrease in the difference in resting anal pressure before and after maximum squeeze maneuvers suggests post-contraction sphincter spasticity, indicating impaired pelvic floor coordination in multiple sclerosis patients. A knowledge of manometric alterations in such patients may be clinically relevant in the selection of patients for appropriate treatments and for planning targeted rehabilitation therapy.

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Efficacy of Korean Medicine Combination Treatment on Recurrent Neck Pain After Medical Procedures: A Retrospective Study

Journal of Acupuncture Research ◽

10.13045/jar.2020.00262 ◽

2021 ◽

Vol 38 (1) ◽

pp. 32-40

Author(s):

Hyo-Seung Huh ◽

Wu-Jin Jeong ◽

Ki-Tae Park ◽

Sun-Ho Lee ◽

Sun-A Kim ◽

...

Keyword(s):

Cervical Spine ◽

Neck Pain ◽

Combination Treatment ◽

Medical Procedures ◽

Korean Medicine ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Group B ◽

Admission Group

Background: The aim of this study was to evaluate the efficacy of Korean medicine combination treatment on recurrent neck pain after medical procedures.Methods: This retrospective study included 158 inpatients of the Daejeon Jaseng Hospital of Korean Medicine who were diagnosed with “Cervical disc disorder with radiculopathy (M50.1)” between December 14th, 2017 and May 29th, 2019. The patients were assigned to 1 of 2 groups based on whether they received medical procedures on the cervical spine at least once. Korean medicine combination treatment was evaluated using EuroQol-5 dimensions index (EQ-5D), numeric rating scale (NRS), and neck disability index (NDI) scores.Results: Before and after treatment, the patients who received medical procedures on the cervical spine at least once before admission (Group A) showed a statistically significant difference in the NDI and NRS scores but not in the EQ-5D scores. This was similar to the patients who had not received medical procedures on the cervical spine before admission (Group B) they showed a statistically significant difference in the NDI and NRS scores but not in the EQ-5D scores. When comparing the results of Group A and Group B before and after treatment, no statistically significant differences were observed in the EQ-5D, NDI, and NRS scores.Conclusion: Korean medicine combination treatment improves the neck functional disability of patients who suffer from recurrent neck pain despite patients having undergone medical procedures.

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A Randomized Trial of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients.

10.21203/rs.3.rs-38896/v1 ◽

2020 ◽

Cited By ~ 2

Author(s):

Abu Taiub Mohammed Mohiuddin Chowdhury ◽

Mohammad Shahbaz ◽

Md Rezaul Karim ◽

Johirul Islam ◽

Dan Guo ◽

...

Keyword(s):

Single Dose ◽

Combination Therapy ◽

Randomized Trial ◽

Effective Treatment ◽

Rt Pcr ◽

Early Disease ◽

Positive Time ◽

Group A ◽

The Difference ◽

Group B

Abstract Background The worldwide COVID-19 pandemic was caused by a newly discovered Coronavirus. The treatment methods for COVID-19 are emerging and rapidly evolving. Existing drugs, including Ivermectin and Hydroxychloroquine, offer the hope of effective treatment in early disease. In this study, we investigated and compared outcomes of Ivermectin-Doxycycline vs. Hydroxychloroquine-Azithromycin combination therapy COVID19 patients with mild to moderate disease.Methods Patients with mild to moderate COVID-19 disease, tested positive by RT PCR for SARS-CoV-2 infection at Chakoria Upazilla Health Complex, Cox's Bazar, Bangladesh, were included in this study. Patients were divided randomly into two groups: Ivermectin 200µgm/kg single dose + Doxycycline 100 mg BID for 10days in group A, and Hydroxychloroquine 400 mg 1st day, then200mg BID for 9days + Azithromycin 500 mg daily for 5 days in group B. PCR for SARS-CoV-2 was repeated in all symptomatic patients on the second day onward without symptoms, or, for those who were asymptomatic (throughout the process), on the 5th day after taking medication and repeated every two days onward if the result is positive. Time to negative PCR and time to full symptomatic recovery was measured for each group.Results All subjects in the Ivermectin-Doxycycline group (group A) reached a negative PCR for SARS-CoV-2, at a mean of 8.93days, and all reached symptomatic recovery, at a mean of 5.93days, with 55.10% symptom-free by the 5th day. In the Hydroxychloroquine-Azithromcyin group (group B), 96.36% reached a negative PCR at a mean of 6.99days and were symptoms-free at 9.33days. Group A patients had symptoms that could have been caused by the medication in 31.67% of patients, including lethargy in 14(23.3%), nausea in 11(18.3%), and occasional vertigo in 7(11.66%) of patients. In Group B, 46.43% had symptoms that could have been caused by the medication, including 13(23.21%) mild blurring of vision and headache; 22(39.2%) increased lethargy and dizziness, 10(17.85%) occasional palpitation, and 9(16.07%) nausea and vomiting.Conclusion The Ivermectin-Doxycycline combination showed a trend toward superiority to the Hydroxychloroquine-Azithromycin combination therapy in the case of patients with mild to moderate COVID19 disease, though the difference in time to becoming symptom-free and the difference in time to negative PCR was not statistically significant.

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A comparative study to evaluate the effects of intranasal steroid spray, isotonic saline nasal irrigation and combination therapy in patients with allergic rhinitis

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20212123 ◽

2021 ◽

Vol 7 (6) ◽

pp. 1004

Author(s):

Smitha Soubhagya Gangaraju ◽

Nikitha Pillai ◽

Vijaylaxmi Manthal

Keyword(s):

Allergic Rhinitis ◽

Combination Therapy ◽

Isotonic Saline ◽

Treatment Modalities ◽

Nasal Irrigation ◽

Intranasal Corticosteroids ◽

Nasal Symptoms ◽

Before And After ◽

Group A ◽

Group B

Background: Allergic rhinitis (AR) is characterized by inflammatory changes in the nasal mucosa caused by exposure to inhaled allergens. AR clinically having 2 or more symptoms of anterior or posterior rhinorrhea, sneezing, nasal blockage or itching of the nose during two or more consecutive days for more than 1 hour on most days which are caused by allergen exposure leading to an IgE mediated reaction. Nasal steroids and antihistamines are considered as gold standard treatment of choice in moderate to severe AR. This study was taken to evaluate the efficacy of intranasal steroid spray, isotonic saline nasal irrigation, combination therapy and to compare all 3 treatment modalities.Methods: 75 patients of AR who met inclusion criteria were sequentially divided into 3 groups. Group A was intranasal steroid spray, group B was isotonic saline nasal irrigation, group C was combination of both intranasal steroid spray and saline nasal irrigation. Total nasal symptoms score was compared before and after 1 month of treatment.Results: Mean total nasal symptoms score before treatment in groups A, B and C was found to be 13.72, 12.96 and 13.68 respectively and after 1 month of treatment total nasal symptoms score was seen 8.28, 8.76 and 3.72 respectively.Conclusions: The combined use of saline nasal irrigation along with intranasal corticosteroids is found to be more effective in reducing the symptoms of patients with allergic rhinitis when compared to individual therapies.

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Airway Clearance in Bronchiectasis: A Randomized Control Trial of N-Acetylcysteine with 3% hypertonic saline

Journal of Islamabad Medical & Dental College ◽

10.35787/jimdc.v8i3.389 ◽

2019 ◽

Vol 8 (3) ◽

pp. 146-150 ◽

Cited By ~ 1

Author(s):

Muhammad Imran Shehzad ◽

Muhammad Atiq Ul Mannan ◽

Masood Alam ◽

Abdul Rauf ◽

Muhammad Imran Sharif

Keyword(s):

Acute Exacerbation ◽

Hypertonic Saline ◽

Control Group ◽

P Value ◽

Airway Clearance ◽

Before And After ◽

Group A ◽

The Mean ◽

The Difference ◽

Group B

Background: N-Acetylcysteine and 3% hypertonic saline are being used effectively for sputum clearance in chronic cases of bronchiectasis for quite some time. However, their use in acute condition of the disease seems to be underexplored. The objective of our study is to compare the role of nebulized N-acetylcysteine and 3% hypertonic saline in clearing the airway in patients with acute exacerbation of bronchiectasis. Material and Methods: A total of 136 confirmed cases of bronchiectasis were enrolled in this study. This randomized controlled trial was done in chest ward of Nishtar Hospital Multan from January 2015 to March 2017. Sampling was done by non-probability consecutive sampling and patients were divided into two groups A and B by lottery method. Verbal informed consent was taken from all participants. Group A participants received nebulization of N acetylcysteine mixed in normal saline for ten minutes, while group B participants were nebulized with 10ml of 3% hypertonic saline for ten minutes. Group B was active control group in the study. Data was collected on pre-designed Proforma, and analyzed by SPSS version 22. Numerical variables such as saturation, weight of sputum, age and blood pressure was analyzed by using t test. These were considered significant if the p value was equal or less than 0 .05. For qualitative variables chi square test was applied. Results: The mean O2 saturation of Group A, before and after treatment, was 92.11±3.07% and 94.47±2.18%, respectively. The difference was statistically significant (p value =0.001). The sputum weight of Group A, before and after treatment, was 2.63±2.39 g and 7.41±1.38 g, respectively. The difference was statistically significant (p value =0.001). The frequency of rhonchi of Group A, before and after treatment, was 52% and 76%, respectively. The difference was statistically significant (p value =0.003). While, for Group B, the mean O2 saturation, before and after treatment, was 92.36±3.13% and 93.49±2.27%, respectively. The difference was statistically significant (p value =0.012). The sputum weight, before and after treatment, was 3.11±2.01 g and 5.56±1.02 g, respectively. The frequency of rhonchi, before and after treatment, was 45% and 74% respectively. Again, the difference was statistically significant. Conclusion: Both nebulized N-acetylcysteine and 3% hypertonic saline cause airway clearance by enhancing sputum expectoration in patients with acute exacerbation of bronchiectasis equally. Both these agents also improve oxygen saturation in acute exacerbation of bronchiectasis significantly.

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The Impact of Artificial Aging on the Color Stability and Hardness of Nanocomposite Resin

Frontiers in Materials ◽

10.3389/fmats.2021.722131 ◽

2021 ◽

Vol 8 ◽

Author(s):

Likai Wang ◽

Yan Zheng

Keyword(s):

Artificial Aging ◽

Color Stability ◽

Color Difference ◽

Before And After ◽

Group A ◽

Hardness Change ◽

The Difference ◽

American Society ◽

Group B ◽

The Impact

Objective: This study aimed to investigate the impact of artificial aging on the color stability and hardness of nanocomposite resin.Methods: Four nanocomposite resin materials were used: Filtek Z350 XT (FZ), Synergy D6 (SD), Grandio (GD), and Clearfil Majesty Esthetic (CM). Thirty specimens were created from each material, which were divided into three (A,B,C) groups of 10 specimens each. For each material, the values of visual lightness (L*), degree of redness and greenness (a*), and degree of yellowness and blueness (b*) of the specimens in group A before and after aging, as well as the hardness of the specimens in group B before aging and in group C after aging, were measured. The American Society for Testing and Materials (ASTM) G155 Cycle 1 standard was adopted to test the aging of the specimens. The color difference (ΔE00) value and hardness difference (ΔH) value of the specimens before and after aging were calculated.Results: Aging was found to have an impact on the ΔE00 values of the resin materials in each group (H = 17.6, p = 0.001), and the hardness of the specimens in each group after artificial aging was significantly higher than before aging (p < 0.05). The difference in ΔE00 between the FZ group and the SD, GD, and CM groups was statistically significant (p < 0.05). The FZ group had the highest ΔE00 values. There was no correlation between ΔE00 and the hardness change percentage after aging (r = 0.114).Conclusion: Among the four nanocomposite resins tested in this study, except for Filtek Z350 XT’s ΔE00 values (>1.8) in the clinically unacceptable range, the remaining three kinds of resin ΔE00 values (<1.8) were all in the clinically acceptable range. The hardness of the four nanocomposite resins increased after aging. The results of the present study revealed that there was no correlation between ΔE00 and hardness change percentage in the four nanocomposite resin materials after aging.

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CONTROL OF HYPERTENSION

The Professional Medical Journal ◽

10.29309/tpmj/2010.17.03.2533 ◽

2010 ◽

Vol 17 (03) ◽

pp. 425-430

Author(s):

GHULAM RASOOL BHURGRI ◽

HUSSAIN BUX KOREJO ◽

MUHAMMAD ALI QURESHI ◽

Raj Kumar ◽

Nasrullah Aamir

Keyword(s):

Blood Pressure ◽

Side Effects ◽

Combination Therapy ◽

Systolic Blood Pressure ◽

Diastolic Blood Pressure ◽

Combined Therapy ◽

Group A ◽

The Difference ◽

Group B ◽

Age Range

Objective: To compare the efficacy and tolerability of Losartan and Atenolol in alone and combination in treatment of hypertension. Study Design: Comparative study. Setting: Medical out patients department of Jinnah Postgraduate Medical Centre Karachi from January 2007 to June 2007. Methods: There were 60 patients previously untreated with mild and moderate essential hypertensions were registered for study. The selected patients were divided into three groups. Group A was given atenolol, Group B was given Losartan, and Group C was given both drugs. The target blood pressure was 120-140/80-90 mmHg. There were 42 males and 18 females with age range 25-65 years. Results: The mean baseline score of groups A, B and C were showed systolic blood pressure 182±19, 174 ± 20 and 168 ± 12 respectively. The diastolic blood pressure was 104.5±11, 102.5±9 and 104.5±10 respectively. The difference in mean systolic and diastolic blood pressure was not significant statistically as P = 0.06 and 0.76 respectively. After 4 months of treatment with atenolol, systolic blood pressure decreased to 147±17, and diastolic blood pressure fell to 87±4. Losartan decreased systolic blood pressure 138±13 and diastolic blood pressure 87±4 in 4 months of treatment. The combined therapy decreased systolic blood pressure 115±4.6 and diastolic blood pressure 75±4.7. The effect of treatments on systolic and diastolic blood pressure was significantly different as (p < 0.001) and ( p = 0.036) respectively. Side effects observed in 2 (10%) patients from group C, 8 (40%) in group A and 4 (20%) in group B. Combination therapy proved more effective in controlling hypertension than mono therapy and also fewer side effects. Patients showed better control on combination therapy as compared to mono therapy. Losartan proved a little better in controlling hypertension then atenolol and was more expensive. Conclusion: Patients showed better results with combination therapy for hypertension compared to individual drug.

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Comparative studies on mydriatic effect of tropicamide 0.8% and phenylephrin 5.0% in teenagers & geriatric people

International Journal of Research in Hospital and Clinical Pharmacy ◽

10.33974/ijrhcp.v1i2.112 ◽

2019 ◽

Vol 1 (2) ◽

pp. 65-73

Author(s):

K. Diwakar ◽

Y. Sailaja ◽

V. Palanivel ◽

Shaik Baba Fakruddin ◽

T. Gangadhara ◽

...

Keyword(s):

Pupil Size ◽

Age Groups ◽

Serious Adverse Events ◽

Before And After ◽

Group A ◽

Study Population ◽

The Difference ◽

Group B ◽

Pupillary Size ◽

Two Age Groups

Prospective study on the comparison of mydiriatic effect of Tropicamide 0.8% and Phenylephrine 5% in teenagers and geriatric people was carried out in suthrama Eye Hospital madanapalle, India. The main objective of this study was to compare the mydriatic effect of a combination of drug in teenagers and geriatric people. It also evaluated the ADR’s produced and the efficacy of the drug in two age groups. In this study population majority of the subjects were female in group A and male in group B. Among the whole population under study in group A and B no one has reported with any case of congenital anomalies. A number of ADR’s are reported but no serious adverse events had occurred. The study was carried out in 100 eyes ie. 50 subjects whom are divided into 2 groups based on age. The comparison of mydriatic effect was done in each group after instilling one drop of a combination of 0.08% Tropicamide and 0.5% Phenynilephrine. The pupillary size where measured before and after administration of drug and the results were compared. The results showed that there is a large difference in the normal pupil size between teenagers and geriatric people. After dilation the difference in pupil size was statistically significant among the two groups. The study concludes that the pupillary dilation produced by administering 0.8% Tropicamide and 5% Phenylephrine produces higher mydriatic effect in teenagers than geriatric people.

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Effect of Xinjiang UyghurVernonia anthelminticaWilld Injection Treatment with Silicosis Fibrosis

BioMed Research International ◽

10.1155/2016/5139651 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Guitao Liu ◽

Yingjia Liu ◽

Lu Jin ◽

Cuidong Li ◽

Liping Nie ◽

...

Keyword(s):

Amyloid Beta ◽

Principal Component ◽

Hierarchical Cluster ◽

Tree Model ◽

Curative Effect ◽

Alpha Chain ◽

Before And After ◽

Group A ◽

The Difference ◽

Group B

Objective. To observe the curative effect of VAWI on Xinjiang Uygur patients with silicosis fibrosis.Methods. After we diagnosed the 40 patients with the first phase of silicosis, we randomly divided them into two groups: the basic treatment group (group A,n=20) and the VAWI group (group B,n=20). At the same time, we selected the age-matched healthy patients (n=20). We applied the combined protein chip with SELDI-TOF-MS to carry out the serum analysis. The data were analyzed throughout data preprocessing, difference in PEAK screening, hierarchical cluster analysis, and Principal Component Analysis (PCA). We built decision tree model and predict the difference between the PEAK corresponding proteins.Results. The proteins peaks corresponding to name, predicted protein, and gene name were as follows: M2001_69, amyloid beta a4 protein, APP, and M2017_02, amyloid beta a4 protein, APP. The different expression of proteins in patients with silicosis was found before and after with VAWI treatment. The predicted proteins were as follows: M1982_50, amyloid beta a4 protein, APP; M3164_50, fibrinogen alpha chain frag, FGA; M3379_28, fibrinogen alpha chain frag, FGA; and so on.Conclusion. VAWI presented curative effect on patients with silicosis fibrosis via the alternation of proteins expression in serum.

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Comparing the Efficacy of Plaque Removal between Salvadora persica (Miswak) and Manual Toothbrush in 12 to 15 Years School Children

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1049 ◽

2011 ◽

Vol 2 (1) ◽

pp. 29-33

Author(s):

Aruna M Devi ◽

Pooja Hampannavar ◽

G Radha ◽

Sushi Kadanakuppe ◽

SR Nagashree ◽

...

Keyword(s):

School Children ◽

Plaque Index ◽

Base Line ◽

Salvadora Persica ◽

Plaque Removal ◽

Before And After ◽

Group A ◽

Manual Toothbrush ◽

The Difference ◽

Group B

ABSTRACT Aim To compare the efficacy of plaque removal between chewing stick (Miswak—Salvadora persica) and manual toothbrush in 12 to 15 years old school children. Methods A randomized, examiner-blind, parallel design study was conducted over a 2-month period, among 12 to 15 years old students of Sri Sajjan Rao Vidya Samasthe, Bengaluru. A sample size of 60 subjects was randomly allocated into two groups, 30 subjects in group A (manual toothbrush) and 30 subjects in group B (chewing stick). The plaque index (Turesky et al, modified Quigley Hein plaque index) was used for base line, pre- and postintervention assessment. Then the data was collected and subjected to statistical analysis and the test used was Student-t test. Results The results were given separately for between and within group comparison. The difference in mean PI score between toothbrush users and tooth stick users is found to be statistically significant (p < 0.01). Higher mean PI score was found in tooth stick users compared to toothbrush users and the mean difference was statistically significant. The difference in mean PI score in both the groups, before and after intervention was statistically significant (p < 0.001). Conclusion Manual toothbrush and Miswak tooth sticks (Salvadora persica) both are effective in removal of plaque, but manual toothbrush was more effective than Miswak tooth stick, which was statistically significant.

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