Metabolic syndrome in patients with chronic plaque psoriatic disease: a case-control study from western Uttar Pradesh, India

Background: Various studies on psoriasis and metabolic syndrome have shown a large variation in their results. An increasing frequency is imposing a substantial burden on the overall health of psoriasis patients that needs to be appropriately foreseen and addressed. Aim of this study was to study various aspects of metabolic syndrome in patients with chronic plaque psoriatic disease in northern Indian region.Methods: A cohort of patients registering for treatment of chronic plaque psoriasis at Dermatology outpatients’ department formed the study population. Detailed history was captured. General physical examination was carried out. A thorough cutaneous examination was undertaken which captured details on type, distribution and arrangement of primary lesions and secondary changes in patients. After overnight fasting, venous blood samples were collected from the subjects and were analysed for serum glucose, triglyceride and HDL-cholesterol. Results: Metabolic syndrome in psoriasis was associated with higher age. Gender wise male preponderance was observed. Among the psoriasis cases, 64% had metabolic syndrome whereas among the control subjects 48% had the condition (p-value 0.158). The mean for serum triglyceride level for psoriasis patients (159.42 mg/dL) was higher than controls (144.25 mg/dL). Forty six percent of cases fulfilled elevated triglycerides ≥150 mg/dl as a criterion of metabolic syndrome, compared to 40% of controls. Conclusions: We observed a higher frequency of metabolic syndrome among psoriasis cases in a northern Indian population. An association of dyslipidemia with psoriasis was also noted. Routine screening of the condition to facilitate early diagnosis and treatment should be undertaken.

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Metabolic Abnormalities in Hypertensive patients and their Risk Factors

10.53350/pjmhs211571494 ◽

2021 ◽

Vol 15 (7) ◽

pp. 1494-1496

Author(s):

M. Imran Ashraf ◽

Shazana Rana ◽

M. Salee Makhtar ◽

Adnan Afzal ◽

Bushra Suhail ◽

...

Keyword(s):

Metabolic Syndrome ◽

Selection Criteria ◽

Hdl Cholesterol ◽

Serum Glucose ◽

P Value ◽

Qualitative Variable ◽

Hypertensive Patients ◽

The Metabolic Syndrome ◽

Gender Based ◽

Basic Features

Background: Metabolic syndrome is a disorder which is categorized by the presence of various features like hypertension, obesity, insulin resistance and dyslipidemia. One of the basic features of this syndrome is hypertension that may lead to increased incidence of cardiovascular incidents. Aim: To determine the gender based comparison of metabolic syndrome among the hypertensive patients who reported in the outpatient department. Study Time: The present study was conducted from January 2019 to June 2019 over a period of six months. Methods: Known hypertensive patients aged between 20 to 50 years who fulfilled the selection criteria were included in this study. After informed written consent, the physical examination and required laboratory investigation were done. The data was entered and analysed by using SPSS version 23 Mean±standard deviation was recorded for the quantitative variables while frequency was utilized for the qualitative variable. The p-value of ≤0.05 was taken as significant. Results: A total of 85 known patients of hypertension were included in the study comprising (70.12%) males and (35.40%) females. They were evaluated for the metabolic syndrome using the Adult Treatment Panel III- A (ATP –III A) criteria. Their blood pressure was recorded and fasting blood sample were taken to determine the levels of serum glucose, HDL-cholesterol and triglyceride. Conclusion: Metabolic syndrome is more prevalent in the hypertensive patients Keywords: Metabolic syndrome, Hypertension, Dyslipidemia

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Association of metabolic syndrome in patients of vitiligo

IP Indian Journal of Clinical and Experimental Dermatology ◽

10.18231/j.ijced.2021.063 ◽

2021 ◽

Vol 7 (4) ◽

pp. 337-340

Author(s):

Yashdeep Jat ◽

Krishnendra Varma ◽

Ujjwal Kumar ◽

Aishwarya Mahadik

Keyword(s):

Metabolic Syndrome ◽

Tertiary Care ◽

Fasting Blood Glucose ◽

Visceral Obesity ◽

Serum Triglyceride ◽

Clinical Feature ◽

P Value ◽

Serum Triglyceride Level ◽

Care Hospital ◽

The Metabolic Syndrome

The metabolic syndrome is the term used to describe a constellations of metabolic derangements that includes insulin resistance, hypertension, Dyslipidemia, central or visceral obesity, type 2 DM & accelerated cardiovascular disease. An oxidative imbalance is responsible for the development of both metabolic syndrome & vitiligo. In the present study we have evaluated the association of metabolic syndrome with Vitiligo.In this observational cross-sectional study we selected 40 subjects attending skin OPD with age matched 40 controls and assessed the waist circumference, blood pressure, serum triglyceride level, cholesterol and high-density cholesterol along with Fasting blood glucose level at tertiary care Hospital. A detailed history including age, gender, diabetes mellitus, hypertension, smoking and onset of vitiligo was taken. The MetS criteria were defined by National Cholesterol Education Program Adult Treatment Panel III 2005 (ATP III) guidelines.We identified metabolic syndrome in 15 subjects with vitiligo and 6 subjects without vitiligo. The P value came 0.022 which is statistically significant. Active vitiligo, segmental vitiligo and increased duration of vitiligo were determined to be independent predictors of metabolic syndrome.The risk of developing metabolic syndrome is increased in patients of vitiligo. Screening and the close follow up of the patients of vitiligo with clinical feature such as in unstable, segmental vitiligo with increased duration is necessary for the early diagnosis of the metabolic syndrome to reduce the morbidity & mortality of the patients

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Lipid Abnormalities in the Natural History of Diabetes

Journal of Medicine ◽

10.3329/jom.v16i2.25432 ◽

2015 ◽

Vol 16 (2) ◽

pp. 83-88

Author(s):

Muhammad Hafizur Rahman ◽

Liaquat Ali

Keyword(s):

Metabolic Syndrome ◽

Natural History ◽

Total Cholesterol ◽

Fasting Glucose ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

Family History Of Diabetes ◽

History Of ◽

Lipid Abnormalities ◽

Design And Methods

Objective: To explore lipid abnormalities in normoglycemic first-degree diabetic relatives (FDRs) and prediabetic and diabetic subjects in the natural history of diabetes.Research design and methods: Thirty six impaired fasting glucose (IFG), 61 isolated impaired glucose tolerance (I-IGT), 64 combined IFG-IGT, 73 diabetic, and 32 FDRs along with 57 normoglycemic healthy controls without family history of diabetes in 1st degree relatives, were selected purposively following 2003 ADA cut-off values and 2006 WHO/IDF grouping. Anthropometry and blood pressure of the subjects were taken. Fasting and 2-h plasma glucose and HbA1C were measured. Fasting plasma triglyceride, total cholesterol and HDL cholesterol were measured by enzymatic colorimetric method.Results: Serum triglyceride was higher in IFG, I-IGT, IFG-IGT, diabetic and FDRs compared to Control [145 (59- 307), 128 (66-584), 166 (68-764), 161 (69-750) and 130 (81-281) vs. 108 (47-219) mg/dl, P<0.01, P<0.01, P<0.001, P<0.001 and P<0.05]. Total cholesterol was raised in IFG-IGT and diabetes compared to Control [185 (105-310), 185 (123-326) vs. 171 (101-235) mg/dl, P<0.05] and FDRs. But HDL did not differ among the groups. Prevalence of metabolic syndrome was higher in IFG, I-IGT, IFG-IGT and diabetes and FDRs than Control [55%, 38%, 57%, 58% and 36% vs. 15%, P<0.001, P<0.01, P<0.001, P<0.001 and P<0.05] and also in IFGIGT and diabetic compared to I-IGT and FDRs (P<0.05).Conclusions: Higher prevalence of metabolic syndrome and raised serum triglyceride is seen among diabetic, prediabetic and 1st degree diabetic-relatives. Total cholesterol and non-HDL cholesterol is raised only in IFG-IGT and diabetes, the more decompensated glycemic states.J MEDICINE July 2015; 16 (2) : 83-88

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P1272ECFECT OF MELATONIN ON DYSLIPIDEMIA IN HEMODIALYSIS PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p1272 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Nargesossadat Zahed ◽

Marjan Pouyamehr ◽

Adineh Taherkhani

Keyword(s):

Total Cholesterol ◽

Serum Triglyceride ◽

Hemodialysis Patients ◽

Small Sample ◽

Inflammatory Factors ◽

P Value ◽

Serum Triglyceride Level ◽

Inclusion Criteria ◽

History Of ◽

Serum Crp

Abstract Background and Aims Cardiovascular disease is one of the major causes of death in hemodialysis patients. Lipid metabolism abnormalities and increased inflammatory factors are related factors. In recent studies melatonin inhibits dyslipidemia and reduces inflammatory factors by inhibiting LDL-c oxidation. The purpose of this study was to evaluate the effect of melatonin supplement on hyperlipidemia and c reactive protein (CRP ) level in hemodialysis patients. Method In this clinical trial ,the inclusion criteria were as follows:age older than 18 years, undergoing dialysis for at least 3 months,triglyceride >150mg/dL,HDL-c<40 mg/dL in males, HDL-c<50 mg/dL in females and serum CRP>5 mg/l Exclusion criteria were: Patients with a history of stroke, myocardial infarction, peripheral vascular disease, malignancy, heart failure, liver cirrhosis, active liver disease, history of infection, hospitalization one month ago, hepatitis B and C.HIV, and taking corticosteroid, statin, Non-steroidal anti-inflammatory drugs. Among 200 hemodialysis patients,only 28 patients fulfilled the inclusion criteria.. Patients were treated with Melatonin supplements 3 mg per day at bedtime during 12 weeks. Serum lipid profile and CRP level were measured after 12 weeks. Five patients were excluded, 2 patients underwent kidney transplantation, and three patients did not cooperate. Data were analyzed by SPSS 20 software. Normal distributed quantitative data were expressed as the mean ± SD and qualitative data was expressed as frequency and percentage. Wilcoxon matched pairs test was used to compare the two groups according to the type of study that had no normal distribution and the number of participants (less than 30) and study type (pre-test and post-test). P <0.05 was considered as the level of significance. Results A total of 23 patients completed the treatment protocol.Baseline demographic characteristics of patient are shown in Table 1.Parcipitant was composed of 13 male and 10female .The participants’ mean age was 30.6± 11.6.Etiology of ESRD was diabetes in 13(56/5%)and hypertension in5(21.7%)patients and other causes was 5(21/7%). After treatment mean total cholesterol levels decreased from 139.95 ± 35.49 mg/dL to 131.13 ± 34.96 mg/dL (p value =0.194 ) which was not statistically significant. But the decrease in serum triglyceride level was statistically significant ,from 242.08 ± 101.05 mg/dL decreased to 178.00 ± 48.02 mg/dL (pvalue = 0.004).HDL-c increased significantly after treatment from 36.20 ±7.08 mg/dL to 40.16 ±4.35mg/dL (pvalue =0.032). Serum CRP levels did not decreased.The limitations of our study were the small sample size and short duration of the investigation. Conclusion Melatonin supplement improves triglyceride and HDL-c in hemodialysis patients but has no effect on total cholesterol-c and CRP in hemodialysis patients.

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Uric acid as a future biomarker in diagnosing metabolic syndrome patients.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.3191 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1911-1915

Author(s):

Shameela Majeed ◽

Brig. Rizwan Hashim

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Uric Acid ◽

Waist Circumference ◽

Serum Uric Acid ◽

Serum Triglyceride ◽

Military Hospital ◽

P Value ◽

Model Assessment ◽

R Value

Objectives: To determine the possible correlation between raised serum uric acid and various components of metabolic syndrome (Waist circumference, serum triglyceride, plasma HDL-C). Study Design: Descriptive case control. Setting: Army Medical College laboratory, Military Hospital, Rawalpindi. Period: One year (November 2014 to October 2015). Material and Methods: Total of 100 subjects were enrolled in this study. WHO criteria were applied for identifying the patients of metabolic syndrome. Fasting plasma glucose, lipid profile and serum uric acid levels were measured by using colorimetric enzymatic method. The formula of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was applied to calculate Insulin resistance. Collected data was analyzed by using SPSS- Window version-17 for statistical analysis. Results: Serum uric acid levels were turned out to be high in metabolic syndrome patients (cases= 6.1±1.3mg/dL) when compared with controls (having no symptoms of MetS=3.6±1.2; p<0.001). Uric acid showed a statistically significant positive association with waist circumference (WC=r-value:0.250; p-value:0.000) and serum triglyceride (TG=r-value:0.341; p-value:0.000). Negative correlation had been found between plasma high-density lipoprotein-cholesterol (HDL-C=r-value: -0.173; p-value:<0.01) with uric acid levels. Conclusion: Serum uric acid levels show a significant association with components of metabolic syndrome making it a powerful biomarker of metabolic syndrome and its various cardiometabolic complications.

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PREVALENCE AND CHARACTERISTICS OF METABOLIC SYNDROME PATIENTS IN CIBEBER VILLAGE CIMAHI INDONESIA

10.54052/jhds.v1n1.p27-37 ◽

2021 ◽

Vol 1 (Volume 1 No 1) ◽

pp. 27-37

Author(s):

Iis Inayati Rakhmat ◽

Hadi Jusuf ◽

Sinta Rachmanita

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Pap Test ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

The Elderly ◽

Cross Sectional ◽

Descriptive Research ◽

Cholesterol Levels ◽

Cross Sectional Design

Metabolic syndrome is a health problem that often occurs among populations in Indonesia. Data on the characteristics of patients with metabolic syndrome is still very limited, despite the importance of cardiovascular disease prevention. The study aims to explain the prevalence and characteristics of patients with metabolic syndrome in Indonesia. The research methodology used descriptive research using a cross-sectional design. The number of respondents was seven men and 34 women, counted by consecutive sampling. The data was collected from the SQ-FFQ questionnaire and calculating the DQI-I score, analyzing physical activity through the GPAQ questionnaire converted into METs, measuring blood pressure, taking blood, measuring waist circumference, measuring fasting blood sugar. Through enzymatic tests, Serum triglyceride levels through the enzymatic colorimetric GPO-PAP test and HDL cholesterol levels were measured by the CHODPAP method. The results showed that the prevalence of SM was 20.45%, and the majority were women. The largest age group were the elderly. Most cases of metabolic syndrome have three components, with the largest components being central obesity (100%) and blood pressure (88.89%). Most categories of activity were moderate, and diet quality was low. All metabolic syndrome patients in this study were found not to smoke and not to consume alcohol. Based on these results, it can be concluded that SM incidence was high. Further research is needed regarding the relationship between acquired risk factors and metabolic syndrome.

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Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis

British Journal Of Nutrition ◽

10.1017/s000711451900254x ◽

2019 ◽

Vol 123 (1) ◽

pp. 1-22 ◽

Cited By ~ 6

Author(s):

‘Mo’ez Al-Islam’ E. Faris ◽

Haitham A. Jahrami ◽

Joud Alsibai ◽

Asma A. Obaideen

Keyword(s):

Metabolic Syndrome ◽

Meta Analysis ◽

Hdl Cholesterol ◽

Serum Glucose ◽

Intermittent Fasting ◽

The Metabolic Syndrome ◽

Muslim People ◽

The Impact ◽

Stable Estimate ◽

Metabolic Syndrome Components

AbstractStudies on the impact of Ramadan diurnal intermittent fasting (RDIF) on the metabolic syndrome (MetS) components among healthy Muslims observing Ramadan month have yielded contradictory results. This comprehensive meta-analysis aimed to obtain a more stable estimate of the effect size of fasting during Ramadan on the MetS components, examine variability among studies, assess the generalisability of reported results and perform subgroup analyses for associated factors. We searched the CINAHL, Cochrane, EBSCOhost, Google Scholar, ProQuest Medical, PubMed/MEDLINE, ScienceDirect, Scopus and Web of Science databases for relevant studies published from 1950 to March 2019. The MetS components analysed were: waist circumference (WC), systolic blood pressure (SBP), fasting plasma/serum glucose (FG), TAG, and HDL-cholesterol. We identified eighty-five studies (4326 participants in total) that were conducted in twenty-three countries between 1982 and 2019. RDIF-induced effect sizes for the MetS components were: small reductions in WC (no. of studies K = 24, N 1557, Hedges’ g = −0·312, 95 % CI −0·387, −0·236), SBP (K = 22, N 1172, Hedges’ g = −0·239, 95 % CI −0·372, −0·106), FG (K = 51, N 2318, Hedges’ g = −0·101, 95 % CI −0·260, 0·004) and TAG (K = 63, N 2862, Hedges’ g = −0·088, 95 % CI −0·171, −0·004) and a small increase in HDL-cholesterol (K = 57, N 2771, Hedges’ g = 0·150, 95 % CI 0·064, 0·236). We concluded that among healthy people, RDIF shows small improvement in the five MetS components: WC, SBP, TAG, FG and HDL.

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Study on Association of Maternal Triglyceride and Preeclampsia

Faridpur Medical College Journal ◽

10.3329/fmcj.v14i2.48184 ◽

2020 ◽

Vol 14 (2) ◽

pp. 82-85

Author(s):

Swapna Biswas Joy ◽

Md Rabiul Islam ◽

Monika Khandoker ◽

Ananta Kumar Biswas

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Diastolic Blood Pressure ◽

Triglyceride Level ◽

Serum Triglyceride ◽

P Value ◽

Serum Triglyceride Level ◽

College Hospital ◽

Urine Albumin ◽

Significant Difference

Preeclampsia is one of the most important pregnancy disorder, diagnosed with hypertension and proteinuria. It is the leading cause of fetal and maternal morbidity and mortality. This cross-sectional study was conducted in 100 pregnant women, of them, 50 were diagnosed cases of preeclampsia and 50 were normal pregnant women attended in the Gynaecology and Obstetrics department of Dhaka Medical College Hospital, Dhaka, during July 2016 to June 2017. Five ml fasting blood sample was collected and was analysed for triglyceride using standard enzymatic method. Mean value of triglyceride was compared between two groups by student unpaired t-test and the triglyceride level was correlated with systolic, diastolic blood pressure and urine albumin in preeclamptic patient was correlated by Pearson's correlation coefficient test. A p-value was considered to be statistically significant at 0.05 at 95% confidence interval. Statistically significant difference of serum triglyceride level was found in preeclamptic women and normal pregnant women (p<0.05). The level was 248.90±31.36 mg/dl in preeclampsia and 197.00±27.04 mg/dl in normal pregnant women respectively. Serum triglyceride was positively correlated with systolic, diastolic blood pressure and urine albumin in preeclamptic women. Faridpur Med. Coll. J. Jul 2019;14(2): 82-85

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Relationship between ultra-processed foods and metabolic syndrome in adolescents from a Brazilian Family Doctor Program

Public Health Nutrition ◽

10.1017/s1368980011001571 ◽

2011 ◽

Vol 15 (1) ◽

pp. 82-87 ◽

Cited By ~ 152

Author(s):

Letícia Ferreira Tavares ◽

Sandra Costa Fonseca ◽

Maria Luiza Garcia Rosa ◽

Edna Massae Yokoo

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Family Doctor ◽

Elevated Serum ◽

Prevalence Ratio ◽

Hdl Cholesterol ◽

Serum Glucose ◽

Processed Foods ◽

Cross Sectional ◽

Statistical Adjustment

AbstractObjectiveTo estimate the association between food intake and metabolic syndrome (MetS).DesignCross-sectional design conducted from July 2006 to December 2007.SettingAdolescents assisted by the Family Doctor Program (FDP) in Niterói, a metropolitan area in Rio de Janeiro State, Brazil.SubjectsSurvey of 210 adolescents. Individuals with three or more of the following components of MetS were classified as having this syndrome: TAG ≥ 110 mg/dl; HDL cholesterol < 50 mg/dl for girls aged 12–19 years and boys aged 12–14 years or <45 mg/dl for boys aged 15–19 years; waist circumference ≥75th percentile; serum glucose >100 mg/dl; and blood pressure ≥90th percentile. A semi-quantitative FFQ was used, and foods were grouped as: unprocessed or minimally processed foods (Group 1), processed culinary and food industry ingredients (Group 2) and ultra-processed foods (Group 3). The associations between food consumption and MetS were adjusted for sociodemographic, behavioural and family history covariates and were estimated using generalized estimation equations with the Poisson regression model.ResultsMetS was diagnosed in 6·7 % of the adolescents; the most frequent diagnostic criteria included the reduction of HDL cholesterol (46·7 %), elevated serum glucose (17·1 %) and the elevation of waist circumference (16·7 %). Crude analysis showed higher average daily intakes of energy, carbohydrates and ultra-processed foods among adolescents with MetS. After statistical adjustment, the intake of ultra-processed foods (≥3rd quartile) remained associated with MetS (prevalence ratio = 2·5; P = 0·012).ConclusionsHigh consumption of ultra-processed foods was associated with the prevalence of MetS in this adolescents group.

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Nutritional and lifestyle intervention strategies for metabolic syndrome in Southeast Asia: A scoping review of recent evidence

PLoS ONE ◽

10.1371/journal.pone.0257433 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0257433

Author(s):

Sze Mun Thor ◽

Jun Wern Yau ◽

Amutha Ramadas

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Southeast Asia ◽

Scoping Review ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

Southeast Asian ◽

Dietary Interventions ◽

Southeast Asians ◽

Asian Populations

Metabolic syndrome (MetS) is frequently associated with various health issues and is a major contributor to morbidity and mortality worldwide, particularly with its recent relevance to coronavirus disease 2019 (COVID-19). To combat its increasing prevalence in Southeast Asia, numerous intervention programs have been implemented. We conducted a scoping review on recent interventions to manage MetS among Southeast Asians using standard methodologies. Cochrane, Embase, Ovid MEDLINE, PubMed, and Scopus databases were systematically searched to yield peer-reviewed articles published between 2010–2020. We included 13 articles describing 11 unique interventions in four Southeast Asian countries: Malaysia, Thailand, Indonesia, and Vietnam. These interventions were broadly categorized into four groups: (i) nutrition (n = 4); (ii) physical activity (n = 2); (iii) nutrition and physical activity (n = 2); and (iv) multi-intervention (n = 3). Most studies investigated the effects of an intervention on components of MetS, which are anthropometry, blood pressure, glucose-related parameters, and lipid profile. Significant improvements ranged from 50% of studies reporting serum triglyceride and HDL-cholesterol levels to 100% for waist circumference. Evidence on interventions for individuals with MetS remains limited in Southeast Asia. More studies from other countries in this region are needed, especially on the effects of dietary interventions, to effectively address gaps in knowledge and provide sufficient data to design the ideal intervention for Southeast Asian populations.

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