scholarly journals P1272ECFECT OF MELATONIN ON DYSLIPIDEMIA IN HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nargesossadat Zahed ◽  
Marjan Pouyamehr ◽  
Adineh Taherkhani
Keyword(s):  
Total Cholesterol ◽  
Serum Triglyceride ◽  
Hemodialysis Patients ◽  
Small Sample ◽  
Inflammatory Factors ◽  
P Value ◽  
Serum Triglyceride Level ◽  
Inclusion Criteria ◽  
History Of ◽  
Serum Crp

Abstract Background and Aims Cardiovascular disease is one of the major causes of death in hemodialysis patients. Lipid metabolism abnormalities and increased inflammatory factors are related factors. In recent studies melatonin inhibits dyslipidemia and reduces inflammatory factors by inhibiting LDL-c oxidation. The purpose of this study was to evaluate the effect of melatonin supplement on hyperlipidemia and c reactive protein (CRP ) level in hemodialysis patients. Method In this clinical trial ,the inclusion criteria were as follows:age older than 18 years, undergoing dialysis for at least 3 months,triglyceride >150mg/dL,HDL-c<40 mg/dL in males, HDL-c<50 mg/dL in females and serum CRP>5 mg/l Exclusion criteria were: Patients with a history of stroke, myocardial infarction, peripheral vascular disease, malignancy, heart failure, liver cirrhosis, active liver disease, history of infection, hospitalization one month ago, hepatitis B and C.HIV, and taking corticosteroid, statin, Non-steroidal anti-inflammatory drugs. Among 200 hemodialysis patients,only 28 patients fulfilled the inclusion criteria.. Patients were treated with Melatonin supplements 3 mg per day at bedtime during 12 weeks. Serum lipid profile and CRP level were measured after 12 weeks. Five patients were excluded, 2 patients underwent kidney transplantation, and three patients did not cooperate. Data were analyzed by SPSS 20 software. Normal distributed quantitative data were expressed as the mean ± SD and qualitative data was expressed as frequency and percentage. Wilcoxon matched pairs test was used to compare the two groups according to the type of study that had no normal distribution and the number of participants (less than 30) and study type (pre-test and post-test). P <0.05 was considered as the level of significance. Results A total of 23 patients completed the treatment protocol.Baseline demographic characteristics of patient are shown in Table 1.Parcipitant was composed of 13 male and 10female .The participants’ mean age was 30.6± 11.6.Etiology of ESRD was diabetes in 13(56/5%)and hypertension in5(21.7%)patients and other causes was 5(21/7%). After treatment mean total cholesterol levels decreased from 139.95 ± 35.49 mg/dL to 131.13 ± 34.96 mg/dL (p value =0.194 ) which was not statistically significant. But the decrease in serum triglyceride level was statistically significant ,from 242.08 ± 101.05 mg/dL decreased to 178.00 ± 48.02 mg/dL (pvalue = 0.004).HDL-c increased significantly after treatment from 36.20 ±7.08 mg/dL to 40.16 ±4.35mg/dL (pvalue =0.032). Serum CRP levels did not decreased.The limitations of our study were the small sample size and short duration of the investigation. Conclusion Melatonin supplement improves triglyceride and HDL-c in hemodialysis patients but has no effect on total cholesterol-c and CRP in hemodialysis patients.

scholarly journals Evaluation of Serum Triglyceride and Total Cholesterol Status in Adolescent Smoker

1970 ◽  
Vol 1 ◽  
pp. 14-18
Author(s):  
L Afrin ◽  
R Sultana ◽  
S Ferdousi ◽  
A Ahmed ◽  
MR Amin
Keyword(s):  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Triglyceride ◽  
Adolescent Male ◽  
Serum Triglyceride Level ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Increased Risk ◽  
The Mean ◽  
Dose Response Effect

Objectives: A cross sectional comparative study was performed to evaluate the changes of the serum lipid profile in apparently healthy adolescent male non smokers and smokers’ subjects. Method: This study was carried out in the department of Physiology of Dhaka Medical College from January to December 2005. For this purpose, total 80 subjects with age range 12-19 years were selected, of whom 20 were non smokers (control) and 60 were smokers (experimental) who smoked for at least one year. Again smokers were grouped according to the number of cigarettes smoked per week, ( mild < 19, moderate 20-59, heavy >60). Fasting serum Triglyceride and total Cholesterol levels of all subjects were measured. Data were compared between smokers and non smokers and between non smoker and mild moderate and heavy smokers and analyzed statistically by unpaired t test. Result: Mean ±SD Triglyceride levels were136.80mg/dl ± 42.18 vs. 153.12mg/dl ± 26.66 and Mean ±SD Total Cholesterol levels were 165.20mg/dl ± 15.13 vs165.36mg/dl ± 10.12 in non smokers and smokers respectively. there were no significant changes in the mean serum total cholesterol levels in adolescent smokers but the mean serum triglyceride level in smokers were significantly higher (p<0.01 )than that of non smokers. hyper Triglyceridemia (TG level> 150mg/dl) were observed in 56% of smoker subjects whereas 36% in non smokers. The dose response effect of smoking was observed in serum triglyceride levels of smoker subgroups. Mean ±SD TG levels in mild, moderate, heavy groups were 148.15mg/dl± 21.32,152.8mg/dl± 29.49,154.12mg/dl± 23.75 respectively. Conclusion: From the result of the present study it may be concluded that, cigarette smoking during adolescent period induces alteration in serum lipid levels in the direction of increased risk for coronary artery disease. J Bangladesh Soc Physiol. 2006 Dec;(1):14-18

scholarly journals Lipid Abnormalities in the Natural History of Diabetes

2015 ◽  
Vol 16 (2) ◽  
pp. 83-88
Author(s):  
Muhammad Hafizur Rahman ◽  
Liaquat Ali
Keyword(s):  
Metabolic Syndrome ◽  
Natural History ◽  
Total Cholesterol ◽  
Fasting Glucose ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Family History Of Diabetes ◽  
History Of ◽  
Lipid Abnormalities ◽  
Design And Methods

Objective: To explore lipid abnormalities in normoglycemic first-degree diabetic relatives (FDRs) and prediabetic and diabetic subjects in the natural history of diabetes.Research design and methods: Thirty six impaired fasting glucose (IFG), 61 isolated impaired glucose tolerance (I-IGT), 64 combined IFG-IGT, 73 diabetic, and 32 FDRs along with 57 normoglycemic healthy controls without family history of diabetes in 1st degree relatives, were selected purposively following 2003 ADA cut-off values and 2006 WHO/IDF grouping. Anthropometry and blood pressure of the subjects were taken. Fasting and 2-h plasma glucose and HbA1C were measured. Fasting plasma triglyceride, total cholesterol and HDL cholesterol were measured by enzymatic colorimetric method.Results: Serum triglyceride was higher in IFG, I-IGT, IFG-IGT, diabetic and FDRs compared to Control [145 (59- 307), 128 (66-584), 166 (68-764), 161 (69-750) and 130 (81-281) vs. 108 (47-219) mg/dl, P<0.01, P<0.01, P<0.001, P<0.001 and P<0.05]. Total cholesterol was raised in IFG-IGT and diabetes compared to Control [185 (105-310), 185 (123-326) vs. 171 (101-235) mg/dl, P<0.05] and FDRs. But HDL did not differ among the groups. Prevalence of metabolic syndrome was higher in IFG, I-IGT, IFG-IGT and diabetes and FDRs than Control [55%, 38%, 57%, 58% and 36% vs. 15%, P<0.001, P<0.01, P<0.001, P<0.001 and P<0.05] and also in IFGIGT and diabetic compared to I-IGT and FDRs (P<0.05).Conclusions: Higher prevalence of metabolic syndrome and raised serum triglyceride is seen among diabetic, prediabetic and 1st degree diabetic-relatives. Total cholesterol and non-HDL cholesterol is raised only in IFG-IGT and diabetes, the more decompensated glycemic states.J MEDICINE July 2015; 16 (2) : 83-88

scholarly journals A study of lipid parameters among GDM and non GDM pregnant women: a hospital based study

2017 ◽  
Vol 6 (12) ◽  
pp. 5488 ◽  
Author(s):  
Bharathi K. R. ◽  
Vijayalakshmi S. ◽  
Shrunga R. P.
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Statistical Significance ◽  
Serum Triglyceride ◽  
Normal Pregnancy ◽  
P Value ◽  
Case Group ◽  
Lipid Levels ◽  
Lipid Parameters

Background: Altered maternal lipid metabolism is common in pregnancy. In women with GDM physiological changes in insulin and lipid levels are exaggerated during pregnancy, leading to significant alterations in lipid levels compared to normal pregnancy. Assessment of raise in certain lipid parameters in pregnant women with GDM and non GDM.Methods: A hospital based case control study done in the Department of OBG AIMS Bellur, Mandya, Karnataka, with sample size of 100 pregnant women. 50 cases of GDM (confirmed by OGCT) and 50 controls (non GDM cases) pregnant women were taken during 1 year study period from June 2015 to June 2016. Mean age of presentation of women was 20-25 yrs. Ethical committee clearance was taken and consent from control and cases was taken. Fasting lipid profile was sent. Parameters obtained were analyzed using student t test for statistical significance.Results: There was no statistical difference in age and parity between control and case group. Triglyceride (cases- 286.4±77.60 mg/dl) (controls-166±26mg/dl), total cholesterol (cases-256.5±41.7 mg/dl) (controls -202.5±20.18mg/dl), VLDL (cases-53.4±13.2 mg/dl) (controls-46.6±13.1mg/dl) showed statistically significant values (p value<0.001). HDL and LDL values did not show any statistical significance (p value >0.5) among GDM and non GDM group. Lipid profile was performed predominately in women in II trimester.Conclusions: Serum triglyceride, total cholesterol and VLDL level are significantly higher among woman with GDM compared to non GDM pregnant women, where in the lipid profile can be used as predictor for gestational diabetes mellitus in future which needs further research.

scholarly journals Metabolic syndrome in patients with chronic plaque psoriatic disease: a case-control study from western Uttar Pradesh, India

2018 ◽  
Vol 6 (2) ◽  
pp. 688
Author(s):  
Shailendra Jain ◽  
Preeti Jain ◽  
Abhishek Singh ◽  
Shewtank Goel
Keyword(s):  
Metabolic Syndrome ◽  
Venous Blood ◽  
Serum Triglyceride ◽  
Uttar Pradesh ◽  
Hdl Cholesterol ◽  
Serum Glucose ◽  
P Value ◽  
Serum Triglyceride Level ◽  
General Physical Examination ◽  
Psoriatic Disease

Background: Various studies on psoriasis and metabolic syndrome have shown a large variation in their results. An increasing frequency is imposing a substantial burden on the overall health of psoriasis patients that needs to be appropriately foreseen and addressed. Aim of this study was to study various aspects of metabolic syndrome in patients with chronic plaque psoriatic disease in northern Indian region.Methods: A cohort of patients registering for treatment of chronic plaque psoriasis at Dermatology outpatients’ department formed the study population. Detailed history was captured. General physical examination was carried out. A thorough cutaneous examination was undertaken which captured details on type, distribution and arrangement of primary lesions and secondary changes in patients. After overnight fasting, venous blood samples were collected from the subjects and were analysed for serum glucose, triglyceride and HDL-cholesterol. Results: Metabolic syndrome in psoriasis was associated with higher age. Gender wise male preponderance was observed. Among the psoriasis cases, 64% had metabolic syndrome whereas among the control subjects 48% had the condition (p-value 0.158). The mean for serum triglyceride level for psoriasis patients (159.42 mg/dL) was higher than controls (144.25 mg/dL). Forty six percent of cases fulfilled elevated triglycerides ≥150 mg/dl as a criterion of metabolic syndrome, compared to 40% of controls. Conclusions: We observed a higher frequency of metabolic syndrome among psoriasis cases in a northern Indian population. An association of dyslipidemia with psoriasis was also noted. Routine screening of the condition to facilitate early diagnosis and treatment should be undertaken.

Evaluation of readmission rates for gastrointestinal bleeds in high risk oncologic patients.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23031-e23031
Author(s):  
Laila Babar ◽  
Veli Bakalov ◽  
Dulabh K. Monga ◽  
Zena Chahine ◽  
Obaid Ashraf
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Cancer Patients ◽  
Hospital Admissions ◽  
P Value ◽  
Inclusion Criteria ◽  
Readmission Rates ◽  
Discharge Disposition ◽  
Oncologic Patients ◽  
History Of

e23031 Background: Gastrointestinal bleeding (GIB) results in high rates of hospital admissions, readmissions, significant morbidity and high healthcare cost. To lower readmission rates, Medicare mandates public reporting, however it does not differentiate between patient populations. GIB is a complex disease with treatment selection and patient outcome changing with different patient populations. We must identify vulnerable groups and high risk characteristics. Malignancy is a hypercoaguable disease and when combined with atrial fibrillation or history of clots, it can increase stroke and pulmonary embolism risk. These patients require anticoagulation putting them at a higher risk of bleeding. In our study, we identified cancer patients with atrial fibrillation and evaluated reasons for differences in readmission rates for GIB. Methods: We queried our EMR for a list of patients from April 2016-April 2018. Inclusion criteria was admission for GIB, a history of cancer, atrial fibrillation, DVT or PE. Patients were divided into groups with and without readmission for GIB, and differences in characteristics were analyzed. Odds ratios(OR) with p-value 0.05 and confidence interval (CI) 95% were calculated. Results: Of 111 patients, 57 met our inclusion criteria, 32 male and 25 female with average age 78.8 years. 18 patients required readmission, 12 for GIB. 32% of our population was readmitted within 30 days of discharge, 21% was readmitted for a GIB. BMI > 30(OR:0.28; CI 0.15-0.54; p = 0.0002), ICU admission during hospitalization(OR:0.083; CI 0.019-037; p = 0.0011), and lower GI tract as site of bleeding (OR:0.54; CI 0.30-0.98; p = 0.04) were associated with a lower incidence of readmission for GIB. Administration of blood transfusion (OR:2.80; CI 1.58-4.99; p = 0.0004)and discharge disposition to skilled facility(OR:1.93; CI 1.04-3.57; p = 0.036) was associated with a higher incidence of readmission. There was no difference with type of anticoagulation. Conclusions: The readmission rates for GIB in our population (32%) was higher than the national average (12%). Cancer patients requiring anticoagulation have a drastically different hospital course and outcomes than healthy patients and should have different quality metrics and treatment algorithms. This will also make Medicare penalties more accurate.

scholarly journals Study on Association of Maternal Triglyceride and Preeclampsia

2020 ◽  
Vol 14 (2) ◽  
pp. 82-85
Author(s):  
Swapna Biswas Joy ◽  
Md Rabiul Islam ◽  
Monika Khandoker ◽  
Ananta Kumar Biswas
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Diastolic Blood Pressure ◽  
Triglyceride Level ◽  
Serum Triglyceride ◽  
P Value ◽  
Serum Triglyceride Level ◽  
College Hospital ◽  
Urine Albumin ◽  
Significant Difference

Preeclampsia is one of the most important pregnancy disorder, diagnosed with hypertension and proteinuria. It is the leading cause of fetal and maternal morbidity and mortality. This cross-sectional study was conducted in 100 pregnant women, of them, 50 were diagnosed cases of preeclampsia and 50 were normal pregnant women attended in the Gynaecology and Obstetrics department of Dhaka Medical College Hospital, Dhaka, during July 2016 to June 2017. Five ml fasting blood sample was collected and was analysed for triglyceride using standard enzymatic method. Mean value of triglyceride was compared between two groups by student unpaired t-test and the triglyceride level was correlated with systolic, diastolic blood pressure and urine albumin in preeclamptic patient was correlated by Pearson's correlation coefficient test. A p-value was considered to be statistically significant at 0.05 at 95% confidence interval. Statistically significant difference of serum triglyceride level was found in preeclamptic women and normal pregnant women (p<0.05). The level was 248.90±31.36 mg/dl in preeclampsia and 197.00±27.04 mg/dl in normal pregnant women respectively. Serum triglyceride was positively correlated with systolic, diastolic blood pressure and urine albumin in preeclamptic women. Faridpur Med. Coll. J. Jul 2019;14(2): 82-85

scholarly journals Tinzaparin Provides Lower Lipid Profiles in Maintenance Hemodialysis Patients: A Cross-Sectional Observational Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Ming-Hsien Tsai ◽  
Yu-Wei Fang ◽  
Jyh-Gang Leu
Keyword(s):  
Multivariate Analysis ◽  
Total Cholesterol ◽  
Univariate Analysis ◽  
Serum Triglyceride ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Maintenance Hemodialysis ◽  
Diabetic Patients ◽  
Significant Difference ◽  
The Impact

As a low-molecular-weight heparin, tinzaparin has effectively been used as an anticoagulant during hemodialysis sessions. However, the impact of different heparin types on dyslipidemia is still controversial. In our study, 434 chronic hemodialysis patients were evaluated. The mean age was 65 ± 13. Forty-eight patients (11%) and 386 patients (89%) were in the tinzaparin and unfractionated heparin (UFH) groups, respectively. Triglyceride had significant difference between the two groups (P=0.001) but total cholesterol, HDL, or LDL did not. In the univariate analysis, the triglyceride level was significantly associated with tinzaparin use [β: −39.9, 95% confidence interval (CI): −76.7 to −3.0], and this association remained following the multivariate analysis (β: −40.8, 95% CI: −75.1 to −6.5). The difference in serum total cholesterol level between tinzaparin and UFH became significant (β: −13, 95% CI: −24.5 to −1.56) after adjustment in the multivariate analysis. Moreover, in a subgroup analysis, male diabetic patients showed lower serum triglyceride levels with the use of tinzaparin, while older, nondiabetic, male patients showed significant advantages in total cholesterol levels with the use of tinzaparin. Based on our findings, tinzaparin shows a significant association with a lower lipid profile in patients with chronic hemodialysis when compared to UFH.

scholarly journals Ansietas Difference in Hemodialisa Patients Based on Gender Perspective

2019 ◽  
Vol 6 (1) ◽  
pp. 019-026
Author(s):  
Muhammad Rosyidul Ibad
Keyword(s):  
Kidney Failure ◽  
Chronic Kidney Failure ◽  
Hemodialysis Patients ◽  
P Value ◽  
Profile Data ◽  
Gender Perspective ◽  
Therapeutic Procedures ◽  
History Of ◽  
Negative Perceptions ◽  
Level Of Understanding

Patients undergoing hemodialysis therapy during their lifetime will depend on the dializzer device, the hemodialysis procedure must be carried out routinely and continuously with a frequency of 2-3 times in one week. Profile data shows that chronic kidney failure in Indonesia is slightly more prevalent in men than in women, individuals who experience chronic kidney failure and who are undergoing a hemodialysis process have the potential to experience emotional problems. Anxiety is the main disorder that can arise due to hemodialysis procedures, a person undergoing hemodialysis will have concerns, fears, and uncertainties resulting from negative perceptions. Researchers have identified differences in anxiety among hemodialysis patients based on a gender perspective through the Kruskal wallis test. The results show that the p-value obtained is P = 0.488, this means that there are no differences in anxiety experienced by both male and female respondents. The emergence of anxiety in general in hemodialysis patients is caused by various factors such as financial problems that must be supported by the use of health insurance, the level of understanding of the disease and therapeutic procedures, and a history of undergoing a therapeutic procedure

scholarly journals A study of serum lipid profile in smokers and non-smokers: evaluation of role of smoking on lipid profile

2019 ◽  
Vol 7 (4) ◽  
pp. 1016
Author(s):  
Chandrashekar V. Kubihal ◽  
Hemalatha D. Naik
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Triglyceride ◽  
Blood Cholesterol ◽  
Serum Lipid Profile ◽  
Serum Triglyceride Level ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Increased Risk

Background: Several studies have reported elevated blood cholesterol levels among persons who regularly smoke cigarettes and lowered blood cholesterol levels among persons quitting smoking. Other studies have also shown that smoking lowers high density lipoprotein level, resulting in an increased risk of coronary heart disease. Smoking also leads to increase in LDL cholesterol and triglyceride levels. The objective was to study serum lipid profile in smokers and non-smokers.Methods: A cross sectional comparative study was carried in 100 subjects. The subjects were divided into two groups. First group consisted of 25 nonsmokers and second group of 75 smokers. The group of 75 smokers was again divided into three equal sub groups of 25 each depending upon the duration and intensity of smoking. Concentration of serum total cholesterol and HDL was determined by Zak’s method. Concentration of serum LDL and VLDL cholesterol was determined by Friedwald’s formula. Concentration of serum triglyceride level was determined by enzymatic end point peroxidase coupled method.Results: All the values of lipid profile i.e., total cholesterol, triglycerides, LDL, VLDL were found to be significantly higher among the smokers compared to the non-smokers. HDL value was significantly lower among smokers. As the degree of smoking increased from mild to heavy smokers, the values of total cholesterol, triglycerides, LDL and VLDL increased. The degree of smoking was inversely proportional to HDL values i.e., the HDL value decreased as the smoking degree increased.Conclusions: Thus, it can be said based on the present study that smoking affects and deranges the lipid profile of the person.

scholarly journals Association of Serum Ceruloplasmin Level with Obesity: Some Components of Metabolic Syndrome and High-Sensitive C-Reactive Protein in Iran

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Seyyed Morteza Safavi ◽  
Rahele Ziaei ◽  
Mohammad Reza Maracy
Keyword(s):  
Total Cholesterol ◽  
Triglyceride Level ◽  
Serum Triglyceride ◽  
Positive Association ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Serum Triglyceride Level ◽  
Metabolic Disturbances ◽  
Serum Ceruloplasmin

Background. One of the mechanisms that has been suggested for obesity related metabolic disturbances is obesity-induced inflammation. Pro-inflammatory cytokines generated in adipose tissue can increase hepatic synthesis of inflammation-sensitive plasma proteins (ISPs) including ceruloplasmin (Cp). In this study we aimed to investigate the relation between serum Cp level and obesity.Methods. 61 persons with body mass index (BMI) ≥ 25 kg/m2(case group) and 61 persons with BMI < 25 kg/m2(control group) were included in this study with a case-control design. Serum Cp levels, triglyceride level, fating blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and hsCRP were measured in both groups.Results. We did not observe any significant association between serum Cp level and BMI in all subjects [OR: 1.02 (CI, 0.967 to 1.07)] and in case (β=0.012,P=0.86) and control groups (β=0.49,P=0.07) separately. However, in control group, this positive association was marginally significant. We found a positive correlation between serum Cp level and serum triglyceride level.Conclusion. Serum Cp level was not related to obesity in this group of subjects. None of the baseline variables could predict obesity in this group of subjects, including serum Cp level, FBS, total cholesterol, LDL and HDL- cholesterols and hsCRP.

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