scholarly journals Pre-exposure hydroxychloroquine prophylaxis for COVID-19 in healthcare workers: a retrospective cohort

2020 ◽  
Vol 9 (1) ◽  
pp. 89
Author(s):  
Raja Bhattacharya ◽  
Sampurna Chowdhury ◽  
Anita Nandi ◽  
Rishav Mukherjee ◽  
Manish Kulshrestha ◽  
...  
Keyword(s):  
Retrospective Cohort ◽  
Healthcare Workers ◽  
Primary Outcome ◽  
Tertiary Care ◽  
Incidence Rates ◽  
Control Group ◽  
Care Hospital ◽  
Care Workers ◽  
Co Morbidity ◽  
Exposure Prophylaxis

Background: While several trials are ongoing for treatment of Corona virus 2019 (COVID-19), scientific research on chemoprophylaxis is still lacking even though it has potential to flatten the curve allowing us time to complete research on vaccines.Methods: This retrospective cohort study explores the potential of hydroxychloroquine (HCQ) as a pre- exposure prophylaxis for COVID-19 among 106 health care workers (HCW) exposed to COVID-19 patients, at a tertiary care hospital in India where there was an abrupt cluster outbreak within on duty personnel. HCWs who had voluntarily taken HCQ prior to exposure were considered one cohort while those who had not were considered to be the Control group. All participants with a verifiable high-risk contact history were tested for COVID-19 by RT- PCR.Results: The two cohorts were comparable in terms of age, gender, co-morbidity and exposure. The primary outcome was incidence rates of RT-PCR positive COVID-19 infection among HCQ users and Controls.106 HCW were examined of whom 54 were HCQ users. The comparative analysis of incidence of infection between the two groups demonstrated that voluntary HCQ usage was associated with lesser likelihood of developing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (4 out of 54 HCW), compared to those who were not on it (20 out of 52 HCW), χ2=14.59, p<0.001. None of the HCQ users noted any serious adverse effects.Conclusions: The study demonstrated that voluntary pre- exposure HCQ prophylaxis by HCWs is associated with a statistically significant reduction in risk of SARS-CoV-2.  

scholarly journals Pre exposure Hydroxychloroquine Prophylaxis for COVID-19 in healthcare workers: a retrospective cohort

2020 ◽  
Author(s):  
Raja Bhattacharya ◽  
Sampurna Chowdhury ◽  
Rishav Mukherjee ◽  
Manish Kulshrestha ◽  
Rohini Ghosh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Healthcare Workers ◽  
Primary Outcome ◽  
Care Center ◽  
Tertiary Care ◽  
Incidence Rates ◽  
Care Workers ◽  
Randomised Controlled ◽  
Exposure Prophylaxis ◽  
Larger Sample

AbstractBackgroundWhile several trials are ongoing for treatment of COVID-19, scientific research on chemoprophylaxis is still lacking even though it has potential to delay the pandemic allowing us time to complete research on vaccines.MethodsWe have conducted a cohort study amongst Health Care Workers (HCW) exposed to COVID-19 patients, at a tertiary care center in India where there was an abrupt cluster outbreak within on duty personnel. HCWs who had voluntarily taken hydroxychloroquine (HCQ) prior to exposure were considered one cohort while those who had not were considered to be another. All participants with a verifiable contact history were tested for COVID-19 by rtPCR. The two cohorts were comparable in terms of age, gender, comorbidities and exposure. The primary outcome was incidence rates of rtPCR positive COVID-19 infection amongst HCQ users and non users.Results106 healthcare workers were examined in this cohort study of whom 54 were HCQ users and rest were not. The comparative analysis of incidence of infection between the two groups demonstrated that voluntary HCQ usage was associated with lesser likelihood of developing SARS-CoV-2 infection, compared to those who were not on it, X2=14.59, p<0.001. None of the HCQ users noted any serious adverse effects.ConclusionsThis study demonstrated that voluntary HCQ consumption as pre-exposure prophylaxis by HCWs is associated with a statistically significant reduction in risk of SARS-CoV-2. These promising findings therefore highlight the need to examine this association in greater detail among a larger sample using Randomised Controlled Trials (RCT).

scholarly journals Clinico-epidemiological profile of COVID-19 among health care workers from a tertiary care hospital

2021 ◽  
Author(s):  
Anuradha Tolpadi ◽  
Abhijeet Mane ◽  
Jitendra Oswal ◽  
Sujata Rege ◽  
Meera Modak ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Tertiary Care ◽  
Management Strategies ◽  
Care Hospital ◽  
Antigen Test ◽  
Rt Pcr ◽  
Tertiary Care Centre ◽  
Care Workers ◽  
Global Health Issue ◽  
Epidemiological Profile

Background: Coronavirus disease 2019 (COVID-19) is a global health issue. Healthcare workers (HCWs) are especially vulnerable to infection by SARS-CoV-2. The present study was conducted to determine the proportion of HCWs infected with COVID 19 in a tertiary care centre with emphasis on the epidemiological and clinical aspectMethods: HCWs (symptomatic and asymptomatic contacts) who tested positive for COVID-19 by SARS-CoV-RTPCR or COVID-19 rapid antigen test were included in the study. Demographic and clinical data of the infected HCWs was obtained through a detailed telephonic interview with structured questionnaire.Results: Out of total 921 HCWs tested for COVID-19 (SARS-CoV-2 RT-PCR and Rapid antigen test), 323 (35%) HCWs were positive. Proportion of COVID-19 positive HCWs among all HCWs was 13.67% (323/2362). Most COVID-19 positive HCWs (88%) were symptomatic. Majority of infected HCWs (62.23%) were between the age group of 21-30 years. Nurses were the most predominantly affected among various categories of HCWs (42.41%). Fever was the most common presenting symptom, seen in 160 (49.50%) HCWs. Comorbidities were found in 28 (8.66%) of infected HCWs. Majority of HCWs (86%) suffered from mild infection.Conclusions: HCWs, especially nurses, face a high risk of COVID-19 infection while providing care for suspected or confirmed COVID-19 patients. It is important to characterize the epidemiological and clinical profile of HCWs regarding COVID-19 for formulation of prevention and management strategies.

scholarly journals ASSESSMENT OF NOVEL CORONA VIRUS (COVID-19) AWARENESS AMONG MEDICAL LABORATORY TECHNOLOGIST IN A TERTIARY CARE HOSPITAL IN DELHI: A QUESTIONANAIRE BASED SURVEY

2020 ◽  
pp. 1-5
Author(s):  
Anjali Sharma ◽  
Manju Kumari ◽  
Heena Heena ◽  
Mukul Singh ◽  
Sunil Ranga ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Healthcare Workers ◽  
Tertiary Care ◽  
Medical Laboratory ◽  
Care Hospital ◽  
Online Questionnaire ◽  
Major Health Problem ◽  
Effective Interventions ◽  
Care Workers

Introduction: COVID-19 is rapidly spreading all over the world and is a major health problem in the current scenario. The aim of this study is to assess the awareness of related to COVID-19 disease among the health care workers. Material and methods: This is an online questionnaire based study comprising of 24 questions related to COVID-19 and included 89 health care workers. The responses were analyzed using SPSS software. Results: There were 50 females and 39 males. Among these 35 were trained and 54 were untrained. On analysis we found that females (96.0%) were more aware than males (92.3%). The response of trained persons were more accurate than those of untrained but was not significant (p=0.98). The most aware age group was 51-60 and most aware department was blood bank followed by microbiology. Conclusion: Awareness and preparedness of healthcare workers is low regarding the coronavirus infection. There is need of urgent effective interventions and training programs for various healthcare workers.

scholarly journals Post exposure prophylaxis for HIV among healthcare workers due to occupational exposure: a record based study at a tertiary care teaching hospital of Kolkata

2021 ◽  
Vol 8 (5) ◽  
pp. 2503
Author(s):  
Paramita Sarkar ◽  
Saibendu Kumar Lahiri
Keyword(s):  
Occupational Exposure ◽  
Healthcare Workers ◽  
Tertiary Care ◽  
Occupational Exposures ◽  
Post Exposure Prophylaxis ◽  
Care Hospital ◽  
Skin Mucus ◽  
Needle Stick ◽  
Post Exposure ◽  
Exposure Prophylaxis

Background: Healthcare workers (HCWs) regularly face the risk of exposure to sharp injuries and splashes as an occupational hazard, which presents major risk for acquiring blood-borne infectious agents like human immunodeficiency virus (HIV) which can be minimized by taking post exposure prophylaxis (PEP) measures. There are limited studies from India documenting details of PEP for HIV. This record-based study aimed to determine the occurrence of needle stick injuries (NSIs) and other high-risk occupational exposures to blood and body fluids (BBFs) among HCWs in a tertiary care hospital, Kolkata. We aimed to study details of PEP regimens used among HCWs exposed to HIV.Methods: Hospital record was analyzed from reported incidences of occupational exposures to BBFs occurred during the period of October 2013 to March 2019. Information on self-reported incidence of occupational exposure, and post-exposure management were collected.Results: A total of 105 incidents of occupational exposure were registered during study period. Interns (37, 35.2%) were most frequently exposed, followed by physicians (22, 21.0%) and nurse (21, 20.0%). 88 (83.8%) of the personnel sustained NSIs, and 17 (7.2%) had splashes to skin, mucus membranes. There was no significant difference between subjects with splashes to skin, mucus membranes and needle-stick cases regarding discontinuation of post exposure prophylaxis (PEP) (11.8% versus 19.3%, p<0.548). No cases of sero-conversion were reported.Conclusions: In spite of high incidences of exposures to HIV source, good efficacy of PEP was observed with no sero-conversion. PEP for HIV was well tolerated. Study emphasized the need for creating awareness about timely reporting of incidence.

scholarly journals Seroprevalence of Antibodies against SARS COV- 2 among Health Care Workers at Tertiary Care Hospital, Uttarakhand: A Retrospective study

2021 ◽  
Author(s):  
Amit K Saini ◽  
Prasan Kumar Panda ◽  
Yogesh Arvind Bahurupi ◽  
Balram Omar ◽  
Akhil T ◽  
...  
Keyword(s):  
Health Care ◽  
Retrospective Study ◽  
Health Care Workers ◽  
Healthcare Workers ◽  
Tertiary Care ◽  
Care Hospital ◽  
Igg Antibodies ◽  
Care Institute ◽  
Care Workers ◽  
Low Prevalence

Abstract Background: The number of confirmed SARS-CoV-2 infections is vastly underestimated. In this context, Seroprevalence surveys are of utmost importance to assess the proportion of the population that has already developed antibodies against the virus and might potentially be protected against subsequent infection. Health care workers face greater risk of developing SARS-CoV-2. Therefore, present retrospective study was undertaken to estimate the prevalence of antibodies against SARS-CoV-2 among healthcare workers at tertiary care institute, Uttarakhand. Material and Methods : Data was gathered from Hospital records of 704 healthcare workers admitted at COVID 19 Unit and attended Covid-OPD of tertiary care institute, Uttarakhand in-between 15th July to 14th Aug 2020. Result: Out of the 704 recruited participants, 14 (1.99%) were seropositive for IgG antibodies against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive RT-PCR) was 4.40%. Conclusion: The present study shows a low prevalence of SARS-CoV-2 IgG antibodies among health care workers. In addition, posting in COVID-19-positive areas was not associated with increased seropositivity. More studies are warranted to assess IgG/IgM antibodies against SARS-CoV-2 among those HCW who are exposed to COVID-19 patients.

scholarly journals Pre-Exposure Prophylaxis with Various Doses of Hdroxychloroquine among high-risk COVID 19 Healthcare Personnel: CHEER randomized controlled trial

2021 ◽  
Author(s):  
Fibhaa Syed ◽  
Mohammad Ali Arif ◽  
Rauf Niazi ◽  
Jaffer Bin Baqar ◽  
Ume Laila Hashmi ◽  
...  
Keyword(s):  
High Risk ◽  
Controlled Trial ◽  
Tertiary Care ◽  
Healthcare Providers ◽  
Healthcare Personnel ◽  
Control Group ◽  
Care Hospital ◽  
Safety And Efficacy ◽  
Novel Coronavirus ◽  
Exposure Prophylaxis

Background: Pre-exposure prophylaxis (PrEP) is a promising strategy to break the chain of transmission of novel coronavirus (2019-nCoV). Aims: This trial aimed to evaluate the safety and efficacy of PrEP with various doses of HCQ against a placebo among high-risk healthcare providers (HCPs). Methods: A phase II, randomized, placebo-controlled trial was conducted at a tertiary care hospital. A total of 228 HCPs were screened, we included 200 subjects with no active or past SARS-CoV-2 infection. Subjects of experimental groups 1-3 received HCQ in various doses and those in the control group received placebo. The study outcomes in terms of safety and efficacy were monitored. Participants exhibiting COVID-19 symptoms were tested for SARS-CoV-2 during the study and also by the end of the 12th week, with PCR or IgM and IgG serology. Results: Overall, 146 of 200 participants reported exposure to a confirmed COVID-19 case in the first month, 189 in the 2nd month and 192 were exposed by the 12th week of the study. Moreover, the precautionary practices, i.e. use of personal protective equipment (PPE), significantly varied; initially more than 80% of the exposed HCPs weren't ensuring the PPE used by the patients treated by them. However, it gradually developed with the increasing knowledge of the virus. As far as safety is concerned, mild treatment-related side effects were observed among the interventional and placebo arm patients. While none of the participants were critical, and a few had mild illness by the end of the 12th week, requiring only outpatient observation with no hospitalization. There was no significant clinical benefit of PrEP with HCQ as compared to placebo (p>0.05). Conclusion: It is concluded from the study findings that the PrEP HCQ does not significantly prevent illness compatible with COVID-19 or confirmed infection among high-risk HCPs.

scholarly journals A retrospective cohort study to find out the association of hydroxychloroquine prophylaxis and COVID 19 infection prevention among health care workers in a tertiary care hospital of New Delhi

2021 ◽  
Vol 33 (2) ◽  
pp. 250-255
Author(s):  
Neeraj Narayan Mathur ◽  
Shweta Arora ◽  
Sanjeev Kumar Rasania ◽  
Manoj Bharatlal Jais ◽  
Tanmaya Talukdar
Keyword(s):  
Health Care ◽  
Cohort Study ◽  
Health Care Workers ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Infection Prevention ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Care Workers

Background- With the high morbidity and mortality year 2020 will be remembered as Covid19 pandemic year. Occupational exposure to COVID 19 among health care workers poses a major risk to their lives. Hydroxychloroquine (HCQ) prophylaxis has been indicated for their use without much scientific evidence. Objective- to find if HCQ prophylaxis had association with Covid19 infection prevention among health care workers. Material &Method- A retrospective cohort study was conducted; through online by utilizing social media platform, among Health care workers of a tertiary care hospital from 1st June 2020 to 27 July 2020. Those HCWs who have taken HCQ (exposed) and who have not taken (nonexposed) and PCR tested Covid19 Positive were taken as diseased.  Results Out of 527 who were analyzed, study subjects who took HCQ prophylaxis had 30% less chance of having Covid19 test positive, {RR- 0.709(0.383-1.296)} as compared those who didn’t took it, but the results were not significant. Conclusion- Hydroxychloroquine prophylaxis does not prevent Covid 19 infection and more evidence may be required for use of HCQ prophylaxis for Covid19 infection. Keywords- Hydroxychloroquine prophylaxis, Covid19 infection, Health care workers, Retrospective cohort study

scholarly journals Risk assesment and management of exposure of health care workers to COVID-19 in a tertiary care hospital of South Gujarat

2021 ◽  
Vol 8 (2) ◽  
pp. 750
Author(s):  
Krishnakant N. Bhatt ◽  
Amit Gamit ◽  
Ashish Patel ◽  
Kalpesh Gohel ◽  
Shiv Pujari ◽  
...  
Keyword(s):  
High Risk ◽  
Healthcare Workers ◽  
Tertiary Care ◽  
Young Male ◽  
Care Hospital ◽  
Age Group ◽  
Rt Pcr ◽  
Care Workers ◽  
Number Of Patients ◽  
Risk Categorization

Background: The COVID-19 outbreak affected 215 countries worldwide and was declared global COVID-19 pandemic on 11th March 2020 by WHO. Healthcare workers (HCWs) in India are faced with an incredibly high number of patients per worker and because of high infectivity of COVID-19, having higher chances of getting COVID-19 infection. The objective of the study was the risk categorization of HCWs and provide recommendation for HCWs exposed to COVID-19 based on risk categorization.Methods: After obtaining informed and valid consent from HCWs based on standard WHO questionnaire HCW, who were exposed to COVID-19 were identified and categorised in to high risk and low risk health worker. Those who were at high risk of getting COVID-19 were advised quarantine for 14 days and rt pcr for Covid-19.Results: Out of 200 participants, 51% were male and 49% were female with the majority of them being in the age group of 18-28 (40%). Out of 200, 190 (95%) were exposed to COVID-19. Majority of HCWs who were having high risk of getting COVID-19 infection were young between age group of 18-28 (66,39.7%, p :0.091), male (91,59.6%, p<0.001), doctors (119, 80.9%, p<0.001).Conclusions: Young male doctors were more prone to get COVID-19 infection. It is important to protect HCWs from getting COVID-19 infections by taking various fundamental preventive measures like wearing proper PPE kits and adherence to strict hand hygiene.

scholarly journals Prevalence and clinical correlates of COVID-19 outbreak among healthcare workers in a tertiary level hospital

2020 ◽  
Author(s):  
Ankit Khurana ◽  
G P Kaushal ◽  
Rishi gupta ◽  
Vansh Verma ◽  
Kabir Sharma ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Preventive Measures ◽  
Tertiary Care ◽  
Protective Role ◽  
Control Group ◽  
Care Hospital ◽  
Universal Testing ◽  
Epidemiological Characteristics ◽  
Level Hospital

In this study, we summarize the epidemiological characteristics of COVID-19 outbreak among Healthcare workers (HCWs) in a tertiary care hospital and compared various parameters and preventive measures taken by positive HCWs to a comparable cohort of COVID negative HCWs. 52.1% of COVID-19 positive HCWs showed symptoms of which only three needed hospitalization possibly due to a younger cohort of HCWs who got infected (35.9 +- 9.3 years). Findings of present study found some protective role of full course prophylactic hydroxychloroquine as compared to a control group (p=0.021) and use of N95 masks over others (p<0.001). Our results did not show any added protection with the use of prophylactic Vitamin C, D, Zinc, or betadine gargles. We also observed outbreak control with increased awareness, near universal testing, PPE provision, sanitization drive, and promoting social distancing among HCWs.

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