Neonatal dengue

Dengue infection is possible in all three trimesters of pregnancy. Dengue during pregnancy is associated with several neonatal complications such as perinatal death, miscarriage, low birth weight and preterm delivery. This is a case report of perinatal transmission of dengue in a baby who was born by an emergency caesarean section. The female baby was diagnosed with dengue fever as her dengue NS1 and ELISA tests were positive like her mother. Early recognition of congenital dengue will significantly reduce maternal and infant mortality. Proper management and supportive treatment is required for thrombocytopenia and hemorrhagic manifestations in dengue fever.

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Perinatal transmission of dengue infection in a preterm neonate: a case report

Tropical Doctor ◽

10.1177/0049475519832677 ◽

2019 ◽

Vol 49 (3) ◽

pp. 239-240

Author(s):

Jenisha Jain ◽

Lakshmi V ◽

Shanmughsundaram R

Keyword(s):

At Risk ◽

Case Report ◽

Vertical Transmission ◽

Preterm Neonate ◽

Dengue Infection ◽

Perinatal Transmission ◽

Interesting Case ◽

Life Threatening ◽

In Pregnancy

Dengue infection during pregnancy carries the risk of vertical transmission to the fetus and newborn. This is higher if the infection occurs late in pregnancy and the mother delivers at the height of viremia. In such a scenario, both mother and neonate are at risk of life-threatening complications. We present an interesting case of dengue infection in a preterm neonate managed at our unit.

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Case Report: False-Positive Dengue Non-Structural Protein 1 Antigen in a Patient with COVID-19 Infection

Archive of Clinical Medicine ◽

10.21802/acm.2020.2.10 ◽

2020 ◽

Vol 26 (2) ◽

Author(s):

Yohanes Firmansyah ◽

Jessica Elizabeth ◽

Hendsun Hendsun ◽

Darren Gosal

Keyword(s):

Case Report ◽

Early Diagnosis ◽

Dengue Fever ◽

False Positive ◽

Dengue Infection ◽

Antigen Test ◽

Structural Protein ◽

Positive Events ◽

Test Strips ◽

Endemic Areas

Abstract: Early diagnosis of dengue fever and COVID-19 is made very easy due to technological advancements. The non-structural protein 1 antigen test strips are widely used in various regions; however, false-positive events have begun to be reported in the dengue-endemic areas with the COVID-19 pandemic, even though statistically non-structural protein 1 antigens are very specific to dengue infection. We reported a case of the false-positive non-structural protein 1 test in a patient with COVID-19 infection.

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FREQUENCY AND SEVERITY OF LIVER INVOLVEMENT IN DENGUE VIRUS INFECTION.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.07.3770 ◽

2019 ◽

Vol 26 (07) ◽

pp. 1074-1078

Author(s):

Masood Tareen ◽

Riaz Hussain Awan ◽

Seema Nayab ◽

Khadim Hussain Awan

Keyword(s):

Dengue Fever ◽

Liver Enzymes ◽

Early Recognition ◽

Dengue Infection ◽

Tertiary Care ◽

Cross Sectional Study ◽

Liver Involvement ◽

Care Hospital ◽

Cross Sectional ◽

Study Setting

Objectives: To determine the frequency & severity of liver involvement in dengue infection among adults at tertiary care hospital. Period: Six months (9th May 2016 to 9th Nov 2016). Study Design: Cross-sectional study. Setting: Department of Gastroenterology and Department of Medicine Liaquat National Hospital, Karachi. Patients and Methods: Results: A total of 343 patients with Dengue fever were selected to conduct this study with mean age of 34.67±9.09 years. Mean duration of the fever was 7.31±1.62 days. Mean duration of hospital stay of the patients came out to be 3.50+0.82 days. Severity of liver enzymes derangement was mild in 80 patients (23%), moderate in 246 (72%) & severe in 17(5%). Mortality was seen in 14% (47 patients) & 100% mortality was seen in dengue fever patients with severely deranged Liver enzymes. Conclusion: Dengue fever patients with deranged liver enzymes had statistically worse outcome thus can lead to early recognition of high risk cases.

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Malignant Hyperthermia - A Case Report of a Paediatric Patient

Journal of Anesthesia & Pain Medicine ◽

10.33140/japm.04.04.04 ◽

2020 ◽

Vol 4 (4) ◽

Keyword(s):

Case Report ◽

Paediatric Patient ◽

Malignant Hyperthermia ◽

General Anesthesia ◽

Early Recognition ◽

Anesthesia Induction ◽

Supportive Treatment ◽

Delayed Onset

We encountered a case of malignant hyperthermia (MH) in a 3-year-old boy during general anesthesia induction for laparotomy. It has been generally reported that sevoflurane can induce the delayed onset of MH in the absence of succinylcholine. Our case of MH was elicited after about 90 mins of sevoflurane administration with 50/50% Air/O2 mixture. However the patient was successfully treated by early recognition of his condition and supportive treatment.

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Allopurinol causing generalized exfoliative dermatitis: a case report

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20172754 ◽

2017 ◽

Vol 6 (7) ◽

pp. 1816

Author(s):

Mila Nu Nu Htay ◽

Wai Wai Myint ◽

Htay Lwin ◽

Win Htay

Keyword(s):

Case Report ◽

Drug Allergy ◽

Early Recognition ◽

Supportive Treatment ◽

Upper Limbs ◽

Skin Involvement ◽

Exfoliative Dermatitis ◽

Culprit Drug ◽

Mortality Case ◽

The Face

Erythroderma is a scaly, erythematous dermatitis of the skin, which occurs in drug allergy, malignancy and underlying skin disorders. The diagnosis is challenging because the extent of skin involvement does not always correlate with the extent of internal organ involvement. Therefore, early recognition of symptoms is vital to minimize morbidity and mortality. Case report: A 52 years old man had asymptomatic hyperuricemia and prescribed allopurinol 300mg, daily. One month later, the rashes started to appear on his trunk and then progressed to the face and upper limbs. Then it continued to spread to the lower extremities. Management involves prompt cessation of the culprit drug, administration of corticosteroids and supportive treatment. It is Concluded that Allopurinol is commonly used in clinical practice for the treatment of symptomatic hyperuricemia and gout. It has been associated with erythroderma especially when used indiscriminately.

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Clinico-laboratory profile and outcome of dengue fever among children attending a tertiary care hospital of rural Telangana, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200114 ◽

2020 ◽

Vol 7 (2) ◽

pp. 382 ◽

Cited By ~ 1

Author(s):

V. Shekar ◽

K. Praveen Kumar ◽

C. Soren ◽

K. Venkataramana Reddy ◽

N. Dharani

Keyword(s):

Dengue Fever ◽

Tertiary Care Hospital ◽

Early Recognition ◽

Dengue Infection ◽

Tertiary Care ◽

Warning Signs ◽

Severe Dengue ◽

Severe Thrombocytopenia ◽

Care Hospital ◽

Presenting Symptoms

Background: Dengue is a self-limiting, vector-borne disease transmitted by Aedes mosquito, causing a major public health threat globally. The objective of this study is to assess the clinical profile and outcome of the dengue infection in children less than 14 years of age September 2018 to August 2019 at the Pediatric Department of S.V.S. Medical College, the tertiary care hospital in Mahabubnagar, Telanagana.Methods: Prospective study of 82 hospitalized children of <14 years with the diagnosis of dengue illness. Children with diagnosis of dengue were classified further in to two groups as per WHO guidelines, Non-severe dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (Dengue Haemorrhagic Fever and/or Dengue Shock Syndrome (DHF/DSS). A separate questionnaire form used for documenting clinical history, laboratory parameters. Haematological parameters were noted, chest x-ray, ultra-sonogram in required cases was done. Children were managed as per WHO protocol. The outcomes of the cases were mentioned as discharge, left against medical advice and death.Results: A total of 82 children with dengue were divided in to 55(67%) non severe dengue and 27(33%) severe dengue with males 56(68.2%) and females 26(31.7%). The most common age of presentation was between 6-10 years 34(41.5%). Fever 73(89%) was the most common presenting symptoms. Pleural effusion and hepatomegaly were the commonest clinical findings 28(34.1%) each, which were more among the severe dengue patients. Gall bladder edema 29(35.3%) was the most common ultra-sonogram finding. Significant elevation of transaminases (SGOP, SGPT) was seen in 39(47.5%). Severe thrombocytopenia was observed in 22(26.8%) children. Management was by administration of colloids and crystalloids.Conclusions: Dengue is a global problem. Presenting features include high grade fever, vomiting, abdominal pain, skin rash. Early recognition of symptoms and proper management can reduce the mortality.

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Pregnancy with Paroxysmal Nocturnal Hemoglobinuria (PNH) : A Case Report

Bangladesh Journal of Obstetrics & Gynaecology ◽

10.3329/bjog.v29i2.30491 ◽

2016 ◽

Vol 29 (2) ◽

pp. 111-115

Author(s):

Tabassum Parveen ◽

Firoza Begum ◽

Nahreen Akhter

Keyword(s):

Abdominal Pain ◽

Case Report ◽

Blood Transfusion ◽

Paroxysmal Nocturnal Hemoglobinuria ◽

Labour Pain ◽

Emergency Caesarean Section ◽

Increased Risk ◽

Anchoring Protein ◽

Female Baby ◽

In Pregnancy

Paroxysmal nocturnal hemoglobinuria (PNH) resulting from failure of expression of anchoring protein glycosylphosphatidylinositol (GPI), is an uncommon acquired hemolytic anemia manifested by hemoglobinuria, abdominal pain, smooth muscle dystonia, fatigue and thrombosis. Pregnancy with PNH is rare, and studies showed an increased risk of foetomaternal complications even death due to worsening cytopenias and consequent thrombosis. Here we reported a case of PNH in pregnancy. Mrs. Nasima, aged 25 years, para: 0+0, was diagnosed as a case of PNH by flowcytometry analysis on granulocytes about 1 year 3months back. Her pregnancy was no planned and she was not on antenatal care but took consultation from haematologist time to time. Her Hb level was 7-8gm/dl throughout pregnancy and needed repeated blood transfusion for anaemia. She was referred from a nearby clinic at 37 weeks of pregnancy with PROM and labour pain to the Foetomaternal medicine wing of Obs & Gynae department of BSMMU. On admission she was mildly icteric. She was treated with steroid as per consultation of haematologist. Due to failure of progress of labour emergency caesarean section was done under spinal anesthesia and a low birth weight female baby of 1.6 kg was delivered. One unit of blood transfusion was given post operatively.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 111-115

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