scholarly journals Clinical profile of dengue fever in children admitted in a district hospital of South India

2020 ◽  
Vol 7 (3) ◽  
pp. 688
Author(s):  
Ramaswami Muthusamy ◽  
Palanivel Sengottaiyan
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Signs And Symptoms ◽  
Clinical Profile ◽  
Mortality And Morbidity ◽  
Rapid Construction ◽  
Bleeding Manifestation ◽  
Laboratory Investigations ◽  
Dengue Epidemic ◽  
Body Ache

Background: To assess the clinical profile of dengue fever in children.Methods: In this Prospective observational study 110 patients who admitted in Government District Headquarters Hospital, Namakkal between 1st August 2019 to 31st December 2019 were included. Those patients with confirmed dengue, with IgM dengue antibody positive were included in this study. Detailed history was taken, and clinical examination was performed, and laboratory investigations were done.Results: In this study 110 patients were studied, majority were males. Fever was present in 100% of patients followed by headache, myalgia. The common signs and symptoms of dengue infection were fever, headache, body ache, retro-orbital pain, bleeding manifestations, and rash in 100%, 97.27%, 92.72%, 77.27%, 8.12%, and 60.90%, respectively. In 90 cases platelet count was less than 100,000/cumm of which bleeding manifestation was found in 9 patients. Pleural effusion and ascites were observed in 25 and 15 cases respectively. Hepatomegaly was noted in 19 cases and splenomegaly in 10. Leucopenia was present in 52 cases whereas raised liver enzymes were present in 51 cases. The mortality rate was 0.9%.Conclusions: Dengue epidemic has increased in recent past probably due to unplanned urbanization with rapid construction activities, unhygienic condition and poor sanitation facilities contributing fertile breeding soil for mosquitoes. Early diagnosis and management can decrease mortality and morbidity of illness. Platelet transfusions have little role in management of dengue patients.

A Retrospective Study on Laboratory Profile and Clinical Parameters of Dengue Fever Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3357-3359
Author(s):  
Ajeet Kumar ◽  
Shahnawaz Sarwari ◽  
Waheed Ahmed Arain ◽  
Suresh Kumar ◽  
Kaneez Fatima ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Laboratory Data ◽  
Gastrointestinal Symptoms ◽  
Clinical Profile ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Laboratory Profile ◽  
Study Laboratory

Introduction: Over the past decade, the number of cases of dengue fever has augmented intensely globally. Half the world's population is now under threat. Pakistan has also very high dengue fever per year, with regular reports of dengue outbreaks compared to other countries. Dengue infection should be treated as a solitary ailment with various clinical pictures, vacillating from symptomless situations to severe clinical sequences, which may result in high mortality and morbidity. Aim: To investigate the laboratory parameters and clinical profile in patients with dengue fever. Study Design: A Retrospective observational study. Place and Duration: In the Department of Medicine of Jalan Bani Bu Ali hospital Oman for one-year duration from July 2020 to July 2021. Methods: At least IgM positive or NS1 positive or IgM with NS1 positive or reactive ELISA assay for dengue fever detection but without any co-infection, bone marrow disease confirmed the cases of dengue without other confounding factors, such as alteration of clinical and laboratory data. The results were analyzed for the study. SPSS 21.0 was applied for Statistical analysis. Results: A total of 52 cases were tested positive for dengue fever. The patients mean age was 27.60 +/- 13.98 years and vacillated from 13 to 75 years. Of the total number of patients, 30 (57.69%) were in the age group 21 to 40 years. Of the 52 cases, 36 (69.23%) were male, 16 (30.77%) were female with M:F ratio was 2.2: 1. 42 (80.77%) of all cases were hospitalized for 5 days or less, and 10 (19.23%) were hospitalized for more than 5 days. The mean hospital stay was 3.67±1.40, ranging from 2 to 8 days. Fever was observed in all (100%) of the total number of cases. Conclusions: In this analysis, all patients have fever, and body pain, headache and malaise were communal signs, but a substantial quantity of cases also had respiratory and gastrointestinal symptoms such as nausea, abdominal pain, vomiting, dry cough and diarrhea. Keywords: Dengue fever, clinical profile, retrospective study, laboratory profile, thrombocytopenia

scholarly journals Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2265 ◽  
Author(s):  
Senthil Kumar K. ◽  
Rajendran N. K. ◽  
Ajith Brabhukumar C.
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

scholarly journals Clinical Profiles of Dengue Infection during an Outbreak in Northern India

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Anish Laul ◽  
Poonam Laul ◽  
Vamsi Merugumala ◽  
Ravi Pathak ◽  
Urvashi Miglani ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Acalculous Cholecystitis ◽  
Signs And Symptoms ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Mosquito Vector ◽  
Diagnostic Dilemma ◽  
Atypical Presentations

Introduction.Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.Materials and Methods. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.Results.The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning signs and symptoms included vomiting, weakness, abdominal pain, breathlessness, vertigo, sweating, and syncope. Other possible signs and symptoms of coinfections, comorbidities, or complications included diarrhea, sore throat, and neurological manifestations. There were seven patients with coinfections and four with comorbidities. The final diagnosis of these patients was DF (73%), DHF (16.5%), DSS (1.7%), and EDS (4.3%). Among EDS patients, the atypical presentations included encephalopathy, lateral rectus nerve palsy, acalculous cholecystitis, and myocarditis. Four patients required ICU care and there was no death in this study.Conclusion. Knowledge of atypical presentations is a must for early diagnosis and timely intervention to prevent life-threatening complications.

scholarly journals Dengue Fever: Clinical, Laboratory Profile and Outcome in Pediatric Patient

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Pooja Gandhi ◽  
Pinkal Taral ◽  
Krunal Patel ◽  
Sanketsinh Rathod ◽  
Bhavini Rathwa
Keyword(s):  
Platelet Count ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Care Center ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Severe Dengue ◽  
Diverse Range ◽  
Laboratory Profile

Introduction: Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virus infection elicits such a broad range of clinical symptoms, early and accurate laboratory diagnosis is essential for appropriate patient management. So a study was carried out to know its clinical profile, correlation between the laboratory profile and the severity of dengue fever and outcome in dengue patients. Aim: To study the clinical profile, correlation between the laboratory profile and the severity of dengue fever and outcome in dengue patients at tertiary care center. Method: Retrospective Observational study from 1st May 2019 to 31st April 2021. Result: Total 323 patients were studied during 1st May 2019 to 31st April 2021. Most common presentation was fever (100%), most common clinical finding is hepatomegaly (14.2%). All severe dengue infection has platelet count < 50000/cumm. In study of 323 patients 194(60%) of dengue fever,85(26.4%) of DHF GRADE 1,9(2.8%) of DHF GRADE 2 were discharged .13(4%) patients of DSS were expired.22 patients (6.8%) went DAMA. Conclusion: Reliable diagnosis of dengue fever in endemic areas can be done by clinical parameters like presence of nausea, vomiting, pain abdomen and hepatomegaly. Monitoring platelet count, hematocrit and WBC count is very useful for management of dengue cases. Keywords: dengue fever, platelet count, outcome

scholarly journals Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India

2017 ◽  
Vol 5 (5) ◽  
pp. 1751 ◽  
Author(s):  
Ch. Manoj Kumar ◽  
K. S. Keerthi Vyas ◽  
Y. Sai Krishna
Keyword(s):  
Retrospective Study ◽  
Dengue Fever ◽  
South India ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Severe Thrombocytopenia ◽  
Care Hospital ◽  
Haemorrhagic Fever

Background: Dengue haemorrhagic fever is a potentially lethal illness that is universally prevalent in the tropics and has become a major health concern globally in recent decades. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. A hallmark of dengue infection is severe thrombocytopenia which causes concern for the patients and treating doctors. The objective of this study was to correlate clinical profile during the evolution of dengue fever with severe thrombocytopenia (platelets <10,000/mm3), and comparing frequencies between the different clinical forms in order to predict the severity of the disease.  The present study includes 40 individuals who were found to be seropositive with the detection of NS1Ag, IgM and IgG antibodies for dengue infection with severe thrombocytopenia. Early diagnosis and monitoring is largely dependent on haematological parameters. As no specific antiviral therapy is available, supportive therapy is of utmost importance.Methods: This is an observational, descriptive and retrospective study of 40 patients with clinical and serological diagnosis of dengue fever with severe thrombocytopenia (platelets<10,000/mm3), in the period from August 2015 to September 2016, who were admitted in a tertiary care hospital in South India. ELISA was performed for the detection of dengue NS1, Ig M and Ig G, haematological parameters by automated analyzer and peripheral smear, coagulation profile analysis were done.Results: Out of 40 cases with severe thrombocytopenia, 50% of the patients had classical dengue fever, 30% cases had DHF with bleeding manifests and 20% cases with DHF plasma leakage signs and 5% lead to DSS. There was lack of association studied between severe thrombocytopenia and bleeding manifestations as p value<0.065 was insignificant. However, the risk of complications increased with decreasing platelet counts in the present study.Conclusions: Thrombocytopenia was most predominant haematological discrepancy. There was no predilection for any age group or gender for thrombocytopenia or bleeding among the dengue patients. The results were relevant in assessing the severity of infection and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.

scholarly journals Clinical Profile of Dengue Fever in Children: A Study from Southern Odisha, India

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Shubhankar Mishra ◽  
Ramya Ramanathan ◽  
Sunil Kumar Agarwalla
Keyword(s):  
Dengue Fever ◽  
Viral Infections ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Case Fatality ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
The Mean

Background. In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality.Objectives. To assess the clinical profile of the dengue infection in children less than 14 years of age and to evaluate the outcomes of dengue fever from September 2013 to August 2015 at the Pediatric Department of Maharaja Krishna Chandra Gajapati Medical College, the largest tertiary care hospital of southern Odisha.Results. A total of 97 cases were classified into 84 (86.59%) nonsevere and 13 (13.40%) severe dengue cases. The most common age of presentation was above 11 yrs. The mean age of admission was 8.7 yrs. The most common presenting symptom was fever seen in 100% and hepatomegaly (43.8%), the most common physical finding. Gastrointestinal bleeding was markedly seen in severe dengue (76.9%). Elevation in aspartate transaminase (SGOT) was found in 47.42% and thrombocytopenia in 27.5%. The correlation between hepatomegaly and elevated SGOT was significant (Pvalue 0.0346). Case fatality rate (CFR) was 1.03%. The mean duration of hospitalisation was 3.8 days.Conclusion. In children, if symptoms like fever, pain, rashes, and vomiting are associated with hepatomegaly and elevated SGOT in context of low TPC, a strong possibility of dengue fever is present, especially in an epidemic setting. Early suspicion and effective management can reduce the severity.

scholarly journals Dengue epidemic in the state of Rio de Janeiro, Brazil: virological and epidemiological aspects

1993 ◽  
Vol 35 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Marize P. Miagostovich ◽  
Rita M.R. Nogueira ◽  
Silvia M.B. Cavalcanti ◽  
Keyla B.F. Marzochi ◽  
Hermann G. Schatzmayr
Keyword(s):  
Rio De Janeiro ◽  
Virus Isolation ◽  
Dengue Infection ◽  
Age Groups ◽  
Signs And Symptoms ◽  
The State ◽  
Isolation Rate ◽  
Two Peaks ◽  
Dengue Epidemic

Laboratorial studies were carried out on 3178 patients with signs and symptoms suggestive of dengue infection from April 1986 to December 1987 in the State of Rio de Janeiro, Brazil. The epidemic had two peaks following the first virus isolation and affected the inhabitants of 17 counties. Both sex and all age groups were affected. Dengue virus type 1 was isolated from 1039 sera and the number of confirmed cases was increased to 1874 (59%) by MAC-ELISA. Isolation rate confirmed cases reached 80% in the specimens obtained until the 4th day after the onset of disease and viraemia ranged from 10 3.0 to 10(8.5) TCID50/ml.

scholarly journals Clinical profile of Dengue fever in children of Nellore city, Andhra Pradesh, India

2019 ◽  
Vol 6 (6) ◽  
pp. 2390
Author(s):  
E. Kishore ◽  
Syam Sundar Junapudi
Keyword(s):  
Health Education ◽  
Dengue Fever ◽  
Andhra Pradesh ◽  
Mosquito Control ◽  
Clinical Profile ◽  
Severe Dengue ◽  
Age Group ◽  
Mortality And Morbidity ◽  
Female Children ◽  
Study Population

Background: India especially Andhra Pradesh is endemic for dengue, in dengue fever mortality and morbidity is more in children when compare to adults. Authors objective was to assess the clinical profile of the Dengue fever in children.Methods: Children below 14 years with serologically positive for dengue included in this study from June 2017 to June 2018, data was collected and analyzed with MS office 2016.Results: In 100 children 84 were suffering with Non Sever dengue , 16 were suffering with severe dengue. In the study population 68 were male children and 32 were female children, more children 68 were in the above 11 age group, 52 children stay in hospital for 3-6 days.Conclusions: Health education and anti-larval measures and anti-adult measures for mosquito control is effective measures.

scholarly journals HUBUNGAN TROMBOSITOPENIA DAN HEMATOKRIT DENGAN MANIFESTASI PERDARAHAN PADA PENDERITA DEMAM DENGUE DAN DEMAM BERDARAH DENGUE

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Andrea Livina ◽  
Linda W. A. Rotty ◽  
Lucia Panda
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Dengue Haemorrhagic Fever ◽  
Haemorrhagic Fever ◽  
Cross Sectional ◽  
Important Indicator ◽  
Mortality Ratio ◽  
Infection Disease ◽  
Bleeding Manifestation ◽  
Spearman Test

Abstract: Dengue fever (DF) and dengue haemorrhagic fever (DHF), an infection disease who still become a health problem in Indonesia. There was increasing cases reported in Indonesia from 2011 to 2012. Thrombocytopenia and plasma leakage signed by haemoconcentration are important indicator in dengue. Bleeding manifestation appears as clinical symptom of DF and DHF that increases mortality ratio of dengue infection. The aim of this study is toinvestigatethe correlation of thrombocytopenia and hematocrit tobleeding manifestation of dengue fever and dengue haemorrhagic fever.This study is retrospective cross-sectional. Forty two men and thirty five women were evaluated in this study, fifty nine of them were diagnosedas DF and eighteen of them were diagnosed asDHF. The correlation of thrombocytes to hematocrit used nonparametric Spearman test, the result were significant with p=0,000 and r=-0,183. The correlation of thrombocytes to the occurrence of bleeding manifestation and hematocrit to the occurrence of bleeding manifestation, both were not significant, with p=0,714 and p=0,153. This study suggest that there were a very weak correlation between thrombocytes and hematocrit and no correlation between thrombocytopenia and hematocrit with bleeding manifestation. Keywords: Dengue Fever, Dengue Haemorrhagic Fever, Thrombocytopenia, Hematocrit, and Bleeding Manifestation.   Abstrak: Demam dengue (DD) dan demam berdarah dengue (DBD) merupakan penyakit infeksi yang masih menjadi masalah kesehatan di Indonesia. Telah dilaporkan terdapat peningkatan jumlah kasus di Indonesiadari tahun 2011 ke tahun 2012. Berdasarkan kriteria laboratorium WHO, jumlah trombosit yang rendah (trombositopenia) dan kebocoran plasma yang ditandai dengan hemokosentrasi merupakan indikator penting pada DD dan DBD. Gejala klinis DD dan DBD dapat disertai dengan manifestasi perdarahan yang akan meningkatkan rasio mortalitas penderita infeksi dengue. Penelitian yang bertujuan untuk mengetahui hubungan trombositopenia dan hematokrit dengan manifestasi perdarahan pada penderita demam dengue dan demam berdarah dengue ini menggunakanmetode retrospektif dengan studi cross-sectional.Sampel pada penelitian ini terdiri dari 42 orang laki-laki dan 35 orang perempuan. Penderita DD berjumlah 59 orang dan penderita DBD berjumlah 18 orang. Uji nonparametrik Spearman terhadap trombosit dan hematokrit mendapat hasil signifikan (p=0,000 ; r=-0,183). Uji nonparametrik Spearman terhadap trombosit dan manifestasi perdarahan mendapat hasil yang tidak signifikan (p=0,714). Uji nonparametrik Spearman terhadap hematokrit dan manifestasi perdarahan mendapat hasil yang tidak signifikan (p=0,153). Dapat disimpulkan bahwa terdapat korelasi yang sangat lemah antara trombosit dan hematokrit, tidak terdapat hubungan yang bermakna antara trombositopenia dan hematokrit dengan manifestasi perdarahan. Kata kunci:Demam Dengue, Demam Berdarah Dengue, Trombositopenia, Hematokrit, dan Manifestasi Perdarahan.

scholarly journals Knowledge, attitude and practice regarding dengue infection among parents of children hospitalized for dengue fever

2018 ◽  
Vol 5 (3) ◽  
pp. 893 ◽  
Author(s):  
Srinivasa S. ◽  
Harish S. ◽  
Shruthi Patel ◽  
Ranganatha A. Devaranavadagi ◽  
Bhavya G. ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Severe Disease ◽  
Dengue Infection ◽  
Signs And Symptoms ◽  
Bed Nets ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Preventive Practices ◽  
Health Care Burden ◽  
And Behavior

Background: Dengue fever is a rapidly emergent infection and is one of the leading causes of hospitalization and health care burden in India. Dengue vectors, human knowledge and behavior have each been reported to play an important role in the transmission of the disease. This study is aimed at assessing the knowledge regarding dengue fever, its transmission, identification of the disease and its complications and its preventive measures among the parents.Methods: This is a hospital based cross sectional survey among parents of dengue patients admitted in Department of Pediatrics, KIMS Bangalore during a period of 6 months. Parents were interviewed with pre-designed questionnaire. The questionnaire was divided into 4 parts-knowledge on 1) transmission, 2) signs and symptoms, 3) attitude towards the illness and 4) practices of prevention and treatment.Results: Overall 195 individuals were interviewed. 7% were illiterate while 17% had a college degree. 91% individuals knew mosquito as the vector, 32% identified clear stagnant water as the breeding place. 88% identified fever as a symptom while 22% knew about bleeding manifestations. 71% felt dengue as a severe disease and 84% had a positive attitude towards consulting a doctor for the illness. 58% relied on mats and coils for personal protection followed by bed nets (12%). Majority of the awareness was through television followed by radio and newspapers.Conclusions: It is of utmost significance to identify barriers to action and to seek ways to translate the knowledge of population about dengue into positive preventive practices that would ultimately reduce the transmission of dengue fever in the community.

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