The prevalence and assessment of chronic kidney disease with diabetes: single center study

Background: The prevalence of chronic kidney disease (CKD) and Type 2 diabetes (T2D) is increasing worldwide, information on Indian populations regarding the CKD patients with T2D is lacking. In this study, we examined the association of gender and age on the prevalence of other complications in CKD with T2D patients.Methods: A cross-sectional study was conducted at Sri Aurobindo Medical College, from March 2018 to April 2019. Source populations were all patients who came our medicine department for routine check-up.Results: A total of 163 CKD patients were included in the study. All the patients were randomly divided in two groups 61(37.4%) patients in CKD with T2D case group and 102 (62.5%) patients in CKD control group. Out of this 107 were males (65.6%) and 56 were females (34.3%). Male-to-female ratio and mean age were higher in the CKD with T2D group. The clinicopathological characteristics of CKD patients with T2D are even more complicated and severe disease in many ways.Conclusions: A male presents was higher as compare to female in CKD with T2D and control group. In present study there is significant difference in older and younger age in CKD with T2D and control group. Age, HNT, CVD, smoking, BMI, and 24-h urinary protein level were identified as possible contributors’ factors of CKD patients with T2D.

Download Full-text

Silent brain infarcts in chronic kidney disease patients with nonspecific neurological symptoms

International Journal of Medical Research and Review ◽

10.17511/ijmrr.2021.i04.11 ◽

2021 ◽

Vol 9 (4) ◽

pp. 274-279

Author(s):

P Sasanka ◽

◽

Dr. T. Jaya Chandra ◽

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Density Lipoprotein ◽

High Sensitivity ◽

Cross Sectional Study ◽

Cross Sectional ◽

Female Ratio ◽

Exact Test ◽

Brain Infarcts ◽

Significant Difference

Introduction: Silent brain infarcts (SBI) are parenchymal lesions of previous infarcts, classified astype III cerebrovascular disorder. A study was undertaken to find the relation between SBIs andnonspecific neurological complaints, an association of high sensitivity C-reactive protein (hsCRP)with silent brain infarcts. Methodology: It was a cross-sectional study conducted in the departmentof Nephrology, GSL Medical College, from January to December 2020. Individuals aged > 18 yearswith nonspecific neurological complaints were included. MRI brain, hsCRP and electrocardiogramwere also carried as per the standard protocol. Fischer exact test was used to find the statisticalsignificance; P < 0.05 was considered statistically significant. Results: A total of 51 members haveincluded the male-female ratio was 1.04. SBI was presented in 27.4% (14). Age-wise, among thecortical SBI patients, maximum (75%) were in the> 61 years group. High density lipoprotein levelswere > 40 mg/dL in 39.2%, normal triglycerides (TGL) were observed in 71% and raised hsCRP in62.7% (32). Statistically, there was no significant difference in TGL levels. hsCRP levels were raisedin 3 (75%) members with cortical SBI; statistically, there was no significant difference. Conclusion:The traditional risk factors associated with stroke were present in the patients with SBI. hsCRP wasraised in chronic kidney disease patients having NSCL and having SBI.

Download Full-text

Dermatological Disorders in Chronic Kidney Disease

Journal of Nepal Medical Association ◽

10.31729/jnma.543 ◽

2013 ◽

Vol 52 (190) ◽

Author(s):

Aparna Shah ◽

Rajani Hada ◽

Bhasker Mohan Mehar Kayastha

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Maintenance Hemodialysis ◽

Duration Of Treatment ◽

Cross Sectional ◽

Female Ratio ◽

Nail Changes ◽

Significant Difference ◽

Dermatological Disorders ◽

Mucosal Changes

Introduction: Dermatological conditions are common complications of Chronic Kidney Disease (CKD) affecting all most all patients. Present study aimed to evaluate the dermatological conditions and their association with age, sex and severity of CKD - without and with maintenance hemodialysis (MHD).Methods: It is a cross sectional and comparative study. Eighty-three patients with established CKD, without MHD (n=35) and with MHD (n= 48), attending nephrology unit, Bir Hospital and Shree Birendra Hospital from June 2008 to May 2009 were examined for dermatological disorders.Results: The mean age of patients were 46+15.6 years with male to female ratio of 1.8:1. Comparison of CKD without MHD and with MHD showed no statistical difference of age, sex, duration of treatment, blood urea and haemoglobin and significant difference of serum creatinine (5.3 + 3.0 mg/dl vs 9.1 + 4.5 mg/dl, p<0.001) respectively.Dermatological conditions were found in 100% CKD patients with pallor 91.5%, xerosis 75.9%, pigmentary changes 65%, pruritus 60.2%, skin infection 36.9%, vascular changes 16.8%, mucosal changes 67.4%, hair changes 59%, non -specific nail changes 81.9% and specific nail changes14.4%,.Specific (23.2% vs. 8.4%, p<0.03) and non- specific (91.4% vs 75%, p < 0.05) nail changes and hair abnormalities (74.3% vs. 47.9%, p<0.01) were significantly higher in CKD without MHD.Conclusions: Dermatological conditions are present in all CKD patients with or without MHD. A further prospective study is necessary to find out pathophysiology and beneficial effect of dialysis and transplantation in these conditions.Key words: chronic kidney disease, dermatological disorder, maintenance hemodialysis.

Download Full-text

Echocardiographic Findings in Children of Chronic Kidney Disease

Asian Journal of Pediatric Research ◽

10.9734/ajpr/2021/v7i430221 ◽

2021 ◽

pp. 28-37

Author(s):

Farhana Yasmin ◽

Shireen Afroz

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Control Group ◽

Case Group ◽

Ventricular Systolic Dysfunction ◽

And Control ◽

Echocardiographic Findings

Background: Patients with Chronic Kidney Disease (CKD) are at significantly increased risk for both morbidity and mortality from cardiovascular disease (CVD). Determining the spectrum of echocardiographic abnormalities in these patients can help in reduction of morbidity and mortality from CKD. Materials and Methods: This cross-sectional study was held on department of Pediatric Nephrology, Dhaka Shishu Hospital, Dhaka, during July 2018 to December 2018 (Six months). A total of thirty-six children with chronic kidney disease with creatinine clearance <60ml/min/1.73 m2 and age ranged from 2 to 16 years on supportive treatment and hemodialysis were included. In control group equal number of age and sex matched healthy children without any preexisting renal or cardiovascular diseases were included. Both study group and control group were assessed for cardiovascular findings by echocardiography. Results: The mean age was 9.09±3.01 years (mean±SD) in case group and 7.85±3.69 years (mean±SD) in control group. Regarding sex, 22 patients (61.1%) in the case group were male and 14 (38.9%) were female. In this study, in CKD patients significant (p<0.001) difference was observed in following cardiac parameters, left ventricular end diastolic diameter (LVEDD) (38.34 vs 34.52), left ventricular end systolic diameter LVESD (26.64 vs 20.75), interventricular septal thickness (IVS) (9.34 vs 7.27), left ventricular posterior wall thickness (LVPWT) (8.36 vs 7.46), ejection fraction (EF) (56.68% vs 70.36%), fractional shortening (FS) (31.88% vs 38.30%) and peak early diastole velocity/peak atrial filling velocity (E/A ratio) (1.15 vs 1.45) when compared to control group. Most common cardiac abnormality in children with chronic kidney disease were left ventricular systolic dysfunction (44.4%), mild pulmonary hypertension (30.6%) and left atrial dilatation (27. 8%). Conclusion: Left ventricular systolic dysfunction was the commonest echocardiographic findings in CKD children. There was also significant difference in diastolic function between study and control group.

Download Full-text

EFFECT OF PROGRESSIVE MUSCULAR RELAXATION ON ANXIETY LEVELS IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS IN THE GENERAL HOSPITAL OF TUGUREJO SEMARANG, INDONESIA

Belitung Nursing Journal ◽

10.33546/bnj.88 ◽

2017 ◽

Vol 3 (4) ◽

pp. 383-389

Author(s):

Ary Astuti ◽

Anggorowati Anggorowati ◽

Andrew Johan

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Rating Scale ◽

Psychosocial Problems ◽

Nursing Intervention ◽

Control Group ◽

P Value ◽

Muscular Relaxation ◽

Significant Difference ◽

And Control

Background: Patients with chronic kidney disease undergoing hemodialysis suffer changes in lifestyle, which cause physical and psychosocial problems, particularly anxiety. Progressive Muscular Relaxation is considered as an intervention to reduce anxiety.Objective: This study aims to examine the effect of progressive muscular relaxation in in reducing anxiety in patients with chronic kidney disease undergoing hemodialysis.Methods: This study used a quasi-experimental design involved 78 respondents, with 38 randomly assigned in the intervention and control group. The progressive muscular relaxation was performed on 14 muscle groups for 4-week period. Hamilton Anxiety Rating Scale was used to measure anxiety. Univariate, bivariate and multivariate analyses were performed for data analyses.Results: The results showed a statistically significant difference in anxiety values between the intervention and control group with p-value 0.000 (<0.05).Conclusion: There was a significant effect of progressive muscular relaxation in reducing anxiety in patients with chronic kidney disease undergoing hemodialysis. The results of this study is expected to be one reference in making the progressive muscular relaxation as a nursing intervention in reducing anxiety in patients undergoing hemodialysis.

Download Full-text

COMPARISON IMMUNOHISTOCHEMISTRY EXPRESSION OF DESIDUAL NATURAL KILLER (dNK) IN SEVERE PREECLAMPSIAAND NORMAL PREGNANCY

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2020v12i3.38306 ◽

2020 ◽

pp. 58-60

Author(s):

MUARA P. LUBIS

Keyword(s):

Normal Pregnancy ◽

Cross Sectional Study ◽

Control Group ◽

Case Group ◽

Vascular Endothelial ◽

Cross Sectional ◽

Maternal Immune System ◽

Significant Difference ◽

Immuno Histochemistry ◽

And Control

Objective: Preeclampsia characterized systematically by extensive vascular endothelial dysfunction and microangiopathy on mother, dNK is very important for the success of placentation. They are the key mediator of maternal immune system interactions with fetal cells. dNK cells are also involved in the modulation of EVT and the remodeling of spiral arteries. Methods: Analytic research with cross-sectional study, with samples of pregnant women who suffer from severe PE and aterm pregnancy which came to H. Adam Malik Hospital and Networking Hospital, November 2015-April 2016. The samples are 46 women, who met the inclusion criteria. Results: Immunohistochemistry examination dNK cell in the severe PE case group and control group, statistically found p<0,05. dNK placenta expression in the severe preeclampsia case group gives an overview of expression with a mean of 2.55±2.31, while the control group of normal pregnancy had higher mean is 8.66±3.16. Conclusion: The examination of immunohistochemistry of dNK cells showed there is a significant difference in the expression of Immuno-histochemistry dNK cells between severe PE case group and non severe PE.

Download Full-text

Study of Lipid Profile in Chronic Kidney Disease Patients

10.53350/pjmhs211572330 ◽

2021 ◽

Vol 15 (7) ◽

pp. 2330-2333

Author(s):

Rashid Ahmad ◽

Khalil Ullah ◽

Ghazala Shaheen ◽

Muhammad Ikram Shah ◽

Muazzam Fuaad ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Lipid Profile ◽

Statistical Significance ◽

Cross Sectional Study ◽

Control Group ◽

Cross Sectional ◽

Female Ratio ◽

Low Hdl ◽

Age Range

Background and Aim: Premature atherosclerosis and increased prevalence of cardiovascular mortality are significantly associated with chronic kidney disease (CKD). The CKD risk factors contribute to cardiovascular and atherogenesis disease. Anemia, inflammation, vascular calcification, lack of physical activity, lipid disorders, endothelial dysfunction, and oxidative stress are various risk-induced factors for CKD patients. The aim of the present study was to evaluate or assess the lipid profile in chronic kidneys disease. Place and Duration of Study: Conducted at Medicine department of Lady Reading hospital, Peshawar and Pak International Medical College, Peshawar for duration of six months between November 2020 and April 2021. Materials and Methods: This cross-sectional study was carried out on 70 patients with chronic kidney disease (CKD) with an age range of 18 and 65 years. The male to female ratio was 1.3:1. A Control group of 70 patients of similar age and sex were enrolled in this study. Lipid profile and collection of blood specimen were managed from both groups were taken. Other parameters such as PPBS, creatinine, FBS, and blood urea results were compared for both groups. Results: The overall mean age of the study group patients was 42.4±11.5 years while the control group's mean age was 51.6±9.8 years. The prevalence of CKD patients was high 17 (24%) in the age range of 30-40 years. The prevalence of Dyslipidemia parameters such as High TC, High TG, High VLDL-C, HIGH LDL-C and low HDL-C was 49.8%, 66.7%, 67%, 42.5%, and 72.9% respectively. Overall dyslipidemia prevalence was 81.7%. Significant decrease in HDL-C while the increase in TG and VLDL-C was reported. On comparing hypertension comorbid conditions with triglyceride, HDL, and VLDL statistical significance was found. SPSS version 24 was used for data analysis. Conclusion: A significant amount of dyslipidemia is found in CKD patients. As a result, treating dyslipidemia will reduce mortality in CKD patients. Patients with CKD are predisposed to accelerated atherosclerosis, which increases the risk of CVD. The presence of an atherogenic lipid profile in CKD is confirmed by this study. Keywords: CKD, Lipid Profile, Hypertension, Dyslipidemia

Download Full-text

Predictors of Taste Dysfunction and Its Severity Among Patients With Chronic Kidney Disease

Ear Nose & Throat Journal ◽

10.1177/01455613211019708 ◽

2021 ◽

pp. 014556132110197

Author(s):

Tajudeen Yusuf ◽

Yemi R. Raji ◽

Taye J. Lasisi ◽

Adekunle Daniel ◽

O. T. Bamidele ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Poor Quality ◽

Control Group ◽

College Hospital ◽

Significant Difference ◽

And Gender ◽

The University ◽

Taste Dysfunction ◽

And Control

Background: Patients with chronic kidney disease (CKD) often complain of taste dysfunction. The prevalent taste dysfunction among patients with CKD predisposes them to malnutrition, poor quality of life, and worsen disease prognoses. To appropriately treat the taste dysfunction in this group of patients, it’s imperative that factors that predict taste dysfunction and its severity are identified for prompt treatment. Aim: To identify factors associated with taste dysfunction and its severity among patients with CKD. Materials and Methods: This was a hospital-based case–control study of adult patients with CKD at the University College Hospital, Ibadan, Nigeria. The control group was made up of age- and gender-matched healthy volunteers with no clinical and laboratory evidence of CKD. Relevant clinical and social data obtained include demographics, symptoms, and signs of taste dysfunction and its risk factors. The 4 basic taste modalities namely sweet, sour, bitter, and salt taste senses of the participants were tested with validated “taste strips.” Factors that predict taste dysfunction were identified among the spectrum of the disease. Results: There were 100 patients with CKD and 100 healthy controls, age ranges between 19 and 86 years (mean ± standard deviation [SD] = 46.3 ± 13.9 years) and 20 and 85 years (mean ± SD = 43.4 ± 14.9 years), respectively. There was no statistically significant difference between cases and control gender distribution ( P = .57). Hypogeusia was found in 27.0% of patients with CKD, while total taste function score of all the control was within normal range. Increasing duration of CKD was identified as a predictor of taste dysfunction among patients with CKD (odds ratio: 4.889, P = .038). The stages of CKD had no statistically significant relationship with the severity of taste dysfunction ( P = .629). Conclusion: The prevalence of taste dysfunction among patients with CKD was high and this showed significant correlation with increasing duration of CKD; in contrast, the severity of CKD is not significant in the development of taste dysfunction.

Download Full-text

Evaluating QT dispersion in children with syncope attacks

Nepalese Heart Journal ◽

10.3126/njh.v15i2.21471 ◽

2018 ◽

Vol 15 (2) ◽

pp. 15-20

Author(s):

Amir Hossein Movahedian ◽

Ali Mohammad Shakiba ◽

Mojtaba Sehat ◽

Maryam Sadat Razavi ◽

Marzieh Heydarzadeh Arani

Keyword(s):

Qt Dispersion ◽

Brain Dysfunction ◽

Control Group ◽

P Value ◽

Case Group ◽

Healthy Children ◽

Cross Sectional ◽

Significant Difference ◽

The Mean ◽

And Control

Background and Aims: Syncope is due to brain dysfunction and is a common compliant among children. It accounts for almost 3% of all emergency departments (ED) visits. The aim of this study was to evaluate the QT dispersion in children with syncope in Shahid Beheshti Hospital of Kashan in 2014.Methods: This was a descriptive cross-sectional study performed among 50 children with syncope attacks (case group) referred to the Clinic of Shahid Beheshti Hospital in Kashan during 2014 and 50 healthy children (control group) referred to the center for causes such as a cold or developmental examination. ECG was taken and QT, QTd (QT dispersion), QTc (Corrected QT interval) and QTcd (QTmin-QTmax =QT dispersion) intervals were studied. After proper explanation to the parents, data was obtained from the case and control group and was analyzed using Chisquare, Mann-Whitney, Kolmogorov–Smirnov, Levene›s, Kruskal-Wallis statistical tests.Results: Total, there were 100 children in the study, the participants were divided into two groups of case (n=50) and control (n=50). Among the studied children, a total of 46 of them (46%) were boys. The mean age range of children in the case and control groups were 7.73± 2.33 and 8.09± 2.31 years, respectively (P-value 0.440). The mean QTmax, QTcmax, QTd and QTcd in the case group were 348.80 ± 46.93, 464.94±48.71, 47.80±19.72, 68.36±24.59 ms (millisecond) respectively and 305.28 ±35.52, 395.70 ±50.05, 29.68±13.45, and 45.16±24.46 ms respectively in the control group. There was a significant difference in terms of each of the 4 parameters (P <0.001), and the value of indices in the control group was significantly less than that of the patient group.Conclusion: According to the results of the study, the QTd and QTcd values in the children with syncope attacks were higher than those in the control group. Therefore, precise ECG examination in children suspected of syncope attacks can be helpful in confirming the incidence of syncope. Additionally, the recurrence of attacks can also be predicted in children with higher QTd and QTcd values.

Download Full-text

Hepatic steatosis: a risk factor for increased COVID-19 prevalence and severity—a computed tomography study

Egyptian Liver Journal ◽

10.1186/s43066-021-00131-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Asmaa Ali ◽

Mona Hasan ◽

Shaimaa Hamed ◽

Amir Elhamy

Keyword(s):

Hepatic Steatosis ◽

Severe Disease ◽

Severe Pneumonia ◽

Liver Disorder ◽

Control Group ◽

Case Group ◽

World Population ◽

Positive Class ◽

The Mean ◽

And Control

Abstract Background Around 25% of the world population was affected by the metabolic-related fatty liver disorder. Hepatic steatosis is frequently observed in conjunction with hypertension, obesity comorbidities, and diabetes. We evaluate the hepatic steatosis frequency found in chest CT exams of COVID-19-positive cases compared to non-infected controls and evaluate the related increased prevalence and severity of COVID. Results Our research includes 355 subjects, 158 with positive PCR for COVID-19 (case group) and 197 with negative PCR and negative CT chest (control group). The mean age in the positive group was 50.6 ± 16 years, and in the control, it was 41.3 ± 16 years (p < 0.001). Our study consists of 321 men (90.5%) and 34 women (9.5%). The number of males in both cases and control groups was greater. In the case group, 93% men vs. 6.9% women, while in controls, 88.3% men vs.11.6% women, p < 0.001. CT revealed normal results in 55.5% of individuals (i.e., CORADs 1) and abnormal findings in 45.5% of participants (i.e., CORADs 2–5). In abnormal scan, CO-RADs 2 was 13.92%, while CO-RADs 3–4 were 20.89% of cases. CO-RADs 5 comprised 65.19% of all cases. Approximately 42.6% of cases had severe disease (CT score ≥ 20), all of them were CO-RADs 5. The PCR-positive class had a greater prevalence of hepatic steatosis than controls (28.5% vs.12.2%, p < 0.001). CO-RADs 2 represented 11.1%, CO-RADs 3–4 represented 15.6%, and CO-RADs 5 represented 73.3% in the hepatic steatosis cases. The mean hepatic attenuation value in the case group was 46.79 ± 12.68 and in the control group 53.34 ± 10.28 (p < 0.001). When comparing patients with a higher severity score (CT score ≥ 20) to those with non-severe pneumonia, it was discovered that hepatic steatosis is more prevalent (73.2% vs. 26.8%). Conclusions Steatosis was shown to be substantially more prevalent in COVID-19-positive individuals. There is a relation among metabolic syndrome, steatosis of the liver, and obesity, as well as the COVID-19 severity.

Download Full-text

Role of Serum Transferrin Receptor in Diagnosing and Differentiating Iron Deficiency Anemia from Anemia of Chronic Disease in Patients with Chronic Kidney Disease

BIRDEM Medical Journal ◽

10.3329/birdem.v7i2.32451 ◽

2017 ◽

Vol 7 (2) ◽

pp. 132-137

Author(s):

Abdul Latif ◽

Muhammad Rafiqul Alam ◽

Asia Khanam ◽

Farhana Hoque ◽

Muhammad Abdur Rahim ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Chronic Disease ◽

Kidney Disease ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Transferrin Receptor ◽

Deficiency Anemia ◽

Control Group ◽

Anemia Of Chronic Disease ◽

Female Ratio

Background: Anemia is common in patients with chronic kidney disease (CKD) and this is generally anemia of chronic disease, but iron deficiency anemia (IDA) is also common. Soluble transferrin receptor (sTfR) is a useful marker for IDA. Present study was undertaken to assess the utility of sTfR as a marker of IDA in selected group of Bangladeshi patients with CKD.Methods: This cross-sectional study was conducted in the Department of Nephrology, BSMMU, Dhaka, Bangladesh from January 2013 to December 2014. Patients with anemia admitted in nephrology department whether on hemodialysis or not and medicine department of BSMMU were taken for study. The study population was further divided into two groups; Group A, patients who are having IDA and Group B, patients with ACD and a control group was also selected. Data were collected by face to face interview and laboratory investigations with a self-administered questionnaire.Results: The mean age of the patients in two study groups were 38.40±13.23 and 34.85±10.52 years respectively and male-female ratio were 0.5:1 and 1:0.5. Mean sTfR level was higher (4.81± 1.64 ?g/ml) in patients with IDA than (2.89±1.40 ?g/ml) in patients with ACD (p <0.0001). In our study mean ferritin level was 599.59± 449.15?g/L in ACD patients whereas 101.23±119.42 in IDA patients (p<0.0001). Total iron binding capacity (TIBC) was more in ACD patients with sTfRe3?g/ml as compared to ACD patients with sTfR<3?g/ml. Transferrin saturation (TSAT) level was significantly decreased in ACD patients with sTfR ?3?g/ml as compared to ACD patients with sTfR<3?g/ml.Conclusion: sTfR has a comparable ability to S. ferritin in diagnosing IDA and ACD. However, sTfR and serum ferritin alone cannot definitely exclude co-existing iron deficiency in ACD. As sTfR is not affected by infection and/or inflammation, thus providing a non-invasive alternative to bone marrow study.Birdem Med J 2017; 7(2): 132-137

Download Full-text