scholarly journals Association between vitamin D level and patients with cholestasis

2018 ◽  
Vol 5 (5) ◽  
pp. 1713
Author(s):  
Manal M. Anwar ◽  
Ahmed E. Arafa ◽  
Dalia S. Morgan ◽  
Khaled K. Mohamed
Keyword(s):  
Vitamin D ◽  
Clinical Laboratory ◽  
Statistical Significance ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Chronic Cholestasis ◽  
Z Scores ◽  
D 20

Background: Estimate the prevalence of vitamin D deficiency among patients diagnosed with chronic cholestasis and investigates the association between their clinical manifestations and lab results of 25(OH) D levels.Methods: A cross sectional study of 50 patients aged > 3 months up to 18 years, who had medical care in the Beni-Suef University hospital, Beni-Suef governorate, Egypt. All patients were fully investigated including routine labs in addition to 25- [OH] D levels and dual energy X-ray absorptiometry (DXA).Results: Mean age was 6.5±4.5 years. Mean serum 25 (OH) D levels was 37.9±28.2; 30% of patients had 25 (OH) D <20 ng/ml and 26% had 25 (OH) D 20-<30 ng/ml. Low BMD was diagnosed in 73.1% of patients. The spine DXA BMD ranged between -5.4 and -1.4 (-2.9±0.9 Z-scores). A delayed milestone was reported in 32% of patients, and 56% had signs of rickets.Conclusions: Deficiency of Vitamin D, signs of rickets and osteoporosis were evident in chronic cholestasis patients. No statistical significance was detected between 25- D [OH] levels and clinical, laboratory and radiological findings.

scholarly journals Vitamin D Status in Postmenopausal Females in Saudi Arabia

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Shatha Alharazy ◽  
Eman Alissa ◽  
Adeel Chaudhary ◽  
Susan Lanham-New ◽  
M. Denise Robertson
Keyword(s):  
Vitamin D ◽  
Saudi Arabia ◽  
Postmenopausal Women ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Older Individuals ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Jeddah City ◽  
King Abdulaziz University

AbstractVitamin D (vitD) deficiency is highly prevalent in the Middle East (including Saudi Arabia) despite the abundance of sunlight. Older individuals in particular are at high risk of being vitD deficient. VitD binding protein (DBP), which acts as a carrier of vitD and its metabolites, has been reported to influence vitD status. In our study we aimed to investigate vitD status among postmenopausal women and its relation to DBP. A cross-sectional study was conducted at the King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. Seventy six postmenopausal females (age ≥ 50 years) who were not taking vitD supplementation and who were resident in Jeddah city, were randomly recruited from internal medicine clinics at King Abdulaziz University Hospital. Anthropometric measures, blood pressure, lifestyle history, dietary vitD intake and fasting blood samples were obtained from all study participants. Serum total 25 hydroxy-vitamin D (25(OH)D), DBP, albumin, parathyroid hormone, calcium, phosphate, magnesium and metabolic bone parameters were analysed. VitD deficiency was defined as serum total 25(OH)D level below 30 nmol/L. The mean (± SD) serum level of total 25(OH)D was 46.9 ± 28.9 nmol/L with 36 % of the study population being vitD deficient. Although non-significant, the vitD deficient group had lower DBP and higher dietary vitD intake levels when compared with those with serum vitD > 30nmol/L. In addition, DBP was inversely correlated with vitD dietary intake (r = -0.233, P = 0.046). In conclusion, vitD deficiency is highly prevalent among postmenopausal women living in Jeddah, Saudi Arabia. Intake of a vitD rich food seems to be associated with low DBP levels. Genetic polymorphisms in DBP will be studied in the future to find out a possible explanation for the differences in vitD status and DBP between individuals as well as the concomitant relationship between dietary vitD intake, DBP and serum 25(OH)D levels.

RESEARCH ON CLINICAL MANIFESTATIONS AND AEROBIC BACTERIA OF QUINSY IN HUE CENTRAL HOSPITAL AND HUE UNIVERSITY HOSPITAL

2012 ◽  
pp. 85-91
Author(s):  
Kim Tri Truong ◽  
Tu The Nguyen ◽  
Lam Phuoc Vo
Keyword(s):  
Antibiotic Prescription ◽  
White Blood Cells ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Aerobic Bacteria ◽  
Sectional Study ◽  
Central Hospital ◽  
Cross Sectional ◽  
Bacteria Culture

Objectives: To identify the paraclinical and clinical mannifestations, aerobic bacteria and antibiogramme of quinsy. Materials and methods: Cross-sectional study was conducted upon 37 patients with quinsy at Hue Central hospital and Hue University Hospital. Results: Clinical and paraclinical symtoms: odynophagy 100%, dysphagy 91.9%. Having treatment with antibiotics before hospitalization 67.6%. White blood cells >15.109/l (54.1%). Positive bacteria culture is 48.6% in which streptococcus α hemolytic 57.9%, staphylococcus aureus 10.5%, streptococcus pneumoniae 10.5%. Antibiogramme: Sensitization: Gentamycin 100%, vancomycin 100%, cefuroxim 100%, ciprofloxacin 80%.Resistance: Erythromycin 60%, ampicillin 41.7%, cefalexin 40%, tetracyclin 40%, ceftriaxon 30.8%.Consclusions: The priority of antibiotic prescription for quinsy should be based on the frequency of bacteria found in bacteria culture and depending on antibiogramme to choose appropriate antibiotics.

The Correlation Between the Vitamin D Level and Glycemic Control Status Among Diabetic Patients - A Clinical Observational Study

2020 ◽  
Vol 7 ◽  
Author(s):  
Nasser Alqahtani ◽  
Eisa Ghazwani ◽  
Awad Alqahtani ◽  
Mohammed Helaly
Keyword(s):  
Vitamin D ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
High Hba1c ◽  
Sugar Levels ◽  
Diabetic Microvascular Complications

Background: Vitamin D deficiency is widespread and coexisted with diabetes. However, the relation between Vitamin D level and glycemic control is not yet fully understood. This study examines the correlation between vitamin D level and glycemia indicators and diabetic microvascular complications.Methods: The study is a cross-sectional study, had been done at the outpatient department in Najran university hospital, Saudi Arabia from May 2019 to February 2020. 220 patients recruited by simple random sampling.Results: 60% of diabetes (n-130) had been using oral anti-glycemic medications, though most of them had uncontrolled glycemic status and had got microvascular complications. It is notable that among diabetes having a low vitamin D level; 55.5% had high FBS, 45.6% had high RBS and 65% had high HBA1C. Besides,17% have retinopathy, 16.6% have nephropathy, 26.2% have peripheral neuropathy and 1.9% have a diabetic foot.Conclusion: The clinical and laboratory assessments are essential to control the glycemic state in diabetes. The study noted that an inverse relationship between the level of vitamin D with blood sugar levels and diabetic microvascular complications. To assure the feasibility of the prediction of vitamin D level in assessing the progress of diabetes further studies are needed.

RESEARCH ON CLINICAL MANIFESTATIONS AND AEROBIC BACTERIA OF ACUTE TONSILITIS IN HUE CENTRAL HOSPITAL AND HUE UNIVERSITY HOSPITAL

2012 ◽  
pp. 30-37
Author(s):  
Kim Tri Truong ◽  
Tu The Nguyen ◽  
Lam Phuoc Vo
Keyword(s):  
Antibiotic Prescription ◽  
White Blood Cells ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Aerobic Bacteria ◽  
Central Hospital ◽  
Cross Sectional ◽  
Group A ◽  
Bacteria Culture

Objective: To study the paraclinical and clinical mannifestations, aerobic bacteria and antibiogramme of acute tonsilitis. Materials and method: A cross-sectional study was conducted upon 34 patients with acute tonsilitis at Hue Central hospital and of Hue University Hospital. Results: Clinical and paraclinical characteristics: odynophagy 94.1%, tonsillar hyperaemia 88.2%. Having treatment with antibiotics before hospitalization 50%. White blood cells >10-15.109/l (58.8%). Positive bacteria culture is 67.6% in which streptococcus β hemolytic group (A) 25%, streptococcus α hemolytic 25%, hemophilus influenzae 25%. Antibiogramme: Sensitization: gentamycin 100%, cefuroxim 100%, ceftriaxone 93.8%, cefalexin 90.9%, vancomycin 86.7%; Resistance: Tetracyclin 85.7%, erythromycin 69.2%, ofloxacin 42.9%, ampicillin 33.3%, ciprofloxacin 33.3%. Consclusions: The priority of antibiotic prescription for acute tonsilitis should be based on the frequency of bacteria found in bacteria culture and depending on antibiogramme to choose appropriate antibiotics.

scholarly journals Predictive Factors for Vitamin D Concentrations in Swiss Athletes: A Cross-sectional Study

2018 ◽  
Vol 02 (05) ◽  
pp. E148-E156 ◽  
Author(s):  
Simeon Zürcher ◽  
Andrea Quadri ◽  
Andreas Huber ◽  
Lothar Thomas ◽  
Graeme Close ◽  
...  
Keyword(s):  
Vitamin D ◽  
High Performance ◽  
Cross Sectional Study ◽  
The Sun ◽  
Cross Sectional ◽  
Outdoor Sports ◽  
Predicted Probability ◽  
Optimal Health ◽  
Z Scores ◽  
And Performance

AbstractVitamin D concentrations corresponding to 75 nmol/L 25(OH)D have been associated with maintained muscle function, growth and regeneration, optimal bone health and immunology in athletes. The objective of this study was to investigate the prevalence and predictors of insufficient 25(OH)D concentrations in athletes. Six hundred three Swiss athletes were assessed. 25(OH)D was analysed by high-performance liquid chromatography (HPLC). A standardized questionnaire was used to gather information about potential predictors for 25(OH)D concentrations; 50.5% showed insufficient 25(OH)D concentrations. Differences in predicted probability of insufficient 25(OH)D were found for those vitamin D supplemented (42%) versus not supplemented (52%), in those performing indoor (58%) versus outdoor sports (43%), and during the sun-deprived seasons of fall (49%), winter (70%) and spring (57%) compared with summer (17%). Higher BMI z-scores and age were associated with higher 25(OH)D concentrations. In conclusion, insufficient 25(OH)D concentrations were common among athletes especially at a younger age, among those not supplemented, in athletes who trained indoors, and during the sun-deprived seasons. Because the prevalence of insufficient 25(OH)D concentrations in this study was high, regular supplementation in athletes may be indicated, except perhaps during the summer season. Further research is needed to determine which 25(OH)D concentrations lead to optimal health and performance in athletes.

scholarly journals Prevalence of Vitamin D Deficiency among Hemodialysis Patients in Palestine: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Zaher A. Nazzal ◽  
Zakaria Hamdan ◽  
Nihal Natour ◽  
Maram Barbar ◽  
Rawan Rimawi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Liver Function ◽  
Vitamin D Deficiency ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
University Hospital ◽  
Cross Sectional

Introduction. The level of vitamin D status and its relationship to kidney function and liver function among patients with and without type 2 diabetes were not studied among Palestinian hemodialysis patients before. The aim of this study was to assess the status of vitamin D in hemodialysis patients with and without type 2 diabetes and its determinants. Methods. Data were collected on 163 patients on hemodialysis therapy in the Nephrology Department at Najah National University Hospital. Information on age, sex, plasma 25 (OH)D, serum calcium, serum phosphate, parathyroid hormone, dialysis period, hypertension, diabetes, ALT, AST, albumin, alkaline phosphates, and BMI was obtained from the medical records. Data were analyzed using SPSS. Findings. The mean level of 25 (OH)D was 17.3 ± 10.5 ng/ml. Only 12.9% of subjects had 25 (OH)D levels >30 ng/ml, whereas 65% had levels between 10 and 30 ng/ml; the remaining 22.1% were severely vitamin D deficient (<10 ng/ml). Vitamin D deficiency was more prevalent among females. It was not related to PTH, calcium, kidney, or liver function tests. Conclusion. Vitamin D deficiency is highly prevalent among patients on hemodialysis with or without DM2.

scholarly journals CHRONIC KIDNEY DISEASE (CKD)

2018 ◽  
Vol 25 (02) ◽  
pp. 264-270
Author(s):  
Adil Manzoor ◽  
Rashid Abasher
Keyword(s):  
Vitamin D ◽  
Statistical Significance ◽  
Transferrin Saturation ◽  
Immunological Response ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
The Relationship

Introduction: Vitamin D deficiency is pretty common among the patients withCKD some studies suggesting it to be starting from CKD 3 when the egfr start falling from60 ml/min. The cause can be due to different reasons including race, obesity, nutrition, lackof exposure to sun, and not the least, decrease in 1,alpha hydroxylase once the gfr starts tofall significantly. Objectives: The hypothesis was that lower Vitamin D level will be associatedwith increased inflammatory burden and decreased immunological response. Study Design:This was a cross-sectional study looking at the relationship between Vitamin D level andinflammatory markers in CKD 4 Pts when egfr started falling from 30 ml/min. Study Design andDuration: The study was started in March 2016 and finished in May 2016 among consecutive100 CKD 4 patients coming to the clinic who were identified to be eligible for the study. Materialsand Methods: We looked at the relationship between Vitamin D level and markers of mineralbone disorder, similarly we also looked at the relationship between erythropoietin dosage,hemoglobin and Vitamin D levels. Erythropoietin dose, hemoglobin, transferrin saturation,were used to study the link between Vitamin D and markers of anemia. Hepatitis B surfaceantigen antibodies were measured to study the response between Vitamin D level and immuneresponse to Hep B vaccine. Results: Vitamin D levels were significantly lower in diabeticscompared to non-diabetics (P = 0.02) and lower in females compared to males (P = 0.009).No statistical significance was observed between Vitamin D levels and immune response tohepatitis B vaccine (P = 0.89), phosphate level (P= 0.1), calcium levels (P = 0.79), parathyroidhormone (PTH) levels (P = 0.57), C-reactive protein (P =0.19), serum albumin (P = 0.17),hemoglobin level (P = 0.18,) and erythropoietin requirement (P = 0.87).Conclusions VitaminD deficiency is highly prevalent in advanced CKD in Saudi Arabia. A RCT is recommendedregarding response to vitamin D supplementation.

scholarly journals Prevalence and Risk Factors for Vitamin D Insufficiency among Adults with Epilepsy at University Hospital in Jeddah, Saudi Arabia: A Cross Sectional Study

2021 ◽  
pp. 49-58
Author(s):  
Doaa K. Mohorjy ◽  
Iman Kamal Ramadan ◽  
Bahaa A. Abalkhail ◽  
Khalid M. Jaamal
Keyword(s):  
Vitamin D ◽  
Antiepileptic Drugs ◽  
Multiple Linear Regression Model ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Epileptic Patients

Background: Vitamin D is essential for bone physical condition, and vitamin D insufficiency may add to further autoimmune diseases, infections or even cancer. Enzyme-inducing antiepileptic drugs have been predominantly linked with osteoporosis hazard proved their impacts on vitamin D. The study aim was to determine the prevalence of vitamin D insufficiency and deficiency and the covariates associated with it among the adult epileptic patients attending King Fahd neurology outpatient clinics. Subjects and Methods: 297 adult epilepsy patients joined this cross-sectional study at King Fahd Hospital in 2017. Vitamin D level was considered as deficiency (<10ng/ml), insufficiency (<30ng/ml), or normal (≥30ng/ml). Antiepileptic drugs were sorted out according to their enzyme inducing criteria. Results: 87.88% adult epileptic patients were between 18 – 50 years of age, more than half were females, married, and with higher degree of education, less than half received monthly income of less than 5,000 SR, nearly two third were either smokers or ex-smokers. Multiple linear regression model for predictors of vitamin D insufficiency and deficiency declared that; enzyme induced antiepileptic drugs, polytherapy, and smoking were significantly correlated with vitamin deficiency and insufficiency (p < 0.05). Conclusion: Vitamin D insufficiency and deficiency is widespread among adult epileptic patients. Screening of vitamin D level should be taken into consideration as part of the regular follow up of epileptic patients.

scholarly journals Integrative Analysis of Epidemiological Profile of Sensitization Clinical Laboratory Markers in Children: Cross-Sectional Study Results

2021 ◽  
Vol 18 (2) ◽  
pp. 118-133
Author(s):  
L. G. Levina ◽  
L. S. Namazova-Baranova ◽  
E. A. Vishneva ◽  
K. S. Volkov ◽  
K. Y. Efendieva ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Statistical Significance ◽  
Skin Testing ◽  
Birch Pollen ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
Optimal Algorithms ◽  
Allergy Diagnosis ◽  
Cross Sectional ◽  
Study Results

Background. The prevalence of various allergic diseases has increased worldwide in recent decades. Allergy diagnosis in children should be economically optimal and as sparing as possible, while ensuring the high quality of medical care. Objective. The aim of the study is to develop optimal algorithms for analysis of sensitization profile in children with allergy family history, or suspected allergy, or atopy phenotype. Methods. Complete examination of 153 children aged from 1 to 17 years 11 months was performed. Children were divided in 4 groups according to the presence and characteristics of complaints, the presence of allergic disease. Sensitization was determined via the “gold standard” of allergy diagnosis — the ImmunoCap method (Phadia, Sweden), and the results of skin testing. Results. 97 (63.4%) children have shown sensitization to various allergens. We have revealed seasonal manifestation of allergy in children to various allergens: Fagales in 89-92% of cases, grasses in 68-72% of cases, weeds in 39-57% of cases. Complaints of all-year manifestations of allergic rhinitis were revealed in 24% of cases to cat dandruff, complaints of coughing and/or bronchospasm — in 100% of cases to birch pollen and in 35% of cases to house dust. The sensitization analysis has revealed strong correlations with confirmed statistical significance between pollen allergen sensitization classes in groups of different plants. Conclusion. Optimal algorithms for sensitization diagnosis in children living in Moscow agglomeration were developed according to the obtained results and revealed correlations.

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