Prevalence of chronic respiratory symptoms in an urban population of North Kerala

Background: Chronic respiratory diseases are becoming a challenge to public health due to its high morbidity and mortality. Most of these diseases are preceded by variable periods of chronic respiratory symptoms. If chronic respiratory symptoms can be diagnosed and managed properly and timely, we can reduce the incidence and complication of chronic respiratory diseases.Methods: A community based cross sectional survey was conducted in 20 electoral wards of Calicut corporation of Northern Kerala among the adult resident population of 20-70 years to assess the prevalence of chronic respiratory symptoms such as chronic cough, phlegm, wheezing, breathlessness and nasal allergy and the factors associated with these chronic symptoms. The information was collected from 1384 eligible subjects selected by cluster sampling using British research council respiratory questionnaire.Results: About 9.2% (n=95) of study population had at-least one of the chronic respiratory symptoms. 1.8% (n=19) had all the chronic respiratory symptoms. Prevalence of various chronic respiratory symptoms was chronic cough (8.7%), Phlegm (14.3%), wheezing (8.5%), breathlessness (2.2%) and nasal allergy (14.5%). Advancing age, current smoking, family history and past history of various respiratory diseases are significantly associated with the development of chronic respiratory symptoms. Female gender, longer duration of stay in Calicut corporation and regular alcoholism were significantly associated with chronic phlegm in the study population. Wheezing, breathlessness and chronic nasal allergy was significantly higher among lower socio economic status.Conclusions: Prevalence of chronic respiratory symptoms is high among the urban population of Northern Kerala. Older age group, smoking, past and family history of respiratory diseases are the major risk factors associated with these respiratory symptoms.

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Determinants of Chronic Respiratory Symptoms among Pharmaceutical Factory Workers

Journal of Tropical Medicine ◽

10.1155/2018/3815689 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Sahle Asfaw ◽

Fikre Enquselassie ◽

Yifokire Tefera ◽

Muluken Gizaw ◽

Samson Wakuma ◽

...

Keyword(s):

Family History ◽

Respiratory Symptoms ◽

Respiratory Diseases ◽

Previous History ◽

Occupational Exposures ◽

Working Environment ◽

Factory Workers ◽

Pharmaceutical Factory ◽

Chronic Respiratory Diseases ◽

History Of

Background. Chronic respiratory symptoms including chronic cough, chronic phlegm, wheezing, shortness of breath, and chest pain are manifestations of respiratory problems which are mainly evolved as a result of occupational exposures. This study aims to assess determinants of chronic respiratory symptoms among pharmaceutical factory workers. Methods. A case control study was carried out among 453 pharmaceutical factory workers with 151 cases and 302 controls. Data was collected using pretested and structured questionnaire. The data was analyzed using descriptive statistics and bivariate and multivariate analysis. Result. Previous history of chronic respiratory diseases (AOR = 3.36, 95% CI = 1.85–6.12), family history of chronic respiratory diseases (AOR = 2.55, 95% CI = 1.51–4.32), previous dusty working environment (AOR = 2.26, 95% CI = 1.07–4.78), ever smoking (AOR = 3.66, 95% CI = 1.05–12.72), and service years (AOR = 1.86, 95% CI = 1.16–2.99) showed statistically significant association with chronic respiratory symptoms. Conclusion. Previous history of respiratory diseases, family history of chronic respiratory diseases, previous dusty working environment, smoking, and service years were determinants of chronic respiratory symptoms. Public health endeavors to prevent the burden of chronic respiratory symptoms among pharmaceutical factory workers should target the reduction of adverse workplace exposures and discouragement of smoking.

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FACTORS ASSOCIATED WITH THE PREVALENCE OF ARTERIAL HYPERTENSION IN THE GENERAL WORKING AGE POPULATION

Complex Issues of Cardiovascular Diseases ◽

10.17802/2306-1278-2018-7-4-6-14 ◽

2018 ◽

Vol 7 (4) ◽

pp. 6-14 ◽

Cited By ~ 2

Author(s):

V. S. Kaveshnikov ◽

V. N. Serebryakova ◽

I. A. Trubacheva

Keyword(s):

Risk Factors ◽

Family History ◽

Arterial Hypertension ◽

Urban Population ◽

Screening Program ◽

P Value ◽

Factors Associated ◽

Salt Consumption ◽

Working Age ◽

History Of

Aim. To determine the factors associated with the prevalence of arterial hypertension (AH) in the unorganized urban population of working age.Methods. Random sample drawn from adult urban population aged 25–64 years (n = 1600, 59%-women) was examined in the standardized cardiologic screening program. The following associative factors were analyzed: age, family status, level of education and income; excessive salt consumption (ESC), low physical activity, alcohol consumption; family history of AH; anxiety/depression (HADS); smoking, body mass index (BMI), heart rate (HR). Logistic regression was used to analyze the relationships. A p value of <5% was considered statistically signifcant.Results. After adjustment for age, the odds for AH were higher in men (OR = 1,57, p<0,001) with the maximum gender effect found in 35–44 years (OR = 3,66, p<0,001). In the singlefactor analysis, age, BMI, family history of AH, HR and ESC were the most signifcant risk factors for AH in men. Secondary education and clinical anxiety in addition with the above-mentioned ones increased odds for AH in women. In the multivariable model, age, BMI, family history of AH and HR were associated with high AH prevalence in men. In women, these factors included age, BMI, family history of AH, HR, ESC, middle education and clinical anxiety. Out of the other modifable risk factors, BMI contributed greatly to the variability in AH prevalence in the examined population.Conclusion. The obtained fndings provides novel data on the comparative signifcance of the studied risk factors. The efforts to prevent excessive weight gain and dietary salt consumption seem promising to reduce AH prevalence in the population. Further studies focusing on the role of genetic, behavioral, and environmental factors for AH development will ensure the establishment of more effective, accurate and personalized prevention approaches in the future.

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Asthma prevalence and associated factors among lebanese adults: the first national survey

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01529-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zeina Akiki ◽

Danielle Saadeh ◽

Rita Farah ◽

Souheil Hallit ◽

Hala Sacre ◽

...

Keyword(s):

Allergic Rhinitis ◽

Family History ◽

Respiratory Diseases ◽

Fruits And Vegetables ◽

Asthma Prevalence ◽

Cluster Sampling ◽

Cross Sectional ◽

Current Asthma ◽

Chronic Respiratory Diseases ◽

History Of

Abstract Background No national research has yet explored the prevalence of asthma among adults in Lebanon. This study aims to evaluate the prevalence of physician-diagnosed asthma and current asthma, and their determinants among Lebanese adults 16 years old or above. Methods A cross-sectional study was carried out using a multistage cluster sampling. The questionnaire used collected information on asthma, respiratory symptoms, and risk factors. Results The prevalence of physician-diagnosed asthma was 6.7% (95% CI 5–8.7%), and that of current asthma was 5% (95% CI 3.6–6.9%). Chronic symptoms such as cough, wheezing, and shortness of breath were worst at night. Factors positively associated with physician-diagnosed asthma were a secondary educational level (adjusted OR, aOR = 4.45), a family history of chronic respiratory diseases (aOR = 2.78), lung problems during childhood (15.9), and allergic rhinitis (4.19). Additionally, consuming fruits and vegetables less than once per week (3.36), a family history of chronic respiratory diseases (3.92), lung problems during childhood (9.43), and allergic rhinitis (8.12) were positively associated with current asthma. Conclusions The prevalence of asthma was within the range reported from surrounding countries. However, repeated cross-sectional studies are necessary to evaluate trends in asthma prevalence in the Lebanese population.

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Factors associated with breast MRI use among women with a family history of breast cancer

The Breast Journal ◽

10.1111/tbj.13063 ◽

2018 ◽

Vol 24 (5) ◽

pp. 764-771 ◽

Cited By ~ 1

Author(s):

Mary C. White ◽

Ashwini Soman ◽

Clarice R. Weinberg ◽

Juan L. Rodriguez ◽

Susan A. Sabatino ◽

...

Keyword(s):

Breast Cancer ◽

Family History ◽

Breast Mri ◽

Factors Associated ◽

History Of

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Characterisation of pulmonary function trajectories: results from a Brazilian cohort

ERJ Open Research ◽

10.1183/23120541.00065-2020 ◽

2020 ◽

Vol 6 (3) ◽

pp. 00065-2020

Author(s):

Priscila Weber ◽

Ana Maria Baptista Menezes ◽

Helen Gonçalves ◽

Rogelio Perez-Padilla ◽

Deborah Jarvis ◽

...

Keyword(s):

Birth Weight ◽

Family History ◽

Pulmonary Function ◽

Birth Cohort ◽

Respiratory Diseases ◽

Smoking Status ◽

Forced Expiratory Volume ◽

Birth Cohort Study ◽

History Of ◽

Brazilian Cohort

BackgroundPulmonary function (PF) trajectories are determined by different exposures throughout the life course. The aim of this study was to investigate characteristics related to PF trajectories from 15 to 22 years in a Brazilian cohort.MethodsA birth cohort study (1993 Pelotas Birth Cohort) was conducted with spirometry at 15, 18 and 22 years. PF trajectories were built based on z-score of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and their ratio using a group-based trajectory model. Associations with exposures reported from perinatal to 22 years were described.ResultsThree trajectories, low (LT), average (AT) and high (HT) were identified in 2917 individuals. Wealthiest individuals belonged to the HT of FEV1 (p=0.023). Lower maternal pregestational body mass index (BMI) (22.4±0.2; p<0.001 and 22.1±0.14; p<0.001) and lower birth weight (3164.8±25.4; p=0.029 and 3132.3±19.4; p=0.005) were related to the LT of FEV1 and FVC. Mother's smoking exposure during pregnancy (37.7%; p=0.002), active smoking at ages 18 and 22 years (20.1% and 25.8%; p<0.001) and family history of asthma (44.8%; p<0.001) were related to the LT of FEV1/FVC. Wheezing, asthma and hospitalisations due to respiratory diseases in childhood were related to the LT of both FEV1 and FEV1/FVC. Higher BMIs were related to the HT of FEV1 and FVC at all ages.ConclusionsPF trajectories were mainly related to income, pregestational BMI, birth weight, hospitalisation due to respiratory diseases in childhood, participant's BMI, report of wheezing, medical diagnosis and family history of asthma, gestational exposure to tobacco and current smoking status in adolescence and young adult age.

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Study of Risk Factors Associated with Suicide Attempt in Patients with Bipolar Disorder Type I

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0040-1709347 ◽

2020 ◽

Vol 11 (02) ◽

pp. 291-298

Author(s):

Karthick Subramanian ◽

Vikas Menon ◽

Siddharth Sarkar ◽

Vigneshvar Chandrasekaran ◽

Nivedhitha Selvakumar

Keyword(s):

Risk Factors ◽

Bipolar Disorder ◽

Logistic Regression ◽

Family History ◽

Suicide Attempt ◽

Coping Strategies ◽

Binary Logistic Regression ◽

Type I ◽

Factors Associated ◽

History Of

Abstract Background Suicide is the leading contributor to mortality in bipolar disorder (BD). A history of suicidal attempt is a robust predictive marker for future suicide attempts. Personality profiles and coping strategies are the areas of contemporary research in bipolar suicides apart from clinical and demographic risk factors. However, similar research in developing countries is rarer. Objectives The present study aimed to identify the risk factors associated with suicidal attempts in BD type I (BD-I). Materials and Methods Patients with BD-I currently in clinical remission (N = 102) were recruited. Sociodemographic details and the clinical data were collected using a semistructured pro forma. The psychiatric diagnoses were confirmed using the Mini-International Neuropsychiatric Interview 5.0. The National Institute of Mental Health–Life Chart Methodology Clinician Retrospective Chart was used to chart the illness course. Presumptive Stressful Life Events Scale, Coping Strategies Inventory Short Form, Buss–Perry aggression questionnaire, Past Feelings and Acts of Violence, and Barratt Impulsivity scale were used to assess the patient’s stress scores, coping skills, aggression, violence, and impulsivity, respectively. Statistical Analysis Descriptive statistics were used for demographic details and characteristics of the illness course. Binary logistic regression analyses were performed to identify the predictors for lifetime suicide attempt in BD-I. Results A total of 102 patients (males = 49 and females = 53) with BD-I were included. Thirty-seven subjects (36.3%) had a history of suicide attempt. The illness course in suicide attempters more frequently had an index episode of depression, was encumbered with frequent mood episodes, especially in depression, and had a higher propensity for psychiatric comorbidities. On binary logistic regression analysis, the odds ratios (ORs) for predicting a suicide attempt were highest for positive family history of suicide (OR: 13.65, 95% confidence interval [CI]: 1.28–145.38, p = 0.030), followed by the presence of an index depressive episode (OR: 6.88, 95% CI: 1.70–27.91, p = 0.007), and lower scores on problem-focused disengagement (OR: 0.72, 95% CI: 0.56–0.92, p = 0.009). Conclusion BD-I patients with lifetime suicide attempt differ from non-attempters on various course-related and temperamental factors. However, an index episode depression, family history of suicide, and lower problem-focused engagement can predict lifetime suicide attempt in patients with BD-I.

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346. Factors Associated with Hypertension in Young Adults with Perinatally-Acquired HIV Infection: a Case–Control Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.419 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S184-S184

Author(s):

Patrick O’Neil ◽

Patrick Ryscavage ◽

Kristen A Stafford

Keyword(s):

Risk Factors ◽

Young Adults ◽

Family History ◽

Case Control Study ◽

Case Control ◽

Systemic Hypertension ◽

Early Management ◽

Factors Associated ◽

History Of ◽

Control Study

Abstract Background The incidence of systemic hypertension (HTN) among perinatally-HIV-infected (PHIV) patients appears to increase as they enter adulthood. Among non-perinatally HIV-infected adults both traditional and HIV-associated risk factors have been found to contribute to HTN. Whether these same factors contribute to HTN in PHIV is unknown. The purpose of this study was to determine the socio-demographic, clinical, virologic, and immunologic factors associated with HTN among a cohort of PHIV adolescents and young adults, aged ≥18 years. Methods We conducted a case–control study among a population of 160 PHIV adults with and without HTN who were receiving care at the University of Maryland and aged 18–35 years as of December 31, 2017. Covariates assessed included traditional risk factors such as age, family history of HTN, and smoking, as well as HIV- and antiretroviral-associated covariates. Results We identified 49 HTN cases (30.6%) and 111 (69.4%) controls. There were no significant differences in the odds of most traditional (age, gender, race, family history of HTN, tobacco, alcohol, and/or other drug use) or HIV-associated (CD4 nadir <100 cells/mm3, individual ART exposure, ART interruption) risk factors among PHIV adults with HTN compared with those with no diagnosis of HTN. Cases had lower odds of a history of treatment with lopinavir/ritonavir (LPV/r). Cases had 3.7 (95% CI 1.11, 12.56) times the odds of a prior diagnosis of chronic kidney disease (CKD) compared with controls after controlling for CD4 nadir and ARV treatment history. Conclusion The results of this study suggest that most traditional and HIV-related risk factors do not appear to increase the odds of having HTN in this PHIV cohort. However, HTN among PHIV may be driven in part by CKD, and a focus on the prevention and early management of CKD in this group may be necessary to prevent the development of HTN. Additionally, there may be as yet unidentified risk factors for HTN among PHIV which require further exploration. Given the large and growing population of PHIV entering adulthood worldwide, it is imperative to explore risk factors for and effects of HTN in large, diverse PHIV populations. Disclosures All authors: No reported disclosures.

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Clinical and Demographic Profiles of Patients Diagnosed as Cough Variant Asthma attended at Tertiary Referral Hospital

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v2i1.32960 ◽

2017 ◽

Vol 2 (1) ◽

pp. 30-33

Author(s):

SK Shahinur Hossain ◽

Md Safiul Islam ◽

Md Mustafizur Rahman ◽

Shubhashish Dey ◽

Khurshid Mahmud

Keyword(s):

Family History ◽

Positive Family History ◽

Challenge Test ◽

Young Male ◽

Tertiary Referral Hospital ◽

Cross Sectional ◽

Cough Variant Asthma ◽

Demographic Profiles ◽

History Of ◽

Study Population

Background: Cough variant asthma is presented with different clinical and demographic characteristics.Objectives: The purpose of the present study was to see the clinico-demographic profiles of cough variant asthma patients.Methodology: This descriptive type of cross-sectional study was carried out in theDepartment of Respiratory Medicine at National Institute of Diseases of the Chest and Hospital (NIDCH), Dhaka, Bangladesh from September 2014 to August 2015 for a period of one year. Patients presented with cough variant asthma attending in NIDCH were selected as study population. Methacholine challenge test was performed to diagnosis of Cough Variant Asthma. Result: A total number of 50 patients were recruited for this study. The mean age±SD was found 19.1±7.6 years. Male was predominant than female with a ratio of 1.4.:1. Among the study population positive family history of asthma was found in 39.0% cases and associated allergic rhinitis was reported in 58.0% cases. Eczema was associated with 16.0% patients;however, only 4% patients had associate conjunctivitis. Conclusion: In conclusion young male is more commonly affected by cough variant asthma of which majority have family history of asthma. Journal of National Institute of Neurosciences Bangladesh, 2016;2(1):30-33

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Predictors of Outcome In Patients with Myelodysplastic Syndromes Living In Western Pennsylvania

Blood ◽

10.1182/blood.v116.21.4971.4971 ◽

2010 ◽

Vol 116 (21) ◽

pp. 4971-4971

Author(s):

Batsirai Mutetwa ◽

Jon Fryzek ◽

Yan Du ◽

Mellissa Yong ◽

Mikkael A. Sekeres ◽

...

Keyword(s):

Platelet Count ◽

Family History ◽

Disease Progression ◽

Myelodysplastic Syndromes ◽

Family History Of Cancer ◽

Factors Associated ◽

Risk Of Death ◽

History Of ◽

Western Pennsylvania ◽

History Of Cancer

Abstract Abstract 4971 Introduction: The myelodysplastic syndromes (MDS) are a collection of hematologic disorders that affect older adults. The baseline characteristics and risk factors for evolution to acute myeloid leukemia (AML) and death in MDS have not been completely defined. To gain a better understanding of MDS disease progression, we analyzed data from a large unselected cohort of MDS patients from the University of Pittsburgh Medical Center Network Cancer Registry in Western Pennsylvania. Methods: Demographic and baseline clinical data, including MDS subtype, treatment, cytogenetics, and cytopenias were derived from both patients' medical charts and electronic medical records. The MDS subtypes were recorded according to the French-American-British classification system (FAB). The IPSS score was calculated by one of the study investigators using the following criteria: bone marrow blasts were scored as 0 for values of <5%, as 0.5 for values of 5–10%, 1.5 for values of 11–20%, and as 2.0 for values of 21–30%. Good cytogenetic characteristics included normal karyotype, -Y, 5q-, and 20q-. Poor cytogenetics included chromosome 7 abnormalities and complex aberrations (>3 abnormalities). The intermediate risk group included all other aberrations. Four risk groups were formed based on the scores; Low, Int-1, Int-2, and High. Multivariable Cox proportional hazard models were developed to assess factors associated with AML evolution and survival. Covariates in these models included gender, race, diagnosis, age, smoking status, alcohol history, family history of cancer, previous cancer, blast percentage, blood parameters, therapies, MDS subtypes, and International Prognostic Scoring System score (IPSS). Differences in survival were tested using the Wilcoxon Log-Rank test. Results: Of 214 MDS patients included in this study, 129 were male (60%), the majority were Caucasian, 34% were diagnosed after the age of 70 years. More than half of the patients (63%) had a history of smoking, while 44% reported alcohol use and roughly half of the population (49%) reported a family history of cancer. Patients were followed for an average of 22 months after diagnosis. At baseline, the median hemoglobin level for all patients was 9.4 g/dL, and median neutrophil count was 1.45 × 109/L, with no significant gender differences. The median platelet count was 88 × 109/mm3 with 26.1% of the patients presenting with a platelet count < 50 × 109/mm3. The median blast count was 4.3% blasts, and female patients had a non statistically significantly lower median count compared to their male counterparts. Overall, the 36-month survival rate was 19.0% (95% CI: 14.0 – 24.5%): 22.4% (95% CI: 16.4 – 29.0%) for lower-risk MDS patients and 5.0% (95% CI: 0.1 – 14.8%) for higher-risk MDS patients (p = 0.0007). During follow-up, 33% of patients developed AML. A family history of cancer (adjusted hazards rate (aHR) =2.4; 95% CI= 1.2 – 4.8) was a significant predictor of disease progression to AML, as was having 5% or more blasts at diagnosis (aHR=4.3; 95% CI=1.7 – 10.9), which was also a predictor for death (aHR=3.1; 95% CI=1.8 – 5.3). Factors associated with a borderline increase in risk of death include age >70 years at diagnosis (aHR = 1.3; 95% CI = 0.9 – 1.8) and previous diagnosis of cancer other than MDS (aHR = 1.3; 95% CI = 0.9 – 1.9). Increasing numbers of chemotherapy sessions (3 or more sessions versus 1: aHR – 0.5; 95% CI = 0.3 – 0.8) and a platelet count of >50×103/mm3 (aHR = 0.8; 95% CI = 0.5 – 1.1) were inversely associated with death. Conclusions: This is one of the first studies to present the contribution of both demographic and clinical factors to survival and AML development in a large population-based cohort of MDS patients. Disclosures: Fryzek: MedImmune: Employment.

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