Stimulus techniques and microelectrode recordings of subthalamic-nuclei neurons in Parkinson`s during functional-neurosurgery

This study discusses the various procedures and issues involved in the acquisition of microelectrode recordings (MER) signals of subthalamic nucleus stimulations with induced deep brain stimulation electrodes very rigorously. Bellicose-invasive physiological detections through the methods of sub cortical physio logical detections, electrical induced stimulations and micro electrode recordings, stereo-tactic technique, macro-stimulation, stereo-tactic functional neurosurgical technique, stimulations such as macro and micro, induced stimuli with current and microelectrode recordings, impedance information monitoring, micro injections of test substances, evoked potentials, biomarkers/local field potentials, microelectrode fabrication methods and setups, sub cortical atlas-mapping with micro recording/microelectrode recording (M.E.R.). Thus, the study is very significant to the electrophysiological neurosurgical point of view and is very useful to the field of microelectrode recording and functional neurosurgery. This study is concerned with invasive physiological detection of deep brain structures with micro- or macro-electrodes prior to surgery followed by imaging techniques and their use in cortical and subcortical detection; detection relevant to the superficial cerebral cortex regions.

Download Full-text

A literature review of magnetic resonance imaging sequence advancements in visualizing functional neurosurgery targets

Journal of Neurosurgery ◽

10.3171/2020.8.jns201125 ◽

2021 ◽

pp. 1-14

Author(s):

Alexandre Boutet ◽

Aaron Loh ◽

Clement T. Chow ◽

Alaa Taha ◽

Gavin J. B. Elias ◽

...

Keyword(s):

Deep Brain Stimulation ◽

White Matter ◽

Globus Pallidus ◽

Subthalamic Nucleus ◽

Brain Stimulation ◽

Preoperative Planning ◽

Imaging Techniques ◽

Anatomical Landmarks ◽

Functional Neurosurgery ◽

Deep Brain

OBJECTIVE Historically, preoperative planning for functional neurosurgery has depended on the indirect localization of target brain structures using visible anatomical landmarks. However, recent technological advances in neuroimaging have permitted marked improvements in MRI-based direct target visualization, allowing for refinement of “first-pass” targeting. The authors reviewed studies relating to direct MRI visualization of the most common functional neurosurgery targets (subthalamic nucleus, globus pallidus, and thalamus) and summarize sequence specifications for the various approaches described in this literature. METHODS The peer-reviewed literature on MRI visualization of the subthalamic nucleus, globus pallidus, and thalamus was obtained by searching MEDLINE. Publications examining direct MRI visualization of these deep brain stimulation targets were included for review. RESULTS A variety of specialized sequences and postprocessing methods for enhanced MRI visualization are in current use. These include susceptibility-based techniques such as quantitative susceptibility mapping, which exploit the amount of tissue iron in target structures, and white matter attenuated inversion recovery, which suppresses the signal from white matter to improve the distinction between gray matter nuclei. However, evidence confirming the superiority of these sequences over indirect targeting with respect to clinical outcome is sparse. Future targeting may utilize information about functional and structural networks, necessitating the use of resting-state functional MRI and diffusion-weighted imaging. CONCLUSIONS Specialized MRI sequences have enabled considerable improvement in the visualization of common deep brain stimulation targets. With further validation of their ability to improve clinical outcomes and advances in imaging techniques, direct visualization of targets may play an increasingly important role in preoperative planning.

Download Full-text

Intraoperative microelectrode recordings from deep brain structures

First International IEEE EMBS Conference on Neural Engineering, 2003. Conference Proceedings. ◽

10.1109/cne.2003.1196866 ◽

2003 ◽

Cited By ~ 2

Author(s):

J.O. Dostrovsky

Keyword(s):

Brain Structures ◽

Microelectrode Recordings ◽

Deep Brain

Download Full-text

Propofol Reduces Microelectrode-Recording Artefacts caused by Parkinsonian Tremor during Deep Brain Stimulation

Journal of Neuroanaesthesiology and Critical Care ◽

10.1055/s-0037-1618321 ◽

2018 ◽

Vol 05 (01) ◽

pp. 21-25

Author(s):

Jason Chui ◽

Rizq Alamri ◽

Frank Bihari ◽

Matthew Hebb ◽

Lakshmikumar Venkatraghavan

Keyword(s):

Deep Brain Stimulation ◽

Subthalamic Nucleus ◽

Brain Stimulation ◽

Spike Activity ◽

Whole Body ◽

Microelectrode Recording ◽

Parkinsonian Tremor ◽

Microelectrode Recordings ◽

The Right ◽

Deep Brain

AbstractA 51-year-old male with medically refractory Parkinson's disease was scheduled for bilateral deep brain stimulation (DBS). During microelectrode recordings (MERs) of right side DBS, the patient developed severe sustained whole-body tremors causing severe artefacts in MER. The right side DBS electrode was inserted with suboptimal MER. For the creation of left burr hole, propofol infusion at a rate of 20 μg/kg/min, was used and soon after, all tremor activity ceased. Propofol infusion was continued during left side MER. With the absence of tremors, left subthalamic nucleus spike activity was better identified and neurological testing could take place. At 6 months after DBS, the patient’s symptoms had improved significantly without the need for levodopa.

Download Full-text

Design process for serious activities inspired by play and games: a problem solving with a board game from disengamement and gamification processes (Preprint)

10.2196/preprints.25269 ◽

2020 ◽

Author(s):

Stéphane Goria ◽

Louise Dupet ◽

Maëva Négroni ◽

Gabriel Sega ◽

Philippe Arnoux ◽

...

Keyword(s):

Cancer Detection ◽

Serious Games ◽

Diagnostic Method ◽

Scientific Literature ◽

Imaging Techniques ◽

Point Of View ◽

Board Game ◽

Advantages And Disadvantages ◽

Design Result

BACKGROUND most serious games and other game-based tools are designed as digital games or escape games. They are designed for learning or sometimes in the field of medicine as an aid to care. However, they can also be seen as an aid to research, in our case, to evaluate the advantages and disadvantages of imaging techniques for cancer detection. OBJECTIVE we present a case study of action research on the design of a serious board game intended to consider the advantages and weaknesses of a diagnostic method in a different ways. The goal was to better understand the principles of designing a tool using game or play. METHODS we explicitly implemented another process than gamification to develop a structure reminiscent of the game to highlight the strengths and weaknesses of different imaging techniques from the point of view of the respondents (in this case specialists not directly involved in the project). Based on this feedback and the scientific literature on this subject, we detail the main categories of games and games developed for serious use in order to understand their differences. Concerning the cancer research part to which game contributes, our method is based on questions asked to experts and practitioners of this specialty. RESULTS an expert point of view translation tool in the form of a game has been realized to apprehend a research in a different way. CONCLUSIONS we show with the help of a diagram, some possible design paths leading to this type of design result including two hidden dimensions to consider (the awareness of the game or play by the "player" and his role as a contributor or recipient).

Download Full-text

High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia

Scientific Reports ◽

10.1038/s41598-021-88114-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Estefanía Hernandez-Martin ◽

Enrique Arguelles ◽

Yifei Zheng ◽

Ruta Deshpande ◽

Terence D. Sanger

Keyword(s):

Deep Brain Stimulation ◽

Peripheral Nerve ◽

Brain Stimulation ◽

High Frequency ◽

Sensory Information ◽

Brain Structures ◽

High Fidelity ◽

Thalamic Nuclei ◽

Frequency Burst ◽

Deep Brain

AbstractHigh-frequency peripheral nerve stimulation has emerged as a noninvasive alternative to thalamic deep brain stimulation for some patients with essential tremor. It is not known whether such techniques might be effective for movement disorders in children, nor is the mechanism and transmission of the peripheral stimuli to central brain structures understood. This study was designed to investigate the fidelity of transmission from peripheral nerves to thalamic nuclei in children with dystonia undergoing deep brain stimulation surgery. The ventralis intermediate (VIM) thalamus nuclei showed a robust evoked response to peripheral high-frequency burst stimulation, with a greatest response magnitude to intra-burst frequencies between 50 and 100 Hz, and reliable but smaller responses up to 170 Hz. The earliest response occurred at 12–15 ms following stimulation onset, suggesting rapid high-fidelity transmission between peripheral nerve and thalamic nuclei. A high-bandwidth, low-latency transmission path from peripheral nerve to VIM thalamus is consistent with the importance of rapid and accurate sensory information for the control of coordination and movement via the cerebello-thalamo-cortical pathway. Our results suggest the possibility of non-invasive modulation of thalamic activity in children with dystonia, and therefore the possibility that a subset of children could have beneficial clinical response without the need for invasive deep brain stimulation.

Download Full-text

A Simulation on Relation between Power Distribution of Low-Frequency Field Potentials and Conducting Direction of Rhythm Generator Flowing through 3D Asymmetrical Brain Tissue

Symmetry ◽

10.3390/sym13050900 ◽

2021 ◽

Vol 13 (5) ◽

pp. 900

Author(s):

Hao Cheng ◽

Manling Ge ◽

Abdelkader Nasreddine Belkacem ◽

Xiaoxuan Fu ◽

Chong Xie ◽

...

Keyword(s):

Brain Tissue ◽

Power Distribution ◽

Low Frequency ◽

Field Potentials ◽

Spatial Spread ◽

Rhythm Generator ◽

Equivalent Dipole ◽

Head Surface ◽

Brain Rhythm ◽

Deep Brain

Although the power of low-frequency oscillatory field potentials (FP) has been extensively applied previously, few studies have investigated the influence of conducting direction of deep-brain rhythm generator on the power distribution of low-frequency oscillatory FPs on the head surface. To address this issue, a simulation was designed based on the principle of electroencephalogram (EEG) generation of equivalent dipole current in deep brain, where a single oscillatory dipole current represented the rhythm generator, the dipole moment for the rhythm generator’s conducting direction (which was orthogonal and rotating every 30 degrees and at pointing to or parallel to the frontal lobe surface) and the (an)isotropic conduction medium for the 3D (a)symmetrical brain tissue. Both the power above average (significant power value, SP value) and its space (SP area) of low-frequency oscillatory FPs were employed to respectively evaluate the strength and the space of the influence. The computation was conducted using the finite element method (FEM) and Hilbert transform. The finding was that either the SP value or the SP area could be reduced or extended, depending on the conducting direction of deep-brain rhythm generator flowing in the (an)isotropic medium, suggesting that the 3D (a)symmetrical brain tissue could decay or strengthen the spatial spread of a rhythm generator conducting in a different direction.

Download Full-text