scholarly journals Amelogenesis imperfecta: A case series

2021 ◽  
Vol 7 (3) ◽  
pp. 145-148
Author(s):  
Jijin M J ◽  
Thabsheera P P ◽  
Mohamed Labeeb K P ◽  
Anjana R

Amelogenesis imperfecta (AI) refers to a group of rare genetic disorders that involve tooth development and that are passed down through families as a dominant trait. This condition is characterized by abnormal enamel formation caused by gene mutations that alter the quality and/or quantity of enamel. This dental problem can impact both primary and permanent dentition, varies among affected individuals, and results in esthetic and functional problems. The treatment planning for patients with AI is related to many factors, including the age of the patient, the type and severity of the disorder, intraoral conditions, and the socioeconomic status of the patient. It is crucial to plan a proper remedy, which requires collaboration among dental specialties to execute comprehensive dental treatment in order to provide a long-term solution with adequate esthetics. This clinical case study looks at three different types of amelogenesis imperfecta patients.

Coatings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 207
Author(s):  
Pavel Koštial ◽  
Zora Koštialová Jančíková ◽  
Robert Frischer

These days there are undeniably unique materials that, however, must also meet demanding safety requirements. In the case of vehicles, these are undoubtedly excellent fire protection characteristics. The aim of the work is to experimentally verify the proposed material compositions for long-term heat loads and the effect of thickness, the number of laminating layers (prepregs) as well as structures with different types of cores (primarily honeycomb made of Nomex paper type T722 of different densities, aluminum honeycomb and PET foam) and composite coating based on a glass-reinforced phenolic matrix. The selected materials are suitable candidates for intelligent sandwich structures, usable especially for interior cladding applications in the industry for the production of means of public transport (e.g., train units, trams, buses, hybrid vehicles).


2021 ◽  
Vol 9 (9) ◽  
pp. 2029-2036
Author(s):  
Asha A Bhat ◽  
Prashanth A S

Skin is one of the most beautiful organs God has ever blessed to anyone. Everyone craves for beautiful skin and makes all possible efforts to make it glow. To achieve this, they are engaged in continuous use of creams, moist- urizers and other cosmetic articles which lead to immediate or long-term skin issues. Itching being the predomi- nant symptom of these cosmetic issues make people highly embarrassed in society. In Ayurveda, almost all skin conditions are explained under one umbrella called Kushta. It is broadly classified into Mahakushta and Kshudra- kushta1. Dadru Kushta one among the Kshudra Kushta is the most common skin condition accounts for 20% in all consultation in general practice2. North Karnataka is well known for its hot and humid conditions making its population at risk of many Tinea infections. Kandu, Raga and Atasi Pushpa Sankashavat Mandala are the cardi- nal features of Dadru3. In the present case study, 40 patients of Dadru Kushta were taken according to inclusion criteria. The combined effect of both Shodhana and Shamana was assessed. Keywords: Dadru Kushta, Aupasargika, Anushangi, Wilcoxon Rank Sum Test


Author(s):  
Jay D. Raman ◽  
Augustyna Gogoj ◽  
Brian D. Saunders ◽  
Daniel J.Canter ◽  
Jay D. Raman ◽  
...  

Introduction: Acquired adrenal insufficiency is a known risk of unilateral adrenalectomy. However, the rates of early and prolonged adrenal insufficiency following unilateral adrenalectomy are not well defined in the literature. Patients and Methods: We reviewed a case series of 184 consecutive patients to determine the likelihood of steroid supplementation at 30 days and 1 year following adrenalectomy. 109 lesions were non-functional and 75 (41%) demonstrated functionality, including 33 pheochromocytomas, 20 cortisol-producing adenomas, 19 aldosteronomas, and 3 cases of cortisol-secreting hyperplasia. No patients with a nonfunctional lesion, pheochromocytoma, or aldosteronoma required steroid supplementation following surgery. Eleven of 23 patients (48%) with primary adrenal Cushing syndrome required cortisol supplementation at 30 days, and only 1 patient (4%) necessitated supplementation one year following surgery. Discussion: Approximately 50% of patients with cortisol-producing lesions in the adrenal gland will require supplementation 30-days following surgery. Only 4% will require persistent exogenous steroids at 1-year. Conversely, less than 1% of patients with different types of functional or non-functional tumors required supplementation after surgery. Conclusion: The incidence of adrenal insufficiency following unilateral adrenalectomy is low. A large majority of patients requiring steroid supplementation 30 days following surgery are able to wean off this requirement by 1 year. With this information, we can better counsel our patients and set clearer expectations for the potential need of cortisol supplementation following adrenalectomy


2021 ◽  
Vol 16 (1-2) ◽  
pp. 10-41
Author(s):  
K. Yu. Mukhin ◽  
O. A. Pylaeva ◽  
M. Yu. Bobylova ◽  
V. A. Chadaev

The disease caused by mutations in the CDKL5 gene (encoding cyclin-dependent kinase 5, CDK5) belongs to the group of early (infantile) epileptic encephalopathies caused by alterations in the genome. Currently, the disease is called “developmental encephalopathy and epileptic encephalopathy type 2”. This disorder is a complex combination of symptoms that develop due to deficiency or absence of the CDKL5 gene product, which is serine/threonine kinase. The CDKL5 gene is located on X chromosome; the disease has an X-linked dominant inheritance pattern. This literature review summarizes relevant studies analyzing the disease caused by CDKL5 gene mutations, including its genetic and epidemiological aspects, clinical manifestations, characteristics of epilepsy, principles of diagnosis, and therapeutic approaches. We present a case series of several patients with genetic disorders involving the CDKL5 gene.


2018 ◽  
Vol 5 (10) ◽  
pp. 180642 ◽  
Author(s):  
Mohsin Adalat ◽  
Muaz A. Niazi ◽  
Athanasios V. Vasilakos

Online social media has completely transformed how we communicate with each other. While online discussion platforms are available in the form of applications and websites, an emergent outcome of this transformation is the phenomenon of ‘opinion leaders’. A number of previous studies have been presented to identify opinion leaders in online discussion networks. In particular, Feng (2016 Comput. Hum. Behav. 54 , 43–53. ( doi:10.1016/j.chb.2015.07.052 )) has identified five different types of central users besides outlining their communication patterns in an online communication network. However, the presented work focuses on a limited time span. The question remains as to whether similar communication patterns exist that will stand the test of time over longer periods. Here, we present a critical analysis of the Feng framework both for short-term as well as for longer periods. Additionally, for validation, we take another case study presented by Udanor et al. (2016 Program 50 , 481–507. ( doi:10.1108/PROG-02-2016-0011 )) to further understand these dynamics. Results indicate that not all Feng-based central users may be identifiable in the longer term. Conversation starter and influencers were noted as opinion leaders in the network. These users play an important role as information sources in long-term discussions. Whereas network builder and active engager help in connecting otherwise sparse communities. Furthermore, we discuss the changing positions of opinion leaders and their power to keep isolates interested in an online discussion network.


2017 ◽  
Vol 76 (8) ◽  
pp. 986-999 ◽  
Author(s):  
Johanna Hokkanen ◽  
Anna-Liisa Elorinne ◽  
Katri Hämeen-Anttila ◽  
Tuula Keinonen

Background: Educating children about medicines and medicine use is part of health education and is often seen as parents’ responsibility. However, to date, little research has been conducted on medicines education as provided in the home. Objective: To explore (1) parents’ attitudes towards medicines, (2) medicines education practices in the home and (3) the interaction in medicines education between the home and at school. Design: Mixed-methods case study. Setting: Pupils and their parents in one comprehensive school in Finland. Method: Before an educational intervention with Year 4 (aged 10–11 years) and Year 7 (aged 13–14 years) students, parents completed a background survey concerning their perceptions, beliefs and knowledge of medicines ( n = 250). Following the intervention, interviews with 12 mothers and 12 children, and medicine cabinet studies ( n = 10) were conducted. Quantitative data were analysed using K-mean cluster analysis to see whether respondents could be divided into different clusters based on their attitudes towards medicines. Qualitative data were analysed using theory-guided content analysis to obtain a picture of home medicines education. Results: Participants, mostly mothers, were divided into different types of medicine educators, whose attitudes towards medicines were either positive or neutral. Medicine consumption practices varied between families, but medicines were usually discussed when the child, a family member, a relative or a friend had a long-term illness; when a family member was suffering from a sickness; and while taking a medicine. In general, interaction between the home and the school was rather limited. Conclusion: The majority of mothers exhibited a strong reliance on public systems of health care. Greater interaction between schools and the home is needed in Finnish medicines education.


2021 ◽  
pp. 096977642110288
Author(s):  
Markus Grillitsch ◽  
Bjørn Asheim ◽  
Hjalti Nielsen

The temporality of agency plays a fundamental role in regional development but has received little attention in economic geography and regional studies. This paper zooms in on two aspects of temporality: the temporality of intentions and the temporality of consequences. The former refers to actors’ perception and valuation of opportunities in the near and distant future, whereas the latter refers to the short- and long-term consequences of actions. This paper studies the temporality of agency in the context of regional development. It investigates how short- and long-term intentions motivate different types of agency, how different types of agency affect short- and long-term regional development outcomes and which conditions enable or constrain different types of agency. We illustrate our arguments with an in-depth case study covering the regional development of a labour market in Norway over the last 20 years.


2018 ◽  
Vol 28 (2) ◽  
pp. 130-139
Author(s):  
Simone M. De la Rie ◽  
Jannetta Bos ◽  
Jeroen Knipscheer ◽  
Paul A Boelen

Introduction: Torture survivors risk developing Posttraumatic Stress Disorder (PTSD) as well as other mental health problems. This clinical case study describes the impact of torture on two survivors who were treated for their PTSD with Narrative Exposure Therapy. Methods: The reports of the narratives of two torture survivors were qualitatively analyzed. It was hypothesized that torture yields overaccommodating cognitions, as well as mental defeat, which in turn, are related to severity of psychological complaints. Results: Both patients have experienced an accumulation of traumatic events. The psychological and physical torture they experienced lead to increased anticipation anxiety, loss of control and feelings of hopelessness, as well as overaccommodating cognitions regarding self and others. Conclusions: Cognitions, culture and beliefs, as well as issues of confidence and a more long-term perspective affect therapeutic work. Building trust, pacing the therapeutic process, and applying tailor-made interventions that focus on cognitions regarding self-esteem, trust in relationships, as well as safety and control are warranted.


2021 ◽  
Vol 33 (1) ◽  
pp. 122-132
Author(s):  
Maria Gabriela Acosta-de Camargo ◽  
Alfredo Enrique Natera-Guarapo ◽  
John Mangles†

Amelogenesis imperfecta (AI) refers to a group of rare genetic disorders that involve tooth development and are passed down through families. Hypoplasic AI phenotypes include the absence of enamel as a result of a defect in the secretory stage. This case report describes the diagnosis and treatment of a patient with hypoplastic AI. The clinical implications include sensitive teeth, functional problems, and aesthetic complaining. The diagnosis was done through history, clinical examination and imaging. The intervention was performed by Direct Resin Veneers. This treatment showed to improve occlusion, esthetics, and selfimage of the teenager. The satisfactory clinical result has made it possible to avoid more invasive and expensive treatments.


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