scholarly journals Clinical Profile of Subclinical Hypothyroidism:A Retrospective Study

2017 ◽  
Vol 6 (2) ◽  
pp. 1475
Author(s):  
Mallikarjuna Shetty ◽  
Krishna Prasad Adiraju ◽  
Nageswar Rao Modugu
Keyword(s):  
Retrospective Study ◽  
Subclinical Hypothyroidism ◽  
Low Dose ◽  
Clinical Symptoms ◽  
Clinical Profile ◽  
Common Symptom ◽  
Number Of Patients ◽  
Age Range ◽  
Symptoms And Signs ◽  
Serum Tsh

<p><strong>Background:</strong> Subclinical hypothyroidism occurs due to an under functioning thyroid gland and presents with varied symptoms and signs. Thyroid disorders are common in Indian population and the prevalence of subclinical hypothyroidism is high.</p><p><strong>Objective:</strong> This study intended to assess the clinical profile of patients presenting with subclinical hypothyroidism.</p><p><strong>Materials and Methods:</strong> This was a retrospective study that analyzed the medical records of adult patients diagnosed with subclinical hypothyroidism for a period of three years.</p><p><strong>Results:</strong> 71 patients within the age range of 18 years to 77 years were diagnosed with subclinical hypothyroidism. Among these 53 (75%) patients had various clinical symptoms. Body pains were the most common symptom (38 %) followed by weight gain(27%) and tiredness (20%). A significant number of patients were obese (25%). Enlarged thyroid(14%) and dyslipidemia (25%) were also recorded. 63 (75%) patients were initiated on low dose levothyroxine.</p><p><strong>Conclusion:</strong> Patients with subclinical hypothyroidism present with varied non-specific clinical symptoms. Treatment with low dose levothyroxine resulted in lowering of serum TSH to normal range and relief of symptoms.</p>

scholarly journals A clinico-epidemiological analysis of subclinical hypothyroidism in a tertiary care health center

2019 ◽  
Vol 6 (4) ◽  
pp. 1079
Author(s):  
Vaibhav Agrawal ◽  
Virendra Patil ◽  
Ashok Kshirsagar
Keyword(s):  
Subclinical Hypothyroidism ◽  
Clinical Symptoms ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Common Symptom ◽  
Age Group ◽  
Free Triiodothyronine ◽  
High Prevalence ◽  
Care Health ◽  
Serum Tsh

Background: Subclinical hypothyroidism (SCH) is defined by increase in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) and free triiodothyronine (FT3) levels within normal range, coupled with absence of typical clinical symptoms. The present study was undertaken to analyse the SCH associated comorbidities, especially lipid disturbances, thyroid autoantibodies, etc.Methods: The present study was retrospective observational study, which was carried out at a tertiary health care center.Results: Out of the 100 patients, majority were in the age group 21 to 30 years (31 patients), followed by 26 patients in age group >51 years and least in age group 41 to 50 years. Prevalence showed female predilection, with female: male ratio of 1.9:1. Most common symptom reported was general fatigue, which was encountered in 40 patients, followed by weight gain, menstrual abnormalities, and constipation. 10 patients were asymptomatic. Serum TSH range in the patients was 5 to 21.1 µIU/l, while mean TSH was 10.9 µIU/l. 20 patients were found to have serum TSH>10.Conclusions: Despite high prevalence, detection rate of subclinical hypothyroidism is very low. Carrying out epidemiological study on national scale is need of the hour, as lack of typical clinical features makes the detection less likely and it has numerous complications, if untreated.

scholarly journals Clinical profile of patients with inferolateral myocardial infarction: a comparison study

2020 ◽  
Vol 8 (12) ◽  
pp. 4320
Author(s):  
Sibaram Panda ◽  
Sunil Kumar Jena ◽  
Uttam Kumar Pattanaik
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Lateral Wall ◽  
Clinical Profile ◽  
Common Symptom ◽  
Inferior Wall ◽  
Ecg Changes ◽  
Killip Class ◽  
Number Of Patients ◽  
Group A

Background: Patient with lateral wall changes in inferior wall myocardial infarction (MI) usually ignored most often. However above lateral MI changes in the clinical setting of inferior wall MI usually impact on final clinical outcome and prognosis of the patients. Our aim of the study is observe diversity in clinical profile of inferolateral MI in comparison to patient with inferior wall without any lateral wall MI changes.Methods: Current study enrolled 405 patients admitted to cardiology emergency with inferior wall MI. Patients divided into three groups on the basis of ECG changes, inferolateral (group A), isolated inferior wall MI (group B) and inferior wall MI with RVMI (group C). Patients with RVMI (group C) excluded from the group. Clinical profile and outcomes compared between group A and B.Results: Around 33.8% pts with inferior wall STEMI have ECG changes of lateral wall AMI. STEMI equivalent in lead V1, V2 which is the most common ECG presentation, seen in 65% inferolateral patients. 45.7% of population of inferolateral MI are above age group of 60 years. 66.2 % of the patients with inferolateral MI having two or more risk factors. Dyspnoea is one of common symptom seen in 29.9% patients. Statistically significant number of patients in inferlateral MI have clinical picture of LVF (crepitation, S3), higher Killip class as compared to inferior wall MI. Incidence of complications like LVF, MR, VT, death is significantly higher in this group.Conclusions: Around 1/3rd patient with lateral MI changes seen in inferior wall MI patients. STEMI equivalent changes in anterior precordial leads are most common ECG presentation. More no patients are older and with multiple risk factors. Complication and death are higher in this group. So meticulous attention should be given to patients with lateral wall MI changes in inferior wall MI. 

scholarly journals Complications and Comorbidities of Acromegaly—Retrospective Study in Polish Center

2021 ◽  
Vol 12 ◽  
Author(s):  
Małgorzata Rolla ◽  
Aleksandra Jawiarczyk-Przybyłowska ◽  
Jowita Halupczok-Żyła ◽  
Marcin Kałużny ◽  
Bogumil M. Konopka ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Life Quality ◽  
Premature Mortality ◽  
Diagnostic Methods ◽  
Endocrine Disorders ◽  
Pituitary Insufficiency ◽  
Systemic Complications ◽  
Endocrine Disturbances ◽  
Number Of Patients ◽  
Age Range

IntroductionIn acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life quality and premature mortality. The aim of our study was to assess the frequency of acromegaly complications and to evaluate diagnostic methods performed toward recognition of them.Materials and MethodsIt was a retrospective study and we analyzed data of 179 patients hospitalized in the Department of Endocrinology, Diabetes and Isotope Therapy in Wroclaw Medical University (Poland) in 1976 to 2018 to create a database for statistical analysis.ResultsThe study group comprised of 119 women (66%) and 60 men (34%). The median age of acromegaly diagnosis was 50.5 years old for women (age range 20–78) and 46 for men (range 24–76). Metabolic disorders (hyperlipidemia, diabetes, and prediabetes) were the most frequently diagnosed complications in our study, followed by cardiovascular diseases and endocrine disorders (goiter, pituitary insufficiency, osteoporosis). BP measurement, ECG, lipid profile, fasting glucose or OGTT were performed the most often, while colonoscopy and echocardiogram were the least frequent.ConclusionsIn our population we observed female predominance. We revealed a decrease in the number of patients with active acromegaly and an increase in the number of well-controlled patients. More than 50% of patients demonstrated a coexistence of cardiac, metabolic and endocrine disturbances and only 5% of patients did not suffer from any disease from those main groups.

scholarly journals A prospective study of clinical profile of patients with acute kidney injury following acute gastroenteritis

2020 ◽  
Vol 16 (1) ◽  
pp. 53-56
Author(s):  
Dnyaneshwar Malharrao Ghuge ◽  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Gastroenteritis ◽  
Early Recognition ◽  
Kidney Injury ◽  
Clinical Profile ◽  
Common Symptom ◽  
Age Group ◽  
Female Ratio ◽  
Number Of Patients ◽  
Co Morbidity

Background: Increasing number of patients of AGE are now diagnosed with AKI.. Over the recent years there has been increasing recognition that relatively small rises in serum creatinine in a variety of clinical settings are associated with worse outcomes. In present study, we aimed to study clinical profile of patients with acute kidney injury following acute gastroenteritis at our tertiary hospital. Material and Methods: Present study was conducted in patients who were diagnosed to have AKI following acute gastroenteritis. Statistical analysis was done using descriptive statistics. Results were expressed as mean and standard deviation for continuous data and frequency as number and percentage. Results: After applying inclusion and exclusion criteria, total 72 patients of AGE with AKI were considered for this study. Most common age group in this study was age group of 61–70 years (28%), followed by age group of 51–60 years (25%). Mean age of study patients was 53.8 ± 11.7 years. Male patients (64%) were more than female patients (36%). Male to female ratio was 1.8:1. According to clinical presentation most common symptom was loose stools (100 %), followed by fever (76 %) and vomiting (68 %). Other complaints were shortness of breath (18 %) and altered sensorium (8 %). Diabetes was the most common co-morbidity noted (39 %) followed by hypertension (34%). AKI was staged for severity according to the KDIGO criteria. At the time of diagnosis most patients were in stage 1 (57%), while 32% and 11% were in stage 2 and 3 respectively.In this study hypotension, hyperkalemia were common complications of Acute Kidney Injury. Other complications were metabolic acidosis, encephalopathy, pulmonary edema, anemia, multi organ dysfunction syndrome (MODS), hypokalemia and hyponatremia. In present study, 11% patients underwent hemodialysis and 3 % mortality was noted. Conclusion: Acute kidney injury in patients with acute gastroenteritis had good prognosis if detected earlier. Early recognition of AKI is essential to ensure prompt and appropriate management, and to avoid progression to deadlier stages of the disease.

scholarly journals Idiopathic Dilated Cardiomyopathy: Clinical Profile of 100 Patients

1970 ◽  
Vol 6 (1) ◽  
pp. 9-12
Author(s):  
Sajal K Banerjee ◽  
Fazlur Rahman ◽  
Mohammad Salman ◽  
Md Abu Siddique ◽  
SM Mustafa Zaman ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Left Ventricular ◽  
Clinical Profile ◽  
Left Ventricular Failure ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Common Symptom ◽  
Ventricular Failure ◽  
Medical University ◽  
Age Range ◽  
Ventricular Ectopics

Clinicians continue to face the challenges of identifying and treating the idiopathic dilated cardiomyopathy to improve symptoms and survival. A study on idiopathic dilated cardiomyopathy was done in the Department of Cardiology, University Cardiac Center, Bangabandhu Sheikh Mujib Medical University, Dhaka, from January 2004 to December 2009. The aim of this study was to examine clinical profile of patients with idiopathic dilated cardiomyopathy. The age range was 18 to 65 years and 70% subjects were male. Most common symptom was dyspnea (86%) and cough (75%). 75% subjects had sinus tachycardia, 42% had ventricular ectopics and 40% had left bundle branch block. Mean diastolic dimension was 60±9 mm, ejection fraction was 28±8%, left atrial dimension was 40±6 mm and 36% were having mitral regurgitation. Left ventricular failure (75%) and various type of arrhythmias (62%) were the main complications. 8% subjects were died during hospital stay. Hence the clinical presentation of idiopathic dilated cardiomyopathy varies from patient to patient, but most patients present later, i.e. at some point in the spectrum of heart failure. Key words: Idiopathic dilated cardiomyopathy; left ventricular failure; ventricular ectopics. DOI: 10.3329/uhj.v6i1.7182University Heart Journal Vol.6(1) 2010 pp.9-12

A Retrospective Study on Laboratory Profile and Clinical Parameters of Dengue Fever Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3357-3359
Author(s):  
Ajeet Kumar ◽  
Shahnawaz Sarwari ◽  
Waheed Ahmed Arain ◽  
Suresh Kumar ◽  
Kaneez Fatima ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Laboratory Data ◽  
Gastrointestinal Symptoms ◽  
Clinical Profile ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Laboratory Profile ◽  
Study Laboratory

Introduction: Over the past decade, the number of cases of dengue fever has augmented intensely globally. Half the world's population is now under threat. Pakistan has also very high dengue fever per year, with regular reports of dengue outbreaks compared to other countries. Dengue infection should be treated as a solitary ailment with various clinical pictures, vacillating from symptomless situations to severe clinical sequences, which may result in high mortality and morbidity. Aim: To investigate the laboratory parameters and clinical profile in patients with dengue fever. Study Design: A Retrospective observational study. Place and Duration: In the Department of Medicine of Jalan Bani Bu Ali hospital Oman for one-year duration from July 2020 to July 2021. Methods: At least IgM positive or NS1 positive or IgM with NS1 positive or reactive ELISA assay for dengue fever detection but without any co-infection, bone marrow disease confirmed the cases of dengue without other confounding factors, such as alteration of clinical and laboratory data. The results were analyzed for the study. SPSS 21.0 was applied for Statistical analysis. Results: A total of 52 cases were tested positive for dengue fever. The patients mean age was 27.60 +/- 13.98 years and vacillated from 13 to 75 years. Of the total number of patients, 30 (57.69%) were in the age group 21 to 40 years. Of the 52 cases, 36 (69.23%) were male, 16 (30.77%) were female with M:F ratio was 2.2: 1. 42 (80.77%) of all cases were hospitalized for 5 days or less, and 10 (19.23%) were hospitalized for more than 5 days. The mean hospital stay was 3.67±1.40, ranging from 2 to 8 days. Fever was observed in all (100%) of the total number of cases. Conclusions: In this analysis, all patients have fever, and body pain, headache and malaise were communal signs, but a substantial quantity of cases also had respiratory and gastrointestinal symptoms such as nausea, abdominal pain, vomiting, dry cough and diarrhea. Keywords: Dengue fever, clinical profile, retrospective study, laboratory profile, thrombocytopenia

scholarly journals Serum TSH and serum thyroid peroxidase antibody fluctuate in parallel and high urinary iodine excretion predicts subsequent thyroid failure in a 1-year study of patients with untreated subclinical hypothyroidism

2008 ◽  
Vol 158 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Jesper Karmisholt ◽  
Peter Laurberg
Keyword(s):  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Urinary Iodine ◽  
Time Shift ◽  
Urinary Iodine Excretion ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibody ◽  
Iodine Excretion ◽  
Symptoms And Signs ◽  
Serum Tsh

ObjectiveTo explore the possibility of predicting decline or improvement in thyroid function over 1 year, and to investigate the correlations of serum TSH (s-TSH) with hypothyroidism-related symptoms and signs, serum thyroid peroxidase antibody (s-TPO-Ab) and urinary iodine excretion in individual patients with untreated subclinical hypothyroidism (SH).DesignMonthly repeated measurement study without intervention.MethodsTwenty-one patients without former thyroid disease who had been identified with s-TSH between 5 and 12 mU/l and normal serum thyroxine (s-T4) at two occasions were enrolled. Subsequently, 13 monthly measurements of s-TSH, hypothyroidism-related symptoms and signs, serum free T4, s-TPO-Ab and urinary iodine excretion were performed.ResultsOver the study year, s-TSH increased significantly in 5 patients, 16 had unchanged s-TSH, whereas none improved. From clinical and biochemical inclusion data, it was not possible to predict who would later increase in s-TSH. In individual patients, a highly significant correlation between s-TSH and s-TPO-Ab was found (r=0.37, P<0.0001) and also between s-TSH and urinary iodine excretion (r=0.14, P=0.034). No correlation between s-TSH and clinical symptoms and signs was observed. Time shift showed best correlation between s-TSH and s-TPO-Ab measured at the same time point, whereas urinary iodine excretion correlated best to s-TSH and s-TPO-Ab obtained 1 month later.ConclusionAt the time of inclusion, it was not possible to identify the 24% of SH patients who would show deterioration in thyroid function over the following year. Impairment in thyroid function varied in parallel with thyroid autoimmunity, whereas high urinary iodine excretion predicted high s-TSH and s-TPO-Ab 1 month later.

scholarly journals Clinical Profile of Thyroid Disorders – A retrospective study at BPKIHS

2018 ◽  
Vol 2 (2) ◽  
pp. 19-25
Author(s):  
Anuskha Agrawal ◽  
Nidhi Rani ◽  
Robin Maskey
Keyword(s):  
Retrospective Study ◽  
Subclinical Hypothyroidism ◽  
Primary Hypothyroidism ◽  
Clinical Profile ◽  
Thyroid Disorders ◽  
American Thyroid Association ◽  
Thyroid Disorder ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Endocrinology Clinic

Background: The thyroid gland produces two key metabolic hormones which regulate metabolic rate, growth and development. They play vital roles in digestion, heart and muscle function, brain development and maintenance of bones. People suffering from thyroid disorders may have autoimmune disease, ranging from primary hypothyroidism, Hashimoto’s thyroiditis, to hyperthyroidism caused by Graves’ disease. Objectives: To study clinical profile of thyroid disorders in endocrinology clinic of BPKIHS, Nepal. Methods: This is a hospital based retrospective study of past five years (2012 – 2017) done in department of internal medicine at B.P. Koirala Institute of Health Sciences, in which thyroid disorder patient records from the endocrinology clinic will be compiled together will be analyzed after classifying them according to the guidelines of the American Thyroid Association (ATA). Results: Among 584 thyroid disorder cases that were sampled, higher prevalence of thyroid disorders was seen in females, and the Male: Female ratio was 1:4.13. Most common type of thyroid disorder was Hypothyroidism (29.6%) followed by Subclinical hypothyroidism (28.3%). Conclusions: Thyroid disorders are more common in females than males and hypothyroidism being commonest thyroid disorder in our setup. Subclinical hypothyroidism is second commonest followed by hyperthyroidism. In Subclinical hypothyroidism Anti TPO antibody is most commonly found to be positive.

scholarly journals A study on clinical profile and outcome of malrotation of intestine in children

2017 ◽  
Vol 4 (6) ◽  
pp. 2054
Author(s):  
Sankkarabarathi Chandrasekaran ◽  
Vivek Shanmugam
Keyword(s):  
Clinical Symptoms ◽  
Barium Meal ◽  
Clinical Signs ◽  
Clinical Profile ◽  
Common Symptom ◽  
Contrast Study ◽  
Female Ratio ◽  
X Ray ◽  
Asymptomatic Children ◽  
One Year

Background: Malrotation is a congenital disorder featured with abnormal positioning of intestine within the peritoneal cavity. Its diagnosis is established within one year of age in most of the cases. The present study was conducted with the aim to analyse in detail the entire clinical profile of malrotation of intestine in children and to analyse the value of imaging in diagnosing suspected cases of malrotation.Methods: This prospective study was carried out during the period from September 2010 to January 2013. 70 patients with suspected malrotation based on clinical symptoms and subsequently proven by surgery were included in the study. The surgery was performed based on the clinical signs and symptoms as well as ultrasound and an upper gastrointestinal contrast study by using barium meal follow through (BMFT).Results: Out of 70 patients in this series, 47 (67.5%) were at the age group of less than one week to one month, 10 (14%) were between one month to one year and 13 (18.5%) were older than year. Male: Female ratio was 4:3. 12 (17%) babies were born to consanguity couple. Bilious vomiting was the most common symptom observed in 61 (87%) patients. After X-ray of abdomen, intussusception was diagnosed in 5 patients, X-ray was suggestive in 35 patients (50%), normal in 16 (23%), double bubble sign noticed in 5 (7%) patients. Out of 70, 51 patients had ultrasound abdomen for malrotation. Among them, 36 patients were noticed with altered SMA/SMV axis, 6 with volvulus, 4 reports were normal and 5 were inconclusive.Conclusions: The incidence of malrotation in symptomatic children can be identified by ultrasound of abdomen whereas in case of asymptomatic children, it was diagnosed initially by using abdominal X-ray and later comfirmed by abdominal ultrasound. Once the diagnosis of malrotation has been established, appropriate surgical approach should be carried out to reduce the risk of mortality in infants and children.

scholarly journals Demographic and clinical profile of chronic rhinosinusitis patients in a rural based tertiary hospital

2019 ◽  
Vol 5 (5) ◽  
pp. 1172
Author(s):  
Deepika Garg ◽  
Ajay Kamble ◽  
Manish Puttewar
Keyword(s):  
Chronic Rhinosinusitis ◽  
Rural Population ◽  
Clinical Symptoms ◽  
Subjective Assessment ◽  
Tertiary Hospital ◽  
Clinical Profile ◽  
Nasal Endoscopy ◽  
Lower Airway ◽  
Nasal Discharge ◽  
Number Of Patients

<p class="abstract"><strong>Background:</strong> Chronic rhinosinusitis (CRS) is one of the most common health problems which incurs significant medical costs and has severe impact on lower airway diseases and general health of the patient. The aim of this study was to describe the demographic and clinical profile of chronic rhinosinusitis patients.</p><p class="abstract"><strong>Methods:</strong> In this study 94 patients were included. After taking a brief history, their clinical symptoms were assessed using SNSG test (sino nasal symptom grading test). The findings were further confirmed by diagnostic nasal endoscopy.  </p><p class="abstract"><strong>Results:</strong> We found that maximum number of patients were in the age group of 18-27 years with a slight male preponderance. Also rural population had more cases of CRS with nasal discharge being the commonest complaint at the time of presentation. After diagnostic nasal endoscopy (DNE) it was found that ethmoidal polyps are more common in CRS patients however more number of CRS patients presented without polyps.</p><p class="abstract"><strong>Conclusions:</strong> We conclude that chronic rhinosinusitis manifests more in male and rural population with nasal discharge and ethomoidal polyps being the most common presentation. The subjective assessment of clinical symptoms could be done by SNSG test; however it further requires detailed studies.</p><p class="abstract"> </p>

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