scholarly journals Evaluation of In-Vitro Anti-Bacterial Qualities of Camels Urine in Somali Region of Ethiopia against Selected Bacterial Pathogens

2021 ◽  
Vol 10 (1) ◽  
pp. 1-14
Author(s):  
Abdifitah Abdullahi Abdi ◽  
Nega Berhane ◽  
Aragaw Zemene
Keyword(s):  
Bacterial Pathogens ◽  
Somali Region

scholarly journals Combining a probiotic with organic salts presents synergistic in vitro inhibition against aquaculture bacterial pathogens

2018 ◽  
Vol 61 (0) ◽  
Author(s):  
Norha Constanza Bolivar ◽  
Esmeralda Chamorro Legarda ◽  
Walter Quadros Seiffert ◽  
Edemar Roberto Andreatta ◽  
Felipe do Nascimento Vieira
Keyword(s):  
Bacterial Pathogens ◽  
Organic Salts ◽  
In Vitro Inhibition

In-vitro activity of cefepime against bacterial pathogens from hospitalized patients

1993 ◽  
Vol 32 (1) ◽  
pp. 164-166 ◽  
Author(s):  
K. P. KLUGMAN ◽  
J. SAUNDERS ◽  
M. KHOOSAL
Keyword(s):  
Bacterial Pathogens ◽  
Hospitalized Patients ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens

2018 ◽  
Vol 62 (5) ◽  
Author(s):  
Susanne Paukner ◽  
Astrid Gruss ◽  
Jørgen Skov Jensen
Keyword(s):  
Chlamydia Trachomatis ◽  
Bacterial Pathogens ◽  
Mycoplasma Genitalium ◽  
Standard Of Care ◽  
Multidrug Resistant ◽  
In Vitro Activity ◽  
First Line ◽  
Content Type ◽  
Sexually Transmitted

ABSTRACT The pleuromutilin antibiotic lefamulin demonstrated in vitro activity against the most relevant bacterial pathogens causing sexually transmitted infections (STI), including Chlamydia trachomatis (MIC 50/90 , 0.02/0.04 mg/liter; n = 15), susceptible and multidrug-resistant Mycoplasma genitalium (MIC range, 0.002 to 0.063 mg/liter; n = 6), and susceptible and resistant Neisseria gonorrhoeae (MIC 50/90 , 0.12/0.5 mg/liter; n = 25). The results suggest that lefamulin could be a promising first-line antibiotic for the treatment of STI, particularly in populations with high rates of resistance to standard-of-care antibiotics.

ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANTS AGAINST MULTI DRUG RESISTANT URINARY TRACT INFECTION CAUSING ORGANISMS

2021 ◽  
Vol 1 (6) ◽  
pp. 85-95
Author(s):  
Perumal G
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Medicinal Plants ◽  
Tract Infection ◽  
Pathogenic Bacteria ◽  
Bacterial Pathogens ◽  
Drug Resistant ◽  
Antibiotic Drug ◽  
Phytochemical Studies

The present study was isolate Bacterial pathogens form Urinary Tract Infection and identified the Bacterial pathogens from UTI patients. Determination of the antibiotic drug resistant pattern of the isolated pathogenic bacteria using standard antibiotic discs Ampicilin (25μg), Erithromycin (15μg), Chloramphenicol (10μg) Gentamicin (10μg) and Tetracycline (30 μg).The study was carried out, in vitro screening of ethanolic extracts of some medicinal plants against the bacterial pathogens Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Pseudomonas aeruginosawere isolate from the UTI. When compared with standard antibiotic disc selected plants extracts were showed maximum zone of inhibition against all the pathogens. This investigation strongly recommends that phytochemical studies are required to determine the types of compounds responsible for the antibacterial effect of these medicinal plants. Key words: Bacterial pathogens, Antibiotic drug resistant pattern and Medicinal plants

scholarly journals RTX Toxins of Animal Pathogens and Their Role as Antigens in Vaccines and Diagnostics

Toxins ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 719 ◽  
Author(s):  
Joachim Frey
Keyword(s):  
Bacterial Pathogens ◽  
Rtx Toxins ◽  
Animal Pathogens ◽  
Genes Encoding ◽  
Specific Receptors ◽  
Diagnostic Applications ◽  
Β2 Integrins ◽  
Important Marker

Exotoxins play a central role in the pathologies caused by most major bacterial animal pathogens. The large variety of vertebrate and invertebrate hosts in the animal kingdom is reflected by a large variety of bacterial pathogens and toxins. The group of repeats in the structural toxin (RTX) toxins is particularly abundant among bacterial pathogens of animals. Many of these toxins are described as hemolysins due to their capacity to lyse erythrocytes in vitro. Hemolysis by RTX toxins is due to the formation of cation-selective pores in the cell membrane and serves as an important marker for virulence in bacterial diagnostics. However, their physiologic relevant targets are leukocytes expressing β2 integrins, which act as specific receptors for RTX toxins. For various RTX toxins, the binding to the CD18 moiety of β2 integrins has been shown to be host specific, reflecting the molecular basis of the host range of RTX toxins expressed by bacterial pathogens. Due to the key role of RTX toxins in the pathogenesis of many bacteria, antibodies directed against specific RTX toxins protect against disease, hence, making RTX toxins valuable targets in vaccine research and development. Due to their specificity, several structural genes encoding for RTX toxins have proven to be essential in modern diagnostic applications in veterinary medicine.

Susceptibility of poultry associated bacterial pathogens to Momordica charantia fruits and evaluation of in vitro biological properties

2019 ◽  
Vol 132 ◽  
pp. 222-229 ◽  
Author(s):  
Esther Lydia D ◽  
Charu Gupta ◽  
Ameer Khusro ◽  
Abdelfattah Z.M. Salem
Keyword(s):  
Bacterial Pathogens ◽  
Biological Properties ◽  
Momordica Charantia

scholarly journals Vitamin B6 Is Required for Full Motility and Virulence in Helicobacter pylori

mBio ◽  
2010 ◽  
Vol 1 (3) ◽  
Author(s):  
Alexandra Grubman ◽  
Alexandra Phillips ◽  
Marie Thibonnier ◽  
Maria Kaparakis-Liaskos ◽  
Chad Johnson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Helicobacter Pylori ◽  
Virulence Factors ◽  
Bacterial Pathogens ◽  
Therapeutic Targets ◽  
Vitamin B ◽  
Human Pathogens ◽  
Chronic Colonization ◽  
H Pylori

ABSTRACTDespite recent advances in our understanding of howHelicobacter pyloricauses disease, the factors that allow this pathogen to persist in the stomach have not yet been fully characterized. To identify new virulence factors inH. pylori, we generated low-infectivity variants of a mouse-colonizingH. pyloristrain using the classical technique ofin vitroattenuation. The resulting variants and their highly infectious progenitor bacteria were then analyzed by global gene expression profiling. The gene expression levels of five open reading frames (ORFs) were significantly reduced in low-infectivity variants, with the most significant changes observed for ORFs HP1583 and HP1582. These ORFs were annotated as encoding homologs of theEscherichia colivitamin B6biosynthesis enzymes PdxA and PdxJ. Functional complementation studies withE. coliconfirmedH. pyloriPdxA and PdxJ to bebona fidehomologs of vitamin B6biosynthesis enzymes. Importantly,H. pyloriPdxA was required for optimal growthin vitroand was shown to be essential for chronic colonization in mice. In addition to having a well-known metabolic role, vitamin B6is necessary for the synthesis of glycosylated flagella and for flagellum-based motility inH. pylori. Thus, for the first time, we identify vitamin B6biosynthesis enzymes as novel virulence factors in bacteria. Interestingly,pdxAandpdxJorthologs are present in a number of human pathogens, but not in mammalian cells. We therefore propose that PdxA/J enzymes may represent ideal candidates for therapeutic targets against bacterial pathogens.IMPORTANCEApproximately half of the world’s population is infected withH. pylori, yet howH. pyloribacteria establish chronic infections in human hosts remains elusive. From gene array studies, we identified two genes as representing potentially novel colonization factors forH. pylori. These genes encoded enzymes involved in the synthesis of vitamin B6, an important molecule for many metabolic reactions in living organisms. Little is currently known regarding vitamin B6biosynthesis in human pathogens. We showed that mutantH. pyloribacteria lacking an enzyme involved inde novovitamin B6biosynthesis, PdxA, were unable to synthesize motility appendages (flagella) and were unable to establish chronic colonization in mice. Thus, this work identifies vitamin B6biosynthesis enzymes as novel virulence factors for bacterial pathogens. Interestingly, a number of human pathogens, but not their mammalian hosts, possess these genes, which suggests that Pdx enzymes may represent ideal candidates for new therapeutic targets.

Nimbolide from Azadirachta indica and its derivatives plus first-generation cephalosporin antibiotics: a novel drug combination for wound-infecting pathogens

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89503-89514 ◽  
Author(s):  
S. R. Dhanya ◽  
S. Nishanth Kumar ◽  
Vandana Sankar ◽  
K. G. Raghu ◽  
B. S. Dileep Kumar ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Drug Combination ◽  
First Generation ◽  
Bacterial Pathogens ◽  
Generation Cephalosporin ◽  
Amide Derivatives ◽  
Cephalosporin Antibiotics ◽  
Novel Drug ◽  
Derivatives Of

We evaluate the in vitro efficacy of nimbolide, desacetylnimbin, and the amide derivatives of nimbolide in combination with first-generation cephalosporin antibiotics against major wound-associated bacterial pathogens.

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