scholarly journals Morphofunctional Changes in Peripheral Immune Organs in Space Flight and Weightlessness Modeling

2021 ◽  
Vol 10 (4) ◽  
pp. 56-67
Author(s):  
A. A. Kordenko ◽  
V. V. Shishkina ◽  
A. N. Kordenko ◽  
D. A. Atyakshin ◽  
D. A. Sokolov ◽  
...  
Keyword(s):  
Immune System ◽  
Space Flight ◽  
The State ◽  
The Body ◽  
Prolonged Stay ◽  
Space Flights ◽  
Wide Range ◽  
Functional Zones ◽  
Microgravity Conditions

Currently, there are many studies devoted to the problems of immunity in space flights. It has been proven that both short-term and long-term stay in space significantly reduces the immune function of the body. There are cases of the development of infectious diseases in astronauts during the flight, there is evidence of an increase in the activity of viruses and microorganisms that can affect the health of crew members. In the light of the upcoming expedition to Mars, it is especially important to study exactly what changes in the immune system can be triggered by prolonged stay in zero gravity and other factors of space flight and what preventive measures can help preserve the health of astronauts both during the flight itself and after its completion. The state of the immune system in space has been studied at various levels, from molecular to organ. There was a change in the morphological parameters of the immune system organs, violations of the ratio of their morpho-functional zones, and cellular composition. Various disorders in signaling pathways of differentiation, activation and death of immune system cells are shown. One of the most studied topics is the decrease in the activity of T-lymphocytes recorded by many researchers, however, even in this matter, the mechanisms of the violations occurring and their connection with the conditions of space flight have not been fully clarified. The relevance of methods for modeling microgravity conditions, such as various types of hanging, rotation on a clinostat, and immobilization is due both to their greater availability for research compared to space flights, and the importance of studying the role of various factors associated with flight in changes occurring in the human and animal bodies. This article presents an overview of publications devoted to a wide range of issues related to the state of the immune system in space flights and ground simulation conditions and attempts to combine the results of various levels of research – molecular, cellular and morphological.

scholarly journals Future of Solid Organ Transplantation: Organ-Specific Tolerance

KIDNEYS ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 130-136
Author(s):  
Yusuf Ercin Sonmez
Keyword(s):  
Immune System ◽  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Immunological Tolerance ◽  
The Body ◽  
Solid Organ ◽  
Donor Organ ◽  
Organ Specific ◽  
Specific Tolerance

A transplant between two people who are not genetically identical is called an allotransplant and the process is called allotransplantation. Donor organs and tissues can be from people who are living, or people who have died because of a significant brain injury or lack of circulation. Allotransplantation can create a rejection process where the immune system of the recipient attacks the foreign donor organ or tissue and destroys it. The recipient may need to take immunosuppressive medication for the rest of their life to reduce the risk of rejection of the donated organ. In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. The adverse effects associated with these agents and the risks of long-term immunosuppression present a number of challenges for the clinician. Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism.

scholarly journals The Immune System Can Hear Noise

2021 ◽  
Vol 11 ◽  
Author(s):  
Andi Zhang ◽  
Tianyuan Zou ◽  
Dongye Guo ◽  
Quan Wang ◽  
Yilin Shen ◽  
...  
Keyword(s):  
Immune System ◽  
Adverse Effects ◽  
Immune Function ◽  
Noise Exposure ◽  
The Body ◽  
Intensity Noise ◽  
Short Term ◽  
Non Hodgkin Lymphoma ◽  
Exposure During Pregnancy

As a stressor widely existing in daily life, noise can cause great alterations to the immune system and result in many physical and mental disorders, including noise-induced deafness, sleep disorders, cardiovascular diseases, endocrine diseases and other problems. The immune system plays a major role in maintaining homeostasis by recognizing and removing harmful substances in the body. Many studies have shown that noise may play vital roles in the occurrence and development of some immune diseases. In humans, both innate immunity and specific immunity can be influenced by noise, and different exposure durations and intensities of noise may exert various effects on the immune system. Short-term or low-intensity noise can enhance immune function, while long-term or high-intensity noise suppresses it. Noise can lead to the occurrence of noise-induced hearing loss (NIHL) through the production of autoantibodies such as anti-Hsp70 and anti-Hsp60 and exert adverse effects related to other immune-related diseases such as some autoimmune diseases and non-Hodgkin lymphoma. The neuroendocrine system, mainly including the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic-adrenal-medullary (SAM) system, is involved in the mechanisms of immune-related diseases induced by noise and gut microbiota dysfunction. In addition, noise exposure during pregnancy may be harmful to the immune system of the fetus. On the other hand, some studies have shown that music can improve immune function and alleviate the adverse effects caused by noise.

scholarly journals Estimated Muscle Loads During Squat Exercise in Microgravity Conditions

2012 ◽  
Author(s):  
Christopher D. Fregly ◽  
Brandon T. Kim ◽  
Zhao Li ◽  
John K. De Witt ◽  
Benjamin J. Fregly
Keyword(s):  
International Space Station ◽  
Space Flight ◽  
Space Station ◽  
Resistive Exercise ◽  
International Space ◽  
Free Weight ◽  
Squat Exercise ◽  
Term Space Flight ◽  
Microgravity Conditions

Loss of muscle mass in microgravity is one of the primary factors limiting long-term space flight [1]. NASA researchers have developed a number of exercise devices to address this problem. The most recent is the Advanced Resistive Exercise Device (ARED) [2], which is currently used by astronauts on the International Space Station (ISS) to emulate typical free-weight exercises in microgravity. ARED exercise on the ISS is intended to reproduce Earth-level muscle loads, but the actual muscle loads produced remain unknown as they cannot currently be measured directly.

scholarly journals COVID-19: Nutrition to Boost Immune System to Fight Infection

2020 ◽  
pp. 1-4
Author(s):  
Syed M. Shahid ◽  
◽  
Muhammad Jawed ◽  
Keyword(s):  
Immune System ◽  
Fruits And Vegetables ◽  
Daily Intake ◽  
The Body ◽  
Food And Nutrition ◽  
Working Together ◽  
Scientific Significance ◽  
Global Population

The immunity and immune system functions to fight against infections are significantly impacted by inappropriate food and nutrition. Long term malnutrition is universally considered as the leading cause of immune system deficiency. A substantial proportion of the global population does not meet the recommended daily intake of nutrients. The COVID-19 pandemic has focused attention on the role of the immune system, with health scientists and nutritionists urging people to take supplements and/or eat particular foods (nutrients) to super-charge their immune systems.The immune system is the most complex system of human body. This system is made up of a complex network of structural and functional units like cells, molecules, tissues and organs all working together to safeguard the body as a whole.This precise review provides a chance to go through the efficacy, efficiency and scientific significance of nutritional components and relevant food (especially fruits and vegetables). This will help you keep appropriate food items in your daily meals so that you can get a progressive increment in your body’s defence mechanisms and immunity to fight appropriately against COVID-19. This will also help to decrease your risk for catching the viral infection and/or reducing the chances of having complications from COVID-19.

scholarly journals ISS - a Platform for Developing a System for Hypogravitational Disturbances Countermeasures in Interplanetary Missions

2020 ◽  
pp. 8-17
Author(s):  
Elena V. Fomina ◽  
◽  
Natalya A. Senatorova ◽  
Viktoriya V. Kirichenko ◽  
Ivan V. Vagner ◽  
...  
Keyword(s):  
Long Range ◽  
Physical Performance ◽  
Human Body ◽  
Space Flight ◽  
The State ◽  
Range Space ◽  
Medical Safety ◽  
Space Flights ◽  
Interplanetary Missions

The paper contains modern understanding of gravity-dependent changes in human body systems that occur during space flight and of modern problems, the solution of which will bring humanity closer to ensuring medical safety in interplanetary missions. Particular consideration is given to the state of the systems limiting physical performance, which is a factor that largely determines the success of planetary activities in ultra-long-range space flights. Hypogravitational disturbances countermeasures used on the ISS are described, with emphasis on some features that are specific to the ISS partners. Prospects for development of countermeasures for hypogravitational disorders in interplanetary missions are considered.

scholarly journals Influence of Cyclical Patterns on Innovation and Transformation Processes in the Economy

2020 ◽  
Vol 11 (1) ◽  
pp. 44-58
Author(s):  
G. A. Shcherbakov
Keyword(s):  
Method Development ◽  
Innovation Policy ◽  
Innovation Process ◽  
The State ◽  
General Idea ◽  
Theoretical Research ◽  
Innovation Activities ◽  
Wide Range ◽  
Cyclic Approach

Purpose: the main purpose of this article is to present and develop a cyclic approach in the theory of innovation. This section of economic theory is based on the understanding of the innovation process as a dynamic system that develops (depending on the type of innovation) within the medium or long-term cycle. The cyclic approach has an insufficiently studied subject of research. In theoretical and practical aspects, this approach is very poorly developed, despite its prospects for this method. The application of the cyclic approach in the practical sphere will increase the effectiveness of activities planning in the field of the state innovation policy, as well as increase the efficiency of the state resources using.Methods: a set of methods of theoretical research is used, including: logical, system and abstract methods, as well as specific scientific (special) research methods. Based on the study of a wide range of scientific literature, as well as statistical and factual information on innovative issues, models (modeling method) were drawn up, which were graphically fixed in the figures illustrating the main provisions of the article.Results: this article develops the cyclic approach to the innovations study, proposed in the works of foreign and domestic scientists. The article describes and presents a scientific method of innovative processes management, called "triad of innovative and transformative activity". The article also contains a brief overview of the cyclic method development in the works of domestic and foreign researchers, giving a general idea of the elaboration degree of the scientific question.Conclusions and Relevance: the analysis of the main theories and concepts in the field of innovation, gives reason to argue that scientific views on the implementation of the innovation process contain a serious omission. It consists in the fact that it does not take into account the influence of cyclical conditions of various medium-term cycle phases or long-term cycle stages. In practice, this leads to asynchronous processes that prevent the effective innovation activities.

scholarly journals Modern aspects of neuropathogenesis and neurological manifestations of COVID-19

2021 ◽  
Vol 17 (2) ◽  
pp. 6-15
Author(s):  
L.A. Dziak ◽  
O.S. Tsurkalenko ◽  
K.V. Chekha ◽  
V.M. Suk
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Psychiatric Symptoms ◽  
Clinical Manifestations ◽  
The Body ◽  
Altered Level ◽  
Wide Range ◽  
The Central Nervous System ◽  
The Brain

Coronavirus infection is a systemic pathology resulting in impairment of the nervous system. The involvement of the central nervous system in COVID-19 is diverse by clinical manifestations and main mechanisms. The mechanisms of interrelations between SARS-CoV-2 and the nervous system include a direct virus-induced lesion of the central nervous system, inflammatory-mediated impairment, thrombus burden, and impairment caused by hypoxia and homeostasis. Due to the multi-factor mechanisms (viral, immune, hypoxic, hypercoagulation), the SARS-CoV-2 infection can cause a wide range of neurological disorders involving both the central and peripheral nervous system and end organs. Dizziness, headache, altered level of consciousness, acute cerebrovascular diseases, hypogeusia, hyposmia, peripheral neuropathies, sleep disorders, delirium, neuralgia, myalgia are the most common signs. The structural and functional changes in various organs and systems and many neurological symptoms are determined to persist after COVID-19. Regardless of the numerous clinical reports about the neurological and psychiatric symptoms of COVID-19 as before it is difficult to determine if they are associated with the direct or indirect impact of viral infection or they are secondary to hypoxia, sepsis, cytokine reaction, and multiple organ failure. Penetrated the brain, COVID-19 can impact the other organs and systems and the body in general. Given the mechanisms of impairment, the survivors after COVID-19 with the infection penetrated the brain are more susceptible to more serious diseases such as Parkinson’s disease, cognitive decline, multiple sclerosis, and other autoimmune diseases. Given the multi-factor pathogenesis of COVID-19 resulting in long-term persistence of the clinical symptoms due to impaired neuroplasticity and neurogenesis followed by cholinergic deficiency, the usage of Neuroxon® 1000 mg a day with twice-day dosing for 30 days. Also, a long-term follow-up and control over the COVID-19 patients are recommended for the prophylaxis, timely determination, and correction of long-term complications.

scholarly journals “Were not that a botchy core?”: the Function of Disease in 2 Henry IV, King Lear, Troilus and Cressida, and Twelfth Night

2021 ◽  
Author(s):  
◽  
Catherine Joule
Keyword(s):  
Early Modern ◽  
The State ◽  
The Body ◽  
King Lear ◽  
Twelfth Night ◽  
Troilus And Cressida ◽  
The Social ◽  
Wide Range ◽  
Henry Iv ◽  
Disease Metaphors

<p>The social currency of disease has developed and changed dramatically over the centuries, and this thesis focuses on how Shakespeare used the currency of early modern disease in his plays. Shakespeare’s use of disease and disease metaphors is discussed within the context of four plays: Henry IV Part Two, Twelfth Night, King Lear, and Troilus and Cressida. The first chapter (of three) finds that the purpose of disease within the body politic metaphors is, inevitably, complication. In order to counter and resolve the disease of the state, advisors become physicians, extending the potential of the analogy further until it permeates the social structure of the plays and our perception of the characters. Disease is employed to imply division, instability, and disorder within the imagined body of the state.  The second chapter shows how the idea of infection is used to highlight interpersonal concerns within the plays. The chapter uses references to early modern sources and beliefs about the four humours to illustrate how Shakespeare connects social disorder, disease, morality, and status. The discussion focuses on Galen’s “nonnaturals” which were believed to affect humoral balance, highlighting the significance of early modern conceptions of diet, exercise, miasma, sleep, and stress which serve to create a pervading sense of disease in the social worlds of the plays.  The personal and often horrifying experiences of mental disease we are presented with in King Lear and Twelfth Night are the focus of the third and final chapter. The display of suffering is found to primarily serve to emphasise the commonality of man. In both plays (though at different levels of seriousness) insanity causes a loss of social status for the sufferer and, through this loss of status, their humanity is stressed. The dramatic potential of madness allows the theatre of the courtroom to be parodied to draw questions about injustice into the plays, though without offering any definitive conclusions to them. The literary nature of madness within these plays, furthermore, allows for the clear presentation of issues of class and justice. Generally Shakespeare abandons absolute realism in favour of using disease and disease metaphors as a disrupting influence on social and political order so as to emphasise a wide range of themes and ideas.</p>

scholarly journals Global challenges and the formation of the digital economy: current state, security problems, development trends

2020 ◽  
pp. 52-60
Author(s):  
Natalya Lytnyeva ◽  
Sergey Voronov ◽  
Natalia Kidanova
Keyword(s):  
Rapid Development ◽  
Information Age ◽  
Economic Security ◽  
The State ◽  
Economic Agents ◽  
State Security ◽  
Current State ◽  
Wide Range ◽  
Main Basis

At present, the issues of economic security seem to be relevant both for the economic development of the state and for complex scientific research. A wide range of the vital activities of society includes indicators that reflect the potential threats that can be encountered by economic agents. The problem of economic security is now becoming increasingly important, and this in turn is caused by the rapid development of a diversified alternative economy that uses the latest achievements of scientific and technological progress. It is quite difficult to predict the development of the country’s economy in the long term when the current challenges and threats are not taken into account. That is why in the information age, where information technology is the main basis for conducting economic activity, and information security is one of the main directions of state development, while the state itself acts as an economic institution. Therefore, the development of the digital economy in Russia poses both opportunities and significant threats.

Diagnosis and correction of immune system disorders

1986 ◽  
Vol 67 (4) ◽  
pp. 289-294 ◽  
Author(s):  
L. V. Kovalchuk ◽  
A. N. Cheredeev
Keyword(s):  
Immune System ◽  
Clinical Immunology ◽  
The State ◽  
Laboratory Evaluation ◽  
In Vitro Methods ◽  
Wide Range ◽  
High Degree

Modern clinical immunology has a wide range of tests that can detect immune system disorders with a sufficiently high degree of accuracy. Laboratory evaluation of the immune system is performed using in vivo and in vitro methods. In vivo methods allow to judge the state of the immune system at the organism level.

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