scholarly journals Effectiveness of Jicama Probiotic Yoghurt (Pachyrhizus erosus) on Blood Glucose in Diabetic Mice

2019 ◽  
Author(s):  
Eva Yuniritha ◽  
Annisa Avelia ◽  
Andrafikar .

Background: Diabetes Mellitus (DM) is a degenerative disease population increases every year. DM was ranked sixth as the cause of death. About 1.3 million people died because of diabetes and 4% died before the age of 70 years. DM auto-oxidation causes glucose to increase reactive oxygen compounds. One of the DM management is a complementary therapy using a functional food ingredient, namely, jicama and probiotics. Probiotics and jicama contain active compounds in the form of inulin and BAL and are able to control blood glucose levels. This study aims to determine the effectiveness of jicama probiotic yogurt on blood glucose levels in diabetic mice. Methods: This research is a quasi-experimental with pre–post-test control group, using a sample of DDY strain mice according to the criteria. Samples were given treatment probiotic yogurt and jicama probiotic yogurt 2 ml for seven days in the treatment group and one group of non-treated controls. The mean obtained were analyzed by dependent t-test, independent t-test, and one-way ANOVA test. Result and Conclusion: The results showed that there was a decrease in blood glucose levels in the probiotic yogurt group amounting to 296.62 mg/dL and jicama probiotic yogurt of 337.57 mg/dL, while the control group increased by 43.57 mg/dL. Results: One way ANOVA test showed jicama probiotic yogurt more effectively decreases blood glucose levels than the probiotic yogurt (p = 0.00). Jicama probiotic yogurt can be used as an alternative complementary therapy for patients with diabetes mellitus.

Author(s):  
Pipit Festi W

 Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000  It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000  that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus


2021 ◽  
Vol 3 (2) ◽  
pp. 285-295
Author(s):  
Umi Romayati Keswara ◽  
Rahma Elliya ◽  
Maya Maya

ABSTRACT: THE EFFECT OF PROGRESIVE MUSCLE RELAXATION (PMR) ON REDUCING BLOOD GLUCOSE LEVELS IN PEOPLE WITH DIABETES MELLITUS IN THE WORK AREA OF OGAN LIMA HEALTH CENTER, WEST ABUNG DISTRICT, NORTH LAMPUNG Introduction: Diabetes mellitus (DM) is a non-communicable disease that often suffers. Diabetes mellitus (DM) is a non-communicable disease that often suffers.Purpose: To determine the effect of progresive muscle relaxation (PMR) on reducing blood glucose levels in people with diabetes mellitus.Method: This type of research is quantitative, quasi-experimental design using non equivalent control groups. The population in this study were all DM patients in the Work Area of Ogan Lima Health Center, West Abung District, North Lampung, with a total sample of 34 respondents. Data analysis used T test analysis (dependent and independent sample t-test).Results: The results of univariate analysis showed that the average blood glucose level of respondents in the pretest group was 247.29 ± 28.431 mg / dL and posttest 210.29 ± 28.711 mg / dL. The average level of respondent's blood glucose at pretest was 255.94 ± 30.738 mg / dL and posttest 230.76 ± 25.69 mg / dL. T-dependent test results obtained by the treatment group p-value = 0,000, and the control group p-value = 0.006. T-independent test results obtained p-value = 0.035.Conclusion: There was a significant difference between the blood glucose levels of diabetics in the treatment group and the control group. Suggestions are expected that health workers can apply PMR training as an alternative therapy for DM patients. Keywords :progresive muscle relaxation, blood glucose level, diabetes mellitus  Latar Belakang: Diabetes Melitus (DM) merupakan penyakit tidak menular yang sering diderita. Data di dunia sebanyak 422 juta orang dewasa hidup dengan diabetes, di Indonesia tahun 2018 prevalensi  diabetes meningkat dari 1,1% menjadi 2,0%, di Provinsi Lampung meningkat dari 0,8% menjadi1,6%, di Kabupaten Lampung Utara meningkat dari 0,9menjadi 1,07 %. Terapi komplementer untuk mengontrol kadar glukosa darah salah satunya dengan relaksasi otot progresif (Progresive Muscle Relaxation (PMR).Tujuan:Diketahui Pengaruh Progresive Muscle Relaxation (PMR) terhadap penurunan kadar glukosa  darah pada penderita diabetes melitus.Metode Penelitian:Jenis penelitian ini adalah kuantitatif, rancangan quasi eksperiment menggunakan non equivalent control group. Populasi dalam penelitian ini adalah seluruh pasien DM di Wilayah Kerja Puskesmas Ogan Lima Kecamatan Abung Barat Lampung Utara, dengan jumlah sampel sebanyak 34 responden.Analisis data menggunakan analisis uji T (dependent dan independent sample t-test).Hasil Penelitian: Hasil analisis univariat bahwa rata-rata kadar glukosa darah responden kelompok perlakuan saat pretest yaitu 247,29 ± 28,431 mg/dL dan posttest 210,29 ± 28,711 mg/dL. Rata-rata kadar glukosa darah responden saat pretest yaitu 255,94 ± 30,738 mg/dL dan posttest 230,76 ± 25,69mg/dL. Hasil uji t-dependen kelompok perlakuan diperoleh p-value=0,000, dan kelompok kontrol p-value=0,006. Hasil uji t-independen diperoleh p-value=0,035.Kesimpulan: Ada perbedaan yang signifikan antara kadar glukosa darah penderita diabetes melitus pada kelompok perlakuan dan kelompok kontrol. Saran diharapkan agar tenaga kesehatan dapat menerapkan latihan PMR sebagai alternative terapi pada pasien DM. Kata Kunci     : progresive muscle relaxation, kadar glukosa darah, diabetes melitus


2021 ◽  
Vol 3 (2) ◽  
pp. 285-295
Author(s):  
Umi Romayati Keswara ◽  
Rahma Elliya ◽  
Maya Maya

ABSTRACT: THE EFFECT OF PROGRESIVE MUSCLE RELAXATION (PMR) ON REDUCING BLOOD GLUCOSE LEVELS IN PEOPLE WITH DIABETES MELLITUS IN THE WORK AREA OF OGAN LIMA HEALTH CENTER, WEST ABUNG DISTRICT, NORTH LAMPUNG Introduction: Diabetes mellitus (DM) is a non-communicable disease that often suffers. Diabetes mellitus (DM) is a non-communicable disease that often suffers.Purpose: To determine the effect of progresive muscle relaxation (PMR) on reducing blood glucose levels in people with diabetes mellitus.Method: This type of research is quantitative, quasi-experimental design using non equivalent control groups. The population in this study were all DM patients in the Work Area of Ogan Lima Health Center, West Abung District, North Lampung, with a total sample of 34 respondents. Data analysis used T test analysis (dependent and independent sample t-test).Results: The results of univariate analysis showed that the average blood glucose level of respondents in the pretest group was 247.29 ± 28.431 mg / dL and posttest 210.29 ± 28.711 mg / dL. The average level of respondent's blood glucose at pretest was 255.94 ± 30.738 mg / dL and posttest 230.76 ± 25.69 mg / dL. T-dependent test results obtained by the treatment group p-value = 0,000, and the control group p-value = 0.006. T-independent test results obtained p-value = 0.035.Conclusion: There was a significant difference between the blood glucose levels of diabetics in the treatment group and the control group. Suggestions are expected that health workers can apply PMR training as an alternative therapy for DM patients. Keywords :progresive muscle relaxation, blood glucose level, diabetes mellitus  Latar Belakang: Diabetes Melitus (DM) merupakan penyakit tidak menular yang sering diderita. Data di dunia sebanyak 422 juta orang dewasa hidup dengan diabetes, di Indonesia tahun 2018 prevalensi  diabetes meningkat dari 1,1% menjadi 2,0%, di Provinsi Lampung meningkat dari 0,8% menjadi1,6%, di Kabupaten Lampung Utara meningkat dari 0,9menjadi 1,07 %. Terapi komplementer untuk mengontrol kadar glukosa darah salah satunya dengan relaksasi otot progresif (Progresive Muscle Relaxation (PMR).Tujuan:Diketahui Pengaruh Progresive Muscle Relaxation (PMR) terhadap penurunan kadar glukosa  darah pada penderita diabetes melitus.Metode Penelitian:Jenis penelitian ini adalah kuantitatif, rancangan quasi eksperiment menggunakan non equivalent control group. Populasi dalam penelitian ini adalah seluruh pasien DM di Wilayah Kerja Puskesmas Ogan Lima Kecamatan Abung Barat Lampung Utara, dengan jumlah sampel sebanyak 34 responden.Analisis data menggunakan analisis uji T (dependent dan independent sample t-test).Hasil Penelitian: Hasil analisis univariat bahwa rata-rata kadar glukosa darah responden kelompok perlakuan saat pretest yaitu 247,29 ± 28,431 mg/dL dan posttest 210,29 ± 28,711 mg/dL. Rata-rata kadar glukosa darah responden saat pretest yaitu 255,94 ± 30,738 mg/dL dan posttest 230,76 ± 25,69mg/dL. Hasil uji t-dependen kelompok perlakuan diperoleh p-value=0,000, dan kelompok kontrol p-value=0,006. Hasil uji t-independen diperoleh p-value=0,035.Kesimpulan: Ada perbedaan yang signifikan antara kadar glukosa darah penderita diabetes melitus pada kelompok perlakuan dan kelompok kontrol. Saran diharapkan agar tenaga kesehatan dapat menerapkan latihan PMR sebagai alternative terapi pada pasien DM. Kata Kunci     : progresive muscle relaxation, kadar glukosa darah, diabetes melitus


2018 ◽  
Vol 3 (2) ◽  
pp. 72
Author(s):  
Setyoadi Setyoadi ◽  
Heri Kristianto ◽  
Siti Nur Afifah

Diabetes mellitus is a disease that required good self-management. Noncompliance in diet and meal plans cause the instability of blood glucose levels. Nutrition education calendar method can improve knowledge and ability to consume food that matches the number, hours and types with dietary adjustments listed in the calendar diet. This study aimed to determine the effect of nutrition education calendar method on blood glucose levels of patients with type 2 diabetes mellitus in Community Health Center Pakis Malang. Pre-experimental design one group pretest-posttest with purposive sampling was conducted in this study and sample obtained as many as 21 people. Blood glucose levels were measured before and after the nutrition education calendar methods. Compliance in using calendar method with the observation sheet. Statistical analysis values obtained by Wilcoxon, the p-value of 0.007 (p <0.05). The results of the analysis, 16 respondents showed a decrease in blood glucose levels and 5 respondents experienced an increase in blood glucose levels after the given intervention. It can be concluded that there are differences between blood glucose levels before and after nutrition education calendar method. Differences in blood glucose levels can be influenced by controlling diet respondent in accordance with the calendar method in education, but also antidiabetic drugs, and sports. Should be added to the control group to determine objectively the effect of nutrition education on the calendar method.


2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Chadakarn Phaloprakarn ◽  
Siriwan Tangjitgamol

Abstract Background Blood glucose levels during pregnancy may reflect the severity of insulin secretory defects and/or insulin resistance during gestational diabetes mellitus (GDM) pregnancy. We hypothesized that suboptimal glycemic control in women with GDM could increase the risk of postpartum type 2 diabetes mellitus (T2DM) or prediabetes. Our objective was to evaluate the impact of plasma glucose levels throughout GDM pregnancy on the risk of postpartum T2DM or prediabetes. Methods The medical records of 706 women with GDM who underwent a postpartum 75-g, 2-hour oral glucose tolerance test at our institution between January 2011 and December 2018 were reviewed. These women were classified into 2 groups according to glycemic control during pregnancy: ≤ 1 occasion of either fasting glucose ≥ 95 mg/dL or 2-hour postprandial glucose ≥ 120 mg/dL was defined as optimal glycemic control or else was classified as suboptimal glycemic control. Rates of postpartum T2DM and prediabetes were compared between women with optimal (n = 505) and suboptimal (n = 201) glycemic control. Results The rates of postpartum T2DM and prediabetes were significantly higher in the suboptimal glycemic control group than in the optimal glycemic control group: 22.4% vs. 3.0%, P < 0.001 for T2DM and 45.3% vs. 23.5%, P < 0.001 for prediabetes. In a multivariate analysis, suboptimal glucose control during pregnancy was an independent risk factor for developing either postpartum T2DM or prediabetes. The adjusted odds ratios were 8.4 (95% confidence interval, 3.5–20.3) for T2DM and 3.9 (95% confidence interval, 2.5–6.1) for prediabetes. Conclusion Our findings suggest that blood glucose levels during GDM pregnancy have an impact on the risk of postpartum T2DM and prediabetes.


2017 ◽  
Vol 4 (2) ◽  
pp. 24
Author(s):  
Fatifa Asmarani ◽  
Bambang Wirjatmadi ◽  
Merryana Adriani

Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukey's Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.


BIOEDUSCIENCE ◽  
2020 ◽  
Vol 4 (2) ◽  
pp. 120-123
Author(s):  
Putri Dafriani ◽  
Mutiara Karamika ◽  
Siska Sakti Anggraini ◽  
Roza Marlinda

Background: Diabetes Mellitus is a chronic metabolic disorder caused by insulin resistance. Noni juice has the potential as herbal medicine which believed to reduce blood glucose levels. This study aims to determine the effect of noni juice on blood sugar levels on diabetic patients. Methods: This study used 16 respondents. They divided two groups, a control group and a treatment group. Each group consists of 8 respondents. The intervention group received 150 ml of noni juice which was given once a day for ten days. Glucose testing was carried out by the glucose-check method. The blood was taken from the respondent's fingertips capillary. The blood glucose levels between the control group and the intervention group were analyzed using independent t-test. Results: The average blood glucose level in the intervention group was 199.88 mg/dl, while the control group was 326.25 mg/dl. The test results of the mean blood glucose levels between the control group and the intervention group had a significant difference with a value of p = 0.003 (p ≤ 0.05). This indicates a significant effect between blood glucose levels in the control group and the intervention group. Conclusion: Noni can reduce blood glucose levels because it contains flavonoid. It has a hypoglycemic effect. Health workers can suggest consuming noni juice to decrease blood glucose in diabetic patients.    


2017 ◽  
Vol 4 (1) ◽  
pp. 006-011
Author(s):  
Nian Afrian Nuari

Blood glucose levels  uncontrolled is a problem that is often found in patients with Diabetes Mellitus. This has an impact on the health of the patient as it would appear some macrovascular and microvascular complications. Number of patients with DM in Indonesia has increased every year and only 50% of patients suffering from diabetes who are aware of, and around 30% of them take medication regularly. The purpose of this study to determine the effect of Self Instructional Training method on blood glucose levels of patients. The method used is pre experiment with purposive sampling technique and the sample size of 16 respondents. Measuring instrument used glucometers to measure blood glucose levels and analyzed with Paired T Test. Based on the results, the entire blood glucose levels before the intervention above 200 mg /dl. After Self Instructional Training Intervention average blood glucose level was 35.75 mg /dl. Blood glucose levels are highest when the post test was 253 mg /dl and the lowest is 197 mg /dl. Based on Paired T Test  analysis obtained Self Instructional Training interventions can reduce blood glucose levels of patients with Diabetes Mellitus Type II (p value = 0.000). Diabetes Mellitus patients expected to be able to apply the  SIT method to perform self-care so that the patient's blood glucose levels can be controlled. Patient can do this methods  at home and needed support from their  family and health professionals to treat the diseases.Keywords : Self, Instructional, Training, level, glucose, blood, DM


2021 ◽  
Vol 3 (2) ◽  
pp. 45
Author(s):  
Galuh Alviana ◽  
Hendro Sudjono Yuwono ◽  
Nova Sylviana

In Indonesia, it is estimated that there would be increasing in number of diabetes mellitus patients become 12 million cases in 2030. The expensive cost of conventional medications motivates people to find alternative medication. Bentonite is a natural clay which is a good absorbent and frequently called as healing clay for its potency in body detoxification. This study is an experimental research to prove bentonite which is a good absorbent and adsorbent in decreasing blood glucose concentration in diabetes mellitus. Subject of this research is 20 female Wistar rats which weigh 150–250 g. These subjects were divided into two groups: control group and bentonite group. Diabetes is induced by alloxan monohydrate 150mg/kg intraperitoneally, causing β cell necrosis in pancreas. Result of independent t-test showed that bentonite could significantly lower blood glucose levels with average value of 131.30 mg/dL (p=0.010). This concludes that bentonite canreduce blood glucose level in diabetic-induced rats.


2017 ◽  
Vol 4 (2) ◽  
pp. 188
Author(s):  
Eryna Laili Putri

Diabetes Mellitus (DM) is a chronic disease with high prevalence, associated with various debilitating complications and can decreases the quality of life in people with it. It is important for people with DM to doing exercise to control the stability of their blood glucose levels. The purpose of this study was to finding out the association between frequency, duration, and intensity of exercise with average blood glucose levels in people with DM. This was an observational study that used case control design. Data obtained from interview with 20 samples from case group and 20 samples from control group, that had been chosen with systematic random sampling technique. Dependent variable of this study was the average blood glucose levels and independents variables were frequency, duration, intensity, and the kind of exercise. This study used Chi Square test 3 × 2 contingency tables to finding out the association and risk of dependent variable with independent variables,. The results showed that exercise factors that associated to average blood glucose levels were duration of exercise (p = 0.022) and intensity of exercise (p = 0.021). The frequency of exercise does not associated to average blood glucose levels (p = 0.340). Diabetic patients who did not do any exercise have the risk of having uncontrolled blood glucose levels. The conclusion was duration and intensity of exercise related significantly to blood glucose levels. By doing exercise three times a week for 30 minutes or more can decreases the risk of uncontrolled blood glucose levels in people with DM.Keywords: Diabetes mellitus, exercise, average blood glucose levels


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