scholarly journals THE EFFECTS OF CORN FLOUR WITH TEMPEH FLOUR SUPPLEMENTATION FEEDING IN DIABETES MELLITUS WISTAR RATS TOWARD BLOOD GLUCOSE LEVEL

2017 ◽  
Vol 4 (2) ◽  
pp. 24
Author(s):  
Fatifa Asmarani ◽  
Bambang Wirjatmadi ◽  
Merryana Adriani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Wistar Rats ◽  
Control Group ◽  
Standard Diet ◽  
Corn Flour ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukey's Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.

scholarly journals HUBUNGAN KECEMASAN DENGAN KADAR GLUKOSA DARAH PENDERITA DIABETES MELLITUS DI WILAYAH KERJA PUSKESMAS SUMBERSARI BANTUL KEC. METRO SELATAN KOTA METRO

2017 ◽  
Vol 2 (1) ◽  
pp. 5
Author(s):  
Ludiana Ludiana
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Standard Deviation ◽  
Blood Sugar ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
The World ◽  
Patients With Diabetes ◽  
Sugar Levels ◽  
The Relationship

Diabetes mellitus is a chronic metabolic disorder marked increase in blood glucose. According to the World Health Organization (WHO) in 2013 the incidence of diabetes mellitus in the world reached 347 million people in Indonesia alone ranks among the seven countries with the highest diabetes prevalence of 7.6 million people. Among the causes of the increase in blood glucose levels in diabetics is due to psychological factors, namely anxiety. In the pre-survey results in Puskesmas Sumbersari Bantul note that from 8 patients with diabetes mellitus, there are 6 people experiencing anxiety and 2 do not complain any signs of anxiety. The purpose of this study was to determine the relationship of anxiety with blood glucose levels of diabetics mellitus in Puskesmas Sumbersari Bantul District of South Metro City. The type quantitative research, form design used is cross sectional. The population in this study are patients with diabetes mellitus in Puskesmas Sumbersari Bantul District of South Metro totaling 408 samples taken as many as 41 people. The analysis in this study using the test Person Product Moment. Statistical analysis showed that anxiety patients with diabetes mellitus are at an average score of 27.44 with a standard deviation of 4.353 and the average blood sugar levels of people with diabetes mellitus are at 339.78 mg / dL with a standard deviation of 74.742. In the Person Product Moment test results proved no relationship anxiety with blood sugar levels of people with diabetes mellitus (p-value = 0.000 <a 0.05). Pearson correlation results obtained value of 0.817 towards a positive correlation with the strength of the relationship is very strong. Conclusions research shows there is an anxiety relationship with blood glucose levels of diabetics mellitus.

scholarly journals Potential Effects of Alkaloid vindolicine Substances in Tapak Dara Leafs (Catharanthus roseus (L.) G. Don) in Reducing Blood Glucose Levels

2019 ◽  
Vol 2 (4) ◽  
Author(s):  
Agung B S Satyarsa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Catharanthus Roseus ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a degenerative disease that commonly found and related to an unhealthy lifestyle and genetic factors. Current management of diabetes mellitus includes control of blood sugar levels and prevention of complications. Recent studies found that many phytochemicals have the potential to control blood sugar levels in patients with diabetes. Alkaloid substances from leaves of Tapak Dara have an effect on decreasing blood glucose. This review article aims to describe the potential effects of the Alkaloid vindolicine from Tapak Dara leaves (Catharanthus Roseus L.) in reducing blood glucose levels in patients with type 2 diabetes mellitus. The activity of vindolicine alkaloid against ? cells in previous studies has shown to improve ? cells activity and induce insulin secretion thus preventing further hyperglycemia. In addition, the vindolicine alkaloid also has a role in activating pancreatic ?-TC6 cells and carrying out an immediate reaction in blood vessels. As conclusion, further research is needed to prove the maximum effect of the utilization of tread leaf extract as well as the toxicity test to determine the toxic effects of the alkaloid substances in the tread leaf. Keywords: Type 2 Diabetes Mellitus, Vindolicine Alkaloid, Tapak Dara, blood glucoselevels

scholarly journals The Effect of Belimbing Wuluh (Averrhoa Bilimbi L.) and Red Guava (Psidium Guajava L.) Extract on Fasting Blood Glucose Levels of Diabetic Wistar Rats Model

2019 ◽  
Vol 5 (2) ◽  
pp. 57
Author(s):  
Yesi Warisman ◽  
Arinda Lironika Suryana ◽  
Zora Olivia
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Standard Diet ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes mellitus is a metabolic disease with special characteristic which increased blood glucose level (hiperglicemic), its happens because of the abnormality of insulin secretion, insulin mechanisme or both of them. Belimbing wuluh and red guava extract can become alternative functional drink that contain rich of vitamin C to help controlling blood glucose level. The aimed of this study was to determined the effect of belimbing wuluh and red guava extract on blood glucose levels of Rattus novergicus strain Wistar diabetic model. This research was an true experimental study with a randomized post-test control group design. Twentyfour (24) male wistar strain rats weighing 200-250 grams, aged 2-3 months, were divided into 4 groups. The control group (K-) non-diabetic rats, the control group (K+) diabetic rats given standard diet, and the treatment group diabetic rats given standard diet and belimbing wuluh and red guava extract intervetion doses 10,7 ml/day (P1) and 21ml/day (P2). Measurement of pretest posttest fasting blood glucose levels was carried out using biolyzer. The data were analyzed by One Way Anova test. The results showed that there were significant differences in delta pretest and posttest fasting blood glucose levels between all groups. Blood glucose levels decreased at 55.6%. In conclusion, belimbing wuluh and red guava extract 21ml/day most effectively decreased fasting blood glucose levels in diabetic wistar rats moldel.   Keywords: belimbing wuluh, blood glucose level, diabetes mellitus, red guava

scholarly journals PENGARUH PEMBERIAN EKSTRAK UMBI BAWANG MERAH (Allium cepa L) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) YANG DIINDUKSI DENGAN ALOKSAN

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Bryan Y. Kairupan ◽  
Mona P. Wowor ◽  
Christi Mambo
Keyword(s):  
Blood Sugar ◽  
Allium Cepa ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Control Group ◽  
Glucose Levels ◽  
Onion Bulbs ◽  
Blood Glucose Levels ◽  
Allium Cepa L ◽  
Sugar Levels

Abstract: People sure that onion bulbs ( Allium cepa L ) has a lot of advantage for health one of which is to lower blood sugar levels. The objective of this research were study the effectiveness of administration of onion bulbs extract on blood glucose levels of Wistar rats (Rattus norvegicus) induced by alloxan. The subject of research using laboratory animals such as male Wistar rats that were 18 samples were divided into 6 groups, the negative control group, and 5 groups of Wistar rats with alloxan-induced hyperglycemic dose of 130 mg / kg body weight of rats. In the group with hyperglycemic rats given onion bulbs extract at a dose of 9 mg, 18 mg, and 36 mg / 200 g body weight of rats, the positive control group was given novomix flexpen, and 1 group were only given alloxan. Data obtained from the results of blood sugar tests in all groups Wistar rats on the first day, second day, third in minutes 0, 6, 12, 18, and 24 hours. The results showed extract of onion bulbs (Allium cepa L) had an effect on blood glucose levels drop Wistar rats that had induced alloxan.Keywords: Allium cepa L, onion bulbs, blood sugar levels, alloxanAbstrak: Umbi bawang merah (Allium cepa L) diyakini masyarakat memiliki banyak manfaat bagi kesehatan salah satunya yaitu menurunkan kadar gula darah. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak umbi bawang merah terhadap kadar gula darah tikus wistar (Rattus norvegicus) yang diinduksi aloksan. Subjek penelitian menggunakan hewan uji berupa tikus wistar jantan yang berjumlah 18 ekor yang dibagi dalam 6 kelompok, kelompok kontrol negatif, dan 5 kelompok tikus wistar hiperglikemik yang diinduksi aloksan dengan dosis 130 mg/kg berat badan tikus. Kelompok tikus hiperglikemik diberi ekstrak umbi bawang merah dengan dosis 9 mg, 18 mg, dan 36 mg/ 200 g BB tikus, kelompok kontrol positif diberikan novomix flexpen, dan 1 kelompok yang hanya diberikan aloksan. Data diperoleh dari hasil pemeriksaan gula darah pada semua kelompok tikus wistar pada hari pertama, hari kedua, ketiga pada menit ke- 0, jam ke- 6, 12, 18, dan 24. Hasil penelitian menunjukkan pemberian ekstrak umbi bawang merah (Allium cepa L) mempunyai efek terhadap penurunan kadar gula darah tikus Wistar yang telah diinduksi aloksan.Kata kunci: Allium cepa L, Umbi Bawang Merah, Kadar Gula Darah, Aloksan

scholarly journals Effectiveness of Giving Muntingia Calabura Leaves and Muntingia Calabura Fruit (Muntingia Calabura L) on Blood Sugar Levels In Type 2 Diabetes Mellitus Patients: Literature Review

2021 ◽  
Vol 10 (1) ◽  
pp. 20
Author(s):  
Konita Shafira ◽  
Abu Bakar ◽  
Erna Dwi Wahyuni
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Metabolic Diseases ◽  
Polar Compounds ◽  
Flavonoid Compound ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels ◽  
Muntingia Calabura

Introduction : Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia caused by abnormalities in insulin secretion, thus impacting on blood glucose levels. Calabura muntingia leaves are traditionally used as an alternative medicine because they contain flavonoid compounds which have anti-diabetic properties. In general, it is known that how to make traditional medicine is by boiling it, where the solvent only uses water so that the polar compounds will be attracted. The purpose of this study is to explain effectiveness the effect of administration between calabura muntingia leaves and calabura muntingia fruit through a review of studies related to blood sugar levelsin the last ten years.Method : Search for journals or articles using Scopus, Proquest, and Scholar indexed databases using appropriate keywords. The Center for Review and Dissemination and The Joanna Briggs Institute was used to assess the quality of the study. The framework used for the review is PICOS and the inclusion criteria used are English and Indonesian journals published in 2010 to 2020. Data analysis and tabulation are carried out in articles or journals. Title, abstract, full text and methodology are assessed to determine the eligibility of the article or journal.Results : Six hundred and forty-one articles were identified, there were eleven articles that fit the research criteria. The leaves of muntingia calabura and fruit of muntingia calabura contain flavonoids and saponins which can reduce blood sugar levels. A flavonoid compound that is thought to have activity in reducing blood glucose levels is quercetin.Conclusion : The form of extract, infusion, juice and stew did not change the content of the calabura muntingia plant.

scholarly journals Uji efek ekstrak daun papaya (Carica papaya L.) terhadap kadar gula darah tikus Wistar (Rattus norvegicus) yang diinduksi aloksan

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Cynthia C.C. Senduk ◽  
Henoch Awaloei ◽  
Edward Nangoy
Keyword(s):  
Blood Glucose ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Control Group ◽  
Elevated Blood ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

Abstract: Indonesia is a tropical country with more than 9,600 kinds of medicinal plants; one of them is papaya. Extract of papaya leaf (Carica papaya) is presumed to have hypoglycemia effect because it contains flavonoid, alkaloid, saponin, and tannin. This study aimed to evaluate the effect of papaya leaf extract on elevated blood glucose levels on Wistar rats induced with alloxan. This was an experimental study with 18 male Wistar rats as subjects, divided into 6 groups (3 rats in each group). Group 1, the negative control group, was given aquadest only. Group 2, the positive control group, was treated with alloxan 120 mg/kg body weight (BW) followed by novomix 0.2 iu/200 g BW. Group 3 and 4 were treated with alloxan 120 mg/kg BW followed by papaya leaf extract dosing 250 mg and 500 mg/kg BW respectively. Group 5 and 6 were treated with papaya leaf extract dosing 250 mg and 500 mg/kg BW without alloxan induction. Blood glucose levels were measured on day 1, day 2, and day 3 every six hours at 0, 6, 12, 18, and 24 hours. The results showed that 250 mg/kg BW and 500 mg/kg BW of papaya leaf extract could reduce the elevated blood glucose on Wistar rats for 12 hours after treatment. Conclusion: The extract of papaya leaves could reduce blood sugar levels in hyperglicemic Wistar rats induced by alloxan. Keywords: papaya leaves (carica papaya L.), blood sugar levels, alloxan. Abstrak: Indonesia merupakan salah satu negara beriklim tropis yang memiliki banyak jenis tumbuhan. Sekitar 9.600 spesies tumbuhan merupakan tumbuhan yang berkhasiat obat, salah satunya ialah pepaya. Ekstrak daun pepaya (Carica papaya L.) diduga mempunyai efek hipoglikemia karena mengandung flavonoid, alkaloid, saponin, dan tannin. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak daun pepaya (Carica papaya L.) terhadap kadar gula darah tikus Wistar (Rattus norvegicus) yang diinduksi aloksan. Jenis penelitian ini eksperimental. Subyek penelitian yang digunakan ialah 18 ekor tikus Wistar jantan yang dibagi menjadi 6 kelompok (setiap kelompok terdiri dari 3 tikus). Kelompok 1 (K1) merupakan kelompok kontrol negatif hanya diberikan aquades; kelompok 2 (K2) merupakan kelompok kontrol positif diberikan aloksan dan novomix 0,2 iu/200 g BB; kelompok 3 (K3) dan kelompok 4 (K4) merupakan kelompok perlakuan diberikan aloksan kemudian ekstrak daun pepaya dengan dosis 250 mg/kg BB dan 500 mg/kg BB; kelompok 5 (K5) dan kelompok 6 (K6) merupakan kelompok perlakuan diberikan daun pepaya dengan dosis 250 mg/kg BB dan 500 mg/kg BB tanpa induksi aloksan. Data diperoleh dari pemeriksaan kadar gula darah dari semua kelompok tikus Wistar pada hari ke-1, ke-2, dan ke-3 pada jam ke-0, 6, 12, 18, dan 24. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun pepaya dengan dosis 250 mg dan 500 mg/kg BB tikus berefek menurunkan kadar gula darah tikus wistar selama 12 jam pasca pemberian ekstrak daun pepaya. Simpulan: Ekstrak daun pepaya berpotensi memiliki efek dalam menurunkan kadar gula darah pada tikus Wistar.Kata kunci: daun pepaya (carica papaya L.), kadar gula darah, aloksan

scholarly journals Analisis Intervensi Senam Diabetes dalam Upaya Menurunkan Kadar Gula Darah

2020 ◽  
Vol 2 (1) ◽  
pp. 41-50
Author(s):  
Eni Hastuti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Control Group ◽  
Control Group Design ◽  
Study Approach ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Quasi Experimental

This study aims to determine the effect of diabetes exercise on reducing blood glucose levels in people with diabetes. This type of research is a quasi-experimental design with a non-equivalent control group design with a simple case study approach. A case study conducted in 5 days for 30 minutes showed that Diabetes Gymnastics was effective in reducing blood sugar levels in people with Diabetes Mellitus by 7.1%. In conclusion, diabetes exercises conducted for five consecutive days, effectively lower blood glucose levels in people with diabetes.   Keywords: Diabetes Mellitus, Blood Sugar, Gymnastics

scholarly journals Efektivitas Relaksasi Progresif dalam Mengurangi Gejala Depresi Pasien Diabetes Melitus Tipe 2

2018 ◽  
Vol 9 (3) ◽  
pp. 451
Author(s):  
Hotma Rumahorbo ◽  
Nani Avianti ◽  
Desmaniarti Zaini
Keyword(s):  
Diabetes Mellitus ◽  
Depressive Symptoms ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Progressive Relaxation ◽  
Hospital Treatment ◽  
Depression Symptoms ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

The prevalence of Diabetes Mellitus (DM) in Indonesia shows an increase from 1.1% in 2007 to 2.1% in 2013, with the most cases being Type 2 Diabetes Mellitus. DM is a chronic disease that cannot be cured but can be controlled by healthy lifestyle and medicine. DM patients who cannot control their blood sugar levels, they will experience acute and chronic complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, causing the patient to undergo hospital treatment for the management of blood sugar levels and complaints arising from the accompanying illness. This situation makes the patient stress and depression which will aggravate the disease. This study was to measure the effectiveness of progressive relaxation interventions on depressive symptoms of DMT-2 patients. The study design used Quasi-Experimental two groups pre and post-test design, with 61 samples consisting of 31 intervention groups and 30 control groups. The intervention group was given guidance and progressive relaxation exercises 2 times a day for 3 consecutive days with a duration of 30 minutes each exercise. The results showed that progressive relaxation interventions in DMT-2 patients reduced depression scores by -11,368 units significantly (p=0.001). Variable that makes it difficult to reduce depression symptoms were blood glucose levels. Blood glucose levels were increasing depression scores by 0.012 units. The conclusion was a progressive relaxation intervention effectively reduce depression scores of DMT-2 patients. Controlling the patient's blood glucose levels is important in improving the effectiveness of progressive relaxation interventions to reduce depressive symptoms of DMT-2 patients.

Gambaran Diabetes Melitus Sebagai Komorbid Pada Kejadian Covid-19 : Scoping Review

2021 ◽  
Vol 1 ◽  
pp. 1128-1137
Author(s):  
Laili Hikmawati ◽  
S Sugiharto
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Scoping Review ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels ◽  
The Stability ◽  
Diabetes Melitus

AbstractDiabetes mellitus (DM) is one of the comorbidities most susceptible to COVID-19 infection. The morbidity and mortality rates for diabetic patients who are infected with COVID-19 are also very high. This is related to blood sugar levels, immunity, and DM complications. The study aimed to describe DM as a comorbid of COVID-19. The study applied a scoping review method, by searching for articles through PubMed and ProQuest. The inclusion criteria are articles published in 2019-2021, and the respondents are diabetic patients. The results show that the average age of diabetic patients who infected COVID-19 was 64.24 years old, and mostly (52.7%) were female. Type 2 DM is most infected compared to other types of DM. The ACE-2 receptor owned by DM patients is the entry point for the SARS-CoV-2 virus into the human body. Blood glucose levels are a factor in the severity of COVID-19 patients with DM. Moreover, it is necessary to consider the administration of antidiabetics in the setting of COVID-19 related to the risk of hypoglycemia or other side effects. The progression of COVID-19 in patients with co-morbidities of diabetes mellitus is influenced by the stability of blood glucose levels and length of suffering. Therefore, it is recommended to monitor blood sugar levels regularly. For diabetic patients, it is advisable to always maintain health protocols because hyperglycemia conditions can stimulate chronic inflammation and weaken the immunity system against infection.Keywords: Comorbid, COVID-19, Diabetes Mellitus, Scoping Review AbstrakDiabetes mellitus (DM) merupakan salah satu penyakit penyerta yang paling rentan terinfeksi COVID-19. Angka morbiditas dan mortalitas pada diabetisi yang terinfeksi COVID-19 pun sangat tinggi. Hal tersebut terkait dengan kadar gula darah, imunitas, dan juga komplikasi dari DM. Penelitian ini bertujuan untuk mendeskripsikan DM sebagai komorbid pada kejadian COVID-19. Penelitian ini menggunakan metode scoping review, dengan mencari artikel melalui PubMed dan ProQuest. Artikel yang dianalisis adalah artikel yang diterbitkan 2019-2021, dengan respondennya adalah pasien DM. Berdasarkan hasil review dari kelima artikel diperoleh rata- rata usia diabetisi yang terinfeksi COVID-19 adalah 64,24 tahun, dimana 52,7% responden berjenis kelain  perempuan. DM tipe 2 merupakan jenis DM yang paling banyak terinfeksi dibandingkan dengan DM tipe lain. Reseptor ACE-2 yang dimiliki pasien DM merupakan pintu masuk virus SARS-CoV-2 kedalam tubuh manusia. Kadar glukosa darah menjadi salah satu faktor tingkat keparahan pasien COVID-19 dengan DM. Dalam penanganannya, perlu pertimbangan dalam pemberian antidiabetika dalam setting COVID-19 terkait dengan risiko hipoglikemia ataupun efek samping lain. Progresifitas COVID-19 pada pasien dengan penyakit penyerta diabetes melitus dipengaruhi oleh kestabilan kadar gula darah dan lama menderita. Oleh karena itu, disarankan untuk dilakukan pemantauan kadar gula darah secara rutin. Bagi para diabetisi, disarankan untuk selalu menjaga protokol kesehatan karena kondisi hiperglikemia dapat merangsang inflamasi kronik dan melemahkan sistem pertahanan tubuh melawan infeksi.Kata kunci : COVID-19, Diabetes Mellitus, Komorbid, Scoping Review

scholarly journals Effects of Clear Kefir on Biomolecular Aspects of Glycemic Status of Type 2 Diabetes Mellitus (T2DM) Patients in Bandung, West Java [Study on Human Blood Glucose, c Peptide and Insulin]

2014 ◽  
Vol 4 (8) ◽  
pp. 340 ◽  
Author(s):  
J Judiono ◽  
Suharyo Hadisaputro ◽  
K S Indranila ◽  
Bambang Cahyono ◽  
Meiny Suzery ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Standard Diet ◽  
Glycemic Status ◽  
West Java ◽  
C Peptide ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Diabetes Mellitus (DM) triggers an excessive reaction of free-radicals. It increases reactive oxygen species and reduces antioxidants status as well as the β cell damage. Clear kefir was used for DM therapies, however it limited biomolecular exploration of its bioactive roles. Research aimed to investigate the effects of clear kefir on the biomolecular nature of the glycemic status of T2DM in Bandung. Methods: The randomized pretest-posttest control group was conducted by 106 T2DM patients. Research was done in several hospitals in Bandung and Cimahi, West Java from 2012–2013. Samples were divided randomly into three groups: (1) T2DM with HbA1c < 7 was fed a standard diet, supplemented with 200 ml/day of clear kefir, (2) T2DM with HbA1c > 7 fed standard diet and supplemented 200 ml/day by clear kefir, (3) T2DM with HbA1c was fed a standard diet as a control group. Dose response was obtained from a preeliminary vivo study, and then converted to human dosage by year 2011. Intervention was effectively done for 30 days. HbA1c was measured by HPLC. Fasting blood glucose (FBG) and Postprandial blood glucose levels (PBG) were measured by enzymes levels. C Peptide and insulin were measured by Elisa. Data was analyzed by a statictics programme by significance p<0,05. Study was approved by ethic committee. Results : HbA1c was significantly reduced in delta level (p<0.01) and FBG (p<0.015) among kefir groups. PBG was not significantly reduced among groups. C-Peptide was significantly increased in delta level, except in control group (p<0.014). Insulin was reduced significantly, except in control group (p<0.003).Conclusions : Supplementation of clear kefir reduced blood glucose levels (HbA1c, FBG, PBG) and increased c-peptide. Clear kefir’s biomolecular mechanisms and chemistry characterization is a challenge for future studies.Keywords : Diabetes melitus, hyperglicemia, clear kefir, insulin, c peptide

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