scholarly journals Antidiabetic and Wound Healing Effects of Smeathxanthone A

2016 ◽  
Vol 02 ◽  
pp. 5 ◽  
Author(s):  
David Emery Tsala ◽  
Alain Meli Lannang ◽  
Theophile Dimo ◽  
Solomon Habtemariam ◽  
Jean Arnaud Ekanga ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Glucose ◽  
Breaking Strength ◽  
Diabetic Control ◽  
Control Group ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Tissue Healing ◽  
Diabetic Control Group

The purpose of this study was to investigate whether smeathxanthone A isolated from Garcinia smeathmaniiimproves incisional wound healing in diabetic mice. Male albino alloxan-induced diabetic mice (n= 20) were divided into five groups: normal control, diabetic control, 2.5 mg/kg glibenclamide given orally, 0.05 and 0.1 mg/kg smeathxanthone A given subcutaneously. Animals were euthanized on postoperative day 10 after wounding; body weight, blood glucose, breaking strength, and histologic examination were reviewed. Smeathxanthone A significantly increased skin tensile strength (24% higher than diabetic control group when given at 0.1 mg/kg), stimulated hair growth, and reduced signs of inflammation in the scar sections. Smeathxanthone A also reduced blood glucose levels in diabetic mice (45% higher than diabetic control group when given at 0.1 mg/kg). The present study demonstrates that administration of smeathxanthone A after laparotomy expedites wound healing in mice. We suggest that it could confer benefits to tissue healing by significantly enhancing tissue collagen deposition and controlling blood glucose levels.

scholarly journals Evaluation of the oral hypoglycemic activity of methanolic extract of Garcinia indica seeds in streptozotocin induced diabetic Albino rats

2018 ◽  
Vol 7 (6) ◽  
pp. 1147
Author(s):  
Padmaja Shetty K. ◽  
Pushpa V. H.
Keyword(s):  
Blood Glucose ◽  
Diabetic Control ◽  
Hypoglycemic Activity ◽  
Control Group ◽  
Glucose Levels ◽  
Garcinia Indica ◽  
Group 4 ◽  
Blood Glucose Levels ◽  
Diabetic Control Group ◽  
Group 5

Background: Diabetes mellitus is a multifactorial metabolic disorder with several microvascular and macrovascular complications. Several plants have been used as dietary adjuvants to conventional drug therapy. Garcinia indica exhibits significant hypolipidemic and hypoglycemic activity. This study was conducted to evaluate the hypoglycemic effects of methanolic extract of seeds of Garcinia indica on blood glucose levels in Streptozotocin induced diabetic albino rats.Methods: Five groups of wistar albino rats (n=6) weighing 150-200g of either sex aged 3-4 months were obtained for the study. After overnight fasting, streptozotocin (50mg/kg) was administered intraperitoneally to induce diabetes. Five groups are: Group-1: Non diabetic control group, Group-2: diabetic control, Group-3: diabetic standard, Group-4: test group, Group-5: half of test + half of standard. Fasting blood sugar was estimated on 1, 3, 7, 14 and 28th day by capillary blood glucose method. The data obtained were subjected to statistical analysis.Results: In this study, following Streptozotocin administration the blood glucose levels increased in all groups on day 0. In group 2, blood glucose level gradually increased to 445.6±1.75mg/dl over a period of 4 weeks. Following glibenclamide administration in Group 3 - there was a gradual reduction in blood glucose levels: 269.8mg/dl - day 7 to 101.8mg/dl - week 4. Group 4 - persistent and significant (p<0.05) fall in blood glucose levels reaching upto 107mg/dl at the end of 4 weeks. Group 5 - 330mg/dl on day 1 which significantly (p<0.05) reduced to 101mg/dl on day 28. There was improvement in weight in group 4 and group 5 diabetic rats.Conclusions: The extract alone and in combination with glibenclamide showed significant hypoglycemic activity in comparison to diabetic control group.

scholarly journals ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC EFFECTS OF THE ETHANOL EXTRACT OF THE LEAVES AND STEM OF CISSUS GRACILLIS (GULL ET PERR) (VITACEAE)

2021 ◽  
pp. 54-56
Author(s):  
OLUSAYO A SHORINWA ◽  
GORDON EI EMENU
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Phytochemical Screening ◽  
Glucose Levels ◽  
Diabetic Control Group ◽  
Alloxan Monohydrate

Objectives: This study investigated the antidiabetic and antihyperlipidemic potential of the ethanol extract of the leaves and stem of Cissus gracillis on alloxan monohydrate-induced diabetic albino rats. Methods: Preliminary phytochemical screening and acute toxicity were carried out. Animals were assigned into seven groups of five rats each. Groups A and B were administered 10 mg/kg each of glibenclamide and atorvastatin respectively, C, D, and E were given 125, 250 and 500 mg/kg of ethanol extract of C. gracillis, respectively, daily for 21 days through oral gavage, group F was diabetic but untreated (diabetic control group), while group G was non-diabetic and untreated which served as the control group. Results: Phytochemical screening revealed the presence of steroids/triterpenoids and carbohydrates. LD50 was above 5000 mg/kg. The extract at 500 mg/kg showed a statistically significant (p<0.05) decrease in blood glucose level when compared with the glibenclamide group on day 21. However, gradual non- significant reduction in blood glucose levels were observed in the extract treated groups on the 7th, 14th, and 21st days of treatment. The administration of ethanol extract of C. gracillis to alloxan-induced diabetic rats produced a decrease in total cholesterol, triglycerides, and low-density lipoproteins comparable to glibenclamide and atorvastatin. Conclusion: The ethanol extract of the leaves and stem of C. gracillis possess a mildly significant antidiabetic and antihyperlipidemic activity.

scholarly journals Characterization of Alginate from Sargassum duplicatum and the Antioxidant Effect of Alginate–Okra Fruit Extracts Combination for Wound Healing on Diabetic Mice

2020 ◽  
Vol 10 (17) ◽  
pp. 6082
Author(s):  
Zulfa Nailul Ilmi ◽  
Pugar Arga Cristina Wulandari ◽  
Saikhu Akhmad Husen ◽  
Dwi Winarni ◽  
Mochammad Amin Alamsjah ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Glucose ◽  
1H Nmr ◽  
Healing Process ◽  
Size Exclusion ◽  
Proton Nuclear Magnetic Resonance ◽  
Diabetic Mice ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes mellitus is a group of metabolic disorders characterized by high blood-glucose levels over a prolonged period that causes complications when an open wound is present. Alginate is an antioxidant and a good absorbent of exudates. Okra fruit contains flavonoids that can act as antioxidants. The antioxidant properties of extracts combination reduce blood-glucose levels significantly to accelerate the activities of wound-healing processes on diabetic mice. Alginate was characterized by Size Exclusion Chromatography-Multiple Angle Laser Light Scattering (SEC-MALLS), thermal stability and Proton Nuclear Magnetic Resonance (1H-NMR). The evaluation of wound healing on 36 male mice were divided into 12 groups including normal control (NC), diabetics control (DC), alginate (DA) and alginate–okra (DAO) groups in three different times by histopathology test on skin tissue. The results of SEC-MALLS analysis showed that alginate as single and homogeneous polysaccharide. The 1H-NMR spectrum showed that the mannuronate/guluronate ratio of the used alginate was 0.91. Alginate, okra fruit extract and their combination were classified as moderate and strong antioxidants. The numbers of fibrocytes, fibroblasts, collagen densities had significantly increased from three to seven days. In contrast, wound width, neutrophil, macrophages had significantly decreased at 14 days. The administration of extracts combination increased the re-epithelization of the wound area and wound-healing process on diabetic mice.

scholarly journals EFFECTS OF CHROMIUM PICOLINATE ON OXIDATIVE STRESS AND HYPERGLYCEMIA IN EXPERIMENTAL TYPE 2 DIABETIC RATS

2018 ◽  
Vol 11 (10) ◽  
pp. 532 ◽  
Author(s):  
Hamİt Uslu ◽  
GÖzde Atİla Uslu
Keyword(s):  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Chromium Picolinate ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetic Control Group ◽  
Experimental Type

Objective: In this study, we aimed to determine the effects of chromium picolinate (CrPic) on diabetes, one of the most common and fatal diseases in the world, and its associated oxidative damages.Methods: CrPic (100 μg/kg) and metformin (1000 mg/kg) were orally administered for 21 days in rats with nicotinamide + streptozotocin-induced Type 2 diabetes.Results: Significant decreases in fasting blood glucose levels were observed 14 days after initial administration in both CrPic (p<0.01) and metformin (p<0.001) groups compared with a diabetic control group (DC). Malondialdehyde (MDA) levels of all tissues were significantly higher in the DC group than in a normoglycemic control group (p<0.001). MDA levels of the CrPic group significantly decreased in heart (p<0.05) and liver (p<0.01) tissues. Glutathione (GSH) and catalase (CAT) levels in heart, kidney, and liver tissues increased in CrPic group (GSH p<0.001, p<0.05, and p<0.01; CAT p<0.001, p<0.001, and p<0.05, respectively). Superoxide dismutase enzyme levels significantly increased in CrPic group in the liver tissue (p>0.001), but no such changes were observed in heart and kidney tissues (p>0.05).Conclusion: The results obtained from this study indicate that CrPic may be effective in alleviating hyperglycemia and its consequent oxidative damage in experimental Type 2 diabetes.

scholarly journals Ameliorative Activity of Pumpkin (Cucurbita maxima) Fruit and Seeds Powders on Diabetic, Oxidative and Pancreatic Status in Rats

2019 ◽  
pp. 1-9
Author(s):  
Alyae, M. S. Gabal
Keyword(s):  
Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Cucurbita Maxima ◽  
Glucose Levels ◽  
Group I ◽  
Diabetic Control Group ◽  
Increased Risk

Background: Diabetes mellitus is the one of the most common endocrine diseases that is characterized by hyperglycemia, altered metabolism with an increased risk of much complications. Besides drugs classically used for the treatment of diabetes several species of plants have been described as having a hypoglycemic activity with decreased side effects. Aim of the Work: This work aimed to investigate the possible anti-diabetic effect of oral administration of pumpkin (Cucurbita maxima) fruit flesh and seeds powders on Streptozotocin induced diabetic rats via studying blood glucose levels, oxidative biomarkers as well as islets of Langerhans structure changes. Materials and Methods: 60 adult albino rats of Sprague-Dawely strains (200±5 gm) were classified into five groups of ten animals each except diabetic control group was composed of twenty rats as follow Group I: healthy control; Group II: diabetic control ,Group III, IV and V: diabetic rats received 2 g pumpkin fruit, seeds, fruit and seeds mixture powders respectively /kg body weight daily by oral intubation. Results: The results of present study showed that pumpkin powders caused significant improvements (P≤0.05) in blood glucose, insulin levels and glycated hemoglobin percent compared to diabetic control group. Also pumpkin powders improved antioxidants activities and healed Langerhans islets by increasing their number and size in comparison with diabetic control group. Conclusion: The present study showed that pumpkin powders may normalize the various biochemical and pancreatic tissues abnormalities resulted due to diabetes metabolic disorders and it is a source of potent anti-diabetic agent. The diabetic rats that were administered with the pumpkin fruit powder, exhibited the highest improvements.

scholarly journals Effectiveness of Jicama Probiotic Yoghurt (Pachyrhizus erosus) on Blood Glucose in Diabetic Mice

2019 ◽  
Author(s):  
Eva Yuniritha ◽  
Annisa Avelia ◽  
Andrafikar .
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Complementary Therapy ◽  
T Test ◽  
Control Group ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
Probiotic Yogurt ◽  
Blood Glucose Levels ◽  
One Way Anova

Background: Diabetes Mellitus (DM) is a degenerative disease population increases every year. DM was ranked sixth as the cause of death. About 1.3 million people died because of diabetes and 4% died before the age of 70 years. DM auto-oxidation causes glucose to increase reactive oxygen compounds. One of the DM management is a complementary therapy using a functional food ingredient, namely, jicama and probiotics. Probiotics and jicama contain active compounds in the form of inulin and BAL and are able to control blood glucose levels. This study aims to determine the effectiveness of jicama probiotic yogurt on blood glucose levels in diabetic mice. Methods: This research is a quasi-experimental with pre–post-test control group, using a sample of DDY strain mice according to the criteria. Samples were given treatment probiotic yogurt and jicama probiotic yogurt 2 ml for seven days in the treatment group and one group of non-treated controls. The mean obtained were analyzed by dependent t-test, independent t-test, and one-way ANOVA test. Result and Conclusion: The results showed that there was a decrease in blood glucose levels in the probiotic yogurt group amounting to 296.62 mg/dL and jicama probiotic yogurt of 337.57 mg/dL, while the control group increased by 43.57 mg/dL. Results: One way ANOVA test showed jicama probiotic yogurt more effectively decreases blood glucose levels than the probiotic yogurt (p = 0.00). Jicama probiotic yogurt can be used as an alternative complementary therapy for patients with diabetes mellitus.

scholarly journals Amylin induces hypoglycemia in mice

2013 ◽  
Vol 85 (1) ◽  
pp. 349-354 ◽  
Author(s):  
Luiz H. Guerreiro ◽  
Daniel DA Silva ◽  
Mauro Sola-Penna ◽  
Daniella M. Mizurini ◽  
Luís M.T.R. Lima
Keyword(s):  
Blood Glucose ◽  
Whole Blood ◽  
Subcutaneous Administration ◽  
Control Group ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Arterial Plasma ◽  
Tail Tip ◽  
Dose Dependent

Amylin is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia. Amylin has long been shown to induce increases in arterial plasma glucose. We decided to investigate whether amylin plays additional roles in the glucose metabolism. We evaluated glucose homeostasis using whole blood from the tail tip of fasting, conscious, unrestrained normal and streptozotocyn-induced diabetic mice following subcutaneous administration of mouse amylin. Subcutaneous injection of 1 μg mouse amylin caused a transient decrease in whole blood glucose in both normal and diabetic mice in the absence of insulin. The blood glucose levels were lowest approximately 2 hours after amylin administration, after that they gradually recovered to the levels of the control group. The hypoglycemic effect followed a dose-dependent response ranging from 0.1 to 50 µg / mouse. These results reveal the ability for amylin in the direct control of glycemia at low doses in the absence of insulin.

scholarly journals Antidiabetic and anti-oxidant activities of the methanol leaf extract of Vernonia amygdalina in alloxan-induced diabetes in Wistar rats

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Adegbolagun T. Adeoye ◽  
Ademola A. Oyagbemi ◽  
Aduragbenro D. Adedapo ◽  
Temidayo O. Omobowale ◽  
Abiodun E. Ayodele ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Biochemical Indices

The methanolic leaf extract of Vernonia amygdalina (MLVA) was assessed to evaluate its antidiabetic potential in rats. Diabetes was induced in male Wistar rats by the administration of alloxan monohydrate at 100 mg/kg of body weight. After 48 h, rats with fasting blood glucose levels of 200 mg/dL and above were considered diabetic and used for the study. The experimental animals were grouped into five groups (A–E) of 10 animals each. Group A rats were non-diabetic normal control, Group B consisted of diabetic control rats that received no treatment, groups C, D and E rats were diabetic rats but treated with glibenclamide, 200 and 400 mg/kg doses of MLVA respectively. Blood samples were collected at days 14 and 28 after induction for haematological and serum biochemical indices such as triglycerides, LDL, cholesterols etc. The intestine was collected and intestinal homogenate was prepared for the antioxidant studies. The extract at 200 mg/kg and 400 mg/kg doses significantly (p < 0.05) reduced blood glucose levels in extract-treated diabetic rats and also significantly increased weight gain in these rats. Most haematological parameters in treated rats experienced, while platelets and neutrophils were decreased. Biochemical indices measured were reduced in MLVA-treated groups compared with diabetic control. Treatment with MLVA also produced significant (p < 0.05) decrease in markers of oxidative stress but increased levels of enzymic and non-enzymic antioxidant markers in intestinal homogenates of treated groups compared with diabetic control. This study showed that V. amygdalina has antihyperglycaemic and in vivo antioxidant effects.

scholarly journals Effect of Alcoholic Catechin Extract on Hyperglycemia, Hyperlipidemia and Liver Functions in Alloxan Diabetic Mice

2014 ◽  
Vol 11 (3) ◽  
pp. 1192-1200
Author(s):  
Baghdad Science Journal
Keyword(s):  
Blood Glucose ◽  
Diabetic Control ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Diabetic Mice ◽  
Diabetic Control Group ◽  
Liver Functions ◽  
Group A ◽  
Serum Biochemical ◽  
Group B

The objective of this study is to estimate the effect of the hydro-ethanolic catechin extract toward blood glucose, lipid profile and liver functions in alloxan diabetic mice. 50 healthy mice (25-30 g) were divided into five groups of ten animals for each. Group A received normal saline as normal control group. To induce diabetes, alloxan (150 mg/kg), intraperitoneal (i.p.) single dose was injected to groups B, C, D and E. Group B represents diabetic control group. Groups C, D and E received ethanolic catechin extract (30 mg/kg and 40 mg/kg) for different periods of 1, 2 and 3 weeks as treated groups. Blood glucose, serum lipids [Total Cholesterol (TC), Triglycerides (TGs) and High Density Lipoproteins (HDL)], asparagine transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were estimated after one, two and three weeks. Group B showed a significant increase in blood glucose, TC, TGs, AST, ALT and ALP as compared to group A. Groups C, D, and E showed a significant decrease in mentioned serum biochemical parameters in comparison to group B. In contrast, groups C, D and E showed significant increase in serum HDL as compared to B group. The results clearly revealed that ethanolic catechin extract possesses significant antihyperglycemic and antihyperlipidemic activities together with its ability to improve liver functions in alloxan diabetic mice.

scholarly journals A study of hypoglycemic effect of Caesalpinia bonduc extract on alloxan induced diabetic albino rats

2017 ◽  
Vol 6 (9) ◽  
pp. 2153
Author(s):  
Reshma Nadaf
Keyword(s):  
Blood Glucose ◽  
Diabetic Control ◽  
Hypoglycemic Effect ◽  
Control Group ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Test Drug ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: The objective of the study was to scientifically investigate the oral hypoglycemic activity of Caesalpinia bonduc on Alloxan induced diabetic albino rats. To compare the hypoglycemic effect of Caesalpinia bonduc with that of the standard drug Glibenclamide used in the treatment of diabetes mellitus.Methods: Adult healthy albino rats of wister strain of either sex weighing 150-200gms were included in the study. The animals were divided into 4 groups namely control, diabetic control, standard and test groups with 6 animals in each group. Diabetes was chemically induced using alloxan to produce hyperglycemia in rats. Standard drug Glibenclamide suspended in gum acacia was administered for standard group. Test drug Caesalpinia bonduc was administered for test group. Morning around 9 a.m. blood glucose levels were recorded on 1st, 3rd, 7th, 14th, 21st, and 28th days.Results: The control group of rats showed no variation. The diabetic control rats showed consistent hyperglycemia. Comparing the test drug Caesalpinia bonduc to the standard drug Glibenclamide, the test drug was 1.38 times more efficacious than the standard.Conclusions: The alcoholic extract of Caesalpinia bonduc (seeds) has shown more anti diabetic activity by lowering the blood glucose levels in diabetic rats significantly. These findings suggest that hypoglycemic potential of the test compound Caesalpinia bonduc is promising and found to be more significant than the standard compound.

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