scholarly journals Epilepsy and COVID-19: predictors of a positive outcome in patients with epilepsy (based on analysis of clinical cases)

2021 ◽  
Vol 8 (3) ◽  
pp. 22-28
Author(s):  
G. V. Odintsova ◽  
V. D. Bannikova
Keyword(s):  
Health Outcome ◽  
Positive Outcome ◽  
Positive Health ◽  
Modern Drug ◽  
Increased Risk ◽  
Somatic Comorbidities ◽  
Generalized Epilepsy ◽  
Novel Coronavirus ◽  
Patients With Epilepsy ◽  
Positive Health Outcome

Background. Many patients with neurological disorders have an increased risk of infection and the severe course of COVID-19. Studies on positive predictors of seizure outcomes with the 2019 novel coronavirus disease remain limited.The objective is to study predictors for positive health outcomes after COVID infection in patients with epilepsy based on analysis of clinical observations.Design and Methods. Study design - the work is a part of a prospective observational study of seizure dynamics after COVID infection in patients with epilepsy.Results. The presented clinical observation demonstrates a positive health outcome after COVID infection in a young patient with the genetic generalized epilepsy with sustained clinical and electroencephalographic seizure remission on the next generation AED monotherapy (brivaracetam).Conclusion. Predictors for positive health outcome after the 2019 novel coronavirus disease in patients with epilepsy include a young age, absence of somatic comorbidities, seizure remission, modern drug use with no interaction among AEDs and antibiotics and antivirals for the coronavirus disease treatment. Despite the encouraging data on the favourable course of epilepsy in cases of developing COVID-19, further research is needed to continue.

scholarly journals Evaluating of the association between ABO blood groups and coronavirus disease 2019 (COVID-19) in Iraqi patients

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali H. Ad’hiah ◽  
Risala H. Allami ◽  
Raghdan H. Mohsin ◽  
Maha H. Abdullah ◽  
Ali J. R. AL-Sa’ady ◽  
...  
Keyword(s):  
Blood Groups ◽  
Abo Blood Groups ◽  
Risk Of Death ◽  
Increased Risk ◽  
Fluorescence Probing ◽  
Group A ◽  
Risk Of Disease ◽  
Novel Coronavirus ◽  
Polymorphic System ◽  
Made In

Abstract Background Susceptibility to the pandemic coronavirus disease 2019 (COVID-19) has recently been associated with ABO blood groups in patients of different ethnicities. This study sought to understand the genetic association of this polymorphic system with risk of disease in Iraqi patients. Two outcomes of COVID-19, recovery and death, were also explored. ABO blood groups were determined in 300 hospitalized COVID-19 Iraqi patients (159 under therapy, 104 recovered, and 37 deceased) and 595 healthy blood donors. The detection kit for 2019 novel coronavirus (2019-nCoV) RNA (PCR-Fluorescence Probing) was used in the diagnosis of disease. Results Mean age was significantly increased in patients compared to controls (49.8 ± 11.7 vs. 28.9 ± 6.6 years; p < 0.001). A similar observation was made in recovered (42.1 ± 10.4 vs. 28.9 ± 6.6 years; p < 0.001) and deceased (53.6 ± 9.7 vs. 28.9 ± 6.6 years; p < 0.001) cases. The mean age was also significantly increased in deceased cases compared to recovered cases (53.6 ± 9.7 vs. 42.1 ± 10.4 years; p < 0.001). There were gender-dependent differences in COVID-19 prevalence. The percentage of COVID-19 was higher in males than in females (all cases: 59.7 vs. 40.3%; recovered cases: 55.8 vs. 44.2%). Such male-gender preponderance was more pronounced in deceased cases (67.6 vs. 32.4%). Logistic regression analysis revealed that groups AB and B + AB were significantly associated with increased risk to develop COVID-19 (OR = 3.10; 95% CI 1.59–6.05; pc = 0.007 and OR = 2.16; 95% CI 1.28–3.63; pc = 0.028, respectively). No ABO-associated risk was observed in recovered cases. On the contrary, groups A (OR = 14.60; 95% CI 2.85–74.88; pc = 0.007), AB (OR = 12.92; 95% CI 2.11–79.29; pc = 0.042), A + AB (OR = 14.67; 95% CI 2.98–72.33; pc = 0.007), and A + B + AB (OR = 9.67; 95% CI 2.02–46.24; pc = 0.035) were associated with increased risk of death in deceased cases. Conclusions The findings of this study suggest that group AB may be a susceptibility biomarker for COVID-19, while group A may be associated with increased risk of death.

scholarly journals The Epidemiology and Predictors of Outcomes Among Confirmed COVID-19 Cases in a Large Community Healthcare System in South Florida

2021 ◽  
Author(s):  
Shenae Samuels ◽  
Jianli Niu ◽  
Candice Sareli ◽  
Paula Eckardt
Keyword(s):  
Healthcare System ◽  
South Florida ◽  
Health Concern ◽  
Community Healthcare ◽  
Logistic Regression Models ◽  
Icu Admission ◽  
Large Community ◽  
Increased Risk ◽  
Predictors Of Outcomes ◽  
Novel Coronavirus

AbstractThe novel coronavirus disease 2019 (COVID-19) continues to be a major public health concern. The aim of this study was to describe the presenting characteristics, epidemiology and predictors of outcomes among confirmed COVID-19 cases seen at a large community healthcare system which serves the epicenter and diverse region of Florida. We conducted a retrospective analysis of individuals with lab-confirmed SARS-CoV-2 infection who were seen, from March 2, 2020 to May 31, 2020, at Memorial Healthcare System in South Florida. Data was extracted from a COVID-19 registry of patients with lab-confirmed SARS-CoV-2 infection. Univariate and backward stepwise multivariate logistic regression models were used to determine predictors of key study outcomes. There were a total of 1692 confirmed COVID-19 patients included in this study. Increasing age was found to be a significant predictor of hospitalization, 30-day readmission and death. Having a temperature of 38 °C or more and increasing comorbidity score were also associated with an increased risk of hospitalization. Significant predictors of ICU admission included having a saturated oxygen level less than 90%, hypertension, dementia, rheumatologic disease, having a respiratory rate greater than 24 breaths per minute. Being of Hispanic ethnicity and immunosuppressant utilization greatly increased the risk of 30-day readmission. Having an oxygen saturation less than 90% and an underlying neurological disorder were associated with an increased likelihood of death. Results show that a patient’s demographic, underlying condition and vitals at triage may increase or reduce their risk of hospitalization, ICU admission, 30-day readmission or death.

scholarly journals COVID-19 positivity associated with traumatic stress response to childbirth and no visitors and infant separation in the hospital

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gus A. Mayopoulos ◽  
Tsachi Ein-Dor ◽  
Kevin G. Li ◽  
Sabrina J. Chan ◽  
Sharon Dekel
Keyword(s):  
Traumatic Stress ◽  
Neonatal Intensive Care ◽  
Acute Stress ◽  
Psychiatric Morbidity ◽  
Neonatal Intensive Care Units ◽  
Stress Symptoms ◽  
Increased Risk ◽  
The Us ◽  
Control Survey ◽  
Novel Coronavirus

AbstractAs the novel coronavirus (COVID-19) has spread globally, a significant portion of pregnant and delivering women were infected with COVID-19. While emerging studies examined birth outcomes in COVID-19 positive women, knowledge of the psychological experience of childbirth and maternal wellness remains lacking. This matched-control survey-based study included a sample of women recruited during the first wave of the pandemic in the US who gave birth in the previous six months. Women reporting confirmed/suspected COVID-19 (n = 68) during pregnancy or childbirth were matched on background factors with women reporting COVID-19 negativity (n = 2,276). We found nearly 50% of COVID positive women endorsed acute traumatic stress symptoms at a clinical level in response to childbirth. This group was more than twice as likely to endorse acute stress and to have no visitors during maternity hospitalization than COVID negative women; they were also less likely to room-in with newborns. The COVID positive group reported higher levels of pain in delivery, lower newborn weights, and more infant admission to neonatal intensive care units. Our findings suggest COVID-19 affected populations are at increased risk for traumatic childbirth and associated risk for psychiatric morbidity. Attention to delivering women’s wellbeing is warranted during the pandemic.

scholarly journals COVID-19: A Syndemic Requiring an Integrated Approach for Marginalized Populations

2021 ◽  
Vol 9 ◽  
Author(s):  
Rosemary M. Caron ◽  
Amanda Rodrigues Amorim Adegboye
Keyword(s):  
At Risk ◽  
Collective Responsibility ◽  
Health Inequities ◽  
Integrated Approach ◽  
Risk Groups ◽  
Marginalized Populations ◽  
Structural Barriers ◽  
Public Health Services ◽  
Increased Risk ◽  
Novel Coronavirus

The novel coronavirus, SARS-CoV-2, responsible for the COVID-19 pandemic, has challenged healthcare systems globally. The health inequities experienced by immigrants, refugees, and racial/ethnic minorities have been aggravated during the COVID-19 pandemic. The socioeconomic, political, and demographic profile of these vulnerable populations places them at increased risk of contracting COVID-19 and experiencing significant morbidity and mortality. Thus, the burden of the COVID-19 pandemic is disproportionally higher among these at-risk groups. The purpose of this perspective is to: (1) highlight the interactions among the social determinants of health (SDoH) and their bi-directional relationship with the COVID-19 pandemic which results in the current syndemic and; (2) offer recommendations that consider an integrated approach to mitigate COVID-19 risk for marginalized populations in general. For these at-risk populations, we discuss how individual, structural, sociocultural, and socioeconomic factors interact with each other to result in a disparate risk to contracting and transmitting COVID-19. Marginalized populations are the world's collective responsibility. We recommend implementing the Essential Public Health Services (EPHS) framework to promote those systems and policies that enable optimal health for all while removing systemic and structural barriers that have created health inequities. The pledge of “Health for All” is often well-accepted in theory, but the intricacy of its practical execution is not sufficiently recognized during this COVID-19 syndemic and beyond.

scholarly journals Effect of targeted physiotherapy on the quality of life of patients with epilepsy of unknown etiology – a pilot study

2021 ◽  
Vol 24 (2) ◽  
Author(s):  
Elżbieta Szczygieł-Pilut ◽  
Elżbieta Mirek ◽  
Magdalena Filip ◽  
Daniel Pilut ◽  
Szymon Pasiut ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Therapy ◽  
Unknown Etiology ◽  
Study Group ◽  
Life Questionnaire ◽  
Quality Of Life Questionnaire ◽  
Sf 36 ◽  
Generalized Epilepsy ◽  
Patients With Epilepsy

Introduction: Epilepsy is one of the most common diseases of the central nervous system. According to the World Health Organization, it accounts for 1% of the global burden of disease worldwide. Pharmacotherapy remains the primary therapeutic tool in this disease. However, more and more emphasis is placed on approaching this group of patients in an interdisciplinary manner, taking their various needs into account: social, professional, economic or psychological. Attention is also paid to the positive impact of physical activity on the quality of life of patients with epilepsy. The patients with diagnosed epilepsy often complain of a feeling of instability not reflected in standard neurological examination. Early detection of postural control disorders is possible using an objective research tool which is the modified CTSIB test (Clinical Test of Sensory Interaction and Balance). Aim of the study: The aim of the study was to assess the influence of targeted physical therapy on the quality of life among patients with diagnosed epilepsy of unknown etiology using the SF-36 quality of life questionnaire. Materials and methods: The study included 11 professionally active adults with diagnosed generalized epilepsy of unknown etiology, treated at the Department or Outpatient Clinic of Neurology at John Paul II Specialist Hospital in Kraków. Finally, out of the 11 recruited patients (5 women and 6 men), 1 patient was excluded from the study due to a history of craniocerebral trauma. Patients were examined 3 times every month using EEG and the SF-36 quality of life questionnaire. Additionally, between the 2nd and the 3rd month of the pilot study, the study group underwent physical therapy focused on balance disorders using the Biodex SD stabilometric platform. Results: Overall, the quality of life index measured using the SF-36 quality of life questionnaire in the study group improved after the completion of targeted physical therapy. Conclusions: 1. Generalized epilepsy of unknown etiology results in a significant deterioration in the quality of life of patients, which may also be accompanied by disorders of postural control. 2 A targeted program of physiotherapy in the treatment of patients with generalized epilepsy of unknown etiology may has a positive effect on their quality of life. null

scholarly journals Mr. Potato Head

2019 ◽  
pp. 468-487
Author(s):  
Nancy Foldvary-Schaefer ◽  
Thapanee Somboon ◽  
Zahreddin Alsheikhtaha
Keyword(s):  
Sleep Apnea ◽  
Sleep Disorders ◽  
Developmental Delay ◽  
Epileptic Encephalopathy ◽  
Electrode Placement ◽  
Age Related ◽  
Generalized Epilepsy ◽  
Patients With Epilepsy ◽  
Spike Wave

This case illustrates diagnostic challenges in patients with epilepsy and suspected sleep disorders. Specifically, the symptomatic generalized epilepsy Lennox-Gastaut syndrome is an age-related epileptic encephalopathy characterized by developmental delay; multiple seizure types, including tonic seizures in drowsiness and sleep; and generalized slow spike-wave complexes on electroencephalography (EEG). Tonic seizures in sleep can be unrecognized or can be confused with sleep disorders such as sleep apnea. The case demonstrates how to identify generalized epileptic abnormalities and seizures on the limited EEG montage used in routine polysomnography and expanded EEG using the 10-20 system of electrode placement.

Customer Strategy Definition in Elderly Care

2015 ◽  
pp. 1139-1158
Author(s):  
Basel Khashab ◽  
Uday Joshi ◽  
Stephen R. Gulliver
Keyword(s):  
Health Outcome ◽  
Resource Allocation ◽  
Critical Care ◽  
Elderly Care ◽  
Relationship Management ◽  
Customer Relationship ◽  
Positive Health ◽  
Care Services ◽  
Service Creation ◽  
Global Population

With an aging global population, it is important that clinicians empower their patients. Empowering the patient-physician interaction leads to a more positive health outcome. This chapter discusses the potential of adopting Customer Relationship Management (CRM) as a way of guiding non-critical care services (i.e. linking the problems of customer-focused care expectation and resource allocation management). Implementation of CRM solutions would create value for patients by supporting trust and service creation; however, the chapter highlights a need for a common and systematic way to implement CRM solutions in the healthcare domain.

scholarly journals Psychiatric comorbidities in people with epilepsy

2020 ◽  
pp. 10.1212/CPJ.0000000000000874 ◽  
Author(s):  
Marco Mula ◽  
Andres M Kanner ◽  
Nathalie Jette ◽  
Josemir W. Sander
Keyword(s):  
Mental Health ◽  
Psychiatric Disorder ◽  
Mental Health Problems ◽  
Poor Response ◽  
Response To Treatment ◽  
Clinical Implications ◽  
Psychiatric Comorbidities ◽  
Hyperactivity Disorder ◽  
Increased Risk ◽  
Patients With Epilepsy

ABSTRACTPurposeof review: To review the latest evidence concerning the epidemiology, clinical implications and management of psychiatric disorders in epilepsy.Recent findings:People with epilepsy have a 2 to 5 times increased risk of developing any psychiatric disorder and 1 in 3 patients with epilepsy have a lifetime psychiatric diagnosis. Psychiatric comorbidities represent a poor prognostic marker as they have been associated with a poor response to treatment (drugs and surgery), increased morbidity and mortality. Validated screening instruments are available for mood and anxiety disorders in adults as well as attention deficit hyperactivity disorder in children with epilepsy.Summary:All patients with epilepsy should be routinely screened for psychiatric disorder at the onset and at least once a year. Patients with epilepsy and their relatives should be informed of the risk of mental health problems and the implications.

scholarly journals Polygenic risk scores of several subtypes of epilepsies in a founder population

2020 ◽  
Vol 6 (3) ◽  
pp. e416
Author(s):  
Claudia Moreau ◽  
Rose-Marie Rébillard ◽  
Stefan Wolking ◽  
Jacques Michaud ◽  
Frédérique Tremblay ◽  
...  
Keyword(s):  
Mixed Model ◽  
Focal Epilepsy ◽  
Population Based ◽  
Risk Scores ◽  
Founder Population ◽  
Idiopathic Generalized Epilepsy ◽  
Polygenic Risk ◽  
Generalized Epilepsy ◽  
Patients With Epilepsy ◽  
Variance Explained

ObjectivePolygenic risk scores (PRSs) are used to quantify the cumulative effects of a number of genetic variants, which may individually have a very small effect on susceptibility to a disease; we used PRSs to better understand the genetic contribution to common epilepsy and its subtypes.MethodsWe first replicated previous single associations using 373 unrelated patients. We then calculated PRSs in the same French Canadian patients with epilepsy divided into 7 epilepsy subtypes and population-based controls. We fitted a logistic mixed model to calculate the variance explained by the PRS using pseudo-R2 statistics.ResultsWe show that the PRS explains more of the variance in idiopathic generalized epilepsy than in patients with nonacquired focal epilepsy. We also demonstrate that the variance explained is different within each epilepsy subtype.ConclusionsGlobally, we support the notion that PRSs provide a reliable measure to rightfully estimate the contribution of genetic factors to the pathophysiologic mechanism of epilepsies, but further studies are needed on PRSs before they can be used clinically.

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