scholarly journals ​Comparative Studies on Therapeutic Efficacy Intrauterine Turmeric Extract and Ceftiofur Sodium Alone and in Combination with Micronutrients Supplementation in Postpartum Metritic Crossbred Cows

2021 ◽  
Author(s):  
Rajender Kumar ◽  
Sant Prasad Nema ◽  
Sobaran Sing Mahour ◽  
Ashok Kumar Patil ◽  
Madhu Shivhare ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Therapeutic Efficacy ◽  
Negative Energy ◽  
Time Interval ◽  
Micronutrient Supplementation ◽  
Crossbred Cows ◽  
Group Iii ◽  
Turmeric Extract ◽  
Group I ◽  
Ceftiofur Sodium

Background: The postpartum period is crucial in dairy cows and is marked by major physiological and metabolic changes that affect milk production, immune response and fertility. Nutrition remains the most important lever for limiting the negative energy balance and its consequences on general health status in highly selected dairy cows. Therefore, the present study is design to investigate the Therapeutic efficacy intrauterine turmeric extract and ceftiofur sodium alone and in combination with micronutrients supplementation in postpartum metritic crossbred cows. Methods: The present study was conducted on 24 crossbred cows with history of postpartum metritis randomly divided into four treatment groups: intrauterine turmeric extract (group I), intramuscular ceftiofur sodium (group II), intrauterine turmeric extract + micronutrient supplementation (group III) and intramuscular ceftiofur sodium + micronutrient supplementation (group IV). Result: The mean time interval required for resumption of cyclicity was highest in gp II followed by gp I, gp III and gp IV. The group turmeric extract + micronutrients supplementation and ceftiofur sodium + micronutrients supplementation group registered a considerable higher conception rate (66.66) followed by (50%) in turmeric extract and ceftiofur sodium group.

scholarly journals Intracanal medications versus placebo in reducing postoperative endodontic pain – a double – blind randomized clinical trial

2013 ◽  
Vol 24 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Ripu Daman Singh ◽  
Ramneek Khatter ◽  
Rupam Kaur Bal ◽  
C.S. Bal
Keyword(s):  
Postoperative Pain ◽  
Calcium Hydroxide ◽  
Repeated Measures ◽  
Apical Periodontitis ◽  
Time Interval ◽  
Preoperative Pain ◽  
Double Blind ◽  
Group Iii ◽  
Group I ◽  
Chlorhexidine Gel

This prospective randomized, double-blind factorial study aimed to compare the efficacy of three different intracanal medicaments with the placebo in controlling the postoperative pain after complete root canal preparation. The study was performed on 64 mandibular molars of 64 patients with diagnosis of pulp necrosis and acute apical periodontitis. After chemomechanical procedures using the stepback technique and 1% sodium hypochlorite, the teeth were randomized into four treatment groups (n=16). In group I, canals were filled with calcium hydroxide paste mixed with 2% chlorhexidine gel, group II received 2% chlorhexidine gel, group III was treated with calcium hydroxide paste, and group IV received no dressing (control). Before dismissal, preoperative pain experience was recorded using a visual analog pain scale. Patients were then instructed to quantify the degree of pain experienced 4 h after treatment and daily for a further 24, 48, 72 and 96 h. Two-way repeated measures ANOVA test and post hoc Tukey's HSD test revealed that at each time interval groups I and II were significantly more effective in reducing the postoperative pain values than groups III and IV (p<0.05). Dunnett's test showed that groups I and II differed significantly from control whereas difference between group III and control was not significant (p>0.05). Patients with pulp necrosis and acute apical periodontitis that had been dressed with chlorhexidine alone and calcium hydroxide plus chlorhexidine gave rise to less pain than that experienced by patients who had a calcium hydroxide dressing alone or no dressing at all.

scholarly journals Determination of thiol/disulphide homeostasis as a new indicator of oxidative stress in dairy cows with subclinical endometritis

2021 ◽  
Vol 91 (2) ◽  
pp. 137-148
Author(s):  
Birten Emre ◽  
◽  
Ömer Korkmaz ◽  
Ismail Koyuncu ◽  
Selim Çomaklı ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Immunocytochemical Staining ◽  
Control Group ◽  
Roc Curve Analysis ◽  
Group Iii ◽  
Total Thiol ◽  
Group I ◽  
Subclinical Endometritis

The objective of this study was to determine thiol/disulphide homeostasis (TDH) in infertile cows with subclinical endometritis (SCE). Endometrial cytological samples were collected using a cytobrush to diagnose SCE in 36 infertile cows. According to the results of the cytology examination, those with acute endometritis were classified as Group I (n = 20) and those with chronic endometritis were classified as Group II (n = 16). A control group was formed of heifers as Group III (n = 20). Blood samples were taken from each group on the day of diagnosis (day 0) to analyse TDH. In the cytology examination, both the Giemsa method and immunocytochemical staining were applied to determine chronic inflammation and activity status. In 55.55% (20/36) of the infertile cows with cytological endometritis, the inflammation was determined to be active, and in 44.44% (16/36) it had become chronic. The native thiol and total thiol levels were found to be statistically significantly lower in the acute (206.54 ± 8.30 μmol/L; 227.11 ± 9.30 μmol/L) and chronic SCE cases (225.15 ± 11.89 μmol/L; 247.96 ± 10.80 μmol/L) compared to the heathy control group (308.47 ± 13.59 μmol/L; 336.83 ± 15.5 μmol/L respectively) (P<0.001). Disulphide levels, disulphide/total thiol, native thiol/total thiol and disulphide/native thiol ratios were similar in all the groups (P>0.05). The diagnostic accuracy of native thiol, which can be used in the diagnosis of SCE, was 92.8%, that of total thiol was 89.3% and that of disulphide was 64.3% according to the ROC curve analysis. These results demonstrate that TDH is a reliable and sensitive indicator of oxidative stress in cow SCE, and that abnormal TDH might play a role in SCE pathogenic mechanisms. This is the first study to evaluate thiol/disulphide homeostasis in dairy cows with SCE as a new indicator of oxidative stress.

scholarly journals A polyol mixture and molasses-treated beed pulp in the silage based diet of dairy cows: III The effect on the utilization of minerals

1979 ◽  
Vol 51 (1) ◽  
pp. 528-535
Author(s):  
Mikko Tuori
Keyword(s):  
Dairy Cows ◽  
Apparent Digestibility ◽  
Sugar Alcohol ◽  
Sugar Alcohols ◽  
Group Iii ◽  
Apparent Absorption ◽  
Total Intake ◽  
Group I ◽  
Beet Pulp ◽  
Fermentable Carbohydrates

The effect of sugar alcohol (polyol) mixture feeding on the utilization of Ca, Mg, Na, K and P was studied in a balance trial with 12 dairy cows. The cows were divided into 3 groups: Group I received a grain concentrate mixed with 26 % of polyoltreated beet pulp, Group II the concentrate mixed with 29 % of molasses beet pulp, and Group III only the grain concentrate. Cows were given 7—8 kg/d of concentrate, 2 kg/d of hay, and silage at almost ad lib. level. The intake of sugar alcohols was 484 g/d in Group I and total intake of sugars was 461, 736 and 435 g in Groups I, II and IIII, respectively. No polyols were secreted in the faeces, and in the urine only 0.7 % of the intake, most of which was xylitol, rhamnitol and arabinitol. Small amounts of polyols were also secreted in the urine of the molasses beet pulp group. There were no clear effects of polyol feeding on the apparent digestibility or utilization of minerals. However, the readily fermentable carbohydrates in the diet tends to increase the apparent absorption and utilization of magnesium. Secretion of potassium was significantly (P < 0.05) lower in the polyol beet pulp group than in the molasses beet pulp group.

The Value of Prognostic Grouping of Prostatic Carcinomas for Urologists and Pathologists

2015 ◽  
Vol 95 (4) ◽  
pp. 436-444 ◽  
Author(s):  
Burkhard Helpap ◽  
Daniel Ringli ◽  
Jürgen Breul ◽  
Jens Tonhauser ◽  
Immanuel Poser ◽  
...  
Keyword(s):  
Specific Antigen ◽  
Good Prognosis ◽  
Tnm Staging ◽  
Time Interval ◽  
Low Grade ◽  
Intermediate Grade ◽  
Group Iii ◽  
Intermediate Group ◽  
Group I ◽  
Prognostic Stratification

Objectives: To improve the prognostic stratification for different therapeutic options of prostatic carcinomas (PCa) with low and intermediate grade by combining Gleason grading with cytological findings and prognostic grade grouping. Methods: We analyzed PCa after radical prostatectomy using the combined grading of Gleason and Helpap, which allows an exact differentiation particularly of low and intermediate grade tumors. Additionally, we attached time-interval and percentage value of recurrences of prostate-specific antigen (PSA) as well as death on disease (DoD) to the prognostic grade grouping. Results: Carcinomas of group I/V are very low-grade tumors with very good prognosis without biochemical recurrence and DoD predestining for active surveillance (AS). The group II/V with low progress of PSA without DoD allows the options of an active treatment or AS and shows a prognostic separation of the intermediate group III/V. Within the high-grade groups, a differentiation is necessary between GS 7b (4 + 3), 8, and 9-10 regarding TNM staging and rate of DoD. Prognosis of GS 7b (4 + 3) group III/V is more favourable without DoD in contrast to group IV and V/V with cases of DoD. Conclusion: Morphologically prognostic classification by using combined grading may improve the prognostic stratification of patients with PCa.

SPECIMENS OF URINE OBTAINED FROM YOUNG GIRLS BY CATHETER VERSUS VOIDING

PEDIATRICS ◽  
1959 ◽  
Vol 23 (3) ◽  
pp. 441-452
Author(s):  
Charles V. Pryles ◽  
Nina L. Steg
Keyword(s):  
Urinary Tract ◽  
Epithelial Cells ◽  
Time Interval ◽  
Pertinent Literature ◽  
Diagnostic Significance ◽  
Group Iii ◽  
Group I ◽  
Female Children ◽  
Follow Up Studies

The pertinent literature on bacteriologic study of the urine has been reviewed in brief. Bacteriologic studies, including cultures, Gram stains and colony counts, of catheterized and voided specimens of urine from girls aged 2 to 12 years, were carried out in three groups: Group I: paired specimens (catheter and clean voided). Group II: clean voided specimens. Group III: random non-clean voided specimens. There was a 96.5% positive correlation between catheter and clean voided specimens obtained by a standardized technique from the same patients; the time interval between the two types of examinations was less than 1 hour. Colony counts provide a valid means of differentiating infection from contamination in both clean voided and catheter specimens from female children. The data suggest that urines containing less than 1,000 colonies/ml are indicative of contamination; urines containing between 1,000 and 100,000 colonies/ml are to be suspected of infection, and urines containing more than 100,000 colonies/ml of urine are indicative of infection. Clean voided specimens are valid only if the patient is prepared before collection of the specimen as carefully as for catheterization. Where doubtful results are obtained, the study of more than one specimen of urine is absolutely necessary. In our experience, follow-up studies resolved doubtful findings in every instance. Under certain circumstances, catheterization must remain a necessary procedure in the diagnosis and management of infection of the urinary tract, with the full realization that the use of this instrumentation may involve the risk of introducing infection. Our results confirm previous findings that the presence of organisms in Gram stains in the absence of epithelial cells from catheter or clean voided specimens of urine is of diagnostic significance.

scholarly journals Modulatory Effects of Honey on Gastric Acidity and Plasma Postprandial Bicarbonate in Wistar Rats

2020 ◽  
Vol 10 (3) ◽  
pp. 48-50
Author(s):  
Uchechukwu Ifeanyichukwu Apugo ◽  
Onyebuchi Obia
Keyword(s):  
Gastric Acidity ◽  
Wistar Rats ◽  
Direct Action ◽  
Gastric Ph ◽  
Control Group ◽  
Time Interval ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Ph Level

Introduction: Honey is a naturally occurring sweet substance of plant origin composed mainly of fructose, glucose, water, antioxidants and other constituents. Its enormous constituents confer it with medicinal and nutritive usefulness. Objectives: To assess the modulatory effects of honey on gastric acidity and plasma postprandial bicarbonate in wistar rats. Method: A total of 24 male wistar rats weighing 200-250g were divided into four groups of six rats each; Group I served as control, Group II received 50% Honey (10ml/kg), Group III received omeprazole (20mg/kg) and Group IV received a combination of Omeprazole and Honey. The pH of gastric effluents in each rat was measured 15, 30 and 45mins using a pH meter after administration of the respective substances in each group. Result and Discussion: Both honey and omeprazole respectively caused significant increases in the pH of gastric effluents, however, while that of honey was slow and steady, that of omeprazole was sharp and sustained. The 45-min pH level of omeprazole group was significantly higher than that of honey group. The combined group showed an initial sharp rise similar to omeprazole alone but gradually declined in the succeeding time interval. A combination of omeprazole and honey resulted in 27% reduction in the postprandial serum bicarbonate whereas omeprazole alone caused 41% reduction Conclusion: The present study concludes that honey modulated gastric pH to levels possibly favourable to gastric function by either a direct action of reducing gastric acidity or acting as an antacid or both. Honey therefore could be described as a buffer in omeprazole stimulated gastric acid inhibition and a potential antacid. Keywords: Honey, Gastric acidity, Gastric pH, bicarbonate.

scholarly journals Comparison of Surgical Outcomes with Time Interval of Operation among extradural haematoma (EDH) Patients

2018 ◽  
Vol 4 (1) ◽  
pp. 33-39
Author(s):  
MM Ehsanul Haque ◽  
Shamima Sultana ◽  
Md Saiful Alam ◽  
Wahida Begum ◽  
Syeda Asfiya Ara
Keyword(s):  
Surgical Intervention ◽  
Group Iv ◽  
Time Interval ◽  
Extradural Haematoma ◽  
Group Iii ◽  
Medical College ◽  
Group I ◽  
Study Population ◽  
Death Cases

Background: Post-operative outcome of extradural haematoma (EDH) patients depends on the time interval of operation.Objectives: The purpose of the present study was to evaluate the role of time interval and surgical intervention in EDH.Methodology: This interventional study was carried out in the Department of Neurosurgery at Dhaka Medical College and Hospital, Dhaka, Bangladesh from July 2001 to July 2003 for a period of two (02) years. Patients with the history of head trauma admitted in Neurosurgery unit of Dhaka Medical College and Hospital which were being diagnosed as EDH both clinically and radiologically were included as study population. All patients were treated surgically and haematoma was evacuated. Outcome regarding neurological status, functional recovery, associated morbidity and mortality were assessed in each case as per Glasgow Outcome Scale and was compared between the two groups of patients who were treated surgically within 3rd day and 4th to 7th day after infliction of injury. The study population was devided into 4 groups on the basis of the consciousness level on admission of the patients. The EDH patietns who had GCS <5, 5 to 8, 9 to 12 and 13 to 15 were categorized as group I, II, III and IV respectively. On the basis of pre operative time interval, surgical intervention was done within 3 days of injury and from 4th to 7th day of injury. Craniotomy and craniectomy were done depending on patient’s condition and situation of haematoma.Result: A total 63 patients were included. During admission out of 63 patients majority of the patients were in the group III which was 29(46%) cases. During pre-operqative period out of 63 patients majority of the patients were in the group III which was 30(47.6%) cases. Out of 63 cases a total number of 40 cases were performed the surgery within 72 hours and the rest 23 patients were from 4th day to 7th day of injury. In group I at 8th POD, 3 death cases were recorded at 3rd day operation group and 2 cases at 4th to 7th cases. In group IV at 8th POD follow up good recovery was reported in 6 cases at 3rd day and 3 cases at 4th to 7th day. In group I after 1 month, 3 death cases were recorded at 3rd day operation group and 2 cases at 4th to 7th cases. In group IV after 1 month follow up good recovery was reported in 6 cases at 3rd day and 3 cases at 4th to 7th day; however, moderate disability was reported in 2 cases at 4th to 7th day.Conclusion: In conclusion mortality rate is reduced in patients with EDH who are treated in the earliest possible time after head injuryJournal of National Institute of Neurosciences Bangladesh, 2018;4(1): 33-39

scholarly journals Metabolites able to predict uterine diseases in crossbred dairy cows during the transition period

2018 ◽  
Vol 39 (3) ◽  
pp. 1037 ◽  
Author(s):  
Erick Daibert ◽  
Paula Batista de Alvarenga ◽  
Amanda Lima Rezende ◽  
Nádia Simarro Fagundes ◽  
Barbara Cristina Krüger ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Transition Period ◽  
Body Condition Score ◽  
Negative Energy ◽  
Transitional Period ◽  
Holstein Cows ◽  
Crossbred Cows ◽  
Significant Difference ◽  
Beta Hydroxybutyrate ◽  
Uterine Diseases

This study aimed to identify possible metabolites able to predict puerperal uterine diseases in crossbred dairy cows (Holstein x Gir) in the transition period. We hypothesized that, as what has been observed for Holstein cows, a negative energy balance (NEB) may increase the incidence of uterine diseases. Thirty-four lactating crossbred cows (½HG, ¼HG, ¾HG, and 5/8HG) were evaluated during prepartum (-60d and -30d), calving, and postpartum (+14d, +21d, and +35d) periods, being divided into two groups (with and without uterine diseases). NEB evaluations were based on the concentrations of non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) at calving and 14 days postpartum. Nearly 1/3 of the crossbred cows presented an NEB, characterized by a significant increase in NEFA with no BHBA increase; however, it was less intense than that observed in Holstein cows during the transition period. There was a significant difference between cows with and without uterine diseases in NEFA and calcium concentrations at partum, as well as body condition score (BCS) during prepartum. In conclusion, the occurrence of uterine diseases during the transitional period is related to the BCS in the prepartum period, besides serum NEFA and calcium concentrations at partum.

Abstract 124: Safety of Carotid Endarterectomy and Carotid Stenting in the Early Period After the Neurologic Index Event - Results From the German Quality Assurance Registry on > 50,000 Patients

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Pavlos Tsantilas ◽  
Andreas Kühnl ◽  
Lars Maegdefessel ◽  
Thomas König ◽  
Thorben Breitkreuz ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Regression Analysis ◽  
Mortality Rate ◽  
Carotid Artery ◽  
Carotid Endarterectomy ◽  
Early Period ◽  
Time Interval ◽  
Group Iii ◽  
Index Event ◽  
Group I

Objectives: Current guidelines recommend that carotid endarterectomy (CEA) should be performed within two weeks after the neurologic index event in patients with a 50-99% symptomatic carotid artery stenosis (sCS). Safety of early CEA and early carotid artery stenting (CAS) within those two weeks remains unclair. This study aims to analyze the safety of CEA and CAS in sCS in Germany. Methods: By German law all extracranial carotid procedures have to be documented prospectively in a nationwide quality assurance registry. We analysed data on 56,336 CEAs (68% male, mean age 71 years (SD ± 9.6) and 4,726 CAS (68% male, median age 70 years (SD ± 9.8) treated between 2009-2014 for sCS. The patient cohort was divided into four time interval groups (I: 0-2 days, II: 3-7 days, III: 8-14 days and IV: 14-180 days respectively). Primary endpoint was the combined in-hospital stroke and mortality rate. We excluded all emergency CEAs (stroke-in-evolution, acute occlusion) and all procedures for recurrent carotid stenosis from this analysis. We performed chi-squared tests and a multivariable multilevel Poisson-regression analysis to estimate adjusted risk ratios (RR). Results: The procedural combined stroke and mortality rate was 3.0% (157 of 5198)/6.0% (33 of 550) in group I, 2.5% (480 of 19,117)/4.4% (70 of 1579) in group II, 2.6% (427 of 16,205)/2.4% (30 of 1244) in group III and 2.3% (370 of 15,759)/3.0% (40 of 1344) in group IV respectively. In the multivariable regression analysis the time interval was no independent risk factor for patients treated by CEA. However, CAS was associated with a decreased periprocedural risk when performed 8-14 days (group III) after the index event vs. group I (0-2 days) (RR 0.47, 95% CI 0.28-0.79). No significance was found comparing time group II vs. I (RR 0.80, 95% CI0.52-1.24) and IV vs. I (RR 0.64, 95% CI 0.39-1.05). Conclusion: Time interval between neurologic event and CEA has no significant influence on the perioperative stroke and mortality rate. CAS was associated with a higher risk when performed early. In accordance with the guidelines, CEA remains to be the treatment of choice in the early period after cerebral ischemia.

scholarly journals The Effects of Armillarisin A on Serum IL-1β and IL-4 and in Treating Ulcerative Colitis

2014 ◽  
Vol 72 (1) ◽  
pp. 103-106 ◽  
Author(s):  
Ping Wu ◽  
Yonggao Guo ◽  
Fangyuan Jia ◽  
Xiuli Wang
Keyword(s):  
Ulcerative Colitis ◽  
Treatment Group ◽  
Therapeutic Efficacy ◽  
Therapy Group ◽  
Serum Levels ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Control Group Group

Abstract To study the therapeutic effect of Armillarisin A on patients with ulcerative colitis (UC) and on serum IL-1β and IL-4, sixty patients with UC were randomly divided into three groups: Armillarisin A treatment group (Group I), Armillarisin-combined hormone therapy group (Group II), and hormones treatment as the control group (Group III). Patients in Group I received Armillarisin A 10 mg enema in 100 ml saline. Patients in Group II received Armillarisin A 10 mg and dexamethasone 5 mg enema in 100 ml saline. Patients in Group III received only dexamethasone 5 mg enema in 100 ml saline. The therapeutic efficacy and serum levels of IL-4 and IL-1β were observed. After 4 week treatment, the total effective rates were 90.0 % in Group I and 95.0 % in Group II. Both are higher than it in control group, which was 70.0 %. The serum levels of IL-4 in Groups I and II were significantly higher than it in control group. Compared to IL-4 levels before treatment, the levels of IL-4 after treatment were significantly higher in both Groups I and II. The serum levels of IL-11β were significantly decreased in Groups I and II in comparison to it in control group. Compared to the levels of IL-1β before treatment, the levels of IL-1β were significantly decreased. Armillarisin A shows a significant effect in treating UC. It helps increase IL-4 and lower IL-1β and the mechanism may be related to the body’s immunity regulation.

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