Assessment Of Probiotic Activity and Anti-Oxidant Potential Of Commercially Available Probiotic Chocolate In India

SummaryThe effect of alfa-tocopherol on the cell-cell interactions at the vessel wall were studied, using an in vitro model of human umbilical vein endothelial cell cultures (HUEC). Immune triggered granulocytes (PMN) will adhere to and damage HUEC and platelets enhance this PMN mediated endothelial injury. When HUEC are cultured in the presence of vitamin E, 51Cr-leakage induced by complement stimulated PMN is significantly decreased and the enhanced cytotoxicity by platelets is completely abolished (p <0.001).The inhibition of PMN induced endothelial injury is directly correlated to a diminished adherence of PMN to vitamin E- cultured HUEC (p <0.001), which may be mediated by an increase of both basal and stimulated endogenous prostacyclin (PGI2) from alfa-tocopherol-treated HUEC (p <0.025). The vitamin E-effect is abolished by incubation of HUEC with the irreversible cyclo-oxygenase inhibitor, acetylsalicylic acid, but the addition of exogenous PGI2 could not reproduce the vitamin E-mediated effects.We conclude that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, partly by modulating intrinsic endothelial prostaglandin production. The failure to reproduce vitamin E-protection by exogenously added PGI2 may suggest additional, not yet elucidated vitamin E-effects on endothelial metabolism.

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In-Vitro Anti-oxidant And Antimicrobial Study Of Ficus hispida

Journal of Pharmaceutical Technology Research and Management ◽

10.15415/jptrm.2015.32012 ◽

2015 ◽

Vol 3 (2) ◽

pp. 153-166

Author(s):

Atanu Chatterjee ◽

Jayita Mondal ◽

Rudranil Bhowmik ◽

Anshuman Bhattachayra ◽

Hirak Roy ◽

...

Keyword(s):

Antimicrobial Study ◽

Anti Oxidant ◽

Ficus Hispida

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Anti-hyperglycemic and Anti-oxidant Activities of Submerged Culture Mycelia and Broth of Caterpillar Mushroom Cordyceps militaris (Ascomycetes) in Diabetic Rats

International Journal of Medicinal Mushrooms ◽

10.1615/intjmedmushrooms.2020037439 ◽

2020 ◽

Author(s):

Wen-Tzu Wu ◽

Tai-Hao Hsu ◽

Hui-Chen Lo

Keyword(s):

Submerged Culture ◽

Diabetic Rats ◽

Cordyceps Militaris ◽

Anti Oxidant

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In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

International Journal of Pharmaceutical Research and Life Sciences ◽

10.26452/ijprls.v7i2.1199 ◽

2020 ◽

Vol 7 (2) ◽

pp. 21-24

Author(s):

Pavani C H

Keyword(s):

Medicinal Plants ◽

Chemical Constituents ◽

The Body ◽

Lipid Lowering ◽

Medical Systems ◽

In Vivo Evaluation ◽

Standard Drug ◽

Anti Oxidant ◽

And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

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Pharmacognostical and pharmacological activity of Justicia gendarussa burm.f.: a comprehensive review

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i3.2475 ◽

2020 ◽

Vol 11 (3) ◽

pp. 3384-3390

Author(s):

Ashish ◽

Anjali ◽

Dixit Praveen K ◽

Nagarajan K ◽

Sahoo Jagannath

Keyword(s):

Pharmacological Activity ◽

Chemical Constituents ◽

Biological Action ◽

Andaman Islands ◽

Comprehensive Review ◽

Medicinal Value ◽

Anti Oxidant ◽

Phytochemical Constituents ◽

Pharmacologically Active ◽

Different Parts

Justicia gendarussa Burm .f. (family Acanthaceae) which is also known as willow-leaves and commonly known as Nili-Nirgundi, it is very commonly found nearby to China and its availability is very common in larger parts of India and Andaman islands. Traditionally it is used to treat various sorts of disorders such as wound healing, anti-inflammatory, anti-oxidant, antiproliferative, anti-arthritic etc. Justicia gendarussa is one of the crucial herbs which has been used in the Ayurveda. Majorly leaves parts of the plant shows the pharmacological activity but the root of the plant Justicia gendarussa is also have the important medicinal values. A large variety of pharmacologically active constituents i.e., alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, aminoacids, tannins, phenolics, coumarines and anthaquinones are also present in this plant and they makes the plant pharmacologically important. The activity of the plant is also dependent on the solvent which is used for the extraction the various vital chemical constituents. The different- different parts of the plants having the different medicinal values also differ in the chemical values. This review is not only focused on the essential phytochemical constituents which is available in the plant but it also explains their necessary medicinal value to shows the essential biological action and phytopharmacological actions of various parts of the plant.

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Pharmacological study on the possible involvement of a Nrf2 -Heme oxygenase pathways in anti-cataract activity of fisetin

International Journal of Research in Phytochemistry and Pharmacology ◽

10.26452/ijrpp.v10i1.1156 ◽

2020 ◽

Vol 10 (1) ◽

pp. 14-19

Author(s):

Krishna Reddy BV ◽

Avinash Kumar Reddy G ◽

Sujitha V ◽

Manasa A

Keyword(s):

Oxidative Stress ◽

Heme Oxygenase ◽

Pharmacological Study ◽

World Population ◽

Central Feature ◽

Beneficial Effects ◽

Radical Production ◽

Anti Oxidant ◽

Diabetic Population ◽

Oxidant Status

DM otherwise diabetes is now a days an epidemic with the percentage of patient population rising to almost 10% of the world population. Out of all the DM complications, cataract leads the way contributing to disabilities to about 60% of diabetic population. But the pathogenesis of DM cataract is still a half-understood area of medicine there by posing a problem in the therapy. The data that we have till now gives us enough evidence to advocate the oxidative stress has a major role for the pathogenesis of DM complications like DMnephropathy, DMneuropathy, and cardiac hypertrophy, which suggests the oxidative stress is a central feature of diabetes. In the current research, the pharmacological evaluation of Fisetin for its DM based anti-cataract property was performed. This research concentrates to estimate the possible involvement of Nrf-2 / heme oxygenase (HO)-pathway in the observed therapeutic effect, if any. The data obtained in this study also indicate that the observed beneficial effects mainly due to activation of Nrf2/HO-1 pathway. These effects probably result in increased tissue anti-oxidant status as well as decreased free radical production, which ultimately responsible for the observed beneficial effects of Fisetin against hyperglycemia-induced cataract.

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In-vivo anti-oxidant screening of Tectona grandis extract

International Research Journal of Pharmaceutical and Applied Sciences ◽

10.26452/irjpas.v9i1.1164 ◽

2020 ◽

Vol 9 (1) ◽

pp. 1-4

Author(s):

Tamilarasi G P ◽

Sabarees G

Keyword(s):

Biochemical Parameters ◽

Tectona Grandis ◽

The Body ◽

Altered Expression ◽

Physiological Conditions ◽

Synthetic Drugs ◽

Significant Difference ◽

Anti Oxidant ◽

Radical Generation

Oxidation is an essential reaction in the human body, which determines the expression of proteins in the body. This results in the altered expression like rapid growth resulting in cancers and other disorders. Many synthetic drugs are available in the market that is effective in limiting the free radical generation and the reaction of radicals with cells. Unfortunately, all those synthetic drugs were found to cause side effects and adverse effects in the body. But given the accuracy of the predictability of the results and administration, this research focuses on testing the anti-oxidant efficiency in rat models testing the biochemical parameters. Investigations have also been done on the anti-oxidant activity of Tectona, but every research was concentrated to prove the anti-oxidant activity only. extract had been tested for anti-oxidant activity by estimating various tissue parameters and it showed better activity. As predicted, there is a significant difference in the and results which can be explained are due to the physiological conditions that exist inside the body.

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