scholarly journals Serotonin level in biological fluids as a marker of neuroorthopedic diseases diagnostics and treatment efficiency

2021 ◽  
Author(s):  
M. E. Winderlich ◽  
N. B. Shchekolova
Keyword(s):  
Clinical Practice ◽  
Conservative Treatment ◽  
Biological Fluids ◽  
Serotonin Level ◽  
Treatment Efficiency ◽  
Different Ages ◽  
Orthopedic Diseases ◽  
And Control

This article discusses the issues of studying the dynamics of changes in serotonin in biological fluids as a marker in various neuro-orthopedic diseases in patients of different ages. For this, an analysis of clinical practice has been carried out. It is concluded that changes in serotonin levels can be considered as an indicator of pain sensations and control of ongoing therapy in neuro-orthopedic pathologies. The need for a further indepth study of the existing practice of assessing changes in the level of serotonin in biological fluids during conservative treatment and after surgery in various cases of neuro-orthopedic diseases in patients of different ages is indicated.

scholarly journals THE IMPORTANCE OF EDUCATION TO REDUCE SELF-DESTRUCTIVE NAIL HABITS

2021 ◽  
Vol 4 ◽  
pp. 491-499
Author(s):  
Ilze Upeniece ◽  
Monta Beltiņa
Keyword(s):  
Clinical Practice ◽  
General Education ◽  
Statistical Significance ◽  
Target Population ◽  
Control Group ◽  
Age Related ◽  
Nail Changes ◽  
Group 2 ◽  
And Control ◽  
Traumatic Damage

Onychophagia and onychotillomania are rarely seen in clinical practice and are considered undervalued. The study aims were to determine the prevalence of onychophagia and onychotillomania habit in the patient group with hand nail damage and control group, to determine which would be the target population to educate. Patients were interviewed about self-destructive habits. Excel and SPSS were used for data analysis. In the nail damage group, 28.6% of the respondents showed self-destructive habits and past habits – 31.4%. In the control group, the result was 22.9% and 31.4%. For 74.3% of patients the cause of nail damage was skin disease (including 61.54% of respondents with nail damage who have psoriasis), for 5.7% it was age-related nail changes, for 20% traumatic damage and for 57.14% of them it was a result of self-destructive habit. In the nail damage group both – present and past self-destructive habits are higher than in the control group, but it has no statistical significance (p=0.785). 1)The prevalence of onychophagia and onychotillomania does not differ between patients and control group. 2)General education of the population is necessary to actualize this problem, which can worsen nail changes.

scholarly journals Overview of the actions to combat bacterial resistance in large hospitals

2021 ◽  
Vol 29 ◽  
Author(s):  
Mariana Sanches de Mello ◽  
Adriana Cristina Oliveira
Keyword(s):  
Clinical Practice ◽  
Bacterial Resistance ◽  
Care Center ◽  
Cross Sectional Study ◽  
Research Committee ◽  
Cross Sectional ◽  
Contact Precautions ◽  
Hospital Infection Control ◽  
Care Coordinators ◽  
And Control

Objective: to analyze, in the clinical practice of large hospitals, how the adoption of measures to prevent and control the spread of bacterial resistance has occurred, and to propose a score for the institutions’ adherence. Method: a cross-sectional study carried out in 30 large hospitals of Minas Gerais, from February 2018 to April 2019, after approval by the Ethics and Research Committee. Interviews were conducted with hospital managers, with Hospital Infection Control Services coordinators, and with the care coordinators of the Inpatient Units and Intensive Care Center. In addition, observations were made of the adoption of preventive measures by the multidisciplinary team in the care units. Results: in the 30 participating hospitals, 93.3% (N=28) had protocols for prophylactic antibiotics, and 86.7% (N=26) performed their audit, 86.7% (N=26) for therapeutic antibiotics and 83.3% (N=25) their audit; 93.3% (N=56) used gloves and cloaks for patients in contact precautions, and 78.3% (N=47) of the professionals were unaware of or answered incompletely on the five moments for hand hygiene. In the score to identify the adoption of measures to control bacterial resistance, 83.3% (N=25) of the hospitals were classified as partially compliant, 13.3% (N=04) as deficient, and 3.4% (N=01) as non-adoption. Conclusion: it was found that the recommended measures to contain bacterial resistance are not consolidated in the clinical practice of the hospitals.

The Role of Prevention in Oncology Practice: Results From a 2004 Survey of American Society of Clinical Oncology Members

2006 ◽  
Vol 24 (18) ◽  
pp. 2948-2957 ◽  
Author(s):  
Patricia A. Ganz ◽  
Lorna Kwan ◽  
Mark R. Somerfield ◽  
David Alberts ◽  
Judy E. Garber ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cancer Prevention ◽  
Risk Reduction ◽  
Clinical Oncology ◽  
Prevention And Control ◽  
Cancer Prevention And Control ◽  
Prevention Activities ◽  
American Society ◽  
Oncology Practice ◽  
And Control

Purpose In 2004, the American Society of Clinical Oncology (ASCO) Cancer Prevention Committee surveyed the members to describe involvement in clinical prevention activities. Methods A previously administered survey, with updated items on genetics, chemoprevention, and survivorship, was mailed to a stratified random sample of 2,000 domestic members and a convenience sample of 3,144 international members. Results A total of 49.7% of domestic members contacted and survey eligible responded (n = 851). Nonresponders were younger (50.5 v 51.7 years; P < .01); 465 international members responded. Overall, 35% had received formal instruction in cancer prevention and control, and most respondents expected increased use of prevention, screening/early detection, and risk reduction/genetic counseling in their practices in the next 5 years. Most reported caring for cancer survivors, including providing general medical care. They also either directly provide or refer patients for cancer prevention and control services (eg, cancer screening, tobacco and nutrition counseling, risk reduction, and chemoprevention). Multivariable modeling found fewer perceived barriers to inclusion of cancer prevention activities in clinical practice among those practicing in an academic setting, seeing a higher proportion of patients without a cancer diagnosis, having formal training in prevention and control, expecting an increase in prevention activities in the next 5 years, and providing community advice on prevention. Conclusion Barriers to the inclusion of cancer prevention and control activities in oncology clinical practice exist. Nevertheless, a substantial proportion of both domestic and international ASCO members report an interest in cancer prevention and control activities, with a desire for more specific educational programs in this emerging area of oncology practice.

scholarly journals Advanced Techniques in Clinical Practice: Use of Lab-on-a-Chip Electrophoresis and Other Methods in Protein Profiling

2009 ◽  
Vol 28 (4) ◽  
pp. 274-278 ◽  
Author(s):  
Olgica Trenčevska ◽  
Vasko Aleksovski ◽  
Kiro Stojanoski
Keyword(s):  
Mass Spectrometry ◽  
Clinical Practice ◽  
Cystatin C ◽  
Biological Fluids ◽  
Neurological Diseases ◽  
Protein Profile ◽  
Lab On A Chip ◽  
Protein Profiling ◽  
Complete Analysis ◽  
Potential Biomarker

Advanced Techniques in Clinical Practice: Use of Lab-on-a-Chip Electrophoresis and Other Methods in Protein ProfilingProteins in clinical practice are analyzed as important parameters in the determination and treatment of different diseases. The scopes of the analyses are mainly concentrated in two levels - analyses of the complete protein profile, or determination of an isolated protein. In this work, despite of the use of conventional methods, mainly electrophoresis, new techniques have been implemented in protein analyses. Lab-on-a-chip is an electrophoretic technique that, when optimized, provides analyses of the total protein profile. When normal samples are compared to samples obtained from patients with different neurological diseases, characteristic patterns can be noted. Also, correlation and comparison can be made between the newly developed microchip electrophoresis method and the results obtained using the conventional techniques. When an analysis of a specific protein is necessary, mass spectrometry has proven to give best results, in both the se lectivity and specificity of analyses. It is believed that cystatin C is a potential biomarker in neurological diseases; therefore, the mass spectrometry method has been developed in order to obtain qualitative and quantitative analyses of biological fluids. Using the developed method of mass spectrometry immunoassay (MSIA), cystatin C was easily isolated and analyzed, obtaining complete analysis within minutes. The resulting mass spectra revealed various levels of cystatin C isoforms in serum and CSF samples.

Aromatase inhibitor (AI)-associated arthralgia (A) and bone pain (BP): Frequency and characterization in clinical practice

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 6137-6137 ◽  
Author(s):  
C. A. Presant ◽  
C. Kelly ◽  
L. Bosserman ◽  
G. Upadhyaya ◽  
M. Vakil ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Bone Pain ◽  
Pain Scale ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Consecutive Series ◽  
Disc Disease ◽  
Cancer Centers ◽  
Age Range ◽  
And Control

6137 Background: Prior studies of AI have identified A and/or BP as side effects. Reported incidences have varied from 4% (IMPACT) to 35.6% (ATAC). In order to determine the frequency of A or BP in clinical practice, we reviewed a consecutive series of patients (PTs) receiving AI in community cancer centers. Methods: The charts of consecutive PTs receiving AI were reviewed, and PTs were interviewed regarding the occurrence of A or BP (ABP), severity, whether ABP was worse than before AI therapy, preexisting co-morbidities, type of therapy for ABP, and pain characterization. Results: 56 PTs were receiving AI. The type of AI used was anastrazole in 44 PTs, letrozole in 10 PTs, and exemestane in 2 PTs. The age range was 45 to 89 years. All PTs had breast cancer. The duration AI usage was 1 to 44 mo. Worsening of ABP compared to pretreatment ABP was reported in 34 PTs (61%). In 11 Pts (20%), severity was sufficient and control poor enough to result in discontinuation of AI at a median of 2 mo of AI therapy. The median severity of ABP, when present, was 7.5 on a 10 point pain scale. The character of the ABP was continuous in 20 (59%) and intermittent in 14 (41%), affected central/axial bones in 20 (36%), and peripheral bones in 35 (64%). Coexisting conditions possibly contributing to worsening of ABP occurred in 36%, consisting of degenerative joint disease 10, fibromyalgia 1, osteoporosis 4, and degenerative disc disease 1. Therapy associated with amelioration of symptoms included acetaminophen in 26%, NSAIDs in 45%, mild opiates in 11%, strong opiates in 5%, and glucosamine in 13%. The occurrence of ABP was not associated with age (68% in PTs less than 60 versus 57% in PTs over 60). The occurrence of ABP was not associated with duration of use of AI (50% of 16 Pts on AI for 3–6 mo, 75% for 7–12 mo, and 56% for over 12 mo). Conclusions: The occurrence of AI associated ABP is higher in a non-clinical trial population of PTs than reported in most clinical trials. This side effect is severe enough to cause discontinuation of needed AI therapy in 20%. Further studies are warranted to determine the mechanism of AI associated ABP, and optimal therapy. It is reasonable to consider glucosamine as well as standard analgesics in controlling this syndrome. No significant financial relationships to disclose.

scholarly journals 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea

2017 ◽  
Vol 65 (12) ◽  
pp. 1963-1973 ◽  
Author(s):  
Andi L Shane ◽  
Rajal K Mody ◽  
John A Crump ◽  
Phillip I Tarr ◽  
Theodore S Steiner ◽  
...  
Keyword(s):  
Public Health ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Healthcare Professionals ◽  
Infection Prevention And Control ◽  
Infectious Diarrhea ◽  
And Control

Abstract These guidelines are intended for use by healthcare professionals who care for children and adults with suspected or confirmed infectious diarrhea. They are not intended to replace physician judgement regarding specific patients or clinical or public health situations. This document does not provide detailed recommendations on infection prevention and control aspects related to infectious diarrhea.

scholarly journals Quantification of Cleaved β2-Microglobulin in Serum from Patients Undergoing Chronic Hemodialysis

2005 ◽  
Vol 51 (7) ◽  
pp. 1177-1184 ◽  
Author(s):  
Dorthe B Corlin ◽  
Jette W Sen ◽  
Søren Ladefoged ◽  
Grethe Bjerregaard Lund ◽  
Mogens H Nissen ◽  
...  
Keyword(s):  
Biological Fluids ◽  
Chronic Hemodialysis ◽  
Mass Spectrometry Analysis ◽  
Dialysis Patients ◽  
Serum Samples ◽  
Polysulfone Membrane ◽  
Β2 Microglobulin ◽  
And Control

Abstract Background: Patients on chronic hemodialysis are prone to develop amyloid deposits of misfolded β2-microglobulin (β2M) in osteoarticular tissues. β2M with various deletions/truncations and chemical modifications has been found together with structurally intact β2M in extracts of β2M amyloid fibrils. The state of the circulating population of β2M molecules has not been characterized previously with high-resolution methods. Methods: We used immunoaffinity–liquid chromatography–mass spectrometry analysis of serum samples to examine whether structurally modified β2M is generated in the circulation. In addition, we developed an immunoassay for the quantification of a cleaved β2M variant in biological fluids based on novel monoclonal antibodies and applied this assay to patient and control sera. Results: A specific alteration compatible with the generation of lysine-58–cleaved and truncated β2M (ΔK58-β2M) was found in the sera of many (20%–40%) dialysis patients but not in control sera or sera from patients with cerebral amyloidosis (Alzheimer disease). Applied to patient sera, specific immunoassays revealed that dialysis, as expected, significantly lowered the total β2M concentration, but the concentrations of ΔK58-β2M remained unchanged after dialysis. The results also show that patients dialyzed with less biocompatible membranes have higher serum concentrations of cleaved β2M (mean, 8.5, 1.8, and 0.7 mg/L in cuprophane membrane-dialyzed, polysulfone membrane-dialyzed, and control sera, respectively). Conclusions: This study for the first time demonstrates and assigns the structure of a specific β2M variant in sera from dialysis patients. Because this variant is conformationally unstable in vitro, it may be involved in in vivo amyloidogenesis.

The Use of Clinical Practice Guidelines (CPGs) to Evaluate Practice and Control Costs in Ventriculoperitoneal Shunt Management

1997 ◽  
Vol 48 (6) ◽  
pp. 536-541 ◽  
Author(s):  
John K Park M.D., Ph.D. ◽  
David M Frim M.D., Ph.D. ◽  
Marc S Schwartz M.D. ◽  
Patricia Reidy R.N., P.N.P. ◽  
Judith A Farley R.N. ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Ventriculoperitoneal Shunt ◽  
And Control

scholarly journals KuLGaP: A Selective Measure for Assessing Therapy Response in Patient-Derived Xenografts

2020 ◽  
Author(s):  
Janosch Ortmann ◽  
Ladislav Rampášek ◽  
Elijah Tai ◽  
Arvind Singh Mer ◽  
Ruoshi Shi ◽  
...  
Keyword(s):  
Experimental Data ◽  
Clinical Practice ◽  
Mouse Models ◽  
Tumor Size ◽  
Human Cancer ◽  
Therapy Response ◽  
Treatment Development ◽  
The Difference ◽  
And Control ◽  
Over Time

AbstractQuantifying response to drug treatment in mouse models of human cancer is important for treatment development and assignment, and yet remains a challenging task. A preferred measure to quantify this response should take into account as much of the experimental data as possible, i.e. both tumor size over time and the variation among replicates. We propose a theoretically grounded measure, KuLGaP, to compute the difference between the treatment and control arms. KuLGaP is more selective than currently existing measures, reduces the risk of false positive calls and improves translation of the lab results to clinical practice.

scholarly journals Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

2013 ◽  
Vol 2 ◽  
pp. 7
Author(s):  
Li Liu
Keyword(s):  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
The Difference ◽  
And Control ◽  
Group Observation

<p><strong>Objective: </strong>To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. <strong>Method: </strong>From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. <strong>Results: </strong>The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, <em>p</em> &lt; 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. <strong>Conclusion: </strong>Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.</p>

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