scholarly journals Radiation-sensitive film compositions for measuring absorbed doses within the 100-1000 Gy range

2019 ◽  
Vol 15 (3) ◽  
pp. 33-40 ◽  
Author(s):  
V. P. Tenishev ◽  
I. A. Emelyanenko
Keyword(s):  
Food Processing ◽  
Dose Range ◽  
Absorbed Dose ◽  
Ionising Radiation ◽  
Film Dosimetry ◽  
Absorbed Doses ◽  
Sensitive Film ◽  
Russian Research Institute ◽  
Agriculture And Food ◽  
Russian Research

This work was aimed at investigating the spectral features and dose sensitivities of film dosimetry systems developed at the All-Russian Research Institute for Physical-Engineering and Radiotechnical Metrology (VNIIFTRI) and approved as absorbed-dose reference materials. The properties of new radiation-sensitive compositions for high-intensity ionising radiation in the absorbed-dose range from 100 to 1000 Gy were studied. Dosimetric measurements in this range are in demand in the sphere of ionising radiation technologies used in agriculture and food-processing industries.

Acute toxicity of an insecticidal little containing ivermectin and fipronil for white mice

2020 ◽  
pp. 31-32
Author(s):  
Mikhail A. Levchenko ◽  
◽  
Natalia A. Sennikova ◽  
Keyword(s):  
Acute Toxicity ◽  
Lethal Dose ◽  
Live Weight ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Russian Research Institute ◽  
Veterinary Entomology ◽  
Russian Research

Toxicological assessment is a mandatory research step in the development of new insecticidal drugs. At the All-Russian Research Institute of Veterinary Entomology and Arachnology, a prototype of the insecticidal bait Mukhnet IF was obtained with an active ingredient content of 0.06% ivermectin and 0.015% fipronil, which showed a highly effective effect against houseflies. This work presents the results of the study of acute oral toxicity of the above agent. For this, male white mice with a live weight of 16-26 g were selected. They were kept on a starvation diet for one day in individual houses with water. The drug was given in mg/kg body weight the next day. A total of 33 doses have been tested, ranging from 100 mg/kg to 40,000 mg/kg. The animals were observed for 14 days. According to the research results, it was revealed that at doses up to 20,000 mg/kg there were no signs of intoxication, but when tested at 25,000 mg/kg in some mice, these signs were noted, and at 30,000, 35,000 and 40,000 mg/kg deaths were recorded 20±10, 45±30 and 60±20%, respectively. It was not possible to test the drug over the last above dose due to incomplete eaten by mice. According to the degree of danger for warm-blooded animals, the drug belongs to the 4th class of low-hazard drugs (average lethal dose of 5000 mg/kg or more) in accordance with the classification of GOST 12.1.007-76. When analyzing the literature data on the toxicological characteristics of preparations containing ivermectin and chlorfenapyr, it was revealed that the insecticidal agent in its acute toxicity for warm-blooded animals is comparable to known analogues.

scholarly journals α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [223Ra]RaCl2-treated prostate cancer patients

2021 ◽  
Author(s):  
S. Schumann ◽  
U. Eberlein ◽  
C. Lapa ◽  
J. Müller ◽  
S. Serfling ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Patients ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Absorbed Dose ◽  
Peripheral Blood Mononuclear ◽  
Absorbed Doses ◽  
Blood Mononuclear Cells

Abstract Purpose One therapy option for prostate cancer patients with bone metastases is the use of [223Ra]RaCl2. The α-emitter 223Ra creates DNA damage tracks along α-particle trajectories (α-tracks) in exposed cells that can be revealed by immunofluorescent staining of γ-H2AX+53BP1 DNA double-strand break markers. We investigated the time- and absorbed dose-dependency of the number of α-tracks in peripheral blood mononuclear cells (PBMCs) of patients undergoing their first therapy with [223Ra]RaCl2. Methods Multiple blood samples from nine prostate cancer patients were collected before and after administration of [223Ra]RaCl2, up to 4 weeks after treatment. γ-H2AX- and 53BP1-positive α-tracks were microscopically quantified in isolated and immuno-stained PBMCs. Results The absorbed doses to the blood were less than 6 mGy up to 4 h after administration and maximally 16 mGy in total. Up to 4 h after administration, the α-track frequency was significantly increased relative to baseline and correlated with the absorbed dose to the blood in the dose range < 3 mGy. In most of the late samples (24 h – 4 weeks after administration), the α-track frequency remained elevated. Conclusion The γ-H2AX+53BP1 assay is a potent method for detection of α-particle-induced DNA damages during treatment with or after accidental incorporation of radionuclides even at low absorbed doses. It may serve as a biomarker discriminating α- from β-emitters based on damage geometry.

Blue lupine — source of valuable nutrients in forage production

2020 ◽  
pp. 29-33
Author(s):  
П.А. Агеева ◽  
Н.А. Почутина ◽  
М.В. Матюхина
Keyword(s):  
Lupinus Angustifolius ◽  
Maturity Stage ◽  
Forage Production ◽  
Carotene Content ◽  
Green Mass ◽  
Russian Research Institute ◽  
Grain Productivity ◽  
Southwest Region ◽  
Livestock Feeding ◽  
Russian Research

Научная работа выполнена во Всероссийском научно-исследовательском институте люпина в условиях Юго-Западного региона Нечернозёмной зоны Российской Федерации в 2017–2018 годах. Целью исследований было изучение и оценка районированных сортов и перспективных сортообразцов узколистного люпина (Lupinus angustifolius L.) собственной селекции по урожайности зерна, зелёной массы, выходу сырого протеина и других питательных веществ, необходимых при приготовлении кормов для различных животных и птицы. По урожайности зерна (соответственно 3,00 и 2,93 т/га) и зелёной массы (38,3 и 36,3 т/га) выделились новые сортономера Узколистный 53-02 и СмW 62-17. Диапазон превышения по отношению к стандарту по этим показателям составил: по Узколистному 53-02 — 18,1–21,0%, по СмW 62-17 — 22,2–29,0%. Содержание алкалоидов в зерне этих вариантов — 0,041–0,042%. Минимальная алкалоидность (0,038%) отмечена у сортов Белорозовый 144 и Смена. Максимальный сбор белка (1003 кг/га) с урожаем зерна обеспечил Узколистный 53-02; с урожаем зелёноукосной продукции — сорт Белорозовый 144 (1002 кг/га). Максимальное содержание каротина (73,3 мг/кг) получено у сорта Брянский кормовой в фазу цветения. В период технологической спелости зелёной массы по содержанию каротина (45,2 мг/кг) он также был в числе лучших. Во Всероссийском НИИ люпина разработаны сбалансированные по необходимым питательным веществам рационы с использованием зерна и зелёной массы различных сортов узколистного люпина и проведены многочисленные опыты на различных производственных группах крупного рогатого скота, свиньях и птице. Привлекательность узколистного люпина для использования в производстве связана с тем, что из крупносемянных видов он один из самых скороспелых, холодостойких и устойчивых к антракнозу. The research was conducted in the Southwest region of the Non-Chernozem zone of Russia in 2017–2018. The aim was to evaluate promising genotypes of blue lupine (Lupinus angustifolius L.) regarding their grain productivity, yields of green mass, crude protein and other valuable nutrients for livestock feeding. “Uzkolistnyy 53-02” and SmW 62-17 genotypes had the highest productivity of grain (3.00 and 2.93 t ha-1) and green mass (38.3 and 36.3 t ha-1, respectively). Hence yield increases amounted to 18.1–21.0% (“Uzkolistnyy 53-02”) and 22.2–29.0% (SmW 62-17), respectively. Alkaloid concentration reached 0.041–0.042% in their grain. Grains of “Belorozovyy 144” and “Smena” varieties accumulated the least alkaloids. Grain of “Uzkolistnyy 53-02” and green mass of “Belorozovyy 144” were rich in protein — 1003 and 1002 kg ha-1, respectively. “Bryanskiy kormovoy” had the highest carotene content of 73.3 mg/kg at flowering time. It showed high carotene concentration also at green mass maturity stage. The All-Russian Research Institute of Lupine developed balanced diets for grain and green forage from blue lupine and tested their effect on cattle, pigs, and poultry. Blue lupine is a valuable crop for forage production due to large seed size, early ripeness as well as resistance to cold and pod spot.

STUDY OF POLYMORPHISM OF RED CURRANT VARIETIES MICROSATELLITE LOCUS

1970 ◽  
pp. 20-23
Author(s):  
М. А. Dolzhikova ◽  
А. А. Pavlenko ◽  
А. V. Pikunova ◽  
O. D. Golyaeva
Keyword(s):  
Microsatellite Locus ◽  
Red Cross ◽  
Fragment Analysis ◽  
Russian Research Institute ◽  
The Usa ◽  
Specific Locus ◽  
The Russian Federation ◽  
Grape Varieties ◽  
Red Currant ◽  
Russian Research

In the presented studies the genotypes of 46 varieties of red currant (Ribes rubrum) from the All-Russian Research Institute of Fruit Crops Breeding (VNIISPK) the collection were studied for 14 microsatellite locus. The data were obtained by the detection method of – fragment analysis using capillary electrophoresis. Varieties with rare, unique alleles and combinations of alleles have been identified. In most cases, no more than two fragments were identified for each genotype for a specific locus, but three fragments at some loci were amplified in the samples (Orlovchanka, Konstantinovskaya, Nadezhda – e3-B02; Marmeladnitsa – g2-G12; Nadezhda – g2-J08; Svetlitsa, Tatianina – g1-L12). The profiles of the cultivars Cascad and Red cross are identical to each other, although they differ from the others. The Red cross [(Cherry × White Grape] and Cascad [(free pollination of the variety Diploma (Cherry × White grape)]] varieties were developed in the USA and have common ancestors. It can be assumed the collection under different names contains the same genotype or that these pairs of varieties are so similar that the polymorphism of the analyzed loci is not enough to distinguish them. To prevent a shift in the size of alleles control varieties were selected and proposed, zoned in the territory of the Russian Federation – Gazelle (originator of VNIISPK: Chulkovskaya × Maarses Prominent) and Valentinovka (originator of VNIISPK: Rote Shpetlese × Jonker van Tets). The data obtained on the polymorphism microsatellite loci Red currant can be used for further identification.

scholarly journals Agrophysical and Biological Properties of Drainage Soils in Land Reclamation

2017 ◽  
Vol 9 (11) ◽  
pp. 259
Author(s):  
Yu. I. Mitrofanov ◽  
G. Yu. Rabinovich
Keyword(s):  
Land Reclamation ◽  
Biological Properties ◽  
Soil Conditions ◽  
Integral Index ◽  
Technique Effect ◽  
Nitrogen Fixers ◽  
Russian Research Institute ◽  
Number Of Microorganisms ◽  
Land Improvement ◽  
Russian Research

This paper presents the results of the research carried out in the All-Russian Research Institute of Reclaimed Lands. It has been established that land improvement techniques increased the integral index of physical soil conditions from 0.41-0.60 to 0.80-0.86. The soil demonstrated a greater total number of microorganisms, as well as certain physiological groups such as actinomycetes, autochthonous and especially nitrogen-fixers; but the number of fungi and denitrifiers, as well as the fungi causing the Fusarium wilt of the plants, decreased.Average crops increase achieved with the help of deep reclaiming band tillage of drained gleyish soil to depth 50-60 cm was 9.0-24.1% in both wet and dry years. This land improvement technique effect lasts for two-three years or longer. The ridged plowing compared to the ordinary plowing raised the spring crops by 0.55-0.61 ton/ha (by 16.9-17.5%) without making any additional expenditures.

scholarly journals Is nuclear medicine really safe?

2002 ◽  
Vol 45 (spe) ◽  
pp. 115-118
Author(s):  
Nicole Colas-Linhart
Keyword(s):  
Nuclear Medicine ◽  
Human Serum Albumin ◽  
Radiation Dose ◽  
Serum Albumin ◽  
Human Serum ◽  
Absorbed Dose ◽  
Cellular Level ◽  
Whole Body ◽  
Absorbed Doses ◽  
Standard Models

In nuclear medicine, radiation absorbed dose estimates calculated by standard models at the whole body or organ are very low. At cellular level, however, the heterogeneity of radionuclide distributions of radiation dose patterns may be significant. We present here absorbed doses at cellular level and evaluate their possible impact on the usually assumed risk/benefit relationships in nuclear medicine studies. The absorbed dose values calculated are surprisingly high, and are difficult to interpret. In the present study, we show calculated doses at the cellular level and discuss possible biological consequences, for two radiopharmaceuticals labelled with technetium-99m: human serum albumin microspheres used for pulmonary scintigrapies and HMPAO used to labelled leukocytes.

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