scholarly journals Super Long Green Persistent Luminescence from X-Ray Excited β-NaYF4: Tb3+

2019 ◽  
Author(s):  
Yue Hu ◽  
Yanmin Yang ◽  
Xiaoxiao Li ◽  
Xin Wang ◽  
Yunqian Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Source ◽  
Green Emission ◽  
Persistent Luminescence ◽  
Tunneling Model ◽  
X Ray ◽  
Long Afterglow ◽  
Photo Stability ◽  
F Centers

Here, we have discovered a X-ray excited long afterglow phosphor β-NaYF4: Tb3+. After the irradiation of X-ray, the green emission can persist for more than 240 h. After 36 h, the afterglow intensity arrived at 0.69 mcd•m-2, which can clearly be observed by naked eyes. Even after 84 h, the afterglow emission brightness still reached 0.087 mcd•m-2. Also, combined with the results of thermoluminescence and photoluminescence, the super long afterglow emission of β-NaYF4: Tb3+ can be ascribed to the tunneling model associated with F centers. More importantly, the super long green afterglow emission of β-NaYF4: Tb3+ has been successfully used as in vivo light source to activate g-C3N4 for photodynamic therapy（PDT）and bacteria destruction. Furthermore, super long persistent luminescence of β-NaYF4: Tb3+ could be repeatedly charged by X-ray for many circulations, which indicates that the phosphors have high photo stability under repeated cycles of alternating X-ray irradiation.

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

scholarly journals The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applications

2020 ◽  
Vol 27 (5) ◽  
pp. 1395-1414 ◽  
Author(s):  
Benedikt Günther ◽  
Regine Gradl ◽  
Christoph Jud ◽  
Elena Eggl ◽  
Juanjuan Huang ◽  
...  
Keyword(s):  
Light Source ◽  
Phase Contrast ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
X Ray ◽  
Inverse Compton Scattering ◽  
University Of Munich ◽  
Inverse Compton ◽  
Compact Light Source

Inverse Compton scattering provides means to generate low-divergence partially coherent quasi-monochromatic, i.e. synchrotron-like, X-ray radiation on a laboratory scale. This enables the transfer of synchrotron techniques into university or industrial environments. Here, the Munich Compact Light Source is presented, which is such a compact synchrotron radiation facility based on an inverse Compton X-ray source (ICS). The recent improvements of the ICS are reported first and then the various experimental techniques which are most suited to the ICS installed at the Technical University of Munich are reviewed. For the latter, a multipurpose X-ray application beamline with two end-stations was designed. The beamline's design and geometry are presented in detail including the different set-ups as well as the available detector options. Application examples of the classes of experiments that can be performed are summarized afterwards. Among them are dynamic in vivo respiratory imaging, propagation-based phase-contrast imaging, grating-based phase-contrast imaging, X-ray microtomography, K-edge subtraction imaging and X-ray spectroscopy. Finally, plans to upgrade the beamline in order to enhance its capabilities are discussed.

In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source

2019 ◽  
Author(s):  
Kaye Morgan ◽  
Regine Gradl ◽  
Martin Dierolf ◽  
Christoph Jud ◽  
Benedikt Günther ◽  
...  
Keyword(s):  
Light Source ◽  
Respiratory System ◽  
X Ray ◽  
X Ray Imaging ◽  
Compact Light Source

scholarly journals Technical and dosimetric realization of in vivo x‐ray microbeam irradiations at the Munich Compact Light Source

2020 ◽  
Vol 47 (10) ◽  
pp. 5183-5193 ◽  
Author(s):  
Karin Burger ◽  
Theresa Urban ◽  
Annique C. Dombrowsky ◽  
Martin Dierolf ◽  
Benedikt Günther ◽  
...  
Keyword(s):  
Light Source ◽  
X Ray ◽  
Compact Light Source

scholarly journals Persistent luminescence materials for deep photodynamic therapy

Nanophotonics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2999-3029 ◽  
Author(s):  
Aurélie Bessière ◽  
Jean-Olivier Durand ◽  
Camille Noûs
Keyword(s):  
Photodynamic Therapy ◽  
Uv Light ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Charge Trapping ◽  
Full Potential ◽  
Persistent Luminescence ◽  
Living Tissues

Abstract Persistent luminescence (PerL) materials continue emitting light long after their excitation has stopped. Prepared in the form of nanoparticles they revealed their full potential as bio-nanoprobes for in vivo small animal imaging in the last 15 years. PerL materials enable to overcome the limitation of weak light penetration in living tissues. As such, they constitute remarkable light mediators to implement photodynamic therapy (PDT) in deep-seated tissues. This article reviews the recent achievements in PerL-mediated PDT in vitro as well as in small animal cancer models in vivo. PerL-mediated PDT is realized through the smart choice of a tandem of a PerL material and a photosensitizer (PS). The physical association of the PerL material and the PS as well as their targeting ability is debated. Implants or mesoporous nanoparticles emerge as particularly valuable cargos that further permit multimodality in imaging or therapy. The diversity of charge-trapping mechanisms in a few PerL materials enables a large versatility in the excitation protocols. Although the PerL agent can be pre-excited by UV light before its introduction into the animal, it also induces effective PDT after simple infrared or visible LED illumination across tissues as well as after a mild X-ray irradiation.

scholarly journals X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors

2019 ◽  
Vol 116 (34) ◽  
pp. 16823-16828 ◽  
Author(s):  
Samana Shrestha ◽  
Jing Wu ◽  
Bindeshwar Sah ◽  
Adam Vanasse ◽  
Leon N Cooper ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Method ◽  
The Body ◽  
Target Cells ◽  
X Rays ◽  
X Ray ◽  
Mouse Tumors ◽  
Study Results ◽  
New Type

Photodynamic therapy (PDT), a treatment that uses a photosensitizer, molecular oxygen, and light to kill target cells, is a promising cancer treatment method. However, a limitation of PDT is its dependence on light that is not highly penetrating, precluding the treatment of tumors located deep in the body. Copper-cysteamine nanoparticles are a new type of photosensitizer that can generate cytotoxic singlet oxygen molecules upon activation by X-rays. In this paper, we report on the use of copper-cysteamine nanoparticles, designed to be targeted to tumors, for X-ray–induced PDT. In an in vivo study, results show a statistically significant reduction in tumor size under X-ray activation of pH-low insertion peptide–conjugated, copper-cysteamine nanoparticles in mouse tumors. This work confirms the effectiveness of copper-cysteamine nanoparticles as a photosensitizer when activated by radiation and suggests that these Cu-Cy nanoparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conjugated to a tumor-targeting molecule.

Synthesis of Fe3O4/ZnO Core-shell Nanoparticles for Photodynamic Therapy Applications

2010 ◽  
Vol 1257 ◽  
Author(s):  
Juan C. Beltran Huarac ◽  
Surinder P. Singh ◽  
Maharaj S. Tomar ◽  
Sandra Peňa ◽  
Luis Rivera ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photoelectron Spectroscopy ◽  
Green Emission ◽  
Core Shell ◽  
Light Sources ◽  
X Ray Diffraction ◽  
Shell Nanoparticles ◽  
X Ray ◽  
Core Shell Nanoparticles

AbstractThe use of nanoparticles as carriers of photosensitizer (PS) molecules for photodynamic therapy (PDT) has attracted much interest on core-shell nanosize structures. Herein, we used a simple aqueous solution method to synthesize Fe3O4/ZnO core-shell nanoparticles. X-ray diffraction (XRD) analyses showed the presence of well defined peaks corresponding to Fe3O4 and ZnO in as-synthesized nanocrystals. Vibrating sample magnetometer (VSM) measurements showed that these nanoparticles exhibited superparamagnetic behavior of the core with no coercivity nor remanence. X-ray photoelectron spectroscopy (XPS) analyses revealed the presence of Zn1/2 and Zn3/2 species on the surface of nanocrystals. Photoluminescence measurements showed excitonic emission of ZnO co-existing with a weak and broad defect- related green emission at room temperature. The generation of singlet oxygen was monitored via the photooxidation of diphenyl-1,3-isobenzofuran (DPBF) with different light sources, followed by absorption spectroscopy at 409 nm. The capability of synthesized nanoparticles to generate singlet oxygen has also been verified.

scholarly journals Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS)

2008 ◽  
Author(s):  
Russell Kincaid ◽  
Andrzej Krol ◽  
Sylvain Fourmaux ◽  
Jean-Claude Kieffer ◽  
Cristina Serbanescu ◽  
...  
Keyword(s):  
Light Source ◽  
Biomedical Applications ◽  
Phase Contrast ◽  
Laser Light ◽  
Ultrafast Laser ◽  
Micro Ct ◽  
X Ray ◽  
Laser Light Source
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