scholarly journals Quantitative Analysis of the Steroidal Calcitriol-Mediated Regulation of the Serological Components Responsible for IDA and TSH Disorders in Reproductive and Nonproductive Women

2021 ◽  
Author(s):  
Salauddin Al Azad ◽  
Sharmin Ahmed ◽  
Partha Biswas ◽  
Md. Abdur Rashid Mia ◽  
Mithila Farjana ◽  
...  
Keyword(s):  
Binding Capacity ◽  
Age Groups ◽  
Thyroid Stimulating Hormone ◽  
Strong Interactions ◽  
Health Issues ◽  
Child Bearing ◽  
The Individual ◽  
Serological Data ◽  
Iron Binding Capacity ◽  
Hormone Analysis

Anemia and thyroid disorders are global health issues that affect all ages but are more apparent in women. In this case, some serological components responsible for IDA and TSH disorders in women have been found actively regulated through a complex steroidal-calcitriol mediated pathway. This research has been investigated the correlation between Calcitriol and the serological components responsible for IDA and TSH disorders in childbearing and non-child-bearing women of different health conditions. Experimental sampling from 452 women suffering from both IDA and TSH disorders were taken, aged between 0 and 70 years. Serological parameters, such as iron, total iron-binding capacity and ferritin, were assessed for IDA profiling, whereas thyroid-stimulating hormone and free thyroxin were for TSH profiling based on the individual’s serum calcitriol status. The resulted serological data were interpreted using sophisticated computer programming language and algorithms for quantitative biochemical analysis. The study resulted in a significant correlation between FT4 and Calcitriol (P<0.0001) for all age groups. TSH also showed strong interactions with the fluctuation of calcitriol level (P<0.0001), except for the children aged below 10 years (P<0.063). The iron, TIBC, TSH, and FT4 showed phenomenal regulation with the steroidal-calcitriol concentration for congenital patients. Unlike the others, ferritin has a substantial connection with Calcitriol (P<0.0064) fluctuation in the serum. To ratify, the concentrations of TSH, FT4, iron, TIBC, and ferritin were found to be significantly interconnected in terms of serum calcitriol level in women suffering from IDA and TSH disorders simultaneously. To understand the accuracy and efficacy of the Calcitriol in IDA and TSH disorders, some other inflammatory markers and parathyroid hormone analysis are need in future studies, besides a large number of samples.

Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey

2006 ◽  
Vol 44 (7) ◽  
Author(s):  
Yesim Ozarda Ilcol ◽  
Diler Aslan
Keyword(s):  
Binding Capacity ◽  
Clinical Chemistry ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Patient Data ◽  
Clinical Chemical ◽  
Laboratory Results ◽  
Total Triiodothyronine ◽  
Iron Binding Capacity ◽  
Indirect Reference

AbstractIn the present study we used patient data to calculate laboratory-specific indirect reference intervals. These values were compared with reference intervals obtained for a healthy group according to recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine and manufacturer suggestions. Laboratory results (422,919 records) from all subjects of 18–45years of age over a 1-year period were retrieved from our laboratory information system and indirect reference intervals for 40 common analytes were estimated using a modified Bhattacharya procedure. Indirect reference intervals for most of the biochemical analytes were comparable, with small differences in lower [alkaline phosphatase (ALP) (male), alanine aminotransferase (ALT), creatine kinase, iron (male), total iron-binding capacity, folic acid, calcium (female), lactate dehydrogenase (LDH), lipoprotein (a) [Lp(a)], thyroid-stimulating hormone (TSH), total triiodothyronine (TClin Chem Lab Med 2006;44:867–76.

Herpesvirus infection as one of the causes of anemia

2019 ◽  
Vol 24 (2) ◽  
pp. 161-166 ◽  
Author(s):  
О. A. Uspenskaya ◽  
S. A. Spiridonova
Keyword(s):  
Chronic Disease ◽  
Viral Infection ◽  
Binding Capacity ◽  
Herpesvirus Infection ◽  
Hemoglobin Content ◽  
Anemia Of Chronic Disease ◽  
Tnf Α ◽  
Iron Binding Capacity ◽  
Timely Treatment ◽  
Average Hemoglobin

Relevance. One of the causes of chronic disease is herpetic infection, lifelong persistence in the human body and activates the macrophage protection system, which leads to disruption of iron utilization by the cells of the hematopoietic system and the development of anemia of chronic disease. To prove the influence of herpesvirus infection on the occurrence of anemia of chronic disease.Materials and methods. The study involved 75 people suffering from herpes-viral infection. 3 groups were allocated: the frst group (25 people) received acyclovir 1 tablet (200 mg) 5 times a day, 5 days; The 2-nd group (25 people) used famvir for 1 tablet (250 mg) 2 times a day, 5 days; The third group (25 people) – famvir 1 tablet (250 mg) 2 times a day, 5 days and kagocel 2 tablets (12 mg) 3 times a day, 5 days.Result. All subjects examined at the time of treatment showed an increase in the content of IL 1β mRNK and TNF-α and a decrease in mRNK of IL 8 and IL 10; on day 14 of the study, a decrease in IL 1β mRNK and TNF-α mRNK and an increase in IL 10 mRNK. In the study of erythrocyte indices – the average volume of erythrocytes and the average hemoglobin content in erythrocyte and the parameters of iron-serum iron metabolism and the total iron binding capacity of the serum, slight deviations from the norm were obtained.Conclusions. Thus, we concluded that the cause of anemia, in addition to the lack of iron, can be chronic herpesvirus infection, and thus timely treatment of a viral infection excludes the use of ferrotherapy.

scholarly journals Validity of the Gender Dysphoria diagnosis and incidence trends in Sweden: a nationwide register study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Malin Indremo ◽  
Richard White ◽  
Thomas Frisell ◽  
Sven Cnattingius ◽  
Alkistis Skalkidou ◽  
...  
Keyword(s):  
Gender Dysphoria ◽  
Age Groups ◽  
Medical Intervention ◽  
Future Research ◽  
Advantages And Disadvantages ◽  
Incidence Trends ◽  
Interaction Terms ◽  
Definition Of ◽  
The Individual ◽  
Nationwide Register Study

AbstractThe aim of this study was to examine the validity of the Gender Dysphoria (GD) diagnoses in the Swedish National Patient Register (NPR), to discuss different register-based definitions of GD and to investigate incidence trends. We collected data on all individuals with registered GD diagnoses between 2001 and 2016 as well as data on the coverage in the NPR. We regarded gender confirming medical intervention (GCMI) as one proxy for a clinically valid diagnosis and calculated the positive predictive value (PPV) for receiving GCMI for increasing number of registered GD diagnoses. We assessed crude and coverage-adjusted time trends of GD during 2004–2015 with a Poisson regression, using assigned sex and age as interaction terms. The PPV for receiving GCMI was 68% for ≥ 1 and 79% for ≥ 4 GD-diagnoses. The incidence of GD was on average 35% higher with the definition of ≥ 1 compared to the definition of ≥ 4 diagnoses. The incidence of GD, defined as ≥ 4 diagnoses increased significantly during the study period and mostly in the age categories 10–17 and 18–30 years, even after adjusting for register coverage. We concluded that the validity of a single ICD code denoting clinical GD in the Swedish NPR can be questioned. For future research, we propose to carefully weight the advantages and disadvantages of different register-based definitions according to the individual study’s needs, the time periods involved and the age-groups under study.

scholarly journals Incidence of Characteristic Findings during Veterinary Carcass Inspections 2010–2019 in the Czech Republic and the Relation to the Level of Health and Welfare of Individual Classes of Cattle

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 537
Author(s):  
Michal Kaluza ◽  
Vladimir Vecerek ◽  
Eva Voslarova ◽  
Zbynek Semerad ◽  
Annamaria Passantino
Keyword(s):  
Czech Republic ◽  
Health Issues ◽  
Pathological Findings ◽  
Pathological Changes ◽  
Great Intensity ◽  
The Czech Republic ◽  
Stunted Growth ◽  
Liver And Pancreas ◽  
Systemic Disorder ◽  
The Individual

Pathological findings in individual classes of cattle were assessed from the viewpoint of their localization and category. The objective of the study was to evaluate whether there are differences in the range and number of findings made between the individual classes of cattle. The results of veterinary inspections on 2,514,666 head of cattle slaughtered in the Czech Republic in the period 2010–2019 were used for the assessment. In terms of localization, the most frequent findings in cows were in the liver and pancreas (46.13%), the urinary tract (40.76%) and the lungs (36.23%). These findings also predominated in heifers and bulls, though they were recorded at lower frequencies (p < 0.01) than in cows. The most frequent pathological changes in heifers and bulls were chronic findings in the lungs (16.09% and 12.27%, respectively). The range of findings in calves differed significantly from other classes of cattle, primarily as the result of respiratory and diarrheal syndrome being the most frequent diseases in calves. Calves were the class of cattle most frequently diagnosed with findings in the lungs (44.89%), as well as other unclassified changes (24.43%) and overall changes (21.55%), which point to a systemic disorder of the organism. The results of this study confirmed the differing states of health in the individual classes of cattle and the differing health issues to which treatment and the prevention of the most frequently occurring infectious and non-infectious diseases must be adapted. Cattle welfare is affected not only by the level of health but also by the herd management and economics. This is confirmed by the range of findings, and the deterioration of living conditions especially in cows, likely because of great intensity of farming, but also in calves which suffered from emaciation or stunted growth.

scholarly journals Empowerment among adult patients with type 2 diabetes: age differentials in relation to person-centred primary care, community resources, social support and other life-contextual circumstances

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nina Simonsen ◽  
Anne M. Koponen ◽  
Sakari Suominen
Keyword(s):  
Social Support ◽  
Community Health ◽  
Age Groups ◽  
Community Support ◽  
Community Resources ◽  
Age Group ◽  
Health Issues ◽  
Younger Adults

Abstract Background Rising prevalence of type 2 diabetes (T2D), also among younger adults, constitutes a growing public health challenge. According to the person-centred Chronic Care Model, proactive care and self-management support in combination with community resources enhance quality of healthcare and health outcomes for patients with T2D. However, research is scarce concerning the importance of person-centred care and community resources for such outcomes as empowerment, and the relative impact of various patient support sources for empowerment is not known. Moreover, little is known about the association of age with these variables in this patient-group. This study, carried out among patients with T2D, examined in three age-groups (27–54, 55–64 and 65–75 years) whether person-centred care and diabetes-related social support, including community support and possibilities to influence community health issues, are associated with patient empowerment, when considering possible confounding factors, such as other quality of care indicators and psychosocial wellbeing. We also explored age differentials in empowerment and in the proposed correlates of empowerment. Method Individuals from a register-based sample with T2D participated in a cross-sectional survey (participation 56%, n = 2866). Data were analysed by descriptive statistics and multivariate logistic regression analyses. Results Respondents in the youngest age-group were more likely to have low empowerment scores, less continuity of care, and lower wellbeing than the other age-groups, and to perceive less social support, but a higher level of person-centred care than the oldest group. Community support, including possibilities to influence community health issues, was independently and consistently associated with high empowerment in all three age-groups, as was person-centred care in the two older age-groups. Community support was the social support variable with the strongest association with empowerment across age-groups. Moreover, vitality was positively and diabetes-related distress negatively associated with high empowerment in all age-groups, whereas continuity of care, i.e. having a family/regular nurse, was independently associated in the youngest age-group only. Conclusion Person-centred care and community support, including possibilities to influence community health issues, supports empowerment among adults with T2D. Findings suggest that age is related to most correlates of empowerment, and that younger adults with T2D have specific healthcare needs.

The impact of a health introduction course for medical interpreters in the healthcare sector

2020 ◽  
pp. 205715852097518
Author(s):  
Leila Saud Abdulkadir ◽  
Morten Sodemann ◽  
Claire Gudex ◽  
Sören Möller ◽  
Dorthe Susanne Nielsen
Keyword(s):  
Health Knowledge ◽  
Knowledge Score ◽  
University Hospital ◽  
Healthcare Sector ◽  
Health Issues ◽  
Multiple Choice Questions ◽  
Medical Interpreters ◽  
The One ◽  
The Individual ◽  
The Impact

The aim was to examine the impact on interpreters’ health knowledge, attitudes and self-evaluated skills after they participated in a pilot health introduction course at a university hospital in Denmark. The study was conducted as an intervention study using a questionnaire with both closed and open-ended questions. The questionnaire was distributed to interpreters one week before the six-week course started, and again at one week and at three months after course completion. Level of knowledge was calculated based on the number of answers to 18 multiple-choice questions on common health issues, diagnoses and treatments. Of the 100 interpreters who registered for the course, 86 completed the course, and 61 of these participants (70%) completed both the baseline and the one-week questionnaire. The mean knowledge score increased from 48 ( SD 6.9) at baseline to 52 ( SD 3.4; p < 0.001) one week after the course and was 51 ( SD 7.3; p < 0.001) three months after the course ( n = 55). Participants who increased their knowledge score the most were those with the least interpreter experience ( p = 0.001). One week after the course, most participants (83–95%) agreed that the individual lessons had been useful in their subsequent interpreting activities and that they had gained useful information. The health introduction course appeared to be beneficial for interpreters. This study highlights the need for greater focus on education for interpreters working in the healthcare sector.

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