scholarly journals What If the Cleft Child is Yours?

2016 ◽  
Vol 5 (2) ◽  
pp. 318
Author(s):  
Hazel Berret Wahlang
Keyword(s):  
Cleft Lip ◽  
Social Stigma ◽  
Negative Attitude ◽  
The Other ◽  
Small State ◽  
Operation Smile ◽  
The World ◽  
Cleft Lip Palate ◽  
Social Gathering ◽  
The Devil

<div><p><em>Every 3 minutes, a child is born with a cleft lip or cleft palate and make the child to suffer from hunger and thirst, difficulty with speech and social stigma (Operation Smile, n.d.). Yes, Cleft (lip/palate)<strong> </strong>is usually accompanied with stigma from the society especially when they lack information about it. When a baby is born into the world the whole family rejoices but in the case of the cleft (lip/palate)<strong> </strong>child the parents end up in shock and sadness. It even makes the parents and their families think that having a cleft child is a curse in itself. One of the factors that the parents’ of cleft (lip/palate) child limit themselves from taking their cleft (lip/palate) child to social gathering as they are scared that the society may have a negative attitude towards them. Assumptions about its cause make the parents difficult to adjust to the situation. People would talk behind them discussing about the cause of cleft (lip/palate)<strong> </strong>saying that their parents did something wrong that is the reason why their cleft child is the consequence.</em> <em>Twelve year old twins from a small state (Meghalaya) in India do not want to go to school or play with the other children because they were named as daughters of the devil and ugly simply because they were born with a cleft lip. </em></p></div>

scholarly journals International Plastic Surgery: Leaving a Legacy

2011 ◽  
Vol 93 (10) ◽  
pp. 348-349
Keyword(s):  
Surgical Treatment ◽  
Cleft Palate ◽  
Plastic Surgery ◽  
Cleft Lip ◽  
Developing World ◽  
Plastic Surgeon ◽  
Comprehensive Care ◽  
British Association ◽  
Operation Smile ◽  
The World

Per Hall, Consultant Plastic Surgeon and member of the British Association of Plastic, Reconstructive and Aesthetic Surgeons, has for the last four years been a volunteer surgeon for Operation Smile, an international charity providing free cleft lip and cleft palate surgery in the developing world. The charity has moved on from its historical position of providing fly-in/fly-out surgical treatment and is now working hard to develop sustainable comprehensive care centres in the most needy areas of the world.

scholarly journals Diagnostic outcomes of exome gene panel sequencing in patients with unusual syndromic cleft lip/palate phenotypes

2018 ◽  
Author(s):  
Reza Jabalameli
Keyword(s):  
Cleft Lip ◽  
Gene Panel ◽  
Individual Gene ◽  
Orofacial Clefting ◽  
Operation Smile ◽  
Clinical Diagnoses ◽  
Cleft Lip Palate ◽  
Gene Coverage ◽  
Gene Panel Sequencing ◽  
Panel Sequencing

Orofacial clefting (OFC) is a common craniofacial birth defect that has a prevalence of 1.2 in 1,000 live births. Syndromic OFC in which patients present with additional developmental deficits are identified to have a strong genetic component. We applied exome gene panel sequencing in a cohort of 14 Colombian patients identified at Operation Smile in Bogota, Colombia, with syndromic orofacial clefting phenotypes and additional features initially suggesting Aarskog-Scott syndrome (AAS). Gene panel sequencing failed to identify any causal variants in the FGD1 gene which underlies this condition, but variants in a number of genes suggest alternative clinical diagnoses across five patients (~36%). The novel variants identified here maps to developmentally important genes including SRCAP, OFD1, NIPBL, GRIN2A and KMT2D6. Our result demonstrates the extensive heterogeneity underlying OFC and emphasises the need for systematic phenotyping of patients with rare conditions. Gene panel sequencing has the potential to cost-effectively resolve ambiguous clinical diagnoses, but rigorous attention should be paid to gene coverage as our results suggest highly variable read depths across individual gene exons and this may reduce the quality of variant calls at specific locations.

scholarly journals An Evaluation of Muscle Repair Techniques: Implications in Musculoskeletal Healing and Corollaries in Oral-Facial Clefting

2020 ◽  
Author(s):  
Jaehoon Kim ◽  
Jaehoon Choi ◽  
Junhyung Kim ◽  
Taehee Jo ◽  
Il Sun Hwang ◽  
...  
Keyword(s):  
Western Blotting ◽  
Muscle Fiber ◽  
Cleft Lip ◽  
The Other ◽  
Sprague Dawley ◽  
Gait Symmetry ◽  
Tnf Α ◽  
Significant Difference ◽  
Cleft Lip Palate ◽  
The Right

Abstract We performed an animal study to identify the techniques associated with the best muscle healing outcomes in cleft lip/palate surgery. The right triceps of thirty adult male Sprague-Dawley rats were cut and repaired by three different suture techniques: simple (n=10), overlapping (n=10), and splitting sutures (n=10). Muscle tissues were isolated from 5 rats per group 1 and 8 weeks postoperation. The inflammatory response and muscle fiber healing were evaluated by hematoxylin and eosin (H&E) staining, western blotting, immunohistochemistry for TNF-α and IL-1β, and immunofluorescence for laminin and MyoD. Grip strength (N/100 g) and spatial gait symmetry were evaluated before surgery and 1, 2, 4 and 8 weeks postoperation. Eight weeks postoperation, grip force per weight was significantly higher in the simple suture (median, 3.49; IQR, 3.28-3.66) and overlapping groups (median, 3.3; IQR, 3.17-3.47) than the splitting group (median, 2.91; IQR, 2.76-3.05). There was no significant difference in range of motion between groups. The simple group exhibited significant remission of inflammation by H&E staining and lower expression of TNF-α and IL-1β than the other groups by western blotting and immunohistochemistry. Immunofluorescence revealed stronger expression of MyoD and weaker expression of laminin in the splitting group than in the other groups at week 8, indicating prolonged inflammation and healing followed by poor muscle fiber remodeling. Simple interrupted sutures and overlapping sutures showed similar muscle healing in this study. Therefore, there was some limitation to reconstructing the philtral column using overlapping sutures alone, and additional procedures could be needed.

Ein Vierteljahrhundert psychosoziale Hämophilie-Beratung im Wandel der Zeit

2010 ◽  
Vol 30 (S 01) ◽  
pp. S19-S22
Author(s):  
W. Schramm ◽  
M. M. Schneider
Keyword(s):  
Liver Disease ◽  
Social Stigma ◽  
Self Esteem ◽  
The Other ◽  
Clotting Factors ◽  
Professional Help ◽  
Psychosocial Counselling ◽  
The World ◽  
The Impact ◽  
Hiv Negative

SummaryWith the development of clotting-factors in the seventies the haemophilia patients were released from being handicapped and began to live a quite normal life. Thus, psychosocial counselling did not seem to be necessary. But the impact of HIV-infection to the world of haemophilia was so intense that professional help was offered at the Munich Hemophilia Centre since 1985.During the preceeding 25 years we talked to about 120 patients and relatives every year in more than 10 000 psychotherapeutic talks. 70 of our patients were HIV-infected. For about half of them we took care until they died on AIDS or of liver-disease. The other 50 patients (HIV-negative) were also distressed enormously. At the beginning the highlights in counselling were e. g. fear of manifestation of AIDS, dying and death, social stigma. Around 1993 with the decoding of HCV and the first useful HIV therapies the topics in counselling changed: New HIV-medical-treatment, menacing by HCV, wish for own children due to improved HIV medical care etc. Conclusion: Our experiences have shown that self esteem and social integration of haemophilia patients have reached again normality. By our psychosocial counselling we would like to contribute.

#Cleftlip/Palate: What Is the World Talking About?

2020 ◽  
Vol 57 (9) ◽  
pp. 1093-1099
Author(s):  
Alexandra S. Hudson ◽  
Alexander D. Morzycki ◽  
Regan Guilfoyle
Keyword(s):  
Social Media ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
The United States ◽  
The Social ◽  
The World ◽  
Cleft Lip Palate ◽  
Social Media Platforms ◽  
Media Platform ◽  
Published Research

Objective: Studies have begun analyzing how the world converses on social media platforms about medical/surgical topics. This study’s objective was to examine how cleft lip and palate, two of the most common birth defects in the world, are discussed on the social media platform Twitter. No study to date has analyzed this topic. Methods: Tweets were identified using any of the following: cleft, cleft lip, cleft palate, #cleft, #cleftlip, #cleftpalate. Eight months between 2017 and 2018 were analyzed. Main Outcome Measures: The primary outcome was the tweet subject matter. Secondary outcomes were author characteristics, tweet engagement, multimedia, and tweet accuracy Results: A total of 1222 tweets were included. #Cleft was the most common hashtag (71%), and it was significantly associated with more retweets ( P = .03). Twenty-seven countries tweeted, with the United States (34%) and India (27%) producing the most. Charities (36%), hospitals (14%), and physicians (13%) were the most common authors. Over three-quarters of tweets were self-promotional. The top content included charity information (22%) and patients’ cleft stories (14%). Tweets about patient safety/care and surgical service trips generated the most engagement. The accuracy of educational tweets was 38% low accuracy and 1% inaccurate. One hundred forty-nine tweets (12%) discussed a published research article, but 41 tweets did not share a link. Conclusions: Charities dominate the cleft lip/palate “Twitterverse.” Most tweets were self-promotional, and over a third of educational tweets were low accuracy. As the cleft social media community continues to grow, we recommend using the hashtag #cleft to reach a wider audience.

Association of MSX1 with Nonsyndromic Cleft Lip and Palate in a Colombian Population

2007 ◽  
Vol 44 (6) ◽  
pp. 653-656 ◽  
Author(s):  
Liliana Otero ◽  
Sandra Gutiérrez ◽  
Margarita Cháves ◽  
C. Vargas ◽  
Luis Bérmudez
Keyword(s):  
Cleft Lip ◽  
Tandem Repeats ◽  
Cleft Lip And Palate ◽  
Positive Association ◽  
Control Group ◽  
Chi Square ◽  
Operation Smile ◽  
Genotype Frequencies ◽  
Cleft Lip Palate ◽  
Group Population

Objective: To evaluate the association between MSX1 CA polymorphism and nonsyndromic cleft lip with or without cleft palate (CL±P) in a group of patients from Operation Smile Colombia. Design: Four alleles from MSX1 CA microsatellite sequence were analyzed. Polymerase chain reaction was carried out. The amplifications were performed by Short Tandem Repeats (STRs) in ABI PRISM 310 genetic analyzer. Chi-square and odds ratio tests were used to determine the association between genotype frequencies and the risk to the cleft lip/palate in a Colombian group population. Setting: Operation Smile Colombia. Participants: Ninety-four affected patients (49 men and 45 women with CL±P) and 93 control individuals (43 men and 50 women). Results: A significant statistical difference (p < .0106) was found between the patients who carried allele 3 and CL±P. In addition, allele 4 (heterozygous and homozygous form) was the most frequent in CL±P (74%) patients and in the control group (82%). Conclusions: These findings show a positive association between the MSX1 CA polymorphism and CL±P in a Colombian group population.

scholarly journals An Evaluation of Muscle Repair Techniques: Implications in Musculoskeletal Healing and Corollaries in Oral-Facial Clefting

2021 ◽  
Vol 10 (21) ◽  
pp. 4803
Author(s):  
Jaehoon Kim ◽  
Jaehoon Choi ◽  
Junhyung Kim ◽  
Taehee Jo ◽  
Ilseon Hwang ◽  
...  
Keyword(s):  
Western Blotting ◽  
Muscle Fiber ◽  
Cleft Lip ◽  
The Other ◽  
Sprague Dawley ◽  
Gait Symmetry ◽  
Tnf Α ◽  
Significant Difference ◽  
Cleft Lip Palate ◽  
Suture Group

We performed an animal study to identify the techniques associated with the best muscle healing outcomes in cleft lip/palate surgery. The right triceps of thirty adult male Sprague–Dawley rats were cut and repaired by three different suture techniques: simple (n = 10), overlapping (n = 10), and splitting sutures (n = 10). Muscle tissues were isolated from 5 rats per group 1 and 8 weeks postoperation. The inflammatory response and muscle fiber healing were evaluated by hematoxylin and eosin (H&E) staining, Western blotting, immunohistochemistry for TNF-α and IL-1β, and immunofluorescence for laminin and MyoD. Grip strength (N/100 g) and spatial gait symmetry were evaluated before surgery and 1, 2, 4 and 8 weeks postoperation. Eight weeks postoperation, grip force per weight was significantly higher in the simple suture (median, 3.49; IQR, 3.28–3.66) and overlapping groups (median, 3.3; IQR, 3.17–3.47) than the splitting group (median, 2.91; IQR, 2.76–3.05). There was no significant difference in range of motion between groups. The simple group exhibited significant remission of inflammation by H&E staining and lower expression of TNF-α and IL-1β than the other groups by Western blotting and immunohistochemistry. Immunofluorescence revealed stronger expression of MyoD and weaker expression of laminin in the splitting group than in the other groups at week 8, indicating prolonged inflammation and healing followed by poor muscle fiber remodeling. Simple and overlapping sutures demonstrated similar functional healing, although greater inflammation and failure to maintain a thicker muscle belly were observed in the overlapping suture group compared with the simple suture group. Therefore, reconstruction of the philtral column with overlapping sutures alone may result in limited long-term fullness, and additional procedures may be needed.

Is Nasal Airway Size a Marker for Susceptibility toward Clefting?

1992 ◽  
Vol 29 (4) ◽  
pp. 336-339 ◽  
Author(s):  
Hui Liu ◽  
Donald W. Warren ◽  
Amelia F. Drake ◽  
Jefferson U. Davis
Keyword(s):  
Cleft Lip ◽  
Simple Technique ◽  
Monozygotic Twins ◽  
Bimodal Distribution ◽  
The Other ◽  
Nasal Airway ◽  
Cross Sectional ◽  
Cleft Lip Palate ◽  
The Difference ◽  
Cavity Width

Johnston and Hunter (1989) reported that in monozygotic twins discordant for cleft lip ± palate, the noncleft twins demonstrated what appeared to be a bimodal distribution of nasal cavity width. Two thirds showed reduced airway size and one third showed normal or slightly greater airway size. They suggested that the two-thirds group may represent reduced size of the medial nasal prominences and the other may represent underdevelopment of the maxillary prominence. We were particularly interested in the findings because the difference in distribution may represent differences in pathogenesis and therefore have etiologic significance. With this in mind we assessed nasal cross-sectional areas in 37 subjects with cleft lip or cleft lip ± palate using the pressure-flow technique during breathing. A group of 72 noncleft individuals served as controls. As expected, the data revealed that subjects with clefts had a significantly reduced nasal airway (p = .0001). More important, the distribution of nasal airway size in the cleft group was similar to that reported by Johnston and Hunter (1989). This comparability suggests that it may be possible to assign most cleft lip ± palate patients to a particular group. Since heredity may differ among the two groups (Chung et al., 1986), we may have a simple technique to assess the risk of occurrence for cleft lip ± palate.

The Chronicle of Independence: A Short Story

1987 ◽  
Vol 15 ◽  
pp. 70-76
Author(s):  
Manthia Diawara
Keyword(s):  
High School ◽  
Black Men ◽  
Short Story ◽  
Junior High School ◽  
White Men ◽  
The Other ◽  
White People ◽  
The World ◽  
Dangerous Place ◽  
The Devil

We used to play soccer with white boys in Kankan at Saint John, a Catholic elementary and junior high school. Then one day a girl by the name of Dusu told my mother that I had been in the worshipping house of the white people. When I came home my mother was crying, saying that the Devil had entered me. The other women in the compound gathered around her to express their surprise and distress as well. I could hear them talking about how the world had become a dangerous place since the era of the white man. Some said that nowadays the white men had driven Satan deep into the souls of some black men so much so that, like mad dogs, they had turned against their trainers themselves. Some said that the world was coming to an end, and others enjoined that it was all Sekou Toure’s fault. That day my mother locked me up and began whipping me.

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