scholarly journals The Association of Myasthenia Gravis with HLA class II Antigens in Iraqi Patients

2013 ◽  
Vol 10 (1) ◽  
pp. 126-132
Author(s):  
Baghdad Science Journal
Keyword(s):  
Myasthenia Gravis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Control Group ◽  
P Value ◽  
Hla Dq ◽  
Healthy Control ◽  
Hla Dr3 ◽  
Class Ii Antigens ◽  
Hla Dq2

The nature and intensity of the association of myasthenia gravis (MG) with distinct human leukocyte antigen (HLA) haplotypes differ between ethnic populations, so this study determined the association of HLA class II antigens with myasthenia gravis (MG) in Iraq.The study included Iraqi patients diagnosed with MG and two control groups the first of 54 insulin dependent diabetes mellitus patients and the second of 237 subjects as a normal control group. The test used was microlymphocytotoxicity test.The work was done in the Teaching Laboratories/Medical City/Baghdad.Results: positive associations were observed (etiological risk factors) as follows: 1. HLA-DR locus showed one positively associated allele when compared to healthy control and this was HLA-DR3 (RR: 21.05, EF0.73, & P value ? 0.05), While when compared to IDDM control no significant association appeared (since the same allele is positively associated with IDDM). 2. HLA-DQ locus showed only one positively associated allele when compared to healthy control; this was HLA-DQ2 (RR 4.67, EF 0.50, and P value ? 0.05). While no significant association appeared when compared to IDDM control. Other important clinical association were observed; association with age, gender, strong stressful events, thymoma, and other autoimmune disorders. Conclusion: The positively associated antigens which were found as follows HLA-DR3 and HLA-DQ2, while no negative association was detected.

Association between Hla-Class Ii Antigens and Transitional Cell Carcinoma of the Bladder

1997 ◽  
Vol 64 (3) ◽  
pp. 346-347
Author(s):  
Z. Amirghofran ◽  
A. Khezri ◽  
S. Mohammadi
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Class Ii ◽  
Hla Class Ii ◽  
Control Group ◽  
Hla Dq ◽  
Significant Difference ◽  
Carcinoma Of The Bladder ◽  
Class Ii Antigens

A possible association between transitional cell carcinoma of the bladder and HLA-class II antigens (HLA-DR and HLA-DQ) in a group of patients with TCC were investigated. DR2, DR4 and DQw3 with allelic frequencies of 33.3%, 53.3% and 50% respectively were the most common antigens expressed in patients. In the control group the highest frequencies belonged to DR2, DR4 and DQw2 antigens. We found a significant difference in the frequency of HLA-DQw3 between patient and control groups. No significant differences were found at DR loci.

Prevalence of HLA DQ 2, 8 in children with celiac disease

2021 ◽  
pp. 1-6
Author(s):  
Seyed Mohsen Dehghani ◽  
Naqi Dara ◽  
Behrooz Gharesifar ◽  
Iraj Shahramian ◽  
Fatemeh Dalili ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Normal Population ◽  
Failure To Thrive ◽  
Hla Typing ◽  
Control Group ◽  
P Value ◽  
Normal Children ◽  
Hla Dq ◽  
Inducing Factors ◽  
Hla Dq2

OBJECTIVE: Celiac disease is a chronic disease that affect small bowel by making its villi become atrophic. Various environmental and genetic factors have been identify as inducing factors for celiac disease. Most of the patients has one of the HLA DQ forms. Although the prevalence of these genes are variable in different areas of the world, we do not have a comprehensive information about this issue in our region. Thus the aim of present study is to investigate the prevalence of HLA DQ typing of patients who visited Emam Reza Gastroenterology clinic of Shiraz(IRAN). METHODS: In this case-control study all under 18 years old children who were diagnosed with celiac disease and have visited Emam Reza gastroenterology clinic were investigated. The diagnosis of celiac disease was made by history, physical exam, serologic test, and histopathology of duodenal biopsy. Blood sample was taken and HLA typing performed using PCR method at Motahari clinic cytology laboratory. Also those people who neither them self nor their first degree relatives were not case of celiac disease and underwent HLA typing for other reason were identified as control group. The statistical analysis was done using SPSS 18 software. The p value < 0.05 was identified as statistically significant. RESULTS: A total of 139 patients with celiac disease and 146 normal children were studied. The mean age of the patient with celiac disease were 9.1 years old with standard deviation of 3.4 years old. 64% of the celiac patients were girls and 36% were boys. While this proportion was 54.4% for boy and 48.6% for girls in control group. The most common HLA in celiac patients group were HLA DQ2 and 8 but the most common ones in control group were HLA DQ 8 and 5. Failure to Thrive were the most common signs of the celiac patients with a prevalence of 60 children. Total IgA titer were normal in 98.6% of the patients and TTG IgA titer were positive in 93.5% of the patients. The most common co existing disease with the celiac disease were diabetes with a prevalence of 30 children (66.7%). CONCLUSION: present study reveals that the prevalence of the HLA DQ2 and 8 among patients with celiac disease is 72.6% and 53% in our normal population.

scholarly journals Comparative analysis of DQB1 и DQA1 class II genes of human leukocyte antigen system in the population of Azerbaijan

2017 ◽  
Vol 98 (5) ◽  
pp. 704-708
Author(s):  
G A Akhmedov
Keyword(s):  
Comparative Analysis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Control Group ◽  
Healthy Children ◽  
Leukocyte Antigen ◽  
Hla System ◽  
Hla Dq ◽  
Hla Dq2

Aim. To perform comparative analysis of DQB1 and DQA1 class II genes of the human leukocyte antigen (HLA) system in the population of Azerbaijan. Methods. We studied the alleles of HLA DQ gene and subtypes of HLA DRB1*04 in 160 children with diabetes mellitus and in 271 healthy children from the population of Azerbaijan. Out of 160 patients, 50.6% (n=81) were boys, 49.4% (n=79) were girls. All patients with diabetes were under the age of 18 years. As a control group, 271 students of the Medical College No. 1 were involved: 79 (29.1%) boys, 192 (70.9%) girls. The collected blood samples were sent for further investigation to the medical genetic laboratory where polymerase chain reaction-based genotyping of the samples was performed. Results. For the first time, the relationship of diabetes with class II genes of the HLA system was studied. The Azerbaijani were found to have higher risk associated with HLA DQ2 molecule. The molecule HLA DQ8 also increases risk, although it is lower in comparison with HLA DQ2 molecule. What is unusual is that for this population the allele HLA DQB1*0304 was also associated with the risk of diabetes. Conclusion. The haplotype DQB1*0302-DQA1*03/DQB1*02-DQA1*05 (DQ8/DQ2.5) associated with high risk of diabetes is found in 3% of the representatives of the population of Azerbaijan, which is estimated as the average prevalence of diabetes.

scholarly journals The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Vadim Jucaud
Keyword(s):  
Plasma Cells ◽  
Class Ii ◽  
Hla Class Ii ◽  
Binding Affinities ◽  
T Helper ◽  
Hla Matching ◽  
Hla Dr ◽  
Hla Dq ◽  
Class Ii Antigens ◽  
Hla Mismatches

The identification of permissible HLA class II mismatches can prevent DSA in mismatched transplantation. The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the differentiation of B cells into plasma cells. Comparing the binding affinity of self and nonself allo-HLA-derived peptides for recipients’ HLA class II antigens may distinguish immunogenic HLA mismatches from nonimmunogenic ones. The binding affinities of allo-HLA-derived peptides to recipients’ HLA-DR and HLA-DQ antigens were predicted using the NetMHCIIpan 3.1 server. HLA class II mismatches were classified based on whether they induced DSA and whether self or nonself peptide was predicted to bind with highest affinity to recipients’ HLA-DR and HLA-DQ. Other mismatch characteristics (eplet, hydrophobic, electrostatic, and amino acid mismatch scores and PIRCHE-II) were evaluated. A significant association occurred between DSA formation and the predicted HLA-DR presentation of nonself peptides (P=0.0169; accuracy = 80%; sensitivity = 88%; specificity = 63%). In contrast, mismatch characteristics did not differ significantly between mismatches that induced DSA and the ones that did not, except for PIRCHE-II (P=0.0094). This methodology predicts DSA formation based on HLA mismatches and recipients’ HLA-DR phenotype and may identify permissible HLA mismatches to help optimize HLA matching and guide donor selection.

scholarly journals Association Between Myasthenia Gravis and Memory: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoling Zhou ◽  
Yifei Zhou ◽  
Jianian Hua ◽  
Qun Xue
Keyword(s):  
Myasthenia Gravis ◽  
Memory Performance ◽  
Meta Analysis ◽  
Class Ii ◽  
Class I ◽  
Control Group ◽  
Delayed Recall ◽  
Random Effects Models ◽  
Immediate Recall ◽  
Healthy Control

Objective: The studies have produced contradictory results regarding the association between myasthenia gravis (MG) and cognitive function, especially for the cognitive domains of memory. This meta-analysis was dedicated to exploring the association between MG and memory, which was represented by the immediate recall and delayed recall.Methods: Using the random effects models, this study analyzed memory in MG based on data from the studies retrieved from four electronic databases from inception to February 2021. Disease severity was graded according to the Myasthenia Gravis Foundation of America (MGFA) classification. We defined ocular myasthenia gravis (OMG) (MGFA Grade I) as Class I, mild, and moderate generalized myasthenia gravis (GMG) (MGFA Grade IIa, IIb, IIIa, and IIIb) as Class II.Results: In total, eight studies of 274 patients and 211 healthy controls were included. The significant associations were found between MG and memory. Compared with the healthy control group, the patients with MG performed significantly worse in the terms of immediate recall [standardized mean difference (SMD) = −0.65, 95% CI = −0.97 to −0.33, P &lt; 0.001, I2 = 64.1%] and delayed recall (SMD = −0.49, 95% CI = −0.88 to −0.1, P &lt; 0.05, I2 = 76.3%). Compared with the patients with Class I MG, those with Class II MG did not have significantly different scores in immediate recall (SMD = −0.07, 95% CI = −0.35 to 0.21, P = 0.614, I2 = 0%) and delayed recall (SMD = 0.63, 95% CI = −0.29 to 1.55, P = 0.178, I2 = 87.9%).Conclusion: The patients with MG showed lower memory performance, such as both immediate and delayed recall ability. There was no association between the severity of MG and memory. Future studies should address whether these associations are casual and modifiable.

scholarly journals Inhibitor (IK) of IFN-γ induced HLA class II antigens expression also inhibits HLA class II constitutive expression in the human Raji B cell line

Oncogene ◽  
1997 ◽  
Vol 14 (12) ◽  
pp. 1453-1461 ◽  
Author(s):  
Jocelyn Vedrenne ◽  
Eric Assier ◽  
Raffaele Pereno ◽  
Haniaa Bouzinba-Segard ◽  
Bruno Azzarone ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Line ◽  
Constitutive Expression ◽  
Class Ii ◽  
Hla Class Ii ◽  
Ifn Γ ◽  
Class Ii Antigens

Notes: Partial Characterization of anti-H L A Class II Antibodies Isolated by Aid of Sepharose-Peptide Immunoadsorbents

1991 ◽  
Vol 46 (3-4) ◽  
pp. 321-324
Author(s):  
Alberto Chersi ◽  
Maria Cristina Morganti-Kossmann
Keyword(s):  
Immune Response ◽  
Amino Acid ◽  
Membrane Proteins ◽  
Synthetic Peptides ◽  
Class Ii ◽  
Late Response ◽  
Early Immune Response ◽  
Hla Dq ◽  
Class Ii Antigens

Synthetic peptides selected from HLA-DQ and HLADP glycoproteins were coupled to Sepharose, and used for the isolation of anti-HLA Class II antibodies from the immune sera of rabbits immunized with human lymphoblastoid cells expressing Class II antigens. Antibodies from early and late bleedings displayed remarkable differences in affinity for peptides and for soluble membrane proteins: these differences might be due to an early immune response directed preferentially against surface linear determinants, and to a late response to assembled (discontinuous) sites. The possibility that such antibodies might be used for the identification of amino acid stretches involved in the formation of the same assembled determinant is considered.

HLA Class II and class I polymorphism in venezuelan patients with myasthenia gravis

2004 ◽  
Vol 65 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Mercedes T Fernández-Mestre ◽  
Vivian Vargas ◽  
Silvia Montagnani ◽  
Maritza Cotúa ◽  
Violeta Ogando ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class I

scholarly journals HLA class II antigens and haplotypes associated with susceptibility of leukemias and myelodysplastic syndrome

Genetika ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. 361-370
Author(s):  
Svetlana Vojvodic ◽  
Dusica Ademovic-Sazdanic
Keyword(s):  
Risk Factors ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Hla Antigens ◽  
Positive Association ◽  
Class Ii ◽  
Hla Class Ii ◽  
Negative Association ◽  
Male Patients ◽  
Class Ii Antigens

Genetical and environmental factors play an interactive role in the development of acute and chronic leukemias. HLA antigens have been considered as possible genetic risk factors. The aim of this work was to investigate a possible association between HLA class II polymorphisms and leukemias and myelodysplastic syndrome. In the present study we investigated HLA class II antigens, DR/DQ and DR51/DR52/DR53 haplotypes in 100 patients: 7 suffering from myelodysplastic syndrome (MDS),37 from acute lymphoblastic leukemia(ALL),32 from acute myeloid leukemia (AML) and 24 from chronic myeloid leukemia(CML). A panel of 210 healthy unrelated individuals of the same origin, from Vojvodina, served as controls. HLA phenotyping was performed by two color fluorescence method. In patients suffering from MDS was found a positive association with DR7(RR=2.598,EF=0.175) and DQ7(3)(RR=4.419, EF=0.632), while negative association was found for DR15(2)(RR=0.405, PF=0.172) and DQ6(1) (RR=0.889, PF=0,936).Positive association was found in the group of patients with ALL for DR7(RR=2.391,EF=0.688) and DQ2(RR=1.62, EF=0.15),while negative association was found with DQ5(1)(RR=0.075, PF=0.324). In the group of patients with AML, there were positive associations with DR11(5)(RR=1.732,EF=0.211),DQ2(RR= 1.594, EF=0.151) and DQ7(3) (RR=2.547,EF=0.266),while possible protective antigen was DQ5(1) (RR=0.107,RF=0.701). Higher RR than 1 and EF>0.15, in patients suffering from CML was found for DQ6(1)(RR=1.661,EF=0.232), while negative association was found for DR4 (RR=0.182,PF=0.155).Possible protective haplotype in this study was DR3DQ8(3) for patients suffering from AML(RR=0.007, PF=0.501).The distribution of DR53-DR53 haplotypes showed significant difference in male patients with ALL(6% vs 0.09%), while DR52-DR52 haplotype was significantly less frequent in male patients with CML (4% vs 20.47%) and female patients with MDS (1% vs 18.57%), respectively, in comparison to controls. We deduced that DR7 antigen in male patients with ALL has the greatest impact to the higher frequency of DR53-DR53 haplotype in this type of leukemia. The role of HLA antigens as risk factors for development of leukemias in our population was shown and furthermore it could be useful in clinical practice.

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