scholarly journals Hyperprolactenemia in Women with Systemic Lupus Erythematusus

2007 ◽  
Vol 4 (4) ◽  
pp. 617-621
Author(s):  
Baghdad Science Journal
Keyword(s):  
Lupus Erythematosus ◽  
Serum Prolactin ◽  
Control Group ◽  
Immunoradiometric Assay ◽  
Stage Versus ◽  
Active Stage ◽  
Systemic Lupus ◽  
Control Groups ◽  
And Control ◽  
Age And Sex

Recent accumulated evidences suggest that prolactin is an important immunomodulator and may have a role in the pathogenesis of systemic lupus erythematosus (SLE). The aim of this study was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation with disease flares. Serum prolactin levels were measured in 62 women with SLE and 50 age- and sex-matched healthy controls. In patients and control groups prolactin levels were determined by immunoradiometric assay (IRMA). The prolactin level was found to be higher than normal rang in (40.3%) of SLE patients in active stage versus only (8.06%) of the same SLE patients but in the inactive stage and in (4%) of control group, the elevation was ranging between mild (72%), medium (20%) and high (8%). The study concludes that patients who having a flare - up had a trend to higher mean of prolactin (mild and medium) levels than inactive stage patients.

Cold Lymphocytotoxins in Connective Tissue Disorders

1979 ◽  
Vol 24 (1) ◽  
pp. 5-8 ◽  
Author(s):  
J. D. Browning ◽  
Heather M. Dick ◽  
R. Sturrock ◽  
D. Grennan ◽  
W. C. Dick
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Control Group ◽  
Blood Transfusions ◽  
Connective Tissue Disorders ◽  
Systemic Lupus ◽  
Control Groups ◽  
Lymphocytotoxic Antibodies ◽  
Close Proximity ◽  
Absorption Studies

Sixty-eight patients with various connective tissue disorders, 5 relatives of patients and 26 members of staff from the Centre for Rheumatic Diseases were studied for the presence in their sera of cold lymphocytotoxic antibodies. Antibodies were found in 71 per cent of patients with systemic lupus erythematosus, 27 per cent of patients with rheumatoid arthritis, 0 per cent of the small group of relatives and 3.8 per cent of the controls. Absorption studies did not show T or B specificity of the antibodies. The control group, working in close proximity to the patients or their sera did not show any increased incidence of antibodies as compared to control groups of other studies. Red blood cell anti I or HI was found in the sera of 28 per cent of those with cold lymphocytotoxic antibodies. No correlation was found between the presence of the antibodies and number of blood transfusions or pregnancies, increasing age, R 3 titre or antinuclear factor.

Assessment of serum zonulin as a marker of altered intestinal permeability in patients with multiple sclerosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Prof.Dr. Ayman Mohamed Nassef ◽  
Lobna Mohamed ElNabil ◽  
Mohamed Mahmoud Fouad ◽  
Amira Ahmed Moussa
Keyword(s):  
Multiple Sclerosis ◽  
Intestinal Barrier ◽  
Control Group ◽  
P Value ◽  
University Hospitals ◽  
Control Groups ◽  
Cross Sectional ◽  
Progressive Group ◽  
And Control ◽  
Age And Sex

Abstract Background Here we enrolled patients into 3 groups: Relapsing remittent MS in relapse (RRMS) [N = 26], progressive MS (progressive) [N = 19] and relapsing remittent MS in remission (remission) [N = 18] Control group matching age and sex [N = 20] P-Value was <0.001, which is significant in RRMS group in relation to progressive, remission and control groups. P-Value was 0.849, which is insignificant in progressive group in relation to remission group. P-Value was 0.584, which is insignificant in progressive group in relation to control group. P-Value was 0.973, which is insignificant in remission group in relation to control group. Aim of the Work To investigate the possible association between IP changes and MS through measurement serum zonulin in different population of MS for possible implication on treatment. Patients and Methods A. Subjects Type of the Study A case control observational cross sectional study Study Setting The Neurology department of Ain Shams University hospitals. Study Period 6 months to 1 year Study Population This study will enroll 92 subjects who will be divided into 4 groups; group 1 including 24patients with the diagnosis of relapsing remittent MS (RRMS) who are in relapse phase within one week from the time of sample withdrawal, group 2 including 24 patients with the diagnosis of RRMS who are in remission phase, group 3 including 24 patients with secondary progressive MS (SPMS) and group 4 including 20 age- and sex-matched healthy controls. Results In the RRMS group of this study, serum Zonulin varying between (12_ 93) with mean 28.692 and +\-22.894 SD. In the progressive group of this study, serum Zonulin varying between (2_ 18) with mean 8.021 and +\-3.866 SD. In the remission group of this study, serum Zonulin varying between (1.5_ 11) with mean 4.522 and +\-3.026 SD. In the control group of this study, serum Zonulin varying between (1.3_ 6) with mean 2.690 and +\-1.292 SD. P-Value was <0.001, which is significant in RRMS group in relation to progressive, remission and control groups. P-Value was 0.849, which is insignificant in progressive group in relation to remission group. P-Value was 0.584, which is insignificant in progressive group in relation to control group. P-Value was 0.973, which is insignificant in remission group in relation to control group. Conclusion this study included 62 patients diagnosed as multiple sclerosis that are divided into 3 groups and serum Zonulin level was assessed in each group and the results were significant in the relapse group which indicates autoimmune theory of MS and link between gut barrier and CNS also illustrated the role of gut microbiota in the MS. It also supported disintegration of intestinal barrier during the attack of MS for further work up studies regarding oral medication in the acute attack of MS.

scholarly journals Periodontitis Risk in Patients With and Without Systemic Lupus Erythematosus: A Retrospective Study

2021 ◽  
Vol 1 (1) ◽  
pp. 19-30
Author(s):  
Chinhua Hsiao
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Chronic Periodontitis ◽  
Systemic Lupus ◽  
Control Groups ◽  
Temple University ◽  
Periodontal Breakdown ◽  
Increased Risk ◽  
And Control ◽  
The Temple

Objectives: Systemic lupus erythematosus is a systemic, long-term autoimmune condition that has chronic inflammatory effects in connective tissue throughout the body. There are numerous studies that have examined the association between systemic lupus erythematosus and chronic periodontitis, with varying conclusions. The purpose of this cross-sectional study is to evaluate and compare the risk for periodontitis in patients with SLE to patients without SLE. Materials and Methods: Medical and dental records were retrospectively reviewed for patients that had been admitted to the Temple University School of Dentistry from 2010 to 2018. A roster of 22 SLE positive patients were generated from the Temple University patient database and matched to a control population of 22 patients without SLE. Periodontal probing depths were then documented and used to evaluate periodontal statuses in both test and control groups. Sites with probing depths ≥ 5 mm were considered to be at increased risk for periodontal breakdown. Prevalence was defined as the percentage of individuals having at least one site with a ≥ 5 mm probing depth, and extent was defined as the average percentage of sites with increased periodontitis risk. The number of missing teeth in patients from each group were also recorded as a secondary outcome. Results: The prevalence of ≥ 5 mm probing depths in SLE and control groups was 50 % (10/20) and 40.9 % (9/22), respectively. Calculations of relative risk (1.22) and odds ratio (1.44) were not statistically significant between the two populations (p > 0.05). The extent of ≥ 5 mm probing depths was 1.5 % in SLE patients and 3.7 % in healthy patients, which was also not significant between groups (p > 0.05). SLE patients were missing an average of 9.6 teeth per individual compared to 3.8 in healthy patients (p < 0.05). Conclusions: The results of the present study indicate that patients with SLE do not have an increased risk for periodontitis when compared to patients without SLE. Risk analysis on the prevalence and the extent of deeper probing depths were not statistically different between SLE and control groups. Further studies with a larger sample size and elimination of unseen confounders are needed in order to validate our results. An interesting observation was the finding that SLE patients have a significantly greater number of missing teeth. The exact mechanism through which SLE patients experience periodontal breakdown and increased tooth loss is an avenue that warrants future research. Keywords: systemic lupus erythematosus (SLE); chronic periodontitis Abbreviations: SLE: Systemic Lupus Erythematosus, CP: Chronic Periodontitis, SLEDAI: Systemic Lupus Erythematosus Disease Activity Index, BOP: Bleeding on Probing, CAL: Clinical Attachment Level.

Pattern of Arterial Calcification in Patients with Systemic Lupus Erythematosus

2009 ◽  
Vol 36 (10) ◽  
pp. 2212-2217 ◽  
Author(s):  
KAI-HANG YIU ◽  
SILUN WANG ◽  
MO-YIN MOK ◽  
GAIK CHENG OOI ◽  
PEK-LAN KHONG ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cardiovascular Events ◽  
Calcium Score ◽  
Coronary Calcification ◽  
Arterial Calcification ◽  
Control Group ◽  
Systemic Lupus ◽  
Atherosclerotic Process ◽  
Age And Sex

Objective.To evaluate the prevalence and pattern of arterial calcification in patients with asymptomatic systemic lupus erythematosus (SLE) compared with control subjects. SLE patients are prone to adverse cardiovascular events; however, the underlying atherosclerotic process is unknown. Multidetector computed tomography (MDCT) measured arterial calcium score (CS) reflecting underlying atherosclerosis and is closely associated with cardiovascular events.Methods.Fifty age and sex matched SLE patients and controls were enrolled. All subjects underwent 64 slice MDCT scan to evaluate CS in coronary, carotid arteries and the aorta.Results.As compared with controls, SLE patients had higher mean CS and prevalence of CS > 0 across all vascular beds. After adjustment for age and sex, SLE patient odds of having CS > 0 in any vascular bed was 33.6 (95% CI: 9.5–165.2) were higher versus patients in the control group, mainly due to more prevalent coronary calcification (OR 30.0, 95% CI: 6.7–203.8). In SLE patients, the most frequent vessel with CS > 0 was coronary (42%) followed by carotid artery (24%). Further, arterial calcification occurred early involving 40% of SLE patients at age < 40 years, with increasing prevalence as age advanced.Conclusion.Our study confirms that patients with SLE have significantly higher prevalence and extent of systemic arterial calcification compared with age and sex matched controls.

Mean platelet volume in children with systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 30 (1) ◽  
pp. 103-108
Author(s):  
Mohamed A Talat ◽  
Mayy AN Allah ◽  
Naglaa Ali Khalifa ◽  
Maha Mahmoud Hamed Sakr ◽  
Eman Morsy Mohammed ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Biochemical Properties ◽  
Control Group ◽  
Active Stage ◽  
Systemic Lupus ◽  
Platelet Volume ◽  
Simple Method

Background Platelets are heterogeneous in size, density, metabolic, functional, and biochemical properties. Mean platelet volume (MPV) is a measure of the average size of platelet in a blood sample. Aim We aimed to evaluate the mean platelet volume as a marker for disease activity in children with systemic lupus erythematosus. Materials and Methods This was a prospective case-control study, which included 50 patients with SLE and 50 age and sex, matched healthy controls. All subjects were subjected to history taking, physical examination and laboratory parameters in active and remission phases of the diseases. Results The MPV value in the SLE group was significantly higher than control group (9.6 ± 1.3 fL, 9.1 ± 0.57 fL, respectively, p = 0.04). There was a significant increase of weight, blood pressure, urea, creatinine, proteinuria, CRP, ESR, cholestrol, MPV values, SLEDAI-2K scores and significant decrease of HB, albumin, C3, mean platelet volume (MPC) in the active stage than in the remission stage. There was a significant negative correlation between MPV and MPC in active stage of the disease but the correlation was insignificant in remission stage. Conclusion MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE.

scholarly journals Efficacy of Acceptance and Commitment Therapy in Reducing Disappointment, Psychological Distress, and Psychasthenia among Systemic lupus Erythematosus (SLE) Patients

2019 ◽  
Author(s):  
Maryam Sahebari ◽  
Mohammad Javad Asghari Ebrahimabad ◽  
Ali Ahmadi Shoraketokanlo ◽  
Hamidreza Aghamohammadian Sharbaf ◽  
Mandana Khodashahi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Psychological Distress ◽  
Acceptance And Commitment Therapy ◽  
Lupus Erythematosus ◽  
Control Group ◽  
Systemic Lupus ◽  
Acceptance And Commitment ◽  
The Mean ◽  
And Control ◽  
Experimental Group

Objective: The aim of this study was to evaluate the efficacy of acceptance and commitment therapy (ACT) in the reduction of disappointment, psychological distress, and psychasthenia among patients with systemic lupus erythematosus (SLE). Method: This quasi-experimental study was conducted on 24 females with lupus who referred to the Rheumatoid Disease Research Center (RDRC) of Ghaem hospital in Mashhad, Iran. This study had a pretest-posttest control group design. The participants were randomly assigned into 2 groups of experimental and control. The experimental group was treated with ACT. Data were collected using the Beck’s Hopelessness Scale, Kessler’s Psychological Distress Inventory, and Krupp’s Psychasthenia Inventory. Results: Mean age and mean duration of illness were 37.25±4.61 and 5.12±2.33 years, respectively. The mean disappointment score and psychological distress in the experimental group were lower compared to those in control group at the post experimental stage (P<0.001). Moreover, there was a significant difference between the experimental and control groups in the mean scores of psychasthenia in the posttest stage (P<0.001). Conclusion: According to the obtained results of this study, the enhancement of psychological flexibility based on ACT positively affected disappointment, psychological distress, and psychasthenia among the lupus patients. Therefore, it can be concluded that this therapeutic approach could reduce psychasthenia in patients through clarification of the values.

scholarly journals The Effects of Bromocriptine on Preventing Postpartum Flare in Systemic Lupus Erythematosus Patients from South China

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Qiu Qian ◽  
Liang Liuqin ◽  
Li Hao ◽  
Yuan Shiwen ◽  
Zhan Zhongping ◽  
...  
Keyword(s):  
Treatment Group ◽  
Lupus Erythematosus ◽  
Serum Levels ◽  
Prolactin Secretion ◽  
Serum Prolactin ◽  
Control Group ◽  
Disease Relapse ◽  
Systemic Lupus ◽  
Group 2 ◽  
Estradiol Levels

Objective. Prolactin plays an important role on the disease flare of postpartum SLE patients. 76 pregnant SLE patients were enrolled in this study to evaluate the efficacy of bromocriptine (an inhibitor of prolactin secretion) on preventing the postpartum disease relapse.Methods. Patients were randomly divided into the treatment group (bromocriptine, 2.5 mg oral, twice a day for 14 days after delivery) and the control group. All the patients were followed up for 12 months. Clinical features were recorded every 4 weeks. Serum prolactin and estradiol levels were measured at the second week and the second month after delivery. The endpoint of the study was disease relapse and defined when SLEDAI score increased by ≥3 points from the antenatal baseline.Results. (1) Serum levels of prolactin and estradiol decreased significantly in bromocriptine treatment group at the second week (P<0.001) and second month (P<0.05) after delivery compared to control group. (2) The relapse rate of the treatment group was lower than the control group (χ2=4.68,P=0.0305).Conclusions. Two weeks of oral bromocriptine treatment in postpartum SLE patients may relieve the disease from hyperprolactinemia and hyperestrogenemia and may be beneficial in preventing the patients from disease relapse.

scholarly journals Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Ting-Yu Tu ◽  
Chiu-Yu Yeh ◽  
Yao-Min Hung ◽  
Renin Chang ◽  
Hsin-Hua Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Multiple Sclerosis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Lupus ◽  
Control Groups ◽  
And Control ◽  
Control Study

ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk.MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control group and were matched at a case-control ratio of 1:20 by age, sex, and index year. All study individuals were traced from the index date back to their NTS exposure, other relevant covariates, or to the beginning of year 2000. Conditional logistic regression analysis was used to analyze the risk of SLE with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) between the NTS and control groups.ResultsThe mean age was 37.8 years in the case and control groups. Females accounted for 85.5%. The aOR of having NTS infection were significantly increased in SLE relative to controls (aOR, 9.20; 95% CI, 4.51-18.78) in 1:20 sex-age matching analysis and (aOR, 7.47; 95% CI=2.08-26.82) in propensity score matching analysis. Subgroup analysis indicated that the SLE risk was high among those who dwelled in rural areas; had rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome; and developed intensive and severe NTS infection during admission.ConclusionsExposure to NTS infection is associated with the development of subsequent SLE in Taiwanese individuals. Severe NTS infection and other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome also contributed to the risk of developing SLE.

scholarly journals Tooth Size in Patients with Mild, Moderate and Severe Hypodontia and a Control Group

2016 ◽  
Vol 10 (1) ◽  
pp. 382-389 ◽  
Author(s):  
Khaled Khalaf
Keyword(s):  
Size Reduction ◽  
Control Group ◽  
Tooth Size ◽  
Control Groups ◽  
Maxillary Lateral Incisor ◽  
Post Hoc ◽  
And Control ◽  
Congenitally Missing ◽  
Mandibular First Molar ◽  
Age And Sex

Objectives: To compare tooth size between subjects with mild, moderate and severe hypodontia and a control group. Material and Methods: The study comprised 120 patients with hypodontia divided into three groups of 40 mild (≤2 teeth congenitally missing), 40 moderate (3-5 teeth congenitally missing) and 40 severe (≥6 teeth congenitally missing) hypodontia; and 40 age and sex matched controls. Tooth size was recorded by measuring the mesiodistal and buccolingual dimensions of all fully erupted teeth on study models using digital callipers and compared between all hypodontia and control groups using Two-way ANOVA and Post Hoc Tests of subgroup comparison. Results: Two-way ANOVA revealed patients with hypodontia had significantly smaller mesiodistal and buccolingual tooth dimensions compared with controls (p<0.05). Furthermore patients with more severe hypodontia demonstrated significantly smaller tooth dimensions than those in the mild and moderate hypodontia subgroups (p<0.05). The most affected tooth in terms of tooth size reduction was the maxillary lateral incisor and the least affected tooth was the mandibular first molar. Conclusion: Patients with hypodontia have smaller tooth dimensions than control. Tooth size appears to be affected by the degree of hypodontia, with severe hypodontia having a greater effect on tooth size reduction. The findings of this study may contribute to understanding the aetiology of hypodontia and aid the multidisciplinary management of this complex condition.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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