scholarly journals Serum Estradiol Levels Are Inversely Associated With C-Reactive Protein in Premenopausal Women but Not Postmenopausal Women: a cross–sectional study

2019 ◽  
Author(s):  
Jae-Min Park ◽  
Yong-Jae Lee
Keyword(s):  
Regression Analysis ◽  
Postmenopausal Women ◽  
Linear Regression Analysis ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Multiple Linear Regression Analysis ◽  
Serum Estradiol ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Estradiol Levels

Abstract Background Epidemiological studies investigating the link between serum estradiol levels and inflammatory markers have produced inconsistent or conflicting results. We hypothesized that serum estrogen plays differing roles in inflammation according to menopausal status. Thus, we aimed to investigate the association between serum estradiol and C-reactive protein (CRP) levels in women according to their menopausal status.Methods We examined the association between serum estradiol and high-sensitivity CRP levels based on the menopausal status of 151 premenopausal women aged 21–52 years and in 394 postmenopausal women aged 46–75 years who participated in a health examination program. A multiple linear regression analysis was conducted using CRP level as the dependent variable.Results Multiple linear regression analysis showed that serum estradiol levels were inversely associated with CRP levels in premenopausal women (β coefficient = -0.298, P = 0.001). However, this was not the case in postmenopausal women after adjusting for age, body mass index, cigarette smoking, mean arterial pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, aspartate aminotransaminase, and alanine aminotransaminase levels. Serum estradiol levels were inversely associated with CRP in premenopausal women but not in postmenopausal women.Conclusion Our findings suggest that lower estrogenic activity may at least partly contribute to the pathogenesis of chronic inflammation, particularly in premenopausal women.

scholarly journals Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096122
Author(s):  
Jae-Min Park ◽  
Yong-Jae Lee
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Postmenopausal Women ◽  
Linear Regression Analysis ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Multiple Linear Regression Analysis ◽  
C Reactive Protein ◽  
Reactive Protein

Objective Epidemiological studies on the association of serum oestradiol levels and inflammatory markers have reported inconsistent and conflicting results. Therefore, we investigated the association between serum oestradiol and high-sensitivity C-reactive protein (CRP) levels in women on the basis of their menopausal status. Methods This cross-sectional study examined the association between serum oestradiol and CRP levels on the basis of menopausal status in 151 premenopausal women aged 42.7 ± 6.7 years and 394 postmenopausal women aged 58.1 ± 6.7 years who participated in a health examination program. Multiple linear regression analysis was conducted using CRP levels as the dependent variable. Results Multiple linear regression analysis showed that serum oestradiol levels were inversely associated with CRP levels in premenopausal women (β coefficient = −0.298) after adjusting for age, body mass index, smoking, mean arterial pressure, and levels of fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, aspartate aminotransferase, and alanine aminotransferase. However, this association was not found in postmenopausal women after adjusting for the same confounding factors. Conclusions Serum oestradiol levels are inversely associated with CRP levels in premenopausal women, but not in postmenopausal women. Lower oestrogenic activity may at least partly contribute to the pathogenesis of chronic inflammation, particularly in premenopausal women.

scholarly journals Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

2021 ◽  
Vol 10 (10) ◽  
pp. 2077
Author(s):  
Yi-Min Huang ◽  
Chiao Lo ◽  
Chiao-Feng Cheng ◽  
Cheng-Hsun Lu ◽  
Song-Chou Hsieh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Severe Disease ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Serum Biomarkers ◽  
Healthy Controls ◽  
Granulomatous Mastitis ◽  
C Reactive Protein ◽  
Idiopathic Granulomatous Mastitis ◽  
Reactive Protein

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking breast cancer. Limited research has been conducted on the application of serum biomarkers. This study aims to investigate the association of serum biomarkers with disease severity in patients with IGM. From November 2011 to March 2020, medical records of patients with IGM were reviewed. Serum cytokine levels were measured in patients and healthy controls between July 2018 and March 2020. A total of 41 patients with histologically proven IGM were found. Serum interleukin (IL)-6 level was significantly higher in patients with IGM (n = 11) than healthy controls (n = 7). Serum IL-6 and C-reactive protein (CRP) levels were significantly higher in patients with severe disease than mild and moderate disease. Serum IL-6 (Spearman’s ρ = 0.855; p < 0.001) and CRP (Spearman’s ρ = 0.838; p = 0.001) levels were associated with time to resolution. A higher serum CRP level was associated with a longer time to resolution (B = 0.322; p < 0.001) in multiple linear regression analysis. Serum IL-6 and CRP levels can be used as biomarkers for the evaluation of disease severity in IGM. IL-6 may play a crucial role in the immunopathology of IGM.

scholarly journals POS0841 RISK FACTORS OF LOW BONE MINERAL DENSITY IN WOMEN WITH SYSTEMIC SCLEROSIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 674.2-675
Author(s):  
A. Efremova ◽  
N. Toroptsova ◽  
N. Demin ◽  
O. Dobrovolskaya ◽  
O. Nikitinskaya
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Systemic Sclerosis ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Cumulative Dose ◽  
Premenopausal Women ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

Background:Chronic inflammatory rheumatic diseases are risk factors of bone loss and fractures. Systemic sclerosis (SSc) has been recognized to be another potential inflammatory joint disease that may affect bone tissue.Objectives:to evaluate bone mineral density (BMD) and risk factors of low BMD in women with SSc.Methods:173 women, among them 110 postmenopausal (median age 60[55,63] years) and 63 premenopausal (median age 35[31,44] years). BMD was measured at lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry (DXA, Hologic 4500A). Low BMD was diagnosed if the T-score was < -1.0 standard deviation (SD) in postmenopausal women and if the Z-score was < -2.0 SD in premenopausal women. The relationship between BMD and SSc patients’ characteristics was evaluated using univariate linear regression analysis.Results:Low BMD was found in 66% patients: 79% - in postmenopausal and 18% - in premenopausal women. Among postmenopausal persons osteoporosis was discovered in 47% and osteopenia – in 32% cases. In postmenopausal woman BMD of LS, FN and TH were associated with body mass index (BMI) (β=0.27, p=0.010; β=0.47, p<0,001 and β=0.45, p<0,001, respectively), duration of glucocorticoids (GCs) using (β=-0.31, p=0.008; β=-0.34, p=0.003 and β=-0.27, p=0.022, respectively); BMD of FN and TH with C-reactive protein (β= -0.32, p=0.016 and β= -0.29, p=0.029, respectively) and LS BMD with current and cumulative GCs dose (β= -0.24, p=0.039 and β= -0.29, p=0.014, respectively). In premenopausal women BMD of LS, FN and TH were associated with BMI (β=0.51, p<0,001; β=0.45, p=0.003 and β=0.47, p=0.002, respectively), duration of GCs using (β= -0.45, p=0.004; β= -0.47, p=0.003 and β= -0.48, p=0.002, respectively) and GCs cumulative dose (β= -0.48, p=0.002; β= -0.51, p=0.001 and β= -0.46, p=0.004, respectively); BMD of FN and TH with 25(ОН)D level (β=0.52, p=0.008 and β=0.54, p=0.005, respectively), and LS BMD with SSc duration (β= -0.44, p=0.004).Conclusion:Low BMD was diagnosed in 66% of women with SSc. Low BMI, GCs cumulative dose and duration of GCs using were independent risk factors for low BMD in both premenopausal and postmenopausal persons. Additional factors as SSc duration and low vitamin D level were found out for premenopausal and current GCs dose and C-reactive protein level for postmenopausal women.Disclosure of Interests:None declared

scholarly journals Higher Serum C-Reactive Protein Levels in Catatonic Patients: A Comparison to Non-catatonic Patients and Healthy Controls

2020 ◽  
Vol 46 (5) ◽  
pp. 1155-1164
Author(s):  
Fu-Chun Zhou ◽  
Joseph W Y Lee ◽  
Qi-Hang Zhang ◽  
Zuo-Li Sun ◽  
Qijing Bo ◽  
...  
Keyword(s):  
Rating Scale ◽  
Psychiatric Patients ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Complement Component ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Abstract Catatonia is a psychomotor syndrome defined by a constellation of predominantly motor symptoms. The aim of the present study was to determine whether recently admitted psychiatric patients with catatonia exhibited higher serum C-reactive protein (hs-CRP) levels compared to non-catatonic psychiatric patients and healthy controls (HCs). Recently admitted psychiatric patients were screened and evaluated for the catatonia syndrome using the Bush-Francis Catatonia Rating Scale and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The study sample was formed by 150 individuals (39 male and 111 female), including 51 catatonic patients, 55 non-catatonic patients, and 44 HCs. Serum hs-CRP levels were processed with the enzyme-linked immunosorbent assay. Serum levels of creatine kinase (CK), adrenocorticotropic hormone (ACTH), immunoglobulin G (IgG), complement component 3 (C3), and complement component 4 (C4) were also determined. There was a significantly higher percentage of patients with high inflammatory levels (hs-CRP &gt; 3000ng/ml) in the catatonic (43.1%) than in the non-catatonic (14.5%) or HCs group (9.1%) (χ 2 =18.9, P &lt; .001). Logistic regression showed that catatonic patients had significantly higher hs-CRP levels compared to non-catatonic patients even after controlling for other clinical and laboratory variables (OR = 3.52, P = .015, 95% CI 1.28–9.79). Multiple linear regression analysis revealed that log-transformed hs-CRP was independently predicted by body mass index and log-transformed C4, ACTH, and Cortisol in catatonic patients. Findings of the present study suggest that catatonia is specifically linked to a higher level of systemic inflammation, not merely attributable to the overall psychopathology, or alterations in the stress level and complement system.

scholarly journals Development of Pharyngocutaneous Fistula after Total Laryngectomy: The Predictive Value of C-reactive Protein/Albumin Ratio

2020 ◽  
Vol 63 (4) ◽  
pp. 159-163
Author(s):  
Abitter Yücel ◽  
Hilal Yücel ◽  
Fuat Aydemir ◽  
Mert Mutaf ◽  
Mehmet Akif Eryılmaz ◽  
...  
Keyword(s):  
Postoperative Period ◽  
Total Laryngectomy ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Early Postoperative Period ◽  
Pharyngocutaneous Fistula ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Significant Difference

Background: We aimed to evaluate whether C-reactive protein(CRP)/ Albumin ratio (CAR) performed in the early postoperative period after total laryngectomy could be a predictive factor for the development of pharyngocutaneous fistula (PCF). Methods: The files of patients with laryngeal squamous cell carcinoma who underwent total laryngectomy between January 2005 and January 2019 were retrospectively reviewed. Patients were divided into two groups: patients with PCF (PCF group) and without (Non-PCF group). CAR values and risk factors were compared between groups. Results: The overall incidence of PCF was 23.2%. There was a statistically significant difference between the two groups in terms of CRP and CAR levels (p = 0.001). The CAR value of 27.05 (sensitivity = 75.0% , specificity 68.2%, area under curve (AUC) = 0.742, 95% confidence interval 0.616–0.868) was determined as a cutoff value to describe the development of fistula in the early postoperative period. In multiple linear regression analysis, there was an independent relationship between presence of PCF and previous RT and CAR value. Conclusions: CAR, performed in the early postoperative period, may be a new and useful marker for predicting PCF after total laryngectomy.

scholarly journals Relationship between C-Reactive Protein and Cardiovascular Diseases in Patient with ESRD

2022 ◽  
Vol 12 (2) ◽  
pp. 95-99
Author(s):  
Md Abdullah Al Mamun ◽  
Mohammad Mirazul Hasan ◽  
Fazla Alahi Khan ◽  
Momtaz Hossain ◽  
Syed Mahbub Morshed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Regression Analysis ◽  
Cardiovascular Diseases ◽  
Linear Regression Analysis ◽  
Fisher Exact Test ◽  
C Reactive Protein ◽  
Total Study Population ◽  
Reactive Protein ◽  
Esrd Patients

Background- Cardiovascular mortality is significantly higher in ESRD patient.There are various risk factors for development of cardiovascular diseases including traditional risk factors, factors unique to ESRD patients and emerging risk factors.It is believed that their combined actions are integrated in the progression of atherosclerosis and inflammation plays a central role. C-reactive protein is a valuable marker of inflammation. Determination of serum creactive protein levels may be a useful predictor of cardiovascular diseases in ESRD patients Objective-To find out relationship between c-reactive protein and cardiovascular diseases. Methods- This cross sectional study was carried out into department of Nephrology, Dhaka Medical College Hospital, Bangladesh following fulfillment of inclusion and exclusion criteria. For analytical purpose total study population were divided into two groups on the basis of creactive protein level. Patients having c-reactive protein £6 mg/L were considered as group A and >6 mg/L were considered as Group B. The differences between groups were analyzed by unpaired t-test, fisher’ exact test or chi-square (X2) test. Multivariable regression analysis was done to see the association between c-reactive protein and cardiovascular diseases. Results- Patients with raise c-reactive protein have significantly higher cardiovascular disease than that of normal c-reactive protein. Multivariable linear regression analysis after adjusting for age, sex, smoking and diabetes shows that subject with CRP £6 mg/L vs >6 mg/L had 1.51 (95% CI 1.02 to 2.19) times increase risk of having cardiovascular disease. Conclusion- Inflammatory process has a role in development of cardiovascular diseases in ESRD patient. J Shaheed Suhrawardy Med Coll 2020; 12(2): 95-99

Effects of Short-Term Supplementation with Ascorbate, Folate, and Vitamins B6 and B12 on Inflammatory Factors and Estrogen Levels in Obese Postmenopausal Women

2006 ◽  
Vol 76 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Walter Palmas
Keyword(s):  
Postmenopausal Women ◽  
Interleukin 6 ◽  
Inflammatory Factors ◽  
Vitamin Supplementation ◽  
C Reactive Protein ◽  
Open Label ◽  
Reactive Protein ◽  
Hormonal Balance ◽  
Estradiol Levels

Little is known about the effects of commonly used vitamins on serum inflammatory markers and the hormonal balance in obese postmenopausal women. We studied the effects of an 8-week open-label supplementation with vitamins C (500 mg), B6 (25 mg), B12 (1 mg), and folate (5 mg) on C-reactive protein, interleukin-6, and estradiol levels in 20 obese (body mass index ≥ 30) postmenopausal women. Outcomes were assessed in a blinded fashion. Folate and vitamin B12 levels rose significantly, suggesting that the supplement was well absorbed and that participants adhered to the protocol. Weight, blood pressure, and serum lipids remained stable. C-reactive protein, interleukin-6, and leptin levels remained unchanged. Estradiol levels rose from a median of 22.0 pg/mL (IQR = 15.9–25.8) at baseline to a median of 27.8 pg/mL (IQR = 23.1–33.9) at follow-up (p = 0.003). Increments in serum estradiol caused by vitamin supplementation in postmenopausal women have not been previously described and probably merit further investigation.

scholarly journals Detection and predictors of anti-SARS-CoV-2 antibody levels in COVID-19 patients at 8 months after symptom onset

2021 ◽  
pp. 00-00
Author(s):  
Jing Guo ◽  
Li Li ◽  
Qian Wu ◽  
Hongwei Li ◽  
Yajie Li ◽  
...  
Keyword(s):  
Disease Severity ◽  
Symptom Onset ◽  
Protein Level ◽  
Protective Immunity ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Antibody Levels

Aim: To determine SARS-CoV-2 specific IgM and IgG levels of patients with COVID-19 at 8 months after symptom onset and to explore the predictors of antibody levels. Materials & methods: The magnetic chemiluminescence method was used to measure the antibody levels. Clinical data were collected and analyzed retrospectively. Results: A total of 54 patients were enrolled in this study, of whom 59.3% were IgM positive and 96.4% were IgG positive. The multiple linear regression analysis revealed that the duration of RNA shedding, C-reactive protein level and disease severity were independent predictors of IgG levels. Conclusion: COVID-19 patients retained long-term viral-specific protective immunity. Disease severity, C-reactive protein level and duration of RNA shedding were related to antibody levels 8 months after symptom onset.

scholarly journals The influence of menopause and body mass index on serum leptin concentrations

2000 ◽  
pp. 55-60 ◽  
Author(s):  
P Hadji ◽  
O Hars ◽  
K Bock ◽  
G Sturm ◽  
T Bauer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Serum Leptin

OBJECTIVE: The aim of this study was to evaluate the influence of menopausal status, serum estradiol and body mass index (BMI) on serum leptin concentration in a large sample of pre- and postmenopausal women. DESIGN: 434 healthy women (mean age +/-s.d., 52.2 +/- 10.3 years) were recruited at the University of Marburg on the occasion of a routine gynecological visit. Two hundred and eighteen (50.2%) women were premenopausal (mean age, 36.5 +/- 10.4 years) and not on oral contraceptives or hormone replacement therapy (HRT) and 216 (49.8%) women were postmenopausal (mean age 61.8 +/- 8.9 years) not on HRT. To evaluate the influence of menopausal status, estradiol level and BMI on serum leptin concentrations, women were allocated to one of the four groups: (a) premenopausal women BMI <25 kg/m(2) (n=137), (b) premenopausal women BMI >25 kg/m(2) (n=81), (c) postmenopausal women BMI <25 kg/m(2) (n=94) and (d) postmenopausal women BMI >25 kg/m(2) (n=122). RESULTS: Irrespective of the menopausal status, women with a BMI >25 kg/m(2) had significantly higher leptin concentrations in all age groups compared with women with a BMI <25 kg/m(2) (P<0.001). The multiple linear regression analyses showed that BMI was the only statistically significant independent predictor for leptin. In comparison to postmenopausal women, premenopausal women showed a significantly lower mean age, weight, BMI and FSH concentration (P<0. 001), a higher mean height and serum estradiol (P<0.01 and P<0.001 respectively) but significantly lower serum leptin concentration (P<0.01). The multiple linear regression model showed no significant influence of menopausal status or serum estradiol on serum leptin concentration, even after controlling for BMI. CONCLUSIONS: Serum leptin concentrations are significantly higher in pre- and postmenopausal obese women, compared with normal weight controls. Serum leptin concentrations are not influenced by menopausal status or serum estradiol level.

Improved method for calculating calcium fractions in plasma: reference values and effect of menopause.

1989 ◽  
Vol 35 (1) ◽  
pp. 14-17 ◽  
Author(s):  
B E Nordin ◽  
A G Need ◽  
T F Hartley ◽  
J C Philcox ◽  
M Wilcox ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Postmenopausal Women ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Anion Gap ◽  
Ionized Calcium ◽  
Total Calcium ◽  
Improved Method ◽  
Plasma Bicarbonate ◽  
Normal Mean

Abstract Multiple linear regression analysis showed that total calcium was significantly and positively related to albumin, globulin, anion gap, and bicarbonate in plasma from 556 normal postmenopausal women. The residual constant of 1.21 mmol/L approximated the normal mean for ionized calcium in plasma. The coefficients derived from the multiple regression analysis were used to calculate ionized calcium from total calcium and ligand concentrations in a series of 105 clinical cases in whom ionized calcium was measured with the calcium electrode. The regression equation was y = 1.00x -0.0039 mmol/L, where x is measured and y calculated Ca2+ (r = 0.78, P less than 0.001). The protein-bound, ultrafiltrable, and complexed fractions of the calcium were also calculated for plasma from 69 normal young men, 66 normal young women, and 305 normal postmenopausal women. The increased plasma calcium in the postmenopausal group was accounted for by an increase in the complexed fraction, due to increases in plasma bicarbonate and anion gap.

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