scholarly journals NAFLD progression is related with plasma pro-oxidative biomarkers rather than liver tissue-measured nitrogen metabolism biomarkers in population with obesity and metabolic syndrome

2020 ◽  
Author(s):  
Juan Antonio Suárez-Cuenca ◽  
Gabriela Alexandra Domínguez-Pérez ◽  
Rolando Efraín Hernández-Muñóz ◽  
Alejandro Hernández-Patricio ◽  
Eduardo Vera-Gómez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Nitrogen Metabolism ◽  
Liver Tissue ◽  
Cardiometabolic Risk ◽  
Metabolic Phenotype ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Study Population ◽  
And Oxidative Stress

Abstract Background. The metabolic syndrome (MS) is associated with an increased production of nitrogen metabolites and elevated oxidative stress, which favor the development and progression of non-alcoholic fatty liver disease (NAFLD). Subjects with the phenotype known as metabolically unhealthy obese (MUO) meet most of the MS cardiometabolic risk criteria and show a higher prevalence of NAFLD and fibrosis progression risk, compared to the so-known as metabolically healthy obese (MHO). The present study aimed to explore whether liver-specific biomarkers of nitrogen metabolism and oxidative stress, measured in both plasma and in liver tissue, may relate to NAFLD severity and/or metabolic phenotype. Methods. This observational, cross-sectional study included candidates for bariatric surgery with biopsy-proven NAFLD diagnosis and staging. For comparison, the study population was divided according to NAFLD progression (steatohepatitis F0-F1 vs F2-F4) and metabolic phenotype (MHO vs MUO, based on the MS criteria). Hepatic and plasma concentrations of nitrogen metabolites and oxidative stress biomarkers were determined by enzymatic kinetics assays, ELISA and Griess reaction. Results. The study population consisted of 28 patients with obesity and higher prevalence of dyslipidemia, diabetes mellitus and hypertension. NAFLD progression was related with the metabolic phenotype. According to plasma biomarkers, MUO phenotype was related to higher cardiometabolic risk; while NAFLD severity progression was related to higher Hb A1c and triglycerides. Elevated hepatic concentrations of ammonium, nitrites, arginine and citrulline were found in MUO phenotype, but only higher plasma concentration of MDA was found as specifically related to NAFLD progression. Conclusions. Circulating biomarkers of redox state were selectively related with NAFLD progression, supporting prognostic and therapeutic potential target. Hepatic concentrations of nitrogen metabolism biomarkers may be more related to cardiometabolic risk.

scholarly journals Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

2010 ◽  
Vol 2 (3) ◽  
pp. 131
Author(s):  
Waode Nurfina ◽  
Irawan Yusuf ◽  
Mansyur Arif
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Iron Status ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Metabolic Conditions ◽  
Inflammatory State ◽  
And Oxidative Stress

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane

scholarly journals Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

2018 ◽  
Vol 120 (6) ◽  
pp. 645-652 ◽  
Author(s):  
Luciana J. Bernini ◽  
Andréa N. Colado Simão ◽  
Cínthia H. B. de Souza ◽  
Daniela F. Alfieri ◽  
Liliane G. Segura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Inflammatory Markers ◽  
Healthy Subjects ◽  
Antioxidant Defenses ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Inflammatory State ◽  
Baseline Values ◽  
And Oxidative Stress

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

scholarly journals Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Gema Frühbeck ◽  
Victoria Catalán ◽  
Amaia Rodríguez ◽  
Beatriz Ramírez ◽  
Sara Becerril ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
The Metabolic Syndrome ◽  
And Oxidative Stress

scholarly journals Beneficial Effects of Multicomponent Functional Foods in Patients with Metabolic Syndrome

2018 ◽  
Author(s):  
Simona Dragan ◽  
Georgiana Damian ◽  
Dana Velimirovici ◽  
Maria Rada ◽  
Delia Berceanu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Plasma Lipids ◽  
Grape Juice ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Trial Testing ◽  
Balsamic Vinegar ◽  
Group 3 ◽  
And Oxidative Stress

The ANTIATERO-ALIM study was a randomized, parallel design nutritional trial testing functional food (FF) diets against the usual diet recommended in the metabolic syndrome. Functional meals included balsamic vinegar from apples and honey and grape juice enriched with polyphenols from seeds of red grapes. 300 patients with metabolic syndrome were randomized into 4 groups: gr.1: FF + Ω-3 supplements, gr.2: FF, gr.3: Ω-3 supplements, gr.4: control. IRHOMA insulin resistance, plasma lipids and oxidative stress were assessed at inclusion and at 6 months. After 6 months there was a very significant decrease of oxidative stress in group 3, followed by a significant decrease in groups 1 and 2.

Insulin-Leptin Axis, Cardiometabolic Risk and Oxidative Stress in Elderly with Metabolic Syndrome

2018 ◽  
Vol 126 (07) ◽  
pp. 445-452 ◽  
Author(s):  
Daniela Gradinaru ◽  
Husseina Khaddour ◽  
Denisa Margina ◽  
Anca Ungurianu ◽  
Claudia Borsa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Resistance Index ◽  
Hdl Cholesterol ◽  
Elderly Subjects ◽  
Control Group ◽  
Oxidative Stress Biomarkers ◽  
The Metabolic Syndrome ◽  
And Oxidative Stress

AbstractInsulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index (IAR-index). Inflammation and oxidative stress biomarkers evaluated were the high-sensitivity C-reactive protein (hsCRP), the advanced oxidation protein products (AOPP), and the serum antioxidant capacity measured as ferric reducing antioxidant potential (FRAP). The metabolic syndrome group showed significantly (p<0.01) lower levels of ILR and not significant (p=0.09) higher values of IAR-index, as compared to the control group. In metabolic syndrome subjects, the IAR-index was significantly positively correlated with uric acid (r=0.313, p<0.05), FRAP (r=0.347, p<0.05) and AOPP (r=0.677, p<0.01), and negatively correlated with HDL-cholesterol (r=− 0.340, p<0.05) as well as with the ratio FRAP/uric acid (r=− 0.315, p<0.05). ILR and IAR-index reflected the biological state of adipose and pancreatic β-cells and seem to depict the adipo-insular axis status related to metabolic and oxidative stress better than individual markers. Therefore, ILR and IAR-index could represent integrated high-potential biomarkers for disease and patient stratification.

scholarly journals Sagittal abdominal diameter and waist circumference are equally good as identifiers of cardiometabolic risk

2019 ◽  
Author(s):  
Grith Møller ◽  
Christian Ritz ◽  
Louise Kjølbæk ◽  
Stine Vuholm ◽  
Sanne Kellebjerg Korndal ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Cardiometabolic Risk ◽  
International Diabetes Federation ◽  
Metabolic Phenotype ◽  
Low Grade ◽  
Metabolic Disturbances ◽  
Public Health Perspective ◽  
Sagittal Abdominal Diameter ◽  
The Metabolic Syndrome

AbstractBackgroundBody mass index (BMI) and waist circumference (WC) are commonly used markers of cardiometabolic risk. However, sagittal abdominal diameter (SAD) has been proposed to be a better marker of intra-abdominal obesity compared to WC and might better associate with metabolic disturbances in high-risk populations. The objective of this study was to compare SAD, WC, and BMI as determinants of an adverse metabolic phenotype.MethodAnthropometric and metabolic measures of 1516 overweight or obese individuals with features of the metabolic syndrome were included to examine differences between SAD, WC and BMI as measures of an adverse metabolic phenotype. Multiple linear regression and logistic regression models were used to investigate the association between SAD, WC, and BMI and markers of metabolic syndrome, insulin resistance, blood lipids, and low grade inflammation.ResultsBoth SAD and WC correlated with BMI, but as BMI increased, SAD proportionately estimated higher abdominal adiposity compared to WC (slope = 0.0037 (0.0029; 0.0046), p<0.0001). We did not find major differences between SAD, WC and BMI in explained variance in models with the different markers of metabolic risk. Furthermore, we did not find differences between SAD and WC in the ability to identify individuals with metabolic syndrome according to the International Diabetes Federation (IDF) cut-offs, but a few differences from BMI were indicated but mostly before adjustments. Moreover, the differences between SAD and WC associations were not modified by sex or degree of adiposity, but identification of individuals with a metabolic phenotype was generally better in women.ConclusionThese data indicate that SAD and WC are equally good indicators of an adverse metabolic phenotype. Thus, from a public health perspective choice of anthropometric measure may depend only on what is the most practical method in a given situation.

Sign in / Sign up

Export Citation Format

Share Document