scholarly journals Release Characteristics of Enoxaparin Sodium Loaded Polymethylmethacrylate Bone Cement

2020 ◽  
Author(s):  
Hui Sun ◽  
Xinzhe Ma ◽  
Zhiyong Li ◽  
Jianning Liu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Bone Cement ◽  
Enoxaparin Sodium ◽  
Parallel Line ◽  
Control Group ◽  
Plateau Phase ◽  
Short Term ◽  
Pmma Bone Cement ◽  
Loading Amount ◽  
Experimental Group ◽  
Quantitative Response

Abstract Background: This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loading into the PMMA bone cement. Methods: In the experimental group, 40g Palacos®R PMMA bone cement was loaded with various amount of ES 4000, 8000, 12000, 16000, 20000, and 24000 AXaIU, respectively. The control group was not loaded with ES. Scanning electron microscopy (SEM) was used to observe the surface microstructure of the bone cement in the two groups. In the experiment group, the mold was extracted continuously with pH7.4 Tris-HCL buffer for 10 days. The extract solution was collected every day and the anti-FXa potency was measured. The experiment design and statistical analysis were conducted using a quantitative response parallel line method. Results: Under the SEM, it was observed that ES was filled in the pores of PMMA bone cement polymer structure and released from the pores after extraction. There was a burst effect of the release. The release amount of ES on the first day was 0.415, 0.858, 1.110, 1.564, 1.952 and 2.513 respectively from the six groups with various ES loading amount of 4000, 8000, 12000, 16000, 20000 and 24000 AXaIU, all reaching the peak of release on the first day. The release decreased rapidly on the next day and entered the plateau phase on the fourth day. Conclusion: PMMA bone cement can be used as a carrier to effectively release enoxaparin sodium within a short term.

scholarly journals Release characteristics of enoxaparin sodium-loaded polymethylmethacrylate bone cement

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hui Sun ◽  
Xinzhe Ma ◽  
Zhiyong Li ◽  
Jianning Liu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Bone Cement ◽  
Enoxaparin Sodium ◽  
Parallel Line ◽  
Control Group ◽  
Coagulation Therapy ◽  
Pmma Bone Cement ◽  
Long Time ◽  
Application Potential ◽  
Loading Amount ◽  
Experimental Group

Abstract Background This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loading into the PMMA bone cement. Methods In the experimental group, 40 g Palacos®R PMMA bone cement was loaded with various amount of ES 4000, 8000, 12,000, 16,000, 20,000, and 24,000 AXaIU, respectively. The control group was not loaded with ES. Scanning electron microscopy (SEM) was used to observe the surface microstructure of the bone cement in the two groups. In the experiment group, the mold was extracted continuously with pH7.4 Tris-HCL buffer for 10 days. The extract solution was collected every day and the anti-FXa potency was measured. The experiment design and statistical analysis were conducted using a quantitative response parallel line method. Results Under the SEM, it was observed that ES was filled in the pores of PMMA bone cement polymer structure and released from the pores after extraction. There was a burst effect of the release. The release amount of ES on the first day was 0.415, 0.858, 1.110, 1.564, 1.952, and 2.513, respectively, from the six groups with various ES loading amount of 4000, 8000, 12,000, 16,000, 20,000, and 24,000 AXaIU, all reaching the peak of release on the first day. The release decreased rapidly on the next day and entered the plateau phase on the fourth day. Conclusion The prepared ES-PMMA bone cement has high application potential in orthopedic surgery. ES-PMMA bone cement shows good drug release characteristics. The released enoxaparin sodium has a local anti-coagulant effect within 24 h after application, but it will not be released for a long time, which is complementary to postoperative anti-coagulation therapy.

scholarly journals Effects of Massage Therapy on the Development of Babies Born with Down Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Elena Pinero-Pinto ◽  
María-Luisa Benítez-Lugo ◽  
Raquel Chillón-Martínez ◽  
Manuel Rebollo-Salas ◽  
Lorena-María Bellido-Fernández ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mixed Model ◽  
Massage Therapy ◽  
Psychomotor Development ◽  
Control Group ◽  
Short Term ◽  
Infant Massage ◽  
Significant Group ◽  
Developmental Age ◽  
Experimental Group

Objective. To determine the short-term effects of infant massage on the development of Down syndrome babies. Materials and Methods. The study compared two groups (intervention and control), each with 16 babies with Down syndrome between 4 and 8 months old. The variables developmental age and developmental quotient were measured at two distinct time points, at pretest and after 5 weeks, using the Brunet-Lézine Early Childhood Psychomotor Development revised scale. This scale measures the variables of age and development quotient in a partial way (motor, visual-motor coordination, language, and social development) and in a global way. The experimental group received infant massage, applied by the parents, during these 5 weeks, every day for at least 10 minutes. The massage protocol was based on the methodology created by Vimala McClure. The control group received it after 5 weeks. Results. All developmental variables were improved in the experimental group but not in the control group. There were significant differences in developmental age between the two groups, and this outcome was better in the experimental group (p<0.001). The 2-by-2 mixed-model analysis of variance indicates a statistically significant group-by-time interaction for all development quotients, both partial and global (p<0.001), which was significantly higher in the experimental group than in the control group. Conclusion. Infant massage therapy improves the development of babies with Down syndrome in the short term.

scholarly journals Short - Term Effects of Eccentric Hip Abductors and Lateral Rotators Strengthening In Sedentary People with Patellofemoral Pain Syndrome on Pain and Function : A Randomized Control Trail

2016 ◽  
Vol 06 (01) ◽  
pp. 068-073
Author(s):  
Kavitha Shetty ◽  
Lawrence Mathias ◽  
Mahesh V. Hegde ◽  
Sukumar Shanmugam
Keyword(s):  
Statistical Significance ◽  
Pain Syndrome ◽  
Patellofemoral Pain ◽  
Control Group ◽  
Short Term ◽  
Strengthening Exercises ◽  
Post Test ◽  
Hip Abductor ◽  
And Function ◽  
Experimental Group

Abstract Purpose: To investigate the influence of additional eccentric strengthening to the hip abductor and lateral rotator musculature on pain and function in sedentary people with Patellofemoral pain syndrome (PFPS). Methods: 30 sedentary patients between 18 and 40 years of age, with a diagnosis of PFPS, all the subjects received treatment for a period of 4weeks and the subjects were randomly assigned to Control group (CG) and Experimental group (EG). The patients in the Control group (n = 15) performed a conventional knee-stretching and strengthening program, whereas, patients in the Experimental group (n = 15) performed the same exercises as those in the control group ,in addition received eccentric strengthening exercises for the hip abductors and lateral rotators. An 11-point numeric pain rating scale (NPRS), the Lower Extremity Functional Scale (LEFS) and the Anterior Knee Pain Scale (AKPS) were used as outcome measures during the baseline and at the end of 4weeks . Results: Statistics were retrieved using SPSS.16, paired 't' test was conducted to compare AKPS and LEFS values ,whereas, Mann- Whitney U test was used for NPRS value between the groups. After 4 weeks of treatment, the control group, pre and post-test value for AKPS (p<0.001),LEFS (P<0.001),NPRS (p<0.001) shows a statistical significance and even in the experimental group, pre and post-test value for AKPS (p<0.001),LEFS (P<0.001),NPRS (p<0.001) shows a statistical significance in pain and function, but comparing both the group experimental group is significantly more better AKPS (p=0.002),LEFS (P<0.001),NPRS (P<0.001) then a control group. Conclusion: short term Knee strengthening exercises supplemented by eccentric hip abductor and lateral rotator musculature–strengthening exercises were more effective than knee exercises alone in improving function and reducing pain in sedentary people with PFPS.

scholarly journals Limits of cross-modal plasticity? Short-term visual deprivation does not enhance cardiac interoception, thermosensation, or tactile spatial acuity

2021 ◽  
Author(s):  
Dominika Radziun ◽  
Laura Crucianelli ◽  
H. Henrik Ehrsson
Keyword(s):  
Healthy Volunteers ◽  
Washout Period ◽  
Visual Deprivation ◽  
Control Group ◽  
Light Conditions ◽  
Complete Darkness ◽  
Short Term ◽  
Experimental Conditions ◽  
Normal Light ◽  
Experimental Group

In the present study, we investigated the effect of short-term visual deprivation on discriminative touch, cardiac interoception, and thermosensation by asking 64 healthy volunteers to perform four behavioral tasks. The experimental group contained 32 subjects who were blindfolded and kept in complete darkness for 110 minutes, while the control group consisted of 32 volunteers who were not blindfolded but were otherwise kept under identical experimental conditions. Both groups performed the required tasks three times: before and directly after deprivation (or control) and after an additional washout period of 40 minutes, in which all participants were exposed to normal light conditions. Our results showed that short-term visual deprivation had no effect on any of the senses tested. This finding suggests that short-term visual deprivation does not modulate basic bodily senses and extends this principle beyond tactile processing to the interoceptive modalities of cardiac and thermal sensations.

scholarly journals Clinical efficacy of plasma exchange therapy for treatment of autoimmune bullous skin disease

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Xiaoxu Shi ◽  
Lanying Qin ◽  
Jun Peng ◽  
Zishen Zhao ◽  
Haixiang Zhang
Keyword(s):  
Plasma Exchange ◽  
Clinical Efficacy ◽  
Skin Disease ◽  
Treatment Method ◽  
Control Group ◽  
Short Term ◽  
Plasma Exchange Therapy ◽  
Significant Difference ◽  
The Difference ◽  
Experimental Group

Objective: To investigate the clinical efficacy of plasma exchange therapy for autoimmune bullous skin disease. METHODS: Fifty patients with autoimmune bullous skin disease enrolled in our hospital from January 2018 to January 2019 were selected. The patients were grouped by treatment method: 25 control group patients were given conventional hormone therapy, while 25 experimental group patients were treated with plasma exchange therapy; efficacy of treatment was compared between two groups of patients. RESULTS: Initial dose, maximum dose, and cumulative dose of glucocorticoids were lower in experimental group patients than those in control group (P<0.05). Incidence of complication was lower in experimental group patients than those in control group (P<0.05); the difference was significant. There was no significant difference in short-term efficacy between the two groups (P>0.05). Conclusion: The application of plasma exchange therapy was effective for treatment of autoimmune bullous skin disease. It could reduce dosage amount of glucocorticoids and incidence of complications; its application can be promoted.

scholarly journals The Effect of Kryptonite Bone Cement combined with a Standard Kirschner Wire on Tibial Bone Fracture in Rats

2022 ◽  
Vol 9 (01) ◽  
pp. 5808-5913
Author(s):  
Ibrahim EKE ◽  
Mehmet Akif AKCAL ◽  
Yusuf IYETIN ◽  
OguzSükrü POYANLI
Keyword(s):  
Bone Cement ◽  
Bone Repair ◽  
Callus Formation ◽  
Statistical Significance ◽  
Kirschner Wire ◽  
Autogenous Bone ◽  
Control Group ◽  
Complete Fusion ◽  
Non Union ◽  
Experimental Group

Objective This study aims to observe whether Kryptonite Bone Cement combined with a standard Kirschner wire, instead of autogenous bone grafts, increases bone healing and mechanical strength in rats with tibia fractures. Methods The study included sixteen rats, which were divided into two groups as a control group (n=8) and an experimental group (n=8). After segmental fractures were made in both groups, intramedullary fixation of tibia procedures were conducted with the use of a Kirschner wire. No additional procedures were performed inthe control group, but Kryptonite Bone Cement was applied in the experimental group. The rats were evaluated clinically, radiologically and histologically4 times; immediately after the operation, and atthe 1st, 3rd, and 6thweeks following surgery. Results One rat from the experimental and one from the control group had both wound dehiscence and wound site infection. No recovery was observed in any rats either in the control or experimental group immediately after surgery. During week 1, callus formation was identified in 5 rats in the experimental group (p=0.0072), and during week 3, fracture lines disappeared in 4 rats in the experimental group (p=0.064); the differences between control and experimental groups were statistically significant. During week 6, no statistical significance was observed in radiological assessments for the control group and experimental group (p=0.71). The rate of non-union was higher in the control group (37.50%) than in the experimental one, while the rate of complete fusion was higher in the experimental group (87.50%) than that in the control group. Conclusion Osteoconductivity and ergonomic qualities of Kryptonite Bone Cement prove helpful in bone repair. Future studies to be conducted in a prospective and randomized manner will be effective on demonstrating the effectiveness of Kryptonite Bone Cement.

scholarly journals The Effect of Games with Rules on Voluntary Regulation of 6—7-year-old Children

2017 ◽  
Vol 13 (4) ◽  
pp. 56-63 ◽  
Author(s):  
E.A. Savina ◽  
I.A. Savenkova ◽  
I.V. Shchekotikhina ◽  
A.M. Gul'yants
Keyword(s):  
Size Effects ◽  
Short Term Memory ◽  
Control Group ◽  
Verbal Instruction ◽  
Interference Control ◽  
Short Term ◽  
Term Memory ◽  
Voluntary Regulation ◽  
Visual Motor ◽  
Experimental Group

This article discusses the results of experimental study aimed at investigating the effect of games with rules on voluntary regulation of preschool children. The following components of voluntary regulation were studied: short-term and working memory, verbal interference control, the ability to follow verbal instruction, and knowledge of rules of conduct. One hundred and twenty 6—7-year-old children participated in this study. After the intervention, children in experimental group improved their knowledge of rules of conduct, short-term memory for numbers, verbal interference, and the ability to follow verbal instruction when executing a visual-motor integration task. Children in the control group also improved their verbal interference ability and short-term memory for numbers and words. However, size effects were smaller than in the experimental group.

scholarly journals Effect of Taping of Thoracic and Abdominal Muscles on Pelvic Alignment and Forward Reach Distance Among Stroke Subjects: A Randomized Controlled Trial

2019 ◽  
Vol 26 (3-4) ◽  
pp. 10-16
Author(s):  
Megha Mehta ◽  
Abraham M. Joshua ◽  
Suruliraj Karthikbabu ◽  
Zulkifli Misri ◽  
Bhaskaran Unnikrishnan ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Control Group ◽  
P Value ◽  
Abdominal Muscles ◽  
Care Hospital ◽  
Physiotherapy Treatment ◽  
Short Term ◽  
Randomized Controlled ◽  
Conventional Physiotherapy ◽  
Experimental Group

Introduction: The objective of this study was to find the immediate as well as short-term effect on pelvic alignment and forward arm reach distance in sitting among stroke patients following thoracic spine and abdominal muscles taping along with conventional therapy. Methods: Thirty subjects with stroke attending the physiotherapy programme at Department of Physiotherapy at a tertiary care hospital underwent this randomized controlled experimental study. Subjects in the experimental group received taping, along with conventional physiotherapy treatment, for restricting thoracic kyphosis and facilitating abdominal muscles. Subjects in the control group received only conventional physiotherapy treatment. To assess the change in pelvic alignment and forward arm reach distance while sitting, Palpation MeterTM (PALMTM) and sit and reach test were used, respectively. Results: In the experimental group, pelvic obliquity was corrected (4.1 ± 0.94) and anterior pelvic tilt revealed improvement (4.9 ± 2.1, p value < 0.001). In the control group, no improvement in pelvic alignment was recorded. Improvement in forward arm reach distance was similar in both groups ( p value = 0.804). Conclusion: Taping as an adjunctive treatment method to physiotherapy can cause immediate as well as short-term improvement of pelvic alignment in sitting, following stroke. It also, immediately improves the sit and reach distance in the same population.

The influence of processing of hatching eggs by coniferous complex on fetal and postnatal development of quails

2020 ◽  
pp. 59-64
Author(s):  
M. Zadorozhnaya ◽  
S. Lysko ◽  
O. Suntsova
Keyword(s):  
Postnatal Development ◽  
Biochemical Analysis ◽  
Live Weight ◽  
Control Group ◽  
Short Term ◽  
Urgent Task ◽  
Hatching Eggs ◽  
Spread Of Infection ◽  
Maintenance Personnel ◽  
Experimental Group

The hatchery is an important link in the production process of a poultry enterprise, and therefore there is a need to take eff ective measures to prevent the penetration and spread of infection. For this purpose hatching eggs are processed, veterinary and sanitary measures are carried out using disinfectants. The most common chemical disinfectants, but many of them have a short-term eff ect and have a negative infl uence on the embryos, and the task of any incubator is to get high-quality young birds. In most cases poultry farms use formalin, which when used repeatedly has a negative enfl uence not only on the embryos and their development, but also on the maintenance staff . In this regard, the creation of non-toxic, highly eff ective, eco-friendly products that do not pollute the environment, inhibit the growth of microorganisms that do not aff ect the embryo and maintenance personnel is an urgent task for veterinary science and practice. One of these drugs is a complex of coniferous balsamic fi r. The purpose of our researches was to study the infl uence of treatment of hatching eggs with the new drug on the fetal and postnatal development of quails. Egg processing has been performed before laying and during transfer in 15,5 days: in the experimental group with coniferous complex, in the control group with formalin. Biological control has been carried out in 9,5 and 15,5 days, taking into account the hatchability of eggs, the livability and live weight of quails. Blood has been collected at the age of 7 and 14 days for biochemical analysis, examining it for the content of total protein, albumins and globulins. The complex coniferous balsamic fi r did not have the negative infl uence on the fetal and postnatal development of the resulting young birds increased the hatchability of eggs, the livability and live weight of quails. Thus, the live weight of quails in the experimental group at the age of 7 days exceeded the control by 2,3 %, and at 14 days by 0,3 %. The livability of quails obtained from eggs treated with the studied drug the period of 1–14 days was 2,0 % higher compared to the control group.

Increasing the Protection of Newborn Infants in Cars

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 21-25
Author(s):  
Edward R. Christophersen ◽  
Margaret A. Sullivan
Keyword(s):  
American Academy ◽  
Newborn Infants ◽  
Hospital Staff ◽  
Control Group ◽  
Short Term ◽  
American Academy Of Pediatrics ◽  
Car Safety ◽  
Staff Person ◽  
Experimental Group

Recently the American Academy of Pediatrics instituted a major campaign ("The First Ride—A Safe Ride") in order to encourage all parents to use an infant restraint seat for their newborn's first ride in an automobile—the ride home from the hospital. In the present study the effect of the behavior of the hospital staff on parents' use of infant restraint seats was examined. This study involved 30 mother-infant pairs who were selected sequentially from an obstetrics unit and randomly assigned to two groups. A control group was discharged from the obstetrics unit with no particular emphasis on car safety and no loaner restraint seat available. An experimental group was offered a loaner restraint seat at the time of discharge, with a staff person demonstrating how to put the infant into the restraint seat, how to carry the infant in the seat out to the car, and how to fasten the restraint seat in the automobile with the auto lap belt. Correct use of the loaner restraint seat on the first ride home was observed in 67% of the experimental mothers and in none (0%) of the control mothers. Although this difference was no longer significant at four- to six-week follow-up this study points out the short-term impact that hospital staff can have on the parents' use of restraint seats. Additional techniques are needed to maintain parents' use of restraint seats throughout childhood.

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