scholarly journals Release characteristics of enoxaparin sodium-loaded polymethylmethacrylate bone cement

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hui Sun ◽  
Xinzhe Ma ◽  
Zhiyong Li ◽  
Jianning Liu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Bone Cement ◽  
Enoxaparin Sodium ◽  
Parallel Line ◽  
Control Group ◽  
Coagulation Therapy ◽  
Pmma Bone Cement ◽  
Long Time ◽  
Application Potential ◽  
Loading Amount ◽  
Experimental Group

Abstract Background This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loading into the PMMA bone cement. Methods In the experimental group, 40 g Palacos®R PMMA bone cement was loaded with various amount of ES 4000, 8000, 12,000, 16,000, 20,000, and 24,000 AXaIU, respectively. The control group was not loaded with ES. Scanning electron microscopy (SEM) was used to observe the surface microstructure of the bone cement in the two groups. In the experiment group, the mold was extracted continuously with pH7.4 Tris-HCL buffer for 10 days. The extract solution was collected every day and the anti-FXa potency was measured. The experiment design and statistical analysis were conducted using a quantitative response parallel line method. Results Under the SEM, it was observed that ES was filled in the pores of PMMA bone cement polymer structure and released from the pores after extraction. There was a burst effect of the release. The release amount of ES on the first day was 0.415, 0.858, 1.110, 1.564, 1.952, and 2.513, respectively, from the six groups with various ES loading amount of 4000, 8000, 12,000, 16,000, 20,000, and 24,000 AXaIU, all reaching the peak of release on the first day. The release decreased rapidly on the next day and entered the plateau phase on the fourth day. Conclusion The prepared ES-PMMA bone cement has high application potential in orthopedic surgery. ES-PMMA bone cement shows good drug release characteristics. The released enoxaparin sodium has a local anti-coagulant effect within 24 h after application, but it will not be released for a long time, which is complementary to postoperative anti-coagulation therapy.

scholarly journals Release Characteristics of Enoxaparin Sodium Loaded Polymethylmethacrylate Bone Cement

2020 ◽  
Author(s):  
Hui Sun ◽  
Xinzhe Ma ◽  
Zhiyong Li ◽  
Jianning Liu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Bone Cement ◽  
Enoxaparin Sodium ◽  
Parallel Line ◽  
Control Group ◽  
Plateau Phase ◽  
Short Term ◽  
Pmma Bone Cement ◽  
Loading Amount ◽  
Experimental Group ◽  
Quantitative Response

Abstract Background: This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loading into the PMMA bone cement. Methods: In the experimental group, 40g Palacos®R PMMA bone cement was loaded with various amount of ES 4000, 8000, 12000, 16000, 20000, and 24000 AXaIU, respectively. The control group was not loaded with ES. Scanning electron microscopy (SEM) was used to observe the surface microstructure of the bone cement in the two groups. In the experiment group, the mold was extracted continuously with pH7.4 Tris-HCL buffer for 10 days. The extract solution was collected every day and the anti-FXa potency was measured. The experiment design and statistical analysis were conducted using a quantitative response parallel line method. Results: Under the SEM, it was observed that ES was filled in the pores of PMMA bone cement polymer structure and released from the pores after extraction. There was a burst effect of the release. The release amount of ES on the first day was 0.415, 0.858, 1.110, 1.564, 1.952 and 2.513 respectively from the six groups with various ES loading amount of 4000, 8000, 12000, 16000, 20000 and 24000 AXaIU, all reaching the peak of release on the first day. The release decreased rapidly on the next day and entered the plateau phase on the fourth day. Conclusion: PMMA bone cement can be used as a carrier to effectively release enoxaparin sodium within a short term.

scholarly journals 团体心理咨询对大学生自尊提升的干预研究

2019 ◽  
Vol 01 (02) ◽  
pp. 100-111
Author(s):  
童童 李 ◽  
艳 李 ◽  
莉 潘 ◽  
倩 黄 ◽  
喆 王
Keyword(s):  
Training Program ◽  
Interpersonal Relationship ◽  
Personal Communication ◽  
Self Esteem ◽  
Control Group ◽  
Big Five Personality ◽  
Relationship Skills ◽  
Long Time ◽  
And Control ◽  
Experimental Group

目的：探讨团体心理咨询对大学生自尊提升的干预效果以及内在影响机制。方法：招募18 名大学生为研究对象，采用实验组与控制组前后测量的实验设计，实验组接受为期6 周的自尊提升团体心理咨询，使用自尊量表、人际关系综合诊断量表和大五人格量表进行测试。结果：团体心理咨询后，实验组被试的自尊水平提高[（32.67±3.12）vs.（29.33±3.24）， p< 0.001]，人际关系综合诊断量表总分[（6.62±3.66）vs.（12.00±5.27）， p< 0.001] 及人际关系维度分数[（2.11±1.36）vs.（4.00±1.94），p= 0.009] 下降，大五人格问卷外倾性[（3.51±0.31）vs.（3.30±0.41） ，p= 0.002] 与责任心[（3.65±0.34）vs.（3.43±0.35） ，p= 0.026] 分数提高。结论：团体心理咨询对大学生自尊提升的干预有效，这一干预效应存在潜在的长期效应，其内在机制可能是人际关系困扰的降低；自尊提升能够内化成为个体人格外倾性的一部分。 Objectives： This study is focused on a six-week group psychological guidance to enhance self-esteem and to explore its intrinsic mechanism. Methods：Totally 18 students were randomly assigned to one of two group： experimental group（n=9） and control group（n=9）. The experimental group received six-week training program to enhance self-esteem， as compared as control group who received only baseline and post-six-week measurement which included the self-esteem scale，the interpersonal relationship comprehensive diagnosis scale， and the Big Five personality scale. Results： After the training program， the experimental group’s selfesteem was improved [（32.67±3.12）vs.（29.33±3.24）]， total score[（6.62±3.66）vs.（12.00±5.27）] and inter-personal communication[（2.11±1.36） vs.（4.00±1.94）] score of the interpersonal relationship comprehensive diagnosisscale were declined， and score of extraversion[（3.51±0.31）vs.（3.30±0.41）] and conscientiousness[（3.65±0.34）vs.（3.43±0.35）] were increased. Conclusion： It proves that group psychological guidance could enhance students’ self-esteem for a long time， and self-esteem could be a part of personality. The most important is that the improvement of relationship skills could explain why group psychological guidance could enhance self-esteem.

scholarly journals The Effect of Kryptonite Bone Cement combined with a Standard Kirschner Wire on Tibial Bone Fracture in Rats

2022 ◽  
Vol 9 (01) ◽  
pp. 5808-5913
Author(s):  
Ibrahim EKE ◽  
Mehmet Akif AKCAL ◽  
Yusuf IYETIN ◽  
OguzSükrü POYANLI
Keyword(s):  
Bone Cement ◽  
Bone Repair ◽  
Callus Formation ◽  
Statistical Significance ◽  
Kirschner Wire ◽  
Autogenous Bone ◽  
Control Group ◽  
Complete Fusion ◽  
Non Union ◽  
Experimental Group

Objective This study aims to observe whether Kryptonite Bone Cement combined with a standard Kirschner wire, instead of autogenous bone grafts, increases bone healing and mechanical strength in rats with tibia fractures. Methods The study included sixteen rats, which were divided into two groups as a control group (n=8) and an experimental group (n=8). After segmental fractures were made in both groups, intramedullary fixation of tibia procedures were conducted with the use of a Kirschner wire. No additional procedures were performed inthe control group, but Kryptonite Bone Cement was applied in the experimental group. The rats were evaluated clinically, radiologically and histologically4 times; immediately after the operation, and atthe 1st, 3rd, and 6thweeks following surgery. Results One rat from the experimental and one from the control group had both wound dehiscence and wound site infection. No recovery was observed in any rats either in the control or experimental group immediately after surgery. During week 1, callus formation was identified in 5 rats in the experimental group (p=0.0072), and during week 3, fracture lines disappeared in 4 rats in the experimental group (p=0.064); the differences between control and experimental groups were statistically significant. During week 6, no statistical significance was observed in radiological assessments for the control group and experimental group (p=0.71). The rate of non-union was higher in the control group (37.50%) than in the experimental one, while the rate of complete fusion was higher in the experimental group (87.50%) than that in the control group. Conclusion Osteoconductivity and ergonomic qualities of Kryptonite Bone Cement prove helpful in bone repair. Future studies to be conducted in a prospective and randomized manner will be effective on demonstrating the effectiveness of Kryptonite Bone Cement.

scholarly journals Treatment of Osteoporotic Vertebral Compression Fracture by Precise Injection and Staged Perfusion of Bone Cement Kyphoplasty: A Comparison Study

2021 ◽  
Author(s):  
Jian Huang ◽  
Jun Huang ◽  
Ming Chen ◽  
Zongbo Zhou ◽  
Zhifu Lu ◽  
...  
Keyword(s):  
Bone Cement ◽  
Vertebral Body ◽  
Compression Fracture ◽  
Cement Leakage ◽  
Osteoporotic Vertebral Compression Fracture ◽  
Control Group ◽  
The Third ◽  
Significant Difference ◽  
Experimental Group

Abstract Study design: Retrospective cohort study.Objective: To explore the clinical effect of precise injection and staged perfusion of bone cement kyphoplasty in the treatment of osteoporotic vertebral compression fracture.Methods: 110 patients treated with kyphoplasty from January 2020 to June 2021 were selected and divided into experimental group (n = 55) and control group (n = 55) according to different surgical methods. The experimental group was treated with precise injection and staged perfusion of bone cement kyphoplasty, while the control group was treated with traditional kyphoplasty. The operation time,intraoperative blood loss and amount of bone cement injection were recorded. The pain improvement was evaluated by VAS score. The operation effect were evaluated by anterior height of injured vertebral body, middle height of injured vertebral body, wedge angle of injured vertebral body and distribution grade of bone cement. The incidence of surgical complications was evaluated by the number of bone cement leakage.Results: There were no significant difference in the operation time, intraoperative blood loss and the amount of bone cement injection in two groups. There were no significant difference in VAS scores at 2h, 4h and 48h after operation between the two groups (P > 0.05); There were no significant difference in the ratio of anterior height of injured vertebral body between the two groups on the third day after operation and the last follow-up (P > 0.05); There were no significant difference in the ratio of middle height of injured vertebral body between the two groups on the third day after operation and the last follow-up (P > 0.05); There were no significant difference in wedge angle of injured vertebral body between the two groups at the third day after operation and the last follow-up (P > 0.05). There was significant difference in the distribution grade of bone cement between the two groups (P < 0.01); There was significant difference in the number of bone cement leakage between the two groups (P < 0.01), In cases of bone cement leakage, there were 1 case of type C, 1 case of type S in the experimental group, 7 cases of type C and 2 cases of type S in the control group.Conclusion: Precise injection and staged perfusion of bone cement kyphoplasty in the treatment of osteoporotic vertebral compression fracture can effectively reduce surgical complications and improve surgical efficacy.

A bone substitute composed of polymethyl-methacrylate bone cement and Bio-Gene allogeneic bone promotes osteoblast viability, adhesion and differentiation

2020 ◽  
pp. 1-9
Author(s):  
Zhikun Wang ◽  
Zaixue Li ◽  
Xiansen Zhang ◽  
Yingfeng Yu ◽  
Qingyu Feng ◽  
...  
Keyword(s):  
Biological Activity ◽  
Bone Cement ◽  
Bone Substitute ◽  
Biological Properties ◽  
Live Cells ◽  
Control Group ◽  
Allogeneic Bone ◽  
Gene Group ◽  
Pmma Bone Cement ◽  
Pmma Cement

BACKGROUND: Increasing reports on new cement formulations that address the shortcomings of PMMA bone cements and various active components have been introduced to improve the biological activity of PMMA cement. OBJECTIVE: Evaluating the biological properties of PMMA cements-reinforced with Bio-Gene allogeneic bone. METHODS: The MC3T3-E1 mouse osteoblast-like cells were utilized to determine the effects of Bio-Gene + PMMA on osteoblast viability, adhesion and differentiation. RESULTS: The combination of allogeneic bone and PMMA increased the number of adherent live cells compared to both control group and PMMA or Bio-Gene group. Scanning electron microscopy observed that the number of cells adhered to Bio-Gene + PMMA was larger than Bio-Gene and PMMA group. Compared with the control and PMMA or Bio-Gene group, the level of ALP and the number of calcium nodules after osteoinduction was remarkably enhanced in Bio-Gene + PMMA group. Additionally, the combination of Bio-Gene and PMMA induced the protein expression of osteocalcin, osterix and collagen I. CONCLUSION: The composition of PMMA and allogeneic bone could provide a more beneficial microenvironment for osteoblast proliferation, adhesion and differentiation. PMMA bone cement reinforced with Bio-Gene allogeneic bone may act as a novel bone substitute to improve the biological activity of PMMA cement.

scholarly journals Penerapan Pijat Bayi Terhadap Peningkatan Berat Badan Bayi Usia 1-3 Bulan : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 1977-1983
Author(s):  
Runi Karin Majid ◽  
Aida Rusmariana
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Literature Review ◽  
Massage Therapy ◽  
Control Group ◽  
Maximum Value ◽  
Before And After ◽  
Long Time ◽  
Almost All ◽  
Experimental Group

AbstractBaby massage is one of the oldest and most popular types of stimulation or touch therapy that is has been practiced for a long time almost all over the world, including in Indonesia for generations. Baby massage has many benefits if done regularly, one of which can increase body weight. The purpose of this study was to know the weight of babies aged 1-3 months before and after being given baby massage. The method was a literature review of three research articles from Google Sholar used keywords including baby massage, weight gain, infants aged 1-3 months and articles published in the last 10 years. The results of the literarture review of three articles in the experimental group, before being given baby massage, was the median value of 4,592 grams and the minimum-maximum value of 3,533-5,933 grams. The control group had a median value of 4,258 grams and a minimum-maximum value of 3,533-5,200 grams. The experimental group after being given baby massage had a median value of 5,717 grams and a minimum-maximum value of 4,433-6,900 grams. While the control group had a median value of 4,767 grams and a minimum-maximum value of 3,967-5,633 grams. The conclusion of the literature review from these three articles is that baby massage has an effect on increasing body weight in infants aged 1-3 months. The results of the three articles that had been reviewed are babies who get massage therapy had a higher weight gain compared to babies who do not get massage therapy. It is suggested for nurses to be able to apply and provide education to parents to do baby massage in order to overcome the problem of baby growth and development especially the problem of baby massage.Keywords: Infants aged 1-3 months, Baby massage, Eigh gain AbstrakPijat bayi merupakan salah satu jenis stimulasi atau terapi sentuhan tertua dan terpopuler yang sudah lama dilakukan hampir di seluruh dunia termasuk di Indonesia secara turun temurun. Pijat bayi yang dilakukan secara rutin akan memberikan banyak manfaat yaitu salah satunya dapat meningkatkan berat badan. Tujuan dari penulisan ini yaitu untuk mengetahui berat badan bayi usia 1-3 bulan sebelum dan sesudah diberikan pijat bayi. Metode penulisan menggunakan literature review dari tiga artikel penelitian yang didapatkan dari google scholar dengan kata kunci pijat bayi, peningkatan berat badan dan bayi usia 1-3 bulan dan minimal terbit 10 tahun terakhir. Hasil dari literature review ketiga artikel ilmiah sebelum diberikan pijat bayi pada kelompok eksperimen memiliki nilai median 4.592 gram dan nilai minimum-maksimum 3.533-5.933 gram. Pada kelompok kontrol memiliki nilai median 4.258 gram dan nilai minimum-maksimum 3.533-5.200 gram. Sesudah diberikan pijat bayi pada kelompok eksperimen memiliki nilai median 5.717 gram dan nilai minimum-maksimum 4.433-6.900 gram. Sedangkan pada kelompok kontrol memiliki nilai median 4.767 gram dan nilai minimum-maksimum 3.967-5.633 gram. Simpulan literatur review dari ketiga artikel ilmiah yaitu pijat bayi sama-sama memiliki pengaruh untuk meningkatkan berat badan pada bayi usia 1-3 bulan. Hasil dari ketiga artikel ilmiah yang telah dilakukan literature review menunjukkan bahwa bayi yang mendapatkan pijat mengalami peningkatan berat badan lebih tinggi dibandingkan dengan bayi yang tidak mendapatkan terapi pijat. Saran bagi perawat untuk dapat menerapkan dan memberikan edukasi kepada orang tua untuk melakukan pijat bayi guna mengatasi masalah tumbuh kembang pada bayi terutama masalah berat badan bayi.Kata kunci: Bayi Usia 1-3 Bulan; Pijat bayi; Peningkatan Berat Badan

scholarly journals Histostructure of the internal organs and skin of rats for the long-term effect of the drug “VetMikoDerm”

2019 ◽  
Vol 21 (94) ◽  
pp. 136-141
Author(s):  
V. P. Martynyshyn
Keyword(s):  
Skin Toxicity ◽  
Total Surface Area ◽  
Control Group ◽  
Histological Structure ◽  
Renal Tubules ◽  
Internal Organs ◽  
Laboratory Rats ◽  
Long Term Effect ◽  
Long Time ◽  
Experimental Group

The investigation of the skin toxicity of the liniment “VetMikoDerm” for prolonged use was performed on young and healthy laboratory rats with intact skin, body weight 200–220 g. The investigated environment was applied to a clean, non-woolly area (dorsal/lateral surface) of at least 10% of the total surface area. The spotted thistle oil was applied to the pre-prepared area of the skin of the animals of the control group, and the other two experimental groups of animals got the studied drug at the doses of 50 (I) and 500 mg/kg (II), respectively. The drug was applied to the skin daily for 28 days. At the end of the experiment, after the decapitation of the rats conducted under the light etheric anesthesia, a complete pathoanatomical dissection was performed, the coefficients of the mass of the internal organs were determined, samples of liver, kidney and skin tissues were taken for their histological examination. According to the results it was established that the liver and kidneys histology, and skin of rats of the 1st experimental group were similar to those that were of the control animals. At the same time, receiving the maximum dose (10 times the therapeutic dose) of the drug “VetMikoDerm”, the majority of rats of the 2nd group showed a discomplication of the lamellar structure of the liver lobules, hepatocytes were placed in separate groups, sinusoidal capillaries were expanded. The presence of hepatocytes with heterogeneous, granular and weakly colored cytoplasm was observed in the central parts of the lobules, the nuclei of individual hepatocytes were increased, indicating the development of granular protein degeneration of the parenchyma. Histologically, under these conditions, foci of granular dystrophy of the epithelium of the vorticular and direct renal tubules with the expansion of their lumen were found in the structure of kidney of rats. The kernels of individual nephropyelitis had signs of karyopicnosis and cariorexis. The histological structure of skin of rats in all experimental groups was of the same type and consisted of the epidermis, dermis and hypodermis. Animals of the 2nd experimental group which repeatedly and for a long time were applied a “VetMikoDerm” lineulation in a dose that exceeded its optimal amount by 10 times showed the epidermal thickening, the presence of small-mesenchymal polymorphocytic infiltration, microcirculatory corneal disorder and sebaceous gland hyperplasia  glands in the dermis that indicated the development of a compensatory-adaptive reaction in places of application of a 10-fold dose of the investigational medicinal product.

scholarly journals Quality of life of patients with rectal cancer after surgical treatment

2019 ◽  
Vol 9 (4) ◽  
pp. 37-42
Author(s):  
A. A. Medvednikov ◽  
A. V. Shelekhov ◽  
V. V. Dvornichenko ◽  
S. M. Plenkin ◽  
S. I. Radostev
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Control Group ◽  
Wexner Score ◽  
Sphincter Function ◽  
Stool Incontinence ◽  
Distal Rectal Cancer ◽  
Long Time ◽  
Experimental Group

Objective: to analyze functional surgical outcomes in patients with distal rectal cancer and their quality of life at different time-points postoperatively.Materials and methods. This retrospective study included all patients with rectal cancer that underwent either abdominoanal resection of the rectum (with their sigmoid colon brought down into the anal canal) or low intraabdominal resection of the rectum with the formation of a mechanical coloanal anastomosis in Irkutsk Regional Oncology Dispensary between 1999 and 2012. Study participants were divided into two groups: the experimental group included patients who had low intraabdominal resection of the rectum, whereas the control group consisted of patients who had abdominoanal resection of the rectum. We evaluated 5-year survival and patients' quality of life (using the Wexner and FIQL scales).Results. One year postoperatively, 17 patients (25 %) from the control group had unsatisfactory sphincter function (Wexner score 11–20). Sixty-three patients from the control group (95 %) reported fecal incontinence of varying severity. In the experimental group, 40 patients out of 88 (45 %) that survived during the first year had normal sphincter function. The remaining patients had solid stool incontinence or inability to retain feces for a long time (Wexner score <10).Conclusions. Low resections of the rectum ensured better functional outcomes and patients' quality of life than abdominoanal resections of the rectum did. 

scholarly journals Comparative analysis of the use of udder treatment agents in the prevention of mastitis and improving the quality of milk in cows

2021 ◽  
Vol 210 (07) ◽  
pp. 66-74
Author(s):  
Gennadiy Larionov ◽  
Elena Yatrusheva ◽  
Olesya Checheneshkina
Keyword(s):  
Somatic Cells ◽  
Control Group ◽  
Anaerobic Microorganisms ◽  
Facultative Anaerobic ◽  
Long Time ◽  
Group 3 ◽  
Quality Of Milk ◽  
Experimental Group ◽  
Take All

Abstract. The aim of this study is to study the effectiveness of the use of various means for treating the udder of cows in order to prevent the incidence of mastitis and improve the quality of milk. Since in order to prevent the development of mastitis for a long time, it is necessary not only to destroy the disease itself and fight its symptoms, but also to take all kinds of measures to prevent the disease. Methods. To conduct a scientific and economic experiment, 4 groups were formed, of which 3 are experimental and 1 control, according to the method of pairs-analogs using a tethered method of keeping in stalls in all four groups. To treat the udder, agents based on iodine, chlorhexidine, chlorhexidine digluconate and probiotic bacteria were used. Results. The summer use of Priolit Vortex and Algavit Vortex in 1 experimental group showed a decrease in the number of mesophilic aerobic facultative anaerobic microorganisms in cow's milk from 200,000 to 97,000 CFU/cm3, which is 48.5 % less than at the beginning of the experiment. Treatment with disinfectants Priolit Vortex and Elovit Vortex in the 2 nd experimental group made it possible to reduce the number of mesophilic aerobic facultative anaerobic microorganisms by 68.4 %. The use of probiotic agents Skin Cleaner and PIP Cow Teat Cleaner for treating the udder of cows allowed to reduce the number of mesophilic aerobic facultative anaerobic microorganisms in the milk of cows in experimental group 3 from 180,000 to 110,000 CFU / in 1 cm3, which is 61.1 % less than the initial indicators. Somatic cells in the milk of cows of the 1st experimental group decreased from 750,000 to 120,000 in 1 cm3, in the 2nd experimental group the number of somatic cells decreased from 250,000 to 180,000 in 1 cm3, in the 3rd experimental group from 390,000 to 340,000 in 1 cm3. In the control group, an increase in the number of somatic cells was found by 84 %.

scholarly journals Adaptation ability and natural animals resistance of polissia meat breed

2017 ◽  
Vol 19 (74) ◽  
Author(s):  
A. O. Boiko
Keyword(s):  
High Growth ◽  
The Body ◽  
Natural Resistance ◽  
Control Group ◽  
Scientific Publications ◽  
High Productivity ◽  
Long Time ◽  
Adaptive Ability ◽  
Adaptation Ability ◽  
Experimental Group

It  was made the research of the adaptive ability and natural resistance of Polissia meat breed animals, the area of their content was limited by the conditions of the lowland, forested and bogged territory of the Ukrainian Polissia and Precarpathian. Materials for analysis were selected with scientific publications and works, which reflect the issue of the breeding and maintenance of Polissia meat breed animals, as well as their own research on the natural resistance of cows. As a result of the analysis of the obtained  information, it was found out that the cows of the 1st experimental group of the high-growth type, they  possess a high potential of natural resistance, a somewhat lower resistance was detected in the cows of the intermediate type (II control group) and compact type (III experimental group). From these studies it emerges that there is the advisability of a comprehensive study of the type of constitution, since this determines the level of natural resistance and light resistance of animals. Only strong animals are able to be healthy, to give a viable and full-fledged offspring, to have high productivity, to withstand constant operational loads on the body and for a long time to be rationally operated with the greatest economic efficiency.

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