scholarly journals Concentration Mechanism of Fluorine, Arsenic, and Uranium in Groundwater of the Hailar Basin, China

2022 ◽  
Author(s):  
Shengfeng LIU ◽  
Bai Gao ◽  
Huanhuan Qin ◽  
Qin Ge ◽  
Huilan Ling ◽  
...  
Keyword(s):  
Great Influence ◽  
Mineral Dissolution ◽  
World Health ◽  
Current Status ◽  
Weakly Alkaline ◽  
Factors Affecting ◽  
Groundwater Samples ◽  
Hailar Basin ◽  
Health Organization ◽  
Inner Mongolia Autonomous Region

Abstract Located in semi-arid regions of Hulun Buir League in China Inner Mongolia Autonomous Region, Hailar Basin is a region with less precipitation, where groundwater is the most important source for water supply. It is very important to study groundwater characteristics and hydrogeochemical processes for better management of the groundwater resource.The current status of fluorine (F), arsenic (As), and uranium (U) co-contamination exists in groundwater of the Hailar Basin, China. To understand the concentration mechanism of F, As, and U in groundwater in the study area, groundwater samples were collected for detection and analysis. The results showed that the main hydrochemical types were Cl-Na, HCO3-Na, and HCO3-Ca in the study area. The average values of F, As, and U were 3.94 mg/L, 0.04 mg/L, and 0.07 mg/L, respectively, which all exceeded the World Health Organization(WHO) guidelines. Through the Gibbs diagram and the end member diagram, it can be seen that the groundwater in the study area is mainly affected by the hydrogeochemical effects of evaporative crystallization, rock weathering mechanism, and the dissolution of silicate rock and evaporative salt rock minerals. Mineral dissolution, cation exchange, and weakly alkaline environment are important factors affecting F concentration; Low NO3ˉ and SO42- will cause a reducing environment and the competitive adsorption of HCO3ˉ will promote As pollution; The concentration of Ca2+,Mg2+, SO42-,and NO3ˉ have a great influence on the concentration of U.

Groundwater Quality Assessment Using Geospatial Techniques and WQI in North East of Adama Town, Oromia Region, Ethiopia

2020 ◽  
Vol 3 (1) ◽  
pp. 22-36 ◽  
Author(s):  
Shankar Karuppannan ◽  
Nafyad Serre Kawo
Keyword(s):  
Groundwater Quality ◽  
Sustainable Use ◽  
World Health ◽  
Geospatial Techniques ◽  
Distribution Maps ◽  
North East ◽  
Drinking And Irrigation ◽  
Groundwater Samples ◽  
Arc Gis ◽  
Health Organization

Assessment of groundwater quality is vital for the sustainable use of the resources for domestic and agricultural purposes. In this study spatial variation of physicochemical parameters were analyzed for Northeast Adama Town. Water Quality Index (WQI) and irrigation indices were used to determine the suitability of groundwater for drinking and irrigation purposes, respectively. Further, the physical-chemical results were compared with the Ethiopian standards and the World Health Organization (WHO) standards for drinking and public health. Using GIS interpolation methods in Arc GIS 10.3.1, spatial distribution maps of pH, TDS, EC, Cl−, HCO32−, SO42−, Ca2+, Mg2+, Na+ and K+, RSC, SAR, Na% were prepared. Results indicated that except ASTU well 2, all samples are below the desirable limits of WHO. The WQI results indicated that 85% of samples and 15% of samples were in good and poor categories, respectively. Irrigation indices show that the most groundwater samples have excellent water classes, indicating that they are suitable for irrigation purposes.

Heterocycles in the Treatment of Neglected Tropical Diseases

2020 ◽  
Vol 27 ◽  
Author(s):  
Kush K. Maheshwari ◽  
Debasish Bandyopadhyay
Keyword(s):  
Developing Countries ◽  
Heterocyclic Compounds ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Current Status ◽  
Poor People ◽  
Tropical Diseases ◽  
Concise Review ◽  
The World ◽  
Health Organization

Background: Neglected tropical diseases (NTDs) affect a huge population of the world and majority of the victims belong to the poor community of the developing countries. Until now, the World Health Organization (WHO) has identified 20 tropical diseases as NTDs that must be addressed with high priority. However, many heterocyclic scaffolds have demonstrated potent therapeutic activity against several NTDs. Objective: There are three major objectives: (1) To discuss the causes, symptoms, and current status of all the 20 NTDs; (2) To explore the available heterocyclic drugs, and their mechanism of actions (if known) that are being used to treat NTDs; (3) To develop general awareness on NTDs among the medicinal/health research community and beyond. Methods: The 20 NTDs have been discussed according to their alphabetic orders along with the possible heterocyclic remedies. Current status of treatment with an emphasis on the heterocyclic drugs (commercially available and investigational) has been outlined. In addition, brief discussion of the impacts of NTDs on socio-economic condition is included. Results: NTDs are often difficult to diagnose and the problem is worsened by the unhealthy hygiene, improper awareness, and inadequate healthcare in the developing countries where these diseases primarily affect poor people. The statistics include duration of suffering, numbers affected, and access to healthcare and medication. The mechanism of actions of various heterocyclic drugs, if reported, have been briefly summarized. Conclusion: Scientists and pharmaceutical corporations should allocate more resources to reveal the in-depth mechanism of actions of many heterocyclic drugs that are currently being used for the treatment of NTDs. Analysis of current heterocyclic compounds and development of new medications can help in the fight to reduce/remove the devastating effects of NTDs. An opinion-based concise review has been presented. Based on available literature, this is the first effect to present all the 20 NTDs and related heterocyclic compounds under the same umbrella.

scholarly journals Promising Novel Biomarkers in Cardiovascular Diseases

2021 ◽  
Vol 11 (8) ◽  
pp. 3654
Author(s):  
Brigitte Sipos ◽  
Peter Jirak ◽  
Vera Paar ◽  
Richard Rezar ◽  
Moritz Mirna ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Diagnostic Yield ◽  
Accurate Estimate ◽  
World Health ◽  
Current Status ◽  
Fatty Acid Binding ◽  
Type Plasminogen Activator ◽  
Common Causes ◽  
Novel Biomarkers ◽  
Health Organization

Cardiovascular diseases remain the most common causes of death globally, according to the World Health Organization. In recent years, a great number of biomarkers have been investigated, whereas only some have gained value in the diagnosis, prognosis, and risk stratification of different cardiovascular illnesses. As numerous studies have investigated the diagnostic yield of novel biomarkers in various disease entities every year, this review aims to provide an overview of the current status of four promising representatives. In particular, this manuscript refers to soluble suppression of tumorigenicity 2 (sST2), heart-type fatty acid binding protein (H-FABP), growth differentiation factor (GDF-15) and soluble urokinase-type plasminogen activator receptor (suPAR). These markers are of special interest as they are thought to provide an accurate estimate of cardiovascular risk in certain patient populations, especially those with pre-existing diseases, such as obesity or diabetes mellitus. We sought to give an overview of their function, individual diagnostic and predictive value and determination in the laboratory. A review of the literature regarding the aforementioned cardiovascular biomarkers yielded manifold results with respect to their individual diagnostic and prognostic value. Yet, the clinical relevance of these findings remains unclear, warranting further studies to identify their optimal use in clinical routine.

Factors Affecting Resiliency Among Volunteers in Disasters: A Systematic Literature Review

2020 ◽  
pp. 1-7
Author(s):  
Hasan Ghodsi ◽  
Sanaz Sohrabizadeh ◽  
Reaza Khani Jazani ◽  
Amir Kavousi
Keyword(s):  
Disaster Response ◽  
Final Analysis ◽  
International Committee ◽  
World Health ◽  
Red Cross ◽  
Factors Affecting ◽  
Search Terms ◽  
Main Factors ◽  
Relief Operations ◽  
Health Organization

ABSTRACT Objective: Volunteers need considerable resiliency to cope with formidable challenges during their operations in disaster scenes. The present study was conducted to identify factors affecting the different aspects of resiliency among volunteers in disasters. Material and Methods: The databases of Web of Science, Scopus, PubMed, ProQuest, Google Scholar, World Health Organization Library, International Committee of the Red Cross (ICRC) Library, PsycArticles, and SafetyLit were searched until September 29, 2018. The main search terms were resiliency, disaster, humanitarian aid worker, and volunteer. Results: A total of 548 documents were obtained and screened based on the inclusion and exclusion criteria. A number of 8 documents was selected for the final analysis. The main factors contributing to the resilience of volunteers at the 3 stages of pre-, during, and post-disasters were classified into 3 groups of individual, environmental, and organizational. Important factors affecting resilience of volunteers in disasters included previous disaster response experience and disaster-related training. Conclusion: Resiliency should be deemed integral to relief operations. Considering the main factors affecting volunteers’ resiliency, it is highly suggested that organizations active in humanitarian endeavors explore the factors impacting on resilience among their volunteers via various research methods and seek to select those with higher degrees of resilience in order to avert untoward consequences in their missions.

scholarly journals The Incidence of Bleeding and the Factors That Influence Its Development among Patients Admitted With Dengue Fever

2017 ◽  
Vol 9 (2) ◽  
pp. 23-28
Author(s):  
Krishna Bahadur Thapa ◽  
Namrata KC ◽  
T Koirala ◽  
A Bhatttarai
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Medical Center ◽  
Adult Population ◽  
World Health ◽  
Chi Square ◽  
Factors Affecting ◽  
Female Sex ◽  
Unit Increase ◽  
Health Organization

Background: Dengue virus is now classified as a major global health threat by the World Health Organization. Bleeding is a common complication and is one of the most feared. There is an increase incidence in the adult population, hence, the focus of this study.Objectives: To determine the incidence of bleeding and the factors that influence its development among patients admitted with dengue fever at Fatima Medical Center, Phillipines from January 2009 to December 2011.Methods: This is a case control study using chart review. The incidence of bleeding is calculated using risk ratio. Factors affecting bleeding are determined using chi square for qualitative variables and T-test or ANOVA for quantitative variables. Simultaneous determination of factors association with bleeding will be analyzed using multiple logistic regression. Level of significance will be set at alpha = 0.05.Results: The female sex is significantly more prone to develop bleeding (p=0.044). There is no significant increase in bleeding in patients who have co-morbidities (p=0.447). In every one unit increase in WBC (1 x 109) the odds of bleeding decrease by 15%. For every one unit increase in hematocrit the odds of bleeding decreases by 6.8%. For every one unit increase in platelet count the odds of bleeding decreases by 3% that is every 10 unit increase in platelet count the odds of bleeding decrease by 22.9%.Conclusions: Female sex, a low initial WBC and platelet count will increase a patient’s propensity to develop bleeding.Journal of Gandaki Medical College Volume, 09, Number 2, July December  2016, page: 23-28

scholarly journals Suicide trends and characteristics in Brazil

2006 ◽  
Vol 3 (1) ◽  
pp. 5-7
Author(s):  
Carolina de Mello-Santos ◽  
José Manoel Bertolote ◽  
Yuan-Pang Wang
Keyword(s):  
Suicide Rate ◽  
World Health ◽  
Economic Factors ◽  
Factors Affecting ◽  
Youth Population ◽  
Self Harm ◽  
Health Organization ◽  
Populous Country ◽  
Related Mortality ◽  
Socio Economic Factors

Brazil is the largest and most populous country in South America (in 2002 the population was approximately 175 million). Although life expectancy in Brazil has increased, suicide and other forms of injury-related mortality, such as homicide and accident, have increased as a proportion of overall mortality (Oswaldo Cruz Foundation, 1984; Brazil Ministry of Health, 2001). The suicide rate in Brazil (3.0–4.0 per 100 000 inhabitants) is not considered high in global terms (World Health Organization, 1999). Nevertheless, it has followed the world tendency towards growth: during 1980–2000, the suicide rate in Brazil increased by 21%. Elderly people present the highest suicide rates in absolute numbers, but the alarming finding in the Brazilian data is that the youth population is increasingly dying by suicide (Mello-Santos et al, 2005). This statistic partially confirms a forecast by Diekstra & Guilbinat (1993) that the number of deaths by suicide would dramatically increase over the next decades, mainly in developing countries, including Latin America. In these regions, socio-economic factors (such as an increase in divorce and unemployment and a decrease in religiosity) increase the risk of self-harm. We discuss the reasons for the low suicide rate in Brazil and highlight the socio-economic factors affecting its increase among the youth population in particular.

scholarly journals Therapeutic Effectiveness and Safety of Repurposing Drugs for the Treatment of COVID-19: Position Standing in 2021

2021 ◽  
Vol 12 ◽  
Author(s):  
Safaet Alam ◽  
Taslima Binte Kamal ◽  
Md. Moklesur Rahman Sarker ◽  
Jin-Rong Zhou ◽  
S. M. Abdur Rahman ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Case Series ◽  
Basic Knowledge ◽  
World Health ◽  
Current Status ◽  
Drug Candidates ◽  
Health Organization ◽  
Meta Analyses

COVID-19, transmitted by SARS-CoV-2, is one of the most serious pandemic situations in the history of mankind, and has already infected a huge population across the globe. This horrendously contagious viral outbreak was first identified in China and within a very short time it affected the world's health, transport, economic, and academic sectors. Despite the recent approval of a few anti-COVID-19 vaccines, their unavailability and insufficiency along with the lack of other potential therapeutic options are continuing to worsen the situation, with valuable lives continuing to be lost. In this situation, researchers across the globe are focusing on repurposing prospective drugs and prophylaxis such as favipiravir, remdesivir, chloroquine, hydroxychloroquine, ivermectin, lopinavir-ritonavir, azithromycin, doxycycline, ACEIs/ARBs, rivaroxaban, and protease inhibitors, which were preliminarily based on in vitro and in vivo pharmacological and toxicological study reports followed by clinical applications. Based on available preliminary data derived from limited clinical trials, the US National Institute of Health (NIH) and USFDA also recommended a few drugs to be repurposed i.e., hydroxychloroquine, remdesivir, and favipiravir. However, World Health Organization later recommended against the use of chloroquine, hydroxychloroquine, remdesivir, and lopinavir/ritonavir in the treatment of COVID-19 infections. Combining basic knowledge of viral pathogenesis and pharmacodynamics of drug molecules as well as in silico approaches, many drug candidates have been investigated in clinical trials, some of which have been proven to be partially effective against COVID-19, and many of the other drugs are currently under extensive screening. The repurposing of prospective drug candidates from different stages of evaluation can be a handy wellspring in COVID-19 management and treatment along with approved anti-COVID-19 vaccines. This review article combined the information from completed clinical trials, case series, cohort studies, meta-analyses, and retrospective studies to focus on the current status of repurposing drugs in 2021.

Vaccine hesitancy and implications on childhood immunisation in Malaysia

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Noor Hazilah Abd Manaf ◽  
Mohd Azahadi Omar ◽  
Fatin Husna Suib
Keyword(s):  
World Health ◽  
Health Concern ◽  
Vaccine Hesitancy ◽  
Personal Choice ◽  
Childhood Immunisation ◽  
Content Type ◽  
Factors Affecting ◽  
Parental Decision ◽  
Islamic Medicine ◽  
Health Organization

PurposeThe World Health Organization identified vaccine hesitancy as one of the ten threats to global health in 2019. The purpose of this paper is to evaluate the implications and factors affecting parental decision on childhood immunisation in Malaysia.Design/methodology/approachThis paper reviews literature on vaccine hesitancy and evaluation of factors affecting parental decision on childhood immunisation in Malaysia.FindingsVaccine hesitancy is a growing public health concern in Malaysia with factors such as influence of Internet and social media, personal choice and individual right, conspiracy theory, religious reasons and alternative medicine as among the influencing dynamics. An urban, educated demography operating within a postmodern medical paradigm compounds the diminishing value of vaccines.Originality/valueThis paper provides a comprehensive examination of vaccine hesitancy in Malaysia. Critical appraisal on personal choice over societal responsibility within an Asian/Muslim collectivist society has not been discussed in previous studies. The acceptance of homeopathy as an Islamic medicine alternative is peculiar to multi-ethnic, multi-cultural Malaysia.

scholarly journals Physicochemical Analysis of Surface and Ground Water in Ugbomro and Iteregbi, Delta State, Nigeria

2020 ◽  
Vol 24 (3) ◽  
pp. 511-517
Author(s):  
O.B. Ovonramwen
Keyword(s):  
Oxygen Demand ◽  
Physicochemical Analysis ◽  
Total Alkalinity ◽  
World Health ◽  
Total Hardness ◽  
Need For Treatment ◽  
Environmental Status ◽  
Groundwater Samples ◽  
Health Organization ◽  
Surface And Groundwater

Physicochemical analyses of surface and groundwater samples from eleven different locations in Ugbomro and Iteregbi, Delta State, Nigeria were sampled and analyzed for physicochemical parameters according to standard methods for the examination of water and wastewater. The following  mean and standard deviation were obtained from the groundwater of the communities: temp (oC) 22.46 ± 0.50 and 23.23 ± 0.99, pH 6.63 ± 0.68 and6.69 ± 0.24, dissolved oxygen (DO) (mg/L) 5.91 ± 0.46 and 5.73 ± 0.46, chemical oxygen demand (COD) (mg/L) 4.24 ± 0.01 and 4.43 ± 0.10, biochemical oxygen demand (BOD) (mg/L) 3.51 ± 0.38 and 3.84 ± 0.21, Turbidity (NTU) 1.22 ± 1.07 and 3.56 ± 0.77, electrical conductivity (EC) (μs/cm) 748.9 ± 215.79 and 786.67 ± 226.77, color (TCU) 1.22 ± 2.12 and 6.11 ± 2.11, total alkalinity (TA) (mg/L) 6.22 ± 7.38 and 14.11 ± 11.19, HCO3- (mg/L) 6.22 ± 7.38 and 14.11 ± 11.19, NO3 - (mg/L) 1.13 ± 0.62 and 2.89 ± 1.25, total solids (TS) (mg/L) 489.09 ± 180.17 and 664.95 ± 373.37, total suspended solids (TSS) (mg/L) 32.25 ± 24.29 and 123.86 ± 82.79, total dissolved solids (TDS) (mg/L) 456.78 ± 163.73 and 542.20 ± 450.66, Cl- (mg/L) 21.20 ± 3.20 and 20.10 ± 3.89, total hardness (TH) (mg/L) 26.67 ± 22.83 and 46.78 ± 36.17, Na (mg/L) 1.26 ± 0.06 and 1.16 ± 0.04, K (mg/L) 0.04 ± 0.01 and 0.06 ± 0.03, Mg (mg/L) 4.32 ± 3.23 and 6.96 ± 5.49, Ca (mg/L) 8.68 ± 9.35 and 18.12 ± 13.71 respectively. The results obtained were subjected to statistical analysis and compared with the standard set by the Standards Organization of Nigeria (SON) and the World Health Organization (WHO) for water samples. Some of the parameters did not meet the standards, hence the need for treatment. The present physio-chemical analyses of surface and groundwater quality of the two neighboring university areas, Ugbomro and Iteregbi, were done to assess the environmental status of  the environment before socio-economic impacts. Keywords: physicochemical, surface water, groundwater, water quality

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