scholarly journals Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states

2020 ◽  
Author(s):  
Zachary Davis ◽  
Gabriel Benigno ◽  
Charlee Fletterman ◽  
Theo Desbordes ◽  
Terrence Sejnowski ◽  
...  
Keyword(s):  
Traveling Waves ◽  
Large Scale ◽  
Neuronal Excitability ◽  
Operating Mode ◽  
Underlying Mechanism ◽  
Wave Regime ◽  
The Mean ◽  
Horizontal Fiber ◽  
Cortical Fibers ◽  
Spontaneous Fluctuations

Abstract Sensory neuroscience has focused a great deal of its attention on characterizing the mean firing rate that is evoked by a stimulus, and while it has long been recognized that the firing rates of individual neurons fluctuate around the mean, these fluctuations are often treated as a form of internally generated noise1. There is, however, evidence that these “ongoing” fluctuations of activity in sensory cortex during normal, waking function shape neuronal excitability and responses to external input2,3. We have recently found that spontaneous fluctuations are organized into waves traveling at speeds consistent with the speed of action potentials traversing unmyelinated horizontal cortical fibers (0.1-0.6 m/s)4 across the cortical surface5. These waves systematically modulate excitability across the retinotopic map, strongly affecting perceptual sensitivity as measured in a visual detection task. The underlying mechanism for these waves, however, is unknown. Further, it is unclear whether waves are consistent with the low rate, highly irregular, and weakly correlated “asynchronous-irregular” dynamics observed in computational models6 and cortical recordings in vivo7. Here, we study a large-scale computational model of a cortical sheet, with connections ranging up to biological scales. Using an efficient custom simulation framework, we study networks with topographically-organized connectivity and distance-dependent axonal conduction delays from several thousand up to one million neurons. We find that spontaneous traveling waves are a general property of these networks and are consistent with the asynchronous-irregular regime. These waves are well matched to spontaneous waves recorded in the neocortex of awake monkeys. Further, individual neurons sparsely participate in waves, yielding a sparse-wave regime that offers a unique operating mode, where traveling waves coexist with locally asynchronous-irregular dynamics, without inducing deleterious neuronal correlations8.

scholarly journals Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zachary W. Davis ◽  
Gabriel B. Benigno ◽  
Charlee Fletterman ◽  
Theo Desbordes ◽  
Christopher Steward ◽  
...  
Keyword(s):  
Traveling Waves ◽  
Time Delays ◽  
Large Scale ◽  
Local Network ◽  
Perceptual Sensitivity ◽  
Neuronal Responses ◽  
Individual Wave ◽  
Horizontal Fiber ◽  
Sensory Evoked

AbstractStudies of sensory-evoked neuronal responses often focus on mean spike rates, with fluctuations treated as internally-generated noise. However, fluctuations of spontaneous activity, often organized as traveling waves, shape stimulus-evoked responses and perceptual sensitivity. The mechanisms underlying these waves are unknown. Further, it is unclear whether waves are consistent with the low rate and weakly correlated “asynchronous-irregular” dynamics observed in cortical recordings. Here, we describe a large-scale computational model with topographically-organized connectivity and conduction delays relevant to biological scales. We find that spontaneous traveling waves are a general property of these networks. The traveling waves that occur in the model are sparse, with only a small fraction of neurons participating in any individual wave. Consequently, they do not induce measurable spike correlations and remain consistent with locally asynchronous irregular states. Further, by modulating local network state, they can shape responses to incoming inputs as observed in vivo.

Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform

2019 ◽  
Vol 22 (5) ◽  
pp. 346-354
Author(s):  
Yan A. Ivanenkov ◽  
Renat S. Yamidanov ◽  
Ilya A. Osterman ◽  
Petr V. Sergiev ◽  
Vladimir A. Aladinskiy ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Large Scale ◽  
Underlying Mechanism ◽  
Luciferase Assay ◽  
Reporter System ◽  
E Coli ◽  
Starting Point ◽  
High Concentrations ◽  
Mic Value

Aim and Objective: Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was undertaken to identify novel molecules with antibacterial activity. Materials and Methods: Using our unique double-reporter system, in-house large-scale HTS campaign was conducted for the identification of antibacterial potency of small-molecule compounds. The construction allows us to visually assess the underlying mechanism of action. After the initial HTS and rescreen procedure, luciferase assay, C14-test, determination of MIC value and PrestoBlue test were carried out. Results: HTS rounds and rescreen campaign have revealed the antibacterial activity of a series of Nsubstituted triazolo-azetidines and their isosteric derivatives that has not been reported previously. Primary hit-molecule demonstrated a MIC value of 12.5 µg/mL against E. coli Δ tolC with signs of translation blockage and no SOS-response. Translation inhibition (26%, luciferase assay) was achieved at high concentrations up to 160 µg/mL, while no activity was found using C14-test. The compound did not demonstrate cytotoxicity in the PrestoBlue assay against a panel of eukaryotic cells. Within a series of direct structural analogues bearing the same or bioisosteric scaffold, compound 2 was found to have an improved antibacterial potency (MIC=6.25 µg/mL) close to Erythromycin (MIC=2.5-5 µg/mL) against the same strain. In contrast to the parent hit, this compound was more active and selective, and provided a robust IP position. Conclusion: N-substituted triazolo-azetidine scaffold may be used as a versatile starting point for the development of novel active and selective antibacterial compounds.

scholarly journals Quality Control in 3D Printing: Accuracy Analysis of 3D-Printed Models of Patient-Specific Anatomy

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1021
Author(s):  
Bernhard Dorweiler ◽  
Pia Elisabeth Baqué ◽  
Rayan Chaban ◽  
Ahmed Ghazy ◽  
Oroa Salem
Keyword(s):  
Wall Thickness ◽  
Large Scale ◽  
Fused Deposition Modeling ◽  
Vascular Anatomy ◽  
3D Models ◽  
Patient Specific ◽  
Stl File ◽  
Fused Deposition ◽  
3D Printed ◽  
The Mean

As comparative data on the precision of 3D-printed anatomical models are sparse, the aim of this study was to evaluate the accuracy of 3D-printed models of vascular anatomy generated by two commonly used printing technologies. Thirty-five 3D models of large (aortic, wall thickness of 2 mm, n = 30) and small (coronary, wall thickness of 1.25 mm, n = 5) vessels printed with fused deposition modeling (FDM) (rigid, n = 20) and PolyJet (flexible, n = 15) technology were subjected to high-resolution CT scans. From the resulting DICOM (Digital Imaging and Communications in Medicine) dataset, an STL file was generated and wall thickness as well as surface congruency were compared with the original STL file using dedicated 3D engineering software. The mean wall thickness for the large-scale aortic models was 2.11 µm (+5%), and 1.26 µm (+0.8%) for the coronary models, resulting in an overall mean wall thickness of +5% for all 35 3D models when compared to the original STL file. The mean surface deviation was found to be +120 µm for all models, with +100 µm for the aortic and +180 µm for the coronary 3D models, respectively. Both printing technologies were found to conform with the currently set standards of accuracy (<1 mm), demonstrating that accurate 3D models of large and small vessel anatomy can be generated by both FDM and PolyJet printing technology using rigid and flexible polymers.

scholarly journals Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field

2021 ◽  
Author(s):  
Miguel Dasilva ◽  
Christian Brandt ◽  
Marc Alwin Gieselmann ◽  
Claudia Distler ◽  
Alexander Thiele
Keyword(s):  
Attentional Control ◽  
Large Scale ◽  
Neuronal Excitability ◽  
Cell Types ◽  
Receptor Activation ◽  
Frontal Eye Field ◽  
Control Signals ◽  
Cognitive Operations ◽  
Eye Field ◽  
Large Scale Networks

Abstract Top-down attention, controlled by frontal cortical areas, is a key component of cognitive operations. How different neurotransmitters and neuromodulators flexibly change the cellular and network interactions with attention demands remains poorly understood. While acetylcholine and dopamine are critically involved, glutamatergic receptors have been proposed to play important roles. To understand their contribution to attentional signals, we investigated how ionotropic glutamatergic receptors in the frontal eye field (FEF) of male macaques contribute to neuronal excitability and attentional control signals in different cell types. Broad-spiking and narrow-spiking cells both required N-methyl-D-aspartic acid and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation for normal excitability, thereby affecting ongoing or stimulus-driven activity. However, attentional control signals were not dependent on either glutamatergic receptor type in broad- or narrow-spiking cells. A further subdivision of cell types into different functional types using cluster-analysis based on spike waveforms and spiking characteristics did not change the conclusions. This can be explained by a model where local blockade of specific ionotropic receptors is compensated by cell embedding in large-scale networks. It sets the glutamatergic system apart from the cholinergic system in FEF and demonstrates that a reduction in excitability is not sufficient to induce a reduction in attentional control signals.

scholarly journals Relationship between large-scale ionospheric field-aligned currents and electron/ion precipitations: DMSP observations

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Chao Xiong ◽  
Claudia Stolle ◽  
Patrick Alken ◽  
Jan Rauberg
Keyword(s):  
Time Distribution ◽  
Large Scale ◽  
Particle Flux ◽  
Particle Energy ◽  
Lower Latitude ◽  
Particle Precipitation ◽  
Data Set ◽  
The Mean ◽  
Two Parameters ◽  
Meteorological Satellite

Abstract In this study, we have derived field-aligned currents (FACs) from magnetometers onboard the Defense Meteorological Satellite Project (DMSP) satellites. The magnetic latitude versus local time distribution of FACs from DMSP shows comparable dependences with previous findings on the intensity and orientation of interplanetary magnetic field (IMF) By and Bz components, which confirms the reliability of DMSP FAC data set. With simultaneous measurements of precipitating particles from DMSP, we further investigate the relation between large-scale FACs and precipitating particles. Our result shows that precipitation electron and ion fluxes both increase in magnitude and extend to lower latitude for enhanced southward IMF Bz, which is similar to the behavior of FACs. Under weak northward and southward Bz conditions, the locations of the R2 current maxima, at both dusk and dawn sides and in both hemispheres, are found to be close to the maxima of the particle energy fluxes; while for the same IMF conditions, R1 currents are displaced further to the respective particle flux peaks. Largest displacement (about 3.5°) is found between the downward R1 current and ion flux peak at the dawn side. Our results suggest that there exists systematic differences in locations of electron/ion precipitation and large-scale upward/downward FACs. As outlined by the statistical mean of these two parameters, the FAC peaks enclose the particle energy flux peaks in an auroral band at both dusk and dawn sides. Our comparisons also found that particle precipitation at dawn and dusk and in both hemispheres maximizes near the mean R2 current peaks. The particle precipitation flux maxima closer to the R1 current peaks are lower in magnitude. This is opposite to the known feature that R1 currents are on average stronger than R2 currents.

scholarly journals Improved Visual Localization via Graph Filtering

2021 ◽  
Vol 7 (2) ◽  
pp. 20
Author(s):  
Carlos Lassance ◽  
Yasir Latif ◽  
Ravi Garg ◽  
Vincent Gripon ◽  
Ian Reid
Keyword(s):  
Image Retrieval ◽  
Large Scale ◽  
Visual Localization ◽  
Localization Accuracy ◽  
Additional Information ◽  
Feature Representations ◽  
The Mean ◽  
Classical Image ◽  
Vision Based Localization ◽  
Improve Reliability

Vision-based localization is the problem of inferring the pose of the camera given a single image. One commonly used approach relies on image retrieval where the query input is compared against a database of localized support examples and its pose is inferred with the help of the retrieved items. This assumes that images taken from the same places consist of the same landmarks and thus would have similar feature representations. These representations can learn to be robust to different variations in capture conditions like time of the day or weather. In this work, we introduce a framework which aims at enhancing the performance of such retrieval-based localization methods. It consists in taking into account additional information available, such as GPS coordinates or temporal proximity in the acquisition of the images. More precisely, our method consists in constructing a graph based on this additional information that is later used to improve reliability of the retrieval process by filtering the feature representations of support and/or query images. We show that the proposed method is able to significantly improve the localization accuracy on two large scale datasets, as well as the mean average precision in classical image retrieval scenarios.

scholarly journals Mesoscale Features Associated with Tropical Cyclone Formations in the Western North Pacific

2008 ◽  
Vol 136 (6) ◽  
pp. 2006-2022 ◽  
Author(s):  
Cheng-Shang Lee ◽  
Kevin K. W. Cheung ◽  
Jenny S. N. Hui ◽  
Russell L. Elsberry
Keyword(s):  
Tropical Cyclone ◽  
North Pacific ◽  
Western North Pacific ◽  
Large Scale ◽  
North Pacific Ocean ◽  
Deep Convection ◽  
Mesoscale Convective System ◽  
Convective System ◽  
Synoptic Patterns ◽  
The Mean

Abstract The mesoscale features of 124 tropical cyclone formations in the western North Pacific Ocean during 1999–2004 are investigated through large-scale analyses, satellite infrared brightness temperature (TB), and Quick Scatterometer (QuikSCAT) oceanic wind data. Based on low-level wind flow and surge direction, the formation cases are classified into six synoptic patterns: easterly wave (EW), northeasterly flow (NE), coexistence of northeasterly and southwesterly flow (NE–SW), southwesterly flow (SW), monsoon confluence (MC), and monsoon shear (MS). Then the general convection characteristics and mesoscale convective system (MCS) activities associated with these formation cases are studied under this classification scheme. Convection processes in the EW cases are distinguished from the monsoon-related formations in that the convection is less deep and closer to the formation center. Five characteristic temporal evolutions of the deep convection are identified: (i) single convection event, (ii) two convection events, (iii) three convection events, (iv) gradual decrease in TB, and (v) fluctuating TB, or a slight increase in TB before formation. Although no dominant temporal evolution differentiates cases in the six synoptic patterns, evolutions ii and iii seem to be the common routes taken by the monsoon-related formations. The overall percentage of cases with MCS activity at multiple times is 63%, and in 35% of cases more than one MCS coexisted. Most of the MC and MS cases develop multiple MCSs that lead to several episodes of deep convection. These two patterns have the highest percentage of coexisting MCSs such that potential interaction between these systems may play a role in the formation process. The MCSs in the monsoon-related formations are distributed around the center, except in the NE–SW cases in which clustering of MCSs is found about 100–200 km east of the center during the 12 h before formation. On average only one MCS occurs during an EW formation, whereas the mean value is around two for the other monsoon-related patterns. Both the mean lifetime and time of first appearance of MCS in EW are much shorter than those developed in other synoptic patterns, which indicates that the overall formation evolution in the EW case is faster. Moreover, this MCS is most likely to be found within 100 km east of the center 12 h before formation. The implications of these results to internal mechanisms of tropical cyclone formation are discussed in light of other recent mesoscale studies.

scholarly journals Well-Being of Healthcare Workers and the General Public during the COVID-19 Pandemic in Vietnam: An Online Survey

2021 ◽  
Vol 18 (9) ◽  
pp. 4737
Author(s):  
Tuyen Dinh Hoang ◽  
Robert Colebunders ◽  
Joseph Nelson Siewe Fodjo ◽  
Nhan Phuc Thanh Nguyen ◽  
Trung Dinh Tran ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Large Scale ◽  
Online Survey ◽  
Preventive Measures ◽  
Vaccine Coverage ◽  
Health Sector ◽  
Well Being ◽  
Multivariate Logistic Regression Model ◽  
The Mean ◽  
Restrictive Measures

The COVID-19 pandemic and associated restrictive measures implemented may considerably affect people’s lives. This study aimed to assess the well-being of Vietnamese people after COVID-19 lockdown measures were lifted and life gradually returned to normal. An online survey was organized from 21 to 25 April 2020 among Vietnamese residents aged 18 and over. The survey was launched by the Hue University of Medicine and Pharmacy. The WHO-5 Well-Being Index (scored 0–25) was used to score participants’ well-being. A multivariate logistic regression model was used to determine the predictors of well-being. A total of 1922 responses were analyzed (mean age: 31 years; 30.5% male; 88.2% health professionals or students in the health sector). The mean well-being score was 17.35 ± 4.97. Determinants of a high well-being score (≥13) included older age, eating healthy food, practicing physical exercise, working from home, and adhering to the COVID-19 preventive measures. Female participants, persons worried about their relatives’ health, and smokers were more likely to have a low well-being score. In conclusion, after the lockdown measures were lifted, the Vietnamese have people continued to follow COVID-19 preventive measures, and most of them scored high on the well-being scale. Waiting to achieve large-scale COVID-19 vaccine coverage, promoting preventive COVID-19 measures remains important, together with strategies to guarantee the well-being of the Vietnamese people.

scholarly journals Instability wave models for the near-field fluctuations of turbulent jets

2011 ◽  
Vol 689 ◽  
pp. 97-128 ◽  
Author(s):  
K. Gudmundsson ◽  
Tim Colonius
Keyword(s):  
Flow Field ◽  
Large Scale ◽  
Microphone Array ◽  
Near Field ◽  
Turbulent Jets ◽  
Instability Wave ◽  
Mean Flow ◽  
Velocity Fluctuations ◽  
The Mean ◽  
Scale Structures

AbstractPrevious work has shown that aspects of the evolution of large-scale structures, particularly in forced and transitional mixing layers and jets, can be described by linear and nonlinear stability theories. However, questions persist as to the choice of the basic (steady) flow field to perturb, and the extent to which disturbances in natural (unforced), initially turbulent jets may be modelled with the theory. For unforced jets, identification is made difficult by the lack of a phase reference that would permit a portion of the signal associated with the instability wave to be isolated from other, uncorrelated fluctuations. In this paper, we investigate the extent to which pressure and velocity fluctuations in subsonic, turbulent round jets can be described aslinearperturbations to the mean flow field. The disturbances are expanded about the experimentally measured jet mean flow field, and evolved using linear parabolized stability equations (PSE) that account, in an approximate way, for the weakly non-parallel jet mean flow field. We utilize data from an extensive microphone array that measures pressure fluctuations just outside the jet shear layer to show that, up to an unknown initial disturbance spectrum, the phase, wavelength, and amplitude envelope of convecting wavepackets agree well with PSE solutions at frequencies and azimuthal wavenumbers that can be accurately measured with the array. We next apply the proper orthogonal decomposition to near-field velocity fluctuations measured with particle image velocimetry, and show that the structure of the most energetic modes is also similar to eigenfunctions from the linear theory. Importantly, the amplitudes of the modes inferred from the velocity fluctuations are in reasonable agreement with those identified from the microphone array. The results therefore suggest that, to predict, with reasonable accuracy, the evolution of the largest-scale structures that comprise the most energetic portion of the turbulent spectrum of natural jets, nonlinear effects need only be indirectly accounted for by considering perturbations to the mean turbulent flow field, while neglecting any non-zero frequency disturbance interactions.

scholarly journals On interpreting studies of tracer transport by deep cumulus convection and its effects on atmospheric chemistry

2008 ◽  
Vol 8 (20) ◽  
pp. 6037-6050 ◽  
Author(s):  
M. G. Lawrence ◽  
M. Salzmann
Keyword(s):  
Atmospheric Chemistry ◽  
Large Scale ◽  
Deep Convection ◽  
Convective Transport ◽  
Advective Transport ◽  
Tracer Transport ◽  
Transport Models ◽  
Mass Fluxes ◽  
Split Treatment ◽  
The Mean

Abstract. Global chemistry-transport models (CTMs) and chemistry-GCMs (CGCMs) generally simulate vertical tracer transport by deep convection separately from the advective transport by the mean winds, even though a component of the mean transport, for instance in the Hadley and Walker cells, occurs in deep convective updrafts. This split treatment of vertical transport has various implications for CTM simulations. In particular, it has led to a misinterpretation of several sensitivity simulations in previous studies in which the parameterized convective transport of one or more tracers is neglected. We describe this issue in terms of simulated fluxes and fractions of these fluxes representing various physical and non-physical processes. We then show that there is a significant overlap between the convective and large-scale mean advective vertical air mass fluxes in the CTM MATCH, and discuss the implications which this has for interpreting previous and future sensitivity simulations, as well as briefly noting other related implications such as numerical diffusion.

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