scholarly journals Urinary Cotinine-Verified Smoking Status and Serum Lipid Profiles and Lipid Ratios in Korean Older Adults: A Nationwide Cross-Sectional Study

2021 ◽  
Author(s):  
Myung Ji Nam ◽  
Chung-woo Lee ◽  
Hyunjin Kim ◽  
Ji Won Yoo ◽  
Kyu Na Lee ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Serum Lipid ◽  
Smoking Status ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Lipid Ratios ◽  
Urine Cotinine

Abstract Background: Serum lipid profile is an important factor in predicting the risk of cardiovascular disease, and smoking is considered to affect serum lipid levels adversely by altering lipid metabolism. Although traditional lipid profiles are important in patient evaluation for predicting the risk of cardiovascular disease, the clinical significance of lipid ratios has recently gained attention as well. We aimed to investigate the relationship between smoking and serum lipid profiles and ratios in Korean older adults.METHODS: This cross‐sectional analysis used a nationally representative sample from the 2014–2016 Korea National Health and Nutrition Examination Survey (KNHANES). In total, 4,349 participants aged ≥60 years with urine cotinine values were included. The outcome was a comparison of unfavorable lipid profiles/ratios in respect to urine cotinine-verified smoking status (urine cotinine level ≥50 ng/mL), and quantification of the associations between smoking and unfavorable lipid profiles/ratios using multivariable logistic regression analyses. In our analyses, the lowest quartile (Q1) of high-density lipoprotein cholesterol (HDL-C), and the highest quartile (Q4) of low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC), and their ratios (TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C) were considered as unfavorable.Results: The percentages of unfavorable lipid profiles/ratios except for serum TC and LDL-C were significantly higher in the urine cotinine-verified smoker group. The odds ratios (ORs) and 95% confidence intervals (CIs) of urine cotinine-verified smokers for the Q1 of HDL-C and for the Q4 of TG, TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C were 1.67 (95% CI: 1.29–2.17) and 1.49 (95% CI: 1.14–1.96), 1.50 (95% CI: 1.14–1.97), 1.44 (95% CI: 1.10–1.89), and 1.75 (95% CI: 1.35–2.28), respectively.Conclusion: Urine cotinine-verified smoking status was significantly associated with unfavorable serum lipid profiles/ratios in Korean older adults.

scholarly journals Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

2001 ◽  
pp. 705-710 ◽  
Author(s):  
Z Efstathiadou ◽  
S Bitsis ◽  
HJ Milionis ◽  
A Kukuvitis ◽  
ET Bairaktari ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Serum Lipid ◽  
Thyroid Autoimmunity ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Study Results ◽  
Pre Treatment

OBJECTIVE: The significance of dyslipidemia in subclinical hypothyroidism (SH) and the effect of thyroid substitution on lipids remain controversial. The present study aimed to assess the association of SH with lipid abnormalities and to quantify the effect of L-thyroxine therapy on serum lipid profiles. DESIGN: Serum lipid parameters of 66 patients with SH and 75 age- and sex-matched euthyroid controls were evaluated in a cross-sectional study. RESULTS: Patients with SH had higher total cholesterol (TC) (222+/-45 (s.d.) vs 190+/- 32 mg/dl), low-density lipoprotein cholesterol (LDL-C) (139+/-28 vs 118+/-39 mg/dl), apolipoprotein B (149+/-21 vs 139+/-18 mg/dl) and lipoprotein (a) (Lp(a)) (median 12.5 (0.8-101) mg/dl vs 7 (0.8-44) mg/dl) levels compared with euthyroid controls (P<0.05 for all comparisons). In a follow-up study including 37 patients with SH, all measurements were repeated after restoration of a euthyroid state with incremental doses of l-thyroxine. No significant changes in serum lipid profiles were observed except for a decrease in high-density lipoprotein cholesterol (59+/-15 to 55+/-14 mg/dl, P<0.05). However, patients with high pre-treatment TC (> or =240 mg/dl) showed a significant reduction in both TC (278+/-28 vs 257+/-36 mg/dl, P<0.05) and LDL-C (192+/-23 vs 173+/-28 mg/dl, P<0.01) levels. Similar but more pronounced changes were observed in a subgroup of patients with pre-treatment levels of TSH > or =10 microU/ml. Thyroid autoimmunity had no effect on either the baseline or the post-treatment lipid profile. CONCLUSION: Although patients with subclinical hypothyroidism exhibit increased levels of the atherogenic parameters (mainly LDL-C and Lp(a)), thyroid substitution therapy does not seem to significantly improve dyslipidemia in the whole group of patients.

scholarly journals ASSOCIATION OF LIPID PROFILES WITH 10-YEAR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK: STUDY AMONG SUBJECTS IN SLEMAN DISTRICT OF YOGYAKARTA INDONESIA

2017 ◽  
Vol 10 (12) ◽  
pp. 166
Author(s):  
Rita Suhadi ◽  
Dita Maria Virginia ◽  
Christianus Heru Setiawan
Keyword(s):  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional ◽  
Lipid Ratio ◽  
Ascvd Risk

  Objectives: The subjects in the Sleman District of Yogyakarta had medium Framingham risk score (FRS) in the preceding year study. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk was a newer risk estimator than FRS. This study aimed to associate the lipid profiles with the ASCVD risk.Methods: The study was conducted with a cross-sectional design and the subjects were selected with cluster random sampling. The association of lipid profiles and ASCVD risk was analyzed with Mann–Whitney/Kruskal–Wallis tests and Spearman’s rho correlation, whereas the categorical scores within sub-groups were analyzed Chi-square statistics, respectively.Results: The eligible subjects (n=221) had the age at 51.7±8.1 years, systolic/diastolic blood pressure 136.8±22.4/85.0±12.4 mmHg, total-cholesterol (total-C), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride at 202.0±34.9 mg/dl, 52.6±12.5 mg/dl, 126.3±30.0 mg/dl, and 135.9±95.4 mg/dl, respectively; with hypertension treatment 16.7%, smoking 52.9%, diabetes 10.4%, and the median ASCVD risk at 4.4 (0.2-41.4). The ASCVD risk has significant association with non-lipid profiles, total-C, lipid ratio of triglyceride/HDL-C, total-C/HDL-C, and LDL-C/HDL-C, to a lesser extent, HDL-C, LDL-C, and triglyceride.Conclusion: The 10-year ASCVD risk of the subjects was categorized as low and had a significant association with total-C and lipid ratio of triglyceride/ HDL-C, total-C/HDL-C, and LDL-C/HDL-C.

scholarly journals Lipid profiles in smoking and non-smoking male adolescents

2014 ◽  
Vol 54 (4) ◽  
pp. 232
Author(s):  
Sigit Prastyanto ◽  
Mei Neni Sitaresmi ◽  
Madarina Julia
Keyword(s):  
Total Cholesterol ◽  
Tobacco Smoking ◽  
Ldl Cholesterol ◽  
Smoking Status ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Cross Sectional ◽  
Mean Differences

Background The prevalence of smoking in adolescentstends to increase. Smoking is associated with a higher risk ofdyslipidemia.Objective To compare the lipid profiles of tobacco-smoking andnon-tobacco-smoking male adolescents.Methods We performed a cross- sectional study in three vocationalhigh schools in Yogyakarta from January to April 2011. Dataon smoking status, duration of smoking and number cigarettesconsumed per day were collected by questionnaires. We randomlyselected 50 male smokers and 50 male non-smokers as the studysubjects.Results Mean differences between smokers and non-smokerswere 44.5 (95%CI 28. 7 to 60.1) mg/dL for triglyceride levels; 8.0(95% CI 1.0 to 14.9) mg/dL for low density lipoprotein (LDL)cholesterol; 11.8 (1.1 to 22.4) mg/dL for total cholesterol and -5.7mg/dL (95% CI -8.8 to -2.6) for high density lipoprotein (HDL)cholesterol. Mean differences (95% CI) between smokers whohad engaged in smoking for > 2 years and those who had smokedfor :S:2 years were -18.1 (95% CI -33 .9 to -2.3) mg/dL for totalcholesterol; -49.4 (95% CI -67.2 to -3 1.5) mg/dL for triglycerides.Mean differences between those who smoked > 5 cigarettes/dayand :s:5 cigarettes per day were -18 .4 (95% CI -32.8 to -4.1) mg/dL for total cholesterol and -29.1 (95% CI -53.6 to -4.6) mg/dLfor triglycerides.Conclusion Smoking more than 5 cigarettes/day significantlyincreases total cholesterol, LDL cholesterol, and triglyceridelevels, as well as reduces HDL cholesterol levels; while smokingmore than 2 years significantly increases total cholesterol andtriglyceride levels

scholarly journals Association between lipoprotein cholesterol and future cardiovascular disease and mortality in older adults: a Korean nationwide longitudinal study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Seung Hee Kim ◽  
Ki Young Son
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Risk Factor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Incidence Rates ◽  
Brain Disease ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Ischemic Brain

Abstract Background Dyslipidemia is considered an independent health risk factor of cardiovascular disease (CVD), a leading cause of mortality in older adults. Despite its importance, there have been few reports on the association between lipoprotein cholesterol and future CVD and cardiovascular (CV) mortality among elderly Asians aged ≥ 65 years. This study investigated the association between lipoprotein cholesterol and future CVD and CV mortality in an elderly Korean population using a large nationwide sample. Methods From the cohort database of the Korean National Health Insurance Service, 62,604 adults aged ≥ 65 years (32,584 men and 30,020 women) were included. High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were categorized by quartiles. Cox proportional hazard models and linear regression analyses were used to assess the association between the quartiles of lipoprotein cholesterol and future CV events or mortality. Results The mean follow-up period was 3.3 years. The incidence rates of ischemic heart disease and ischemic brain disease were 0.97 and 0.61 per 1,000 person-years, respectively, and the mortality rates from these diseases were 0.22 and 0.34 per 1,000 person-years, respectively. In a completely adjusted model, high HDL-C and LDL-C levels were not associated with total CV events and CVD mortality. However, high LDL-C levels were significantly associated with a lower incidence of ischemic brain disease. Furthermore, diabetic patients with high LDL-C levels were more likely to have higher CV mortality, whereas non-smokers with high LDL-C levels were less likely to be at risk of CV events. Conclusions Neither high LDL-C nor HDL-C levels were significantly associated with future CV mortality in older adults aged ≥ 65 years. High LDL-C levels do not seem to be a risk factor for CVD in elderly individuals, and further studies are required.

scholarly journals Association of Lipoprotein Cholesterol With Future Cardiovascular Disease and Mortality in Older Adults: A Korean Nationwide Longitudinal Study

2020 ◽  
Author(s):  
Seung Hee Kim ◽  
Ki Young Son
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Longitudinal Study ◽  
Screening Program ◽  
Density Lipoprotein ◽  
Incidence Rates ◽  
Brain Disease ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Ischemic Brain

Abstract BackgroundDyslipidemia is an independent health risk of cardiovascular disease (CVD), a leading cause of mortality in older adults. Despite their importance, there have been few reports on the association between lipoprotein cholesterol and future CVD and cardiovascular (CV) mortality among elderly Asians. This longitudinal study investigated the correlations in an elderly Korean population by using a large nationwide sample.MethodsAmong participants in the cohort database of the Korean National Health Insurance Service who completed the National Screening Program, a total of 62,604 adults aged 65 years or older (32,584 men and 30,020 women) were included. High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) values were categorized by quartiles. Cox proportional hazard models were used to assess the association between the quartiles of lipoprotein cholesterol and CV events or CV mortality.ResultsThe mean follow-up period was 3.3 years. The incidence rates of ischemic heart disease and ischemic brain disease were 0.97 and 0.61 per 1,000 person-years, while the mortality rates from these diseases were 0.22 and 0.34 per 1,000 person-years, respectively. In a fully adjusted model, high HDL-C and LDL-C levels were not associated with the total CV events and CV mortality; however, high LDL-C levels were significantly associated with a lower incidence of ischemic brain disease. Furthermore, diabetic patients with high LDL-C were more likely to have higher CV mortality, whereas non-smokers with high LDL-C were less likely to be at risk of CV events. ConclusionsNeither high LDL-C nor HDL-C was significantly associated with future CV mortality in older adults aged ≥65 years. Older adults with diabetes were significantly associated with a higher risk of CV mortality in high LDL-C levels.

scholarly journals Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e024731 ◽  
Author(s):  
Ji Hyung Nam ◽  
Jaeyong Shin ◽  
Sung-In Jang ◽  
Ji Hyun Kim ◽  
Kyu-Tae Han ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Correlation Coefficients ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Nutrition Survey ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Unit Increase

ObjectivesDyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers.DesignA cross-sectional study.SettingThe data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015.Participants2884 adolescents aged 12–18 years and their mothers were included.Primary outcome measuresOutcome variables were adolescents’ lipid levels. Mothers’ lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents’ lipid levels for each unit increase of their mothers’ lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers.ResultsThe mean levels of adolescents’ lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r,95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother’s TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother’s characteristics.ConclusionsMothers’ lipid levels are associated with adolescents’ lipids; therefore, they can serve as a reference for the screening of adolescent’s dyslipidaemia.

scholarly journals Association between Selected Dietary Habits and Lipid Profiles of Patients with Cardiovascular Disease

2020 ◽  
Vol 17 (20) ◽  
pp. 7605
Author(s):  
Jana Kopčeková ◽  
Mária Holovičová ◽  
Martina Gažarová ◽  
Jana Mrázová ◽  
Marta Habánová ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Dietary Habits ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Daily Consumption ◽  
Fruit Consumption ◽  
The Impact

This study evaluated the associations between selected dietary habits and lipid profiles in a group of 800 randomly selected patients hospitalized in the Nitra Cardio Center, Slovakia. Patients were aged 20–101 years (only men, the average age was 61.13 ± 10.47 years). The data necessary for the detection of dietary habits were obtained by a questionnaire method in closed-ended format. Data collection was carried out simultaneously with the somatometric and biochemical examinations of the respondents ensured by the Nitra Cardio Center. The following parameters were evaluated: total cholesterol (T-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and blood glucose. Statistical comparisons between groups were performed using one-way analysis of variance (one-way ANOVA), followed by Tukey’s post hoc test. We detected significant differences (p < 0.05) in the influence of the number of daily meals on T-C and LDL-C, which were higher in men who consumed 1–2 meals compared with 3–4 or 5–6 meals. In the consumption of meat, eggs, and fish, there was no significant effect on the biochemical parameters of blood (p > 0.05). We recorded a significant effect (p < 0.001) on T-C and LDL-C levels between low-fat and whole-fat milk consumption. Except for the impact of fruit consumption on the HDL-C level (p < 0.001), the different frequencies of fruit consumption showed non-significant changes for the lipid profile levels. We detected a significant effect (p = 0.017) of the consumption of vegetables 1–2 times/week on LDL-C in favor of daily consumption. Our results support that monitoring the lipid profile is an important determinant in the prevention and treatment of cardiovascular disease. The conducted research emphasizes the importance of diet dependence on the improvement of the quality of treatment and nutrition of people with this type of disease.

Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats

2014 ◽  
Vol 32 (7) ◽  
pp. 1328-1334 ◽  
Author(s):  
Motunrayo G Akande ◽  
Yusuf O Aliu ◽  
Suleiman F Ambali ◽  
Joseph O Ayo
Keyword(s):  
Oxidative Stress ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Blood Samples ◽  
Lipid Disorders

The aim of this study was to investigate the effects of taurine (TA) on serum lipid profiles following chronic coadministration of chlorpyrifos (CP) and lead acetate (Pb) in male Wistar rats. Fifty rats randomly distributed into five groups served as subjects. Distilled water (DW) was given to DW group, while soya oil (SO; 1 mL kg−1) was given to SO group. The TA group was treated with TA (50 mg kg−1). The CP + Pb group was administered sequentially with CP (4.25 mg kg−1; 1/20th median lethal dose (LD50)) and Pb at 233.25 mg kg−1 (1/20th LD50), while the TA + CP + Pb group received TA (50 mg kg−1), CP (4.25 mg kg−1), and Pb (233.25 mg kg−1) sequentially. The treatments were administered once daily by oral gavage for 16 weeks. The rats were euthanised, and the blood samples were collected at the termination of the study. Sera obtained from the blood samples were analyzed for total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde, and also the activities of serum antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase were analyzed. The low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and atherogenic index were calculated. The results showed that CP and Pb induced alterations in the serum lipid profiles and evoked oxidative stress. TA alleviated the disruptions in the serum lipid profiles of the rats partially by mitigating oxidative stress. It was concluded that TA may be used for prophylaxis against serum lipid disorders in animals that were constantly co-exposed to CP and Pb in the environment.

scholarly journals Relationship Between Serum Lipid Profiles and Carotid Intraplaque Neovascularization in a High–Stroke‐Risk Population: A Cross‐Sectional Study in China

2021 ◽  
Author(s):  
Ying Wang ◽  
Ming Yao ◽  
Mi Zou ◽  
Zhitong Ge ◽  
Siman Cai ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Serum Lipid ◽  
Carotid Plaque ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background Evidence of the association between serum lipid profiles and intraplaque neovascularization (IPN) is still limited. We aimed to study the value of a novel Doppler method, superb microvascular imaging, in correlating serum lipid profiles and evidence of IPN in a population with a high risk of stroke. Methods and Results A community‐based cross‐sectional study was conducted in Beijing, China. Residents (aged ≥40 years) underwent questionnaire interviews, physical examinations, and laboratory testing in 2018 and 2019. Subjects with a high risk of stroke were then selected. Standard carotid ultrasound and carotid plaque superb microvascular imaging examinations were then performed on the high–stroke‐risk participants. Logistic regression was used to evaluate the relationship between serum lipid profiles and carotid plaque IPN. Overall, a total of 250 individuals (mean age, 67.20±8.12 years; 66.4% men) met the study inclusion criteria. Superb microvascular imaging revealed carotid plaque IPN in 96 subjects (38.4%). Subjects with IPN were more likely to be current smokers (34.0% versus 46.9%, P =0.046), and their identified carotid plaques were much thicker (2.35±0.63 mm versus 2.75±0.80 mm, P =0.001). Serum lipids, including total cholesterol, non–high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol were positively associated with the presence of IPN (4.33±1.00 mmol/L versus 4.79±1.12 mmol/L, P =0.001; 2.96±0.92 mmol/L versus 3.40±1.01 mmol/L, P =0.001; 2.18±0.76 mmol/L versus 2.46±0.80 mmol/L, P =0.005, respectively), and after adjustment for other confounders, the positive relationship remained significant. Furthermore, non–high‐density lipoprotein cholesterol (odds ratio, 2.62 [95% CI, 1.35–5.06]) was significantly associated with the presence of carotid plaque IPN even after adjusting for low‐density lipoprotein cholesterol. Conclusions Total cholesterol, non–high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol were positively associated with the presence of carotid IPN in a Chinese high–stroke‐risk population. Further prospective studies should be conducted to better understand how much finding IPN adds to current stroke prediction tools.

Abstract 10041: Increased Triglyceride Levels are Associated With Endothelial Dysfunction: FMD-Japan Registry

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Masato Kajikawa ◽  
Yukihito Higashi ◽  
Tatsuya Maruhashi ◽  
Yumiko Iwamoto ◽  
Akimichi Iwamoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Endothelial Function ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional

Objective: In contrast to low-density lipoprotein cholesterol, and high density lipoprotein cholesterol, which are well-established independent risk factors for cardiovascular disease, the importance of triglycerides remains controversial. In this study, we evaluated the associations between triglycerides and endothelial function in the general population. Methods and Results: We enrolled 4,908 subjects (3842 men and 1066 women; mean age, 48±12 years) who were enrolled in FMD-Japan registry. And, we investigated cross-sectional associations between triglycerides and endothelial function by measurement of flow-mediated vasodilation (FMD). The triglycerides levels were negatively associated with FMD (r=-0.10, P<0.001). Subjects were divided into six groups on the basis of the triglycerides level. FMD was significantly decreased with an increase in the triglycerides level (≤63 mg/dL, 7.0±3.5%; 64 to 83 mg/dL, 6.3±3.5%; 84 to 105 mg/dL, 6.0±3.1%; 106 to 131 mg/dL, 5.8±3.2%; 132 to 179 mg/dL, 5.7±3.1%; ≥180 mg/dL, 5.5±3.0%; P for trend<0.001). After adjustment for age, sex, cardiovascular risk factors including high density lipoprotein cholesterol, high triglycerides level groups independently remained associated with low quartile of FMD using the triglycerides ≤63 mg/dL group as the reference (Table). Conclusions: These findings supported an independent association between triglycerides and cardiovascular disease.

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