Synergetic Potential of Green Synthesized Nano-Antibiotic Combinational Therapy For Wound Healing
Abstract The increasing evidences of chronic surgical wounds and its associated complications in association with bacterial resistance to conventional antibiotics. Therefore, current antibiotic resistance crisis ultimately calls for the need of alternative antibacterial options and nanotechnology could be a solution. Furthermore, nano-antibiotics combinations will provide synergy with reducing the dosage of both agents, which can enhance biocompatibility and may aid in limiting the global crisis of emerging multidrug resistance. Specifically, in the context of cytotoxicity of nanoparticles, in the present study, green synthesized nanoparticles (Ag NPs, ZnO NPs) are used for the combination with antibiotic neomycin to investigate in-vivo wound healing activity to facilitate the tissue repair with minimized toxicity. Our results showed that, in-vivo potent synergetic wound healing effectiveness and faster wound contraction of prepared gel formulations from the green synthesized nanoparticles combinations with neomycin compared with neomycin or nanoparticles alone. These results point to the opportunity provided by this approach to realize the unmet needs and future directions with lustrous prospects in combinational herbal nanomedicine to combat the multi drug resistant bacteria.