DLK1-DIO3 Region as a Source of Candidate Tumor Suppressor miRNAs in Papil- Lary Thyroid Carcinoma

2020 ◽  
Author(s):  
Leonardo Augusto Marson ◽  
Letícia Ferreira Alves ◽  
Micheli Severo Sielski ◽  
Cristina Pontes Vicente ◽  
Edna Teruko Kimura ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Genomic Region ◽  
And Migration ◽  
The Individual ◽  
Computational Resources ◽  
The Impact ◽  
Tumor Suppressor Mirnas ◽  
Shed Light

Abstract Background: DLK1-DIO3 genomic region comprises one of the largest microRNA (miRNAs) clusters in human genome. In previous studies we showed the downregulation of several miRNAs from the genomic region in papillary thyroid carcinoma (PTC). Due to the large number of miRNAs within this region the individual contribution of these molecules to PTC development and progression remains unclear. Methods: We used different computational resources to clarify the contribution of DLK1-DIO3-derived miRNAs to PTC. Results: Our analysis suggests that 12 miRNAs from this region cooperate to modulate distinct cancer-relevant biological processes, potentially responding for most of the impact of DLK1-DIO3-derived miRNAs to PTC development and progression. The overexpression of miR-485-5p in two PTC cell lines decreased proliferation and migration, confirming the biological relevance of in silico data. Conclusion: Our results shed light on the role of DLK1-DIO3 region, harboring several tumor suppressor miRNAs in thyroid cancer and open perspectives for the functional exploration of these miRNAs as therapeutic targets for PTC.

The impact of regional express trains from Moscow on population mobility

2020 ◽  
pp. 27-38
Author(s):  
A. A. Romashina
Keyword(s):  
Spatial Behavior ◽  
Population Mobility ◽  
System Transformation ◽  
Speed Increase ◽  
Settlement Structure ◽  
Migration Potential ◽  
And Migration ◽  
The Individual ◽  
The Impact

The paper is concerned with settlement system transformation in response to transport speed increase and changing the conditions of commuting. The article discusses the role of the individual spatial mobility as a part of settlement structure by the example of directions from Moscow to Tver’, Nizhny Novgorod, Orel, Belgorod, Kursk, where projects of significant railroad speed increase were operated in the 2010s. Transport accessibility improvement between Moscow and listed regional centers, caused by the launch of regional express trains, changed the spatial behavior of the inhabitants of these regions. The study of settlement structure transformation in response to transport connection speed increase was based on dynamics data of various types of trains passenger flows and the results of sociological surveys of regional express trains passengers. Conclusions are drawn about the role of commuting in the settlement structure and the factors of their transformation, depending on the speed characteristics, existing settlement structure and other geographical characteristics of the territory. The influence of these factors was different on the considered directions. Some of mentioned projects affected intra- (Tver’) and inter-agglomeration mobility (Nizhny Novgorod). Some cities (Oryol, Kursk, Belgorod) are characterized by small effects on commuting due to it’s sensitivity to the distance from Moscow and migration potential.

The Role of Threat and Economic Uncertainty in Support for Scottish Independence

2014 ◽  
Vol 23 (1) ◽  
pp. 103-124 ◽  
Author(s):  
Daniel Kopasker
Keyword(s):  
Economic Consequences ◽  
Perceived Threat ◽  
Constitutional Change ◽  
Lack Of Information ◽  
Economic Expectations ◽  
Scottish Independence ◽  
The Individual ◽  
The Impact ◽  
Levels Of Support

Existing research has consistently shown that perceptions of the potential economic consequences of Scottish independence are vital to levels of support for constitutional change. This paper attempts to investigate the mechanism by which expectations of the economic consequences of independence are formed. A hypothesised causal micro-level mechanism is tested that relates constitutional preferences to the existing skill investments of the individual. Evidence is presented that larger skill investments are associated with a greater likelihood of perceiving economic threats from independence. Additionally, greater perceived threat results in lower support for independence. The impact of uncertainty on both positive and negative economic expectations is also examined. While uncertainty has little effect on negative expectations, it significantly reduces the likelihood of those with positive expectations supporting independence. Overall, it appears that a general economy-wide threat is most significant, and it is conjectured that this stems a lack of information on macroeconomic governance credentials.

scholarly journals Factors affecting the organizational performance of manufacturing firms

2017 ◽  
Vol 9 ◽  
pp. 184797901771262 ◽  
Author(s):  
Ahmad Adnan Al-Tit
Keyword(s):  
Organizational Performance ◽  
Measurement Instrument ◽  
Manufacturing Firms ◽  
Factors Affecting ◽  
Mediating Role ◽  
Values And Beliefs ◽  
The Individual ◽  
The Impact ◽  
The Relationship

Numerous studies have been conducted to explore the individual effects of organizational culture (OC) and supply chain management (SCM) practices on organizational performance (OP) in different settings. The aim of this study is to investigate the impact of OC and SCM on OP. The sample of the study consisted of 93 manufacturing firms in Jordan. Data were collected from employees and managers from different divisions using a reliable and valid measurement instrument. The findings confirm that both OC and SCM practices significantly predict OP. The current study is significant in reliably testing the relationship between SCM practices and OP; however, it is necessary to consider cultural assumptions, values and beliefs as the impact of OC on OP is greater than the impact of SCM practices. Based on the results, future studies should consider the moderating and mediating role of OC on the relationship between SCM practices and OP.

Practitioner Review: Continuity and Change: The Fair Work Act in Aviation

2011 ◽  
Vol 53 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Sue Bussell ◽  
John Farrow
Keyword(s):  
Industrial Relations ◽  
Safety Net ◽  
Aviation Industry ◽  
Continuity And Change ◽  
National Debate ◽  
New Development ◽  
Key Issues ◽  
The Individual ◽  
The Impact

This article begins by discussing the specific industrial relations challenges of the highly competitive aviation industry. It then reflects on the outcome of the recent intense national debate over industrial relations, exploring the consequences of that debate for practice and policy, and discusses some key issues that remain in play. Although the Fair Work Act 2009 may have come about as a reaction to what many perceive as the ‘excesses’ of Work Choices, the new Act does not so much ‘wind back the clock’ as represent a significant new development in Australia’s long and unique industrial relations history. This article will discuss the impact of the changes, to date, made by the Fair Work Act on one organization, including the expansion of the ‘safety net’, and how the new compromise between the role of the ‘collective’ and the role of the ‘individual’ struck by the Act has the potential to fundamentally change the nature and structure of bargaining. We offer these comments as practitioners who have worked under successive industrial relations regimes since the early 1980s.

Publishing Productivity in Sport Psychology 1970–2000: An Exploratory Examination of the Lotka-Price Law

2003 ◽  
Vol 25 (4) ◽  
pp. 477-483 ◽  
Author(s):  
Joseph Baker ◽  
Jennifer Robertson-Wilson ◽  
Whitney Sedgwick
Keyword(s):  
Sport Psychology ◽  
Scientific Productivity ◽  
Eminent Scientist ◽  
Research Papers ◽  
Limited Support ◽  
The Impact ◽  
Published Research ◽  
Shed Light

The current study examined whether the distribution of published research papers in the field of sport psychology followed the Lotka-Price Law of scientific productivity. All authors who had published articles in five sport psychology journals from 1970 to 2000 were considered. The impact of those authors was determined by the total number of published papers in all journals. Results provided limited support for the Lotka-Price Law; however, it appeared that the field of sport psychology was less elitist than other fields. Although these findings suggest that productivity in this field is similar to that in other fields of science, more research is needed to shed light on the role of the eminent scientist and the average researcher in the advancement of knowledge in sport psychology.

The Evolution of the Role of U.S. School Nurses in Adolescent Mental Health at the Individual, Community, and Systems Level: An Integrative Review

2022 ◽  
pp. 105984052110681
Author(s):  
Ashwini R. Hoskote ◽  
Emily Croce ◽  
Karen E. Johnson
Keyword(s):  
Mental Health ◽  
Adolescent Mental Health ◽  
School Nurse ◽  
School Nurses ◽  
Integrative Review ◽  
School Nursing ◽  
Individual Level ◽  
The Individual ◽  
The Impact

School nurses are crucial to addressing adolescent mental health, yet evidence concerning their evolving role has not been synthesized to understand interventions across levels of practice (i.e., individual, community, systems). We conducted an integrative review of school nurse roles in mental health in the U.S. related to depressive symptoms, anxiety, and stress. Only 18 articles were identified, published from 1970 to 2019, and primarily described school nurses practicing interventions at the individual level, yet it was unclear whether they were always evidence-based. Although mental health concerns have increased over the years, the dearth of rigorous studies made it difficult to determine the impact of school nurse interventions on student mental health outcomes and school nurses continue to feel unprepared and under supported in this area. More research is needed to establish best practices and systems to support school nursing practice in addressing mental health at all levels of practice.

scholarly journals The Role of Education in Human Development in Iraq for the Period 1980-2012

2016 ◽  
Vol 2 (2) ◽  
pp. 251
Author(s):  
Sabah Faihan Mahmood ◽  
Yassen Taha Mahmood
Keyword(s):  
Human Development ◽  
Human Development Index ◽  
Economic Activities ◽  
Development Index ◽  
Level Of Knowledge ◽  
Index Value ◽  
The Impact ◽  
The Relationship ◽  
Shed Light

      Human Development aims to   enlarge choices in front of people by improving the level of health, education, and income; this means that this process will upgrade both the economic and social development.In other words, human development aimes to raise the average of age and this requires the advancement of the health aspect, raise the level of knowledge and this requires the advancement of  the educational aspect of all kinds., and raise the standard of living, and this requires the advancement of the economic aspect by providing the necessary jobs and promote economic activities.      The study focus on the relationship between education and human development which has great importance as a mean to determine the impact of education on human development. The research seeks to achieve a set of objectives, including:        Review  the concept of human development and its basic elements, shed light on the reality of development in Iraq and follow the path of its development, and find out the role of education in influencing human development through the changes taking place in it and its impact on increase or decrease  human development index during the period of the research.       The research found set of   results, the most important were the important effect of the education index on the level of human development index represented by HDI.  Iraq had a good educational system in the eighties and nineties, reaching good education index value for the year (1990) which was (0.890), making the human development index in Iraq in the highest level and the value of the Human Development Index (0.759) in the first report issued by the United Nations in the year (1990). when the education index fall back there was negatively impact on the value of human development  index in Iraq Directory, so when the education index value became (0.721) , the value of the Human Development Index  was  (0.590) in the year 2011 . This means that the value of the human development index decrease in recent years, although of improvement in the level of health, and the average per capita GDP in Iraq, and this illustrates the significant role of education on the human development process.

scholarly journals The Role of Faith Systems and Religions in the Future of Sustainable Development: An Islamic Outlook

2019 ◽  
Vol 12 (5) ◽  
pp. 23
Author(s):  
Mamdouh M. A. Sobaihi
Keyword(s):  
Sustainable Development ◽  
Belief Systems ◽  
Distant Future ◽  
The Sustainable Development ◽  
Religious Networks ◽  
Development Plans ◽  
Development Goals ◽  
The Individual ◽  
Shed Light

Reference material concerning sustainable development has increased dramatically over the last decades, with more and more countries, agencies and businesses following the sustainable development ideals and principles. However, one of the most basic of human institutions has not contributed, and perhaps not allowed to contribute, to the debate. Religion and faith systems have a great potential in influencing not only the definitions of sustainable development but also concepts of human sustainable practices to achieve sustainable development goals. The main obstacle to the fulfillment of this potential appears to be the lack of outreach and acceptance of the scientific community to the religious and faith system institutions and individuals. In this paper, a review of the literature is carried out to shed light on the root of this schism between science and belief systems. In addition, the paper will highlight how the majority of the literature deals with process rather than the individual human being and how to make him/her a better practitioner of sustainability. It is also aimed that the paper shed some light on how religious and faith system ideals can be incorporated into sustainable development plans and systems. The main focus of the paper is to cast light on the religion of Islam and some of the Islamic teachings and Ideals and how they can be incorporated in delivering the message of sustainable development since the religion of Islam is forecast to be the largest faith on the planet in the not too distant future. In conclusion, a discussion on how the various religious networks can deliver the message of sustainability will be discussed.

scholarly journals Chemo-mechanical Diffusion Waves Orchestrate Collective Dynamics of Immune Cell Podosomes

2021 ◽  
Author(s):  
Ze Gong ◽  
Koen van den Dries ◽  
Alessandra Cambi ◽  
Vivek Shenoy
Keyword(s):  
Actin Polymerization ◽  
Immune Cell ◽  
Wave Dynamics ◽  
Diffusion Waves ◽  
Mechanical Diffusion ◽  
Mechanical Waves ◽  
The Individual ◽  
The Impact ◽  
Cell Mechanosensing

Immune cells, such as macrophages and dendritic cells, can utilize podosomes, actin-rich protrusions, to generate forces, migrate, and patrol for foreign antigens. In these cells, individual podosomes exhibit periodic protrusion and retraction cycles (vertical oscillations) to probe their microenvironment, while multiple podosomes arranged in clusters demonstrate coordinated wave-like spatiotemporal dynamics. However, the mechanisms governing both the individual vertical oscillations and the coordinated oscillation waves in clusters remain unclear. By integrating actin polymerization, myosin contractility, actin diffusion, and mechanosensitive signaling, we develop a chemo-mechanical model for both the oscillatory growth of individual podosomes and wave-like dynamics in clusters. Our model reveals that podosomes show oscillatory growth when the actin polymerization-associated protrusion and the signaling-associated myosin contraction occur at similar rates, while the diffusion of actin monomers within the cluster drives mesoscale coordination of individual podosome oscillations in an apparent wave-like fashion. Our model predicts the influence of different pharmacological treatments targeting myosin activity, actin polymerization, and mechanosensitive pathways, as well as the impact of the microenvironment stiffness on the wavelengths, frequencies, and speeds of the chemo-mechanical waves. Overall, our integrated theoretical and experimental approach reveals how collective wave dynamics arise due to the coupling between chemo-mechanical signaling and actin diffusion, shedding light on the role of podosomes in immune cell mechanosensing within the context of wound healing and cancer immunotherapy.

Beyond legacy: Backstage stigmatisation and ‘trickle-up’ politics of urban regeneration

2018 ◽  
Vol 66 (4) ◽  
pp. 919-934 ◽  
Author(s):  
Kirsteen Paton
Keyword(s):  
Capital Accumulation ◽  
Private Business ◽  
Private Finance ◽  
Business Interests ◽  
Neoliberal Governance ◽  
East End ◽  
The Individual ◽  
Commonwealth Games ◽  
Shed Light

This article explores how stigmatisation is intimately linked with neoliberal governance and capital accumulation in specific ways through processes around the Glasgow Commonwealth Games. It advances the author’s previous research exploring the effects of stigma on the East End community hosting the Games, by looking at some of the processes of power and profit which motivate stigmatising processes by ‘gazing up’, rather than ‘gazing down’. That is, looking at the role of the stigmatisers in this project and not the stigmatised. It draws loosely on Goffman’s concept of ‘backstage’ to shed light on those who produce and profit from these stigmatisation processes, including government bodies and actors and private business interests. Looking at some of the processes through which stigmatisation is profited from reveals not only forms of power vital to this process but that it is a key form of exploitation integral to capital accumulation. Under austerity, the political economy of the Games constitutes state support of private finance and a simultaneous withdrawal of social welfare support, which transfers the burden of debt from the state to the individual and wealth from public funds to private funds.

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