scholarly journals Elevated Serum Levels of Herpes Virus Entry Mediator and IL-5 in Cough Variant Asthma Versus Classic Asthma Patients

2021 ◽  
Author(s):  
Can Yao ◽  
Zhong Yang ◽  
Dandan Chen ◽  
Wei Fang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Demographic Data ◽  
Elevated Serum ◽  
Measurement Data ◽  
Multivariate Logistic Regression Analysis ◽  
Roc Curves ◽  
Serum Levels ◽  
Blood Eosinophil ◽  
Chi Square ◽  
Cough Variant Asthma

Abstract Background Cough variant asthma (CVA) is a special phenotype of asthma. We aimed to elucidate the differential inflammatory features in patients with CVA in contrast to patients with classic asthma (CA). Methods A total of 68 patients with persistent uncontrolled asthma (34 with CVA, 34 with CA) were enrolled. We collected the demographic data, pulmonary function test (PFT) parameters, hematological variables, and several serum biomarkers. The independent-samples t test was used for analyzing measurement data, and Chi-square test was for count data. Multivariate logistic regression analysis was used to determine the possibility of different phenotypes. Receiver operating characteristic (ROC) curves were generated to evaluate the values of biomarkers for distinguishing between CVA and CA. Linear correlation analysis was performed to assess the linear relationship between two variables. Results Compared with CA group, CVA group had a higher percentage of females, lower proportion of asthma family history, shorter disease course, and better pulmonary function (P all < 0.05). Increased levels of blood eosinophil count (P = 0.045), eosinophil percentage (P = 0.046), serum IL-5 (P = 0.011), and serum herpesvirus entry mediator (HVEM) (P = 0.002) were also found in CVA patients compared to those in CA patients compared to those in CA patients. The logistic analysis revealed that serum HVEM had a strong predictive power for CVA group (OR = 1.105, P = 0.015). The sensitivities and specificity of serum HVEM and IL-5 to distinguish between CVA and CA at optimal cut-offs were 85.0% and 61.1%; 85.0% and 61.1%, respectively. Area under the curves (AUCs) of serum HVEM and IL-5 were 0.789 and 0.739, respectively. Furthermore, serum HVEM and IL-5 had no correlation with PFT parameters in CVA group (P all > 0.05). Conclusions Elevated serum levels of HVEM and IL-5 are exhibited in CVA patients, which may indicate their important roles in the pathogenesis and progression of CVA.

scholarly journals Elevated Serum Levels of Herpes Virus Entry Mediator and IL-5 in Cough Variant Asthma Versus Classic Asthma Patients

2021 ◽  
Author(s):  
Can Yao ◽  
Zhong Yang ◽  
Dandan Chen ◽  
Wei Fang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Demographic Data ◽  
Elevated Serum ◽  
Roc Curves ◽  
Serum Levels ◽  
Blood Eosinophil ◽  
Cough Variant Asthma ◽  
Logistic Analysis ◽  
Asthma Patients ◽  
Herpesvirus Entry Mediator

Abstract BackgroundCough variant asthma (CVA) is a special phenotype of asthma. The precise inflammatory features of patients with CVA, however, is still unclear. We aimed to elucidate the differential inflammatory features in patients with CVA in contrast to patients with classic asthma (CA). MethodsA total of 68 patients with persistent uncontrolled asthma (34 with CVA, 34 with CA) in Shenzhen People’s Hospital between August 2018 and May 2019 were enrolled. We collected the demographic data, pulmonary function test (PFT) parameters, hematological variables, and several serum biomarkers. Receiver operating characteristic (ROC) curves were generated to evaluate the values of biomarkers for distinguishing between CVA and CA. ResultsCompared with CA group, CVA group had a higher percentage of females (73.5 vs. 50%, P = 0.046), lower proportion of asthma family history (5.9 vs. 29.4%, P = 0.011), shorter disease course [12.0 (4.8, 39) vs. 96.0 (48.0, 240.0) months, P < 0.001], and better pulmonary function (P all < 0.05). Increased levels of blood eosinophil count [0.35 (0.13, 0.94) vs. 0.34 (0.01, 0.53) X109/L, P = 0.045], eosinophil percentage [6.3 (3.0, 9.8) vs. 4.4 (0.2, 8.4) %, P = 0.046], serum IL-5 [104.19 (89.03, 199.66) vs. 84.57 (26.87, 103.58) ng/L, P = 0.011], and serum herpesvirus entry mediator (HVEM) [128.53 (100.89, 204.83) vs. 90.71 (37.05, 108.08) pg/mL, P = 0.002] were also found in CVA patients compared to those in CA patients. The logistic analysis revealed that serum HVEM had a strong predictive power for CVA group (OR = 1.105, P = 0.015). The sensitivities and specificity of serum HVEM and IL-5 to distinguish between CVA and CA at optimal cut-offs were 85.0% and 61.1%; 85.0% and 61.1%, respectively. AUCs of serum HVEM and IL-5 were 0.789 and 0.739, respectively. Furthermore, serum HVEM and IL-5 had no correlation with PFT parameters in CVA group (P all > 0.05).ConclusionsElevated serum levels of HVEM and IL-5 are exhibited in CVA patients, which may indicate their important roles in the pathogenesis and progression of CVA.

scholarly journals Examining Linkages between Psychological Health Problems, Socio-Demographic Characteristics and Workplace Stressors in Pakistan’s Academia

2016 ◽  
Vol 9 (6) ◽  
pp. 108
Author(s):  
Anwar Khan ◽  
Rosman Bin Md Yusoff ◽  
Khairunesa Binti Isa
Keyword(s):  
Psychological Health ◽  
Quantitative Research ◽  
Demographic Data ◽  
Multivariate Logistic Regression Analysis ◽  
Health Problems ◽  
Demographic Characteristics ◽  
Work Stressors ◽  
Chi Square ◽  
Workplace Stressors ◽  
Potential Risk Factors

<p class="apa">Scholarly work and research are globally known as stressful and challenging. Teachers may develop different psychological health problems once they are exposed to workplace stressors. Considering it as a serious issue of education sector, this study has examined the linkages between prevalent workplace stressors and psychological health problems in Pakistan’s academia. A cross-section quantitative research design was adopted, whereas data was collected by self-administered questionnaire from a sample of 1189 teachers working within 12 universities of Pakistan. Descriptive statistics were used for analysis of demographic data; Chi-square tests were performed to compare psychological health problems with socio-demographic characteristics, whereas Multivariate Logistic Regression Analysis was run to know the relationship between prevalent work stressors and psychological health problems. Results show that the majority of respondents were male (63.8%), unmarried (58.5%), 25 to 40 years old (78.5%) and working as Lecturers or Assistant Professors (77%), thus their average job experience was 05 to 10 years. Psychological health problems were prevailing more among male, unmarried, less experienced and junior teachers. Such socio-demographic characteristics were potential risk factors for psychological health problems. Furthermore, respondents exposed to work stressors like workload, interpersonal and emotional demands were more likely to develop psychological health problems. Findings of the current study will develop awareness among teachers concerning work stress and psychological health. Such findings can be utilized by policy makers of Pakistan for devising policies about occupational health &amp; safety of teachers.<strong> </strong>The prevalence of psychological health problems in academia of Pakistan is a recognized workplace issue. Therefore, it needs immediate corrective measures at individual and institutional levels.</p>

Homocysteine Level in Schizophrenia Patients

2009 ◽  
Vol 43 (8) ◽  
pp. 760-765 ◽  
Author(s):  
Yin Ying Ma ◽  
Chi Chung Shek ◽  
Max C. K. Wong ◽  
Ka Chee Yip ◽  
Roger M. K. Ng ◽  
...  
Keyword(s):  
Homocysteine Level ◽  
Blood Donation ◽  
Clinical Symptoms ◽  
Age Of Onset ◽  
Demographic Data ◽  
Elevated Serum ◽  
Serum Levels ◽  
Diagnostic Interview ◽  
Healthy Controls ◽  
Serum Homocysteine

Objective: Elevated serum levels of homocysteine have been shown to be associated with schizophrenia in some studies, but the evidence is still limited and mixed. The aim of the present study was therefore to evaluate the serum homocysteine level in Chinese in schizophrenia patients and assess its association with clinical phenotypes of the disease. Method: A total of 250 inpatients and 250 healthy controls were identified at Kowloon Hospital and the Red Cross Blood Donation Centre, respectively. Each subject was evaluated with a structured diagnostic interview. Demographic data were collected and blood was analysed for homocysteine level. The Positive and Negative Syndrome Scale was used to grade clinical symptoms of schizophrenia. Confounding factors affecting homocysteine levels were controlled by strict exclusion criteria or statistical methods. Results: Serum homocysteine level was elevated in Chinese schizophrenia patients. Both male (mean, 12.26 µmol L−1; control, 11.40 µmol L−1, p = 0.026) and female (mean, 9.61 µmol L−1; control, 8.33 µmol L−1, p < 0.001) patients had a higher serum homocysteine level than the healthy controls, and these differences persisted after controlling for age. There was no significant association between serum homocysteine level and duration of illness, clinical symptoms or age of onset of schizophrenia. Conclusion: The serum homocysteine levels were elevated in both male and female Chinese schizophrenia patients. The levels were not apparently related to other clinical parameters.

scholarly journals Prognostic and Predictive Value of Serum C-Reactive Protein Levels in Patients with Metastatic Or Locally Recurrent Gastric Cancer

2016 ◽  
Vol 31 (3) ◽  
pp. 294-299 ◽  
Author(s):  
Zhigang Chen ◽  
Yongchen Sun ◽  
Ji Wang ◽  
Xudong Shen ◽  
Lei Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Malignant Tumors ◽  
Elevated Serum ◽  
Roc Curves ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Term Survival ◽  
Reactive Protein ◽  
Serum Crp

Background and Aims Increasing evidence suggests that elevated serum levels of C-reactive protein (CRP) are associated with poor survival in many malignant tumors. However, the prognostic value of CRP in advanced gastric cancer (AGC) remains uncertain. This study was undertaken to evaluate the significance of serum CRP as a biomarker of long-term survival in patients with AGC. Methods The serum CRP levels of AGC patients were analyzed for clinicopathological significance. Data were collected retrospectively for 244 patients treated between October 1, 2006 and September 30, 2013. The prognostic effect of serum CRP levels was evaluated. Results The baseline CRP level before chemotherapy was significantly associated with overall survival. The median survival was 351 days for patients with CRP ≥10 mg/L and 370 days for patients with CRP c10 mg/L (p = 0.033). Cox analysis revealed CRP to be an independent prognostic factor for overall survival. In the 93 patients whose baseline CRP was ≥10 mg/L, a cutoff point of 22% for the CRP declining rate provided optimum sensitivity and specificity for 1-year survival based on ROC curves. A CRP declining rate >22% was found to predict longer overall survival (410 days versus 299 days; p = 0.001). Conclusions Elevated serum CRP baseline levels before chemotherapy were associated with reduced overall survival in patients with AGC. The CRP declining rate was also associated with overall survival. The CRP baseline concentration before chemotherapy and CRP declining rate after chemotherapy may be used as novel, widely available and real-time independent prognostic and predictive markers of AGC.

scholarly journals Elevated Serum Levels of Soluble TNF Receptors and Adhesion Molecules Are Associated with Diabetic Retinopathy in Patients with Type-1 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Shruti Sharma ◽  
Sharad Purohit ◽  
Ashok Sharma ◽  
Diane Hopkins ◽  
Leigh Steed ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Diabetic Retinopathy ◽  
Adhesion Molecules ◽  
Conditional Logistic Regression ◽  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Levels ◽  
Tnf Receptors ◽  
Paired Data ◽  
Markers Of Inflammation

Aims. To examine the association of the serum levels of TNF receptors, adhesion molecules, and inflammatory mediators with diabetic retinopathy (DR) in T1D patients.Methods. Using the multiplex immunoassay, we measured serum levels of eight proteins in 678 T1D subjects aged 20–75 years. Comparisons were made between 482 T1D patients with no complications and 196 T1D patients with DR.Results. The levels of sTNFR-I, sTNFR-II, CRP, SAA, sgp130, sIL6R, sVCAM1, and sICAM1 were significantly higher in the T1D patients with DR as compared to T1D patients with no complications. Multivariate logistic regression analysis revealed significant association for five proteins after adjustment for age, sex, and disease duration (sTNFR-I:OR=1.57, sgp130:OR=1.43, sVCAM1:OR=1.27, sICAM1:OR=1.42, and CRP:OR=1.15). Conditional logistic regression on matched paired data revealed that subjects in the top quartile for sTNFR-I(OR=2.13), sTNFR-II(OR=1.66), sgp130(OR=1.82), sIL6R(OR=1.75), sVCAM1(OR=1.98), sICAM1(OR=2.23), CRP(OR=2.40)and SAA(OR=2.03), had the highest odds of having DR.Conclusions. The circulating markers of inflammation, endothelial injury, and TNF signaling are significantly associated with DR in patients with T1D. TNFR-I and TNFR-II receptors are highly correlated, but DR associated more strongly with TNFR-I in these patients.

Analisis Faktor Determinan yang berhubungan dengan Kepatuhan Rekomendasi Modifikasi Gaya Hidup Pasien Hipertensi

2020 ◽  
Vol 7 (2) ◽  
pp. 256-263
Author(s):  
Abdul Qodir
Keyword(s):  
Blood Pressure ◽  
Lifestyle Modification ◽  
Multivariate Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Lifestyle Modifications ◽  
Chi Square ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Consecutive Sampling ◽  
Knowledge Practice

Penatalaksanaan farmakologis dan non farmakologis dipercaya dapat mengontrol tekanan darah dan mencegah komplikasi, tetapi banyak pasien hipertensi tekanan darahnya tidak terkontrol. Hal tersebut dikarenakan kepatuhan yang buruk dalam melaksanakan rekomendasi gaya hidup. Penelitian ini bertujuan untuk menganalisis determinan faktor yang berhungan dengan kepatuhan melaksanakan rekomendasi modifikasi gaya hidup. Penelitian ini menggunakan metode cross-sectional di pukesmas dinoyo Kota Malang tahun 2019. Teknik pengambilan sampel menggunakan Consecutive Sampling. Kuesioner yang digunakan meliputi : karakteristik demografi, pengetahuan dan rekomendasi mofifikasi gaya hidup pasien hipertensi. Hubungan antara rekomendasi modifikasi gaya hidup dengan variabel independen dianalisis menggunakan uji chi square dan analisis regresi logistik. 140 pasien hipertensi berpartisipasi dalam penelitian ini (60 laki-laki, 80 wanita). Prevalensi kepatuhan adalah 28,6 %. Tingkat pengetahuan berhubungan signifikan  dengan kepatuhan melaksanakan rekomendasi gaya hidup (p=0,00). Jenis kelamin, usia, dan tingkat pendidikan tidak mempunyai hubungan signifikan dengan kepatuhan rekomendasi modifikasi gaya hidup (p= 0,06; p=0,21; p=0,87). Pengetahuan mempunyai hubungan yang signifikan dengan kepatuhan rekomendasi modifikasi gaya hidup. Management of pharmacological and non-pharmacological is believed to control blood pressure and prevent complications,  but many hypertensive patients have uncontrolled blood pressure. This is due to poor adherence to recommended lifestyle modifications. This study was aimed to determine the factors associated with adherence to recommended lifestyle modifications of hypertensive patients. A cross-sectional study was conducted in Pukesmas Dinoyo Malang in 2019. Consecutive Sampling was used to select study subjects. The questionnaire included information about demographic characteristics, knowledge, practice of lifestyle-modification measures. Associations between adherence to lifestyle modification and independent variables were analyzed using chi square and multivariate logistic regression analysis. 140 hypertensive patients participated in the study (60 men, 80 women). The prevalence of adherence was 28.6%. The level of knowledge was significant associated with adherence to recommended lifestyle modifications (p = 0.00). Genders , age, and educational level were no significant associated with to recommended lifestyle modifications (p= 0.06; p=0.21; p=0.87). Knowledge was significant associated with adherence to recommended lifestyle modifications of hypertensive patients.

scholarly journals Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Liang-Yuan Li ◽  
Tian-Sheng Yan ◽  
Jing Yang ◽  
Yu-Qi Li ◽  
Lin-Xi Fu ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Respiratory Symptoms ◽  
Early Stage ◽  
Roc Curves ◽  
Diagnostic Value ◽  
Small Airway ◽  
Impulse Oscillometry ◽  
Additional Method ◽  
Cutoff Values ◽  
Higher Sensitivity

Abstract Background Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reliability is controversial. Impulse oscillometry (IOS) may complete the deficiency of spirometry and have higher sensitivity. We aimed to explore the diagnostic value of IOS to detect SAD in symptomatic subjects with PPF. Methods The evaluation of symptoms, spirometry and IOS results in 209 subjects with chronic respiratory symptoms and PPF were assessed. ROC curves of IOS to detect SAD were analyzed. Results 209 subjects with chronic respiratory symptoms and PPF were included. Subjects who reported sputum had higher R5–R20 and Fres than those who didn’t. Subjects with dyspnea had higher R5, R5–R20 and AX than those without. CAT and mMRC scores correlated better with IOS parameters than with spirometry. R5, R5–R20, AX and Fres in subjects with SAD (n = 42) significantly increased compared to those without. Cutoff values for IOS parameters to detect SAD were 0.30 kPa/L s for R5, 0.015 kPa/L s for R5–R20, 0.30 kPa/L for AX and 11.23 Hz for Fres. Fres has the largest AUC (0.665, P = 0.001) among these parameters. Compared with spirometry, prevalence of SAD was higher when measured with IOS. R5 could detect the most SAD subjects with a prevalence of 60.77% and a sensitivity of 81% (AUC = 0.659, P = 0.002). Conclusion IOS is more sensitive to detect SAD than spirometry in subjects with chronic respiratory symptoms and PPF, and it correlates better with symptoms. IOS could be an additional method for SAD detection in the early stage of diseases.

Facial Fractures Have Similar Outcomes When Managed by Either Otolaryngology or Plastic Surgery: Encounters From a Single Level I Trauma Center

2021 ◽  
pp. 194338752110206
Author(s):  
Ashton Christian ◽  
Beatrice J. Sun ◽  
Nima Khoshab ◽  
Areg Grigorian ◽  
Christina Y. Cantwell ◽  
...  
Keyword(s):  
Plastic Surgery ◽  
Trauma Center ◽  
Demographic Data ◽  
Open Reduction Internal Fixation ◽  
Facial Fractures ◽  
Chi Square ◽  
Single Level ◽  
Baseline Characteristics ◽  
Level I ◽  
Complications And Mortality

Study Design: Retrospective cohort. Objective: Traumatic facial fractures (FFs) often require specialty consultation with Plastic Surgery (PS) or Otolaryngology (ENT); however, referral patterns are often non-standardized and institution specific. Therefore, we sought to compare management patterns and outcomes between PS and ENT, hypothesizing no difference in operative rates, complications, or mortality. Methods: We performed a retrospective analysis of patients with FFs at a single Level I trauma center from 2014 to 2017. Patients were compared by consulting service: PS vs. ENT. Chi-square and Mann-Whitney-U tests were performed. Results: Of the 755 patients with FFs, 378 were consulted by PS and 377 by ENT. There was no difference in demographic data ( P > 0.05). Patients managed by ENT received a longer mean course of antibiotics (9.4 vs 7.0 days, P = 0.008) and had a lower rate of open reduction internal fixation (ORIF) (9.8% vs. 15.3%, P = 0.017), compared to PS patients. No difference was observed in overall operative rate (15.1% vs. 19.8%), use of computed tomography (CT) imaging (99% vs. 99%), time to surgery (65 vs. 55 hours, P = 0.198), length of stay (LOS) (4 vs. 4 days), 30-day complication rate (10.6% vs. 7.1%), or mortality (4.5% vs. 2.6%) (all P > 0.05). Conclusion: Our study demonstrated similar baseline characteristics, operative rates, complications, and mortality between FFs patients who had consultation by ENT and PS. This supports the practice of allowing both ENT and PS to care for trauma FFs patients, as there appears to be similar standardized care and outcomes. Future studies are needed to evaluate the generalizability of our findings.

The effect of practicing yoga during pregnancy on labor stages length, anxiety and pain: a randomized controlled trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ellahe Mohyadin ◽  
Zohreh Ghorashi ◽  
Zahra Molamomanaei
Keyword(s):  
Controlled Trial ◽  
Intervention Group ◽  
Total Duration ◽  
Measurement Data ◽  
Labor Pain ◽  
Control Group ◽  
Chi Square ◽  
Nulliparous Women ◽  
Two Stages ◽  
And Control

AbstractBackgroundAnxiety and fear of labor pain has led to elevated cesarean section rate in some countries. This study was conducted to investigate the effect of yoga in pregnancy on anxiety, labor pain and length of labor stages.MethodsThis clinical trial study was performed on 84 nulliparous women who were at least 18 years old and were randomly divided into two groups of yoga and control groups. Pregnancy Yoga Program consisting of 6 60-min training sessions was started every 2 weeks from week 26 of pregnancy and continued until 37 weeks of gestation. Anxiety severity at maternal admission to labor was measured by the Spielbergers State-Trait Anxiety Inventory, and labor pain was measured by Visual Analogue Scale (VAS) at dilatation (4–5 cm) and 2 h after the first measurement. Data were analyzed using Chi-Square and t-test.ResultsIntervention group reported less pain at dilatation (4–5 cm) (p=0.001) and 2 h after the first measurement (p=0.001) than the control group. Stat anxiety was also lower in intervention group than the control group (p=0.003) at the entrance to labor room. Subjects in the control group required more induction compared to intervention group (p=0.003). Women in intervention group experienced shorter duration of the first phase of the labor than the control group (p=0.002). Also, the total duration of two stages of labor was shorter in intervention group than the control group (p=0.003).ConclusionsPracticing yoga during pregnancy may reduce women’s anxiety during labor; shorten labor stages, and lower labor pain.

scholarly journals Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julien Guiot ◽  
Makon-Sébastien Njock ◽  
Béatrice André ◽  
Fanny Gester ◽  
Monique Henket ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Prognostic Factor ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Pulmonary Function Tests ◽  
Serum Levels ◽  
Roc Curve Analysis ◽  
Significant Deterioration ◽  
Lung Dysfunction

AbstractSystemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (ILD), driving its mortality. Specific biomarkers associated with the progression of this lung disease are highly needed. We aimed to identify specific biomarkers of SSc-ILD to predict the evolution of the disease. For this, we compared prospectively serum levels of several biomarkers associated with lung fibrosis in SSc patients (n = 102), among which SSc-no ILD (n = 63) and SSc-ILD (n = 39), compared to healthy subjects (HS) (n = 39). We also performed a longitudinal study in a subgroup of 28 patients analyzing biomarkers variations and pulmonary function tests over a period of 2 years. Serum level of IGFBP-2 was significantly increased in SSc patients compared to HS, and negatively correlated with pulmonary function (assessed by carbon monoxide transfer coefficient (KCO)) (r = − 0.29, p < 0.01). Two-year longitudinal analysis in a subgroup of 28 SSc patients determined that IGFBP-2 variation was positively correlated with KCO at 2-year follow-up (r = 0.6, p < 0.001). SSc patients with a lower variation of IGFBP-2 (less than 22%) presented significant deterioration of pulmonary function at 2-year follow-up (p < 0.01). ROC curve analysis enabled us to identify that baseline IGFBP-2 > 105 ng/ml was associated with a poor outcome (KCO < 70% predicted) at 2-year follow-up (AUC = 0.75, p < 0.05). We showed for the first time that serum levels of IGFBP-2 might be a prognostic factor of the development of SSc-ILD.

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