scholarly journals The New Direction of Senolytic Drug Research Should Be on Cancer Prevention, Adjuvant Therapies in Cancer and Healthy Aging in Cancer Survivors

2021 ◽  
Author(s):  
Ozgur Tanriverdi ◽  
Ummuhani Ozel Turkcu
Keyword(s):  
Cardiovascular Diseases ◽  
Side Effects ◽  
Cellular Senescence ◽  
Healthy Aging ◽  
Drug Research ◽  
General Information ◽  
Cancer Treatments ◽  
Adjuvant Therapies ◽  
Anti Cancer

Abstract In cases where cellular senescence does not function properly, the use of drugs called senolytics in the prevention of chronic aging-related disorders such as cancer, diabetes and cardiovascular diseases has become a very interesting topic. There are studies showing that senolytic drugs can be used for the purpose of preventing cancer, preventing recurrence in individuals diagnosed with cancer, and delaying multimorbidity situations that may develop as long-term side effects of anti-cancer treatments. This article has been prepared with the aim of reminding general information about senolytic drugs and cellular senescence due to the fact that there are many controversial researches in the field of oncology in the future

scholarly journals The New Direction of Senolytic Drug Research Should Be on Cancer Prevention, Adjuvant Therapies in Cancer and Healthy Senescence in Cancer Survivors (Senolytics and Cancer)

2021 ◽  
Author(s):  
Ozgur Tanriverdi ◽  
Ummuhani Ozel Turkcu
Keyword(s):  
Cardiovascular Diseases ◽  
Side Effects ◽  
Cancer Prevention ◽  
Cellular Senescence ◽  
Drug Research ◽  
General Information ◽  
Cancer Treatments ◽  
Adjuvant Therapies ◽  
Anti Cancer

Abstract In cases where cellular senescence does not function properly, the use of drugs called senolytics in the prevention of chronic aging-related disorders such as cancer, diabetes and cardiovascular diseases has become a very interesting topic. There are studies showing that senolytic drugs can be used for the purpose of preventing cancer, preventing recurrence in individuals diagnosed with cancer, and delaying multimorbidity situations that may develop as long-term side effects of anti-cancer treatments. This article has been prepared with the aim of reminding general information about senolytic drugs and cellular senescence due to the fact that there are many controversial researches in the field of oncology in the future

Young-onset colorectal cancer treatment side effects: Infertility, sexual dysfunction, and quality-of-life outcomes.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 3587-3587
Author(s):  
Laura Diane Porter ◽  
Ronit Yarden ◽  
Kim Lynn Newcomer ◽  
Negeen Fathi ◽  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Side Effects ◽  
Sexual Dysfunction ◽  
Cancer Patients ◽  
Fertility Preservation ◽  
Cancer Treatments ◽  
Young Onset

3587 Background: Colorectal cancer is the third-most commonly diagnosed cancer and the second-leading cause of cancer death in men and women combined in the United States. Young-onset colorectal cancer refers to individuals diagnosed under the age of 50. In recent years, the incidence has increased by 2.2% annually in individuals younger than 50 years and 1% in individuals 50-64, in contrast to a 3.3% decrease in adults 65 years and older. Young-onset (YO) CRC patients and survivors face unique clinical challenges with fertility and sexual dysfunctions, but this risk is not well quantified. There is limited data and public discussion on the long-term effects of colorectal cancer treatments on fertility and sexual dysfunction and the long-term impact on the quality of life. Methods: To explore the unique challenges and unmet needs of the young-adult patient population, a cross-sectional study was conducted. Colorectal cancer patients and survivors (N = 884) diagnosed between the ages of 20 to 50 years old (median age 42 ± 7.0) completed an online questionnaire based on established instruments EORTC-QOL-30, EORTC-CR-29, and EORTC-SHC-22. Results: Thirty-one percent of respondents stated that a medical professional spoke to them about fertility preservation at the time of diagnosis and during treatment. Only 31% were referred to a reproductive endocrinologist, even though 37% of women and 16% of men reported that treatment left them infertile or sterile. Among survey respondents, 12% of women had an egg retrieval procedure, and 36% of men had their sperm preserved prior to the start of treatment. Fifty-three percent of women reported treatment led to premature menopause. Sixty-five percent of respondents suffer from some level of sexual dysfunction due to treatment. In patients who received radiation therapy, women were 12% less likely than men to have discussed sexual side effects with the provider before treatment. Patients who have an ostomy reported more severe sexual dysfunction (17.8%). Rectal cancer patients were 2.5 times more likely than those with colon cancer to report severe dysfunction after their treatment. More than 25% of the respondents said they would have considered alternative treatment if they would have known the risks of sexual dysfunction. Conclusions: Our survey demonstrates inadequate communications between patients and providers about the irreversible fertility and sexual effects of colorectal cancer treatments. Younger patients and survivors face unique long-term challenges and require further information about fertility preservation options and emotional support regarding their sexuality post-treatment. Other studies are needed to assess the physical and psychological side effects endured by young-onset CRC patients and survivors.

Hormone therapy

2018 ◽  
Author(s):  
Jim Cassidy ◽  
Donald Bissett ◽  
Roy A. J. Spence OBE ◽  
Miranda Payne ◽  
Gareth Morris-Stiff
Keyword(s):  
Hormone Therapy ◽  
Late Effects ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Long Term Survivors

There are growing numbers of long-term survivors of increasingly complex anti-cancer treatments. This chapter summarises some of the complex, often multi-organ, late effects of modern cancer treatments.

CANCER TREATMENT AND CARDIOVASCULAR TOXITY: PATHOGENESIS AND ACTUAL APPROACHES TO THE DIAGNOSIS OF HEART FAILURE IN CANCER PATIENTS

2019 ◽  
Vol 65 (2) ◽  
pp. 172-180
Author(s):  
Andrey Obrezan ◽  
Nataliya Shcherbakova
Keyword(s):  
Cardiovascular Diseases ◽  
Side Effects ◽  
Cancer Treatment ◽  
Baseline Risk ◽  
Patients With Cancer ◽  
Treatment Side Effects ◽  
Cardiovascular Side Effects ◽  
Life Saving

The field of cardio-oncology has received increasing attention in recent years. This is due to the fact that the results of a large number of clinical studies on antitumor therapy, covering issues treatments side effects, including associated cardiovascular pathology, are published. Advances in treatment have led to improved survival of patients with cancer, but have also increased clinical significance of treatment side effects. Myocardium, having high metabolic activity, responds to substrate and energy imbalance under the action of increasing malignancy and toxic effects of radio- or chemotherapy. Finding of baseline risk factors, timely identification of cardiovascular diseases, ability to predict the long-term consequences of cancer treatment-associated cardiovascular side effects lead to improving of the prognosis and quality of life, avoiding of over-diagnosis cardiovascular diseases and inappropriating violation of life-saving treatment of a malignant tumor.

scholarly journals A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction

2021 ◽  
Vol 8 ◽  
Author(s):  
Christa Corley ◽  
Antiño R. Allen
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cognitive Dysfunction ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cancer Treatments ◽  
The Usa ◽  
Bibliometric Review ◽  
Long Term Survivors

Inflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods of treating breast cancer patients. Decades later, these patients still report experiencing cognitive side effects. In this present bibliometric review, we applied the VOSviewer tool to describe the existing landscape on literature concerning inflammation as it relates to CMF and cognitive dysfunctions. As time progressed, we saw an increase in interest in the topic. By the mid-2010s there were approximately 1,000 publications per year. Terms related to the brain and CNS did not appear until the later years, and terms related to inflammation and breast cancer were very prevalent throughout the three decades. Also, in more recent years, inflammatory markers and plant-derived compounds used to alleviate side effects of the inflammatory response appeared in the search results. The USA remained the most prolific producer of CMF-, inflammation-, and cognitive dysfunction-related papers throughout the three decades followed by Asia and Europe. As research of cognitive dysfunction caused by inflammation due to chemotherapy treatment progresses, more opportunities emerge for therapeutic methods to improve the quality of life for long-term survivors.

scholarly journals Radiotherapy and Management in Maxillofacial Prosthodontic : Part 1- Before Radiotherapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Wijdane El Hawari
Keyword(s):  
Side Effects ◽  
Oral Cavity ◽  
Dental Care ◽  
Cancer Treatments ◽  
Surgical Interventions ◽  
Rational Planning ◽  
Maxillofacial Prosthesis ◽  
Anti Cancer ◽  
Anticancer Treatment

Anti-cancer treatments (surgery, radiotherapy and chemotherapy) lead to numerous sequelae and side effects, unpleasant or even disabling in the oral cavity. In the absence of appropriate dental care, the consequences can be highly detrimental.The side effects of radiotherapy, the loss of substances following often associated surgical interventions and the unfavorable context of these patients require rational planning and consultation approved by the various practionners.The management of patients before, during and after these anticancer treatments by the specialist in maxillofacial prosthesis is important, in fact the objectives outlined to be achieved in terms of the management of PMF are: restoration of orofacial functions, participation in the proper conduct of anticancer treatment, palliation of its complications and psychological support for these patients.The aim of this article is to review the various complications of radiotherapy, as well as the protocols and recommendations for the management of patients before radiotherapy and to highlight the role of the specialist in maxillofacial prosthodontics in this management.

Use of Homeopathy in Integrative Oncology in Strasbourg, France: Multi-center Cross-Sectional Descriptive Study of Patients Undergoing Cancer Treatment

Homeopathy ◽  
2021 ◽  
Author(s):  
J-L Bagot ◽  
Adeline Legrand ◽  
Ingrid Theunissen
Keyword(s):  
General Practitioner ◽  
Side Effects ◽  
Descriptive Study ◽  
Integrative Oncology ◽  
Cancer Treatments ◽  
Cross Sectional ◽  
Cancer Centers ◽  
Anti Cancer ◽  
Loss Of Libido ◽  
Almost All

Abstract Context The use of homeopathy in oncological supportive care seems to be progressing. The first French prevalence study, performed in 2005 in Strasbourg, showed that only 17% of the subjects were using it. What is the situation 12 years later? Materials and Methods This is a descriptive study, using a questionnaire identical to that used in 2005, on 633 patients undergoing treatment in three anti-cancer centers in Strasbourg. The results of the “homeopathy” sub-group were extracted and studied. Results Of the 535 patients included, 164 used homeopathy: that is 30.7%. The main purpose of its use was to reduce the side effects of cancer treatments (75%). Among the users, 82.6% were “somewhat” or “very” satisfied, against “quite” satisfied for 15.5%, and “not at all” satisfied for 1.9%. The homeopathic treatment was prescribed by a doctor in 75.6% of the cases; the general practitioner was kept informed in 87% of the cases and the oncologist in 82%. Fatigue, pain, nausea, anxiety, sadness and diarrhea were improved in 80% of the cases. However, alopecia, weight disorders and loss of libido were the least improved symptoms. The use of homeopathy was significantly associated with the female sex. Conclusion With a prevalence of 30.7%, homeopathy is the most used complementary medicine in integrative oncology in Strasbourg. Over 12 years, we have witnessed an increase of 83% in its use in the same city. Almost all respondents declare themselves satisfied and tell their doctors more readily than in 2005.

scholarly journals MiRNAs as Anti-Angiogenic Adjuvant Therapy in Cancer: Synopsis and Potential

2021 ◽  
Vol 11 ◽  
Author(s):  
Behnaz Lahooti ◽  
Sagun Poudel ◽  
Constantinos M. Mikelis ◽  
George Mattheolabakis
Keyword(s):  
Side Effects ◽  
Adjuvant Therapy ◽  
Angiogenesis Inhibitors ◽  
Cancer Treatments ◽  
Vascular Growth ◽  
Downstream Signaling ◽  
Anti Cancer ◽  
Tumor Outgrowth ◽  
Tumor Growth And Metastasis

Angiogenesis is a key mechanism for tumor growth and metastasis and has been a therapeutic target for anti-cancer treatments. Intensive vascular growth is concomitant with the rapidly proliferating tumor cell population and tumor outgrowth. Current angiogenesis inhibitors targeting either one or a few pro-angiogenic factors or a range of downstream signaling molecules provide clinical benefit, but not without significant side effects. miRNAs are important post-transcriptional regulators of gene expression, and their dysregulation has been associated with tumor progression, metastasis, resistance, and the promotion of tumor-induced angiogenesis. In this mini-review, we provide a brief overview of the current anti-angiogenic approaches, their molecular targets, and side effects, as well as discuss existing literature on the role of miRNAs in angiogenesis. As we highlight specific miRNAs, based on their activity on endothelial or cancer cells, we discuss their potential for anti-angiogenic targeting in cancer as adjuvant therapy and the importance of angiogenesis being evaluated in such combinatorial approaches.

Cutaneous ulcers following hydroxyurea therapy

Phlebologie ◽  
2004 ◽  
Vol 33 (06) ◽  
pp. 202-205 ◽  
Author(s):  
K. Hartmann ◽  
S. Nagel ◽  
T. Erichsen ◽  
E. Rabe ◽  
K. H. Grips ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Antineoplastic Agent ◽  
Limited Time ◽  
Myeloproliferative Diseases ◽  
Dermatological Side Effects ◽  
Chronic Myeloproliferative Diseases ◽  
Hydroxyurea Therapy

SummaryHydroxyurea (HU) is usually a well tolerated antineoplastic agent and is commonly used in the treatment of chronic myeloproliferative diseases. Dermatological side effects are frequently seen in patients receiving longterm HU therapy. Cutaneous ulcers have been reported occasionally.We report on four patients with cutaneous ulcers whilst on long-term hydroxyurea therapy for myeloproliferative diseases. In all patients we were able to reduce the dose, or stop HU altogether and their ulcers markedly improved. Our observations suggest that cutaneous ulcers should be considered as possible side effect of long-term HU therapy and healing of the ulcers can be achieved not only by cessation of the HU treatment, but also by reducing the dose of hydroxyurea for a limited time.

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