scholarly journals The onset of nausea and vomiting of pregnancy: a prospective cohort study

2020 ◽  
Author(s):  
Roger Gadsby ◽  
Diana Ivanova ◽  
Emma Trevelyan ◽  
Jane Luise Hutton ◽  
Sarah Johnson
Keyword(s):  
Cohort Study ◽  
Luteinising Hormone ◽  
Outcome Measure ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Nausea And Vomiting ◽  
Daily Diaries ◽  
Main Outcome Measure ◽  
The United Kingdom ◽  
Time To Onset

Abstract BackgroundNausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual periodMethodsProspective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last men­strual period (LMP) or luteinising hormone surge until onset of nausea or vomiting.ResultsAlmost all women (88\%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67\%) women experience symp­toms within 11 to 20 days of ovulation.ConclusionsOnset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the fetal-maternal interface.Trial registrationNCT01577147

scholarly journals The onset of nausea and vomiting of pregnancy: a prospective cohort study

2020 ◽  
Author(s):  
Roger Gadsby ◽  
Diana Ivanova ◽  
Emma Trevelyan ◽  
Jane Luise Hutton ◽  
Sarah Johnson
Keyword(s):  
Prospective Cohort ◽  
Outcome Measure ◽  
Human Chorionic Gonadotrophin ◽  
Menstrual Period ◽  
Nausea And Vomiting ◽  
Last Menstrual Period ◽  
Daily Diaries ◽  
The United Kingdom ◽  
Almost All ◽  
Time To Onset

Abstract Background Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period Methods Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last men­strual period (LMP) or luteinising hormone surge until onset of nausea or vomiting. Results Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symp­toms within 11 to 20 days of ovulation. Conclusions Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface. Trial registration NCT01577147

scholarly journals The onset of nausea and vomiting of pregnancy: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Roger Gadsby ◽  
Diana Ivanova ◽  
Emma Trevelyan ◽  
Jane L. Hutton ◽  
Sarah Johnson
Keyword(s):  
Prospective Cohort ◽  
Outcome Measure ◽  
Human Chorionic Gonadotrophin ◽  
Menstrual Period ◽  
Nausea And Vomiting ◽  
Last Menstrual Period ◽  
Daily Diaries ◽  
The United Kingdom ◽  
Almost All ◽  
Time To Onset

Abstract Background Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period Methods Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting. Results Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation. Conclusions Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface. Trial registration NCT01577147. Date of registration 13 April 2012

Frequency of Neonatal Bilirubin Testing and Hyperbilirubinemia in a Large Health Maintenance Organization

PEDIATRICS ◽  
1999 ◽  
Vol 104 (Supplement_6) ◽  
pp. 1198-1203 ◽  
Author(s):  
Thomas B. Newman ◽  
Gabriel J. Escobar ◽  
Veronica M. Gonzales ◽  
Mary Anne Armstrong ◽  
Marla N. Gardner ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Outcome Measure ◽  
Health Maintenance Organization ◽  
Northern California ◽  
Kaiser Permanente ◽  
Health Maintenance ◽  
Main Outcome Measure

Objective. To determine the frequency and interhospital variation of bilirubin testing and identified hyperbilirubinemia in a large health maintenance organization. Design. Retrospective cohort study. Setting. Eleven Northern California Kaiser Permanente hospitals. Subjects. A total of 51 387 infants born in 1995–1996 at ≥36 weeks' gestation and ≥2000 g. Main Outcome Measure. Bilirubin tests and maximum bilirubin levels recorded in the first month after birth. Results. The proportion of infants receiving ≥1 bilirubin test varied across hospitals from 17% to 52%. The frequency of bilirubin levels ≥20 mg/dL (342 μmol/L) varied from .9% to 3.4% (mean: 2.0%), but was not associated with the frequency of bilirubin testing (R2 = .02). Maximum bilirubin levels ≥25 mg/dL (428 μmol/L) were identified in .15% of infants and levels ≥30 mg/dL (513 μmol/L) in .01%. Conclusions. Significant interhospital differences exist in bilirubin testing and frequency of identified hyperbilirubinemia. Bilirubin levels ≥20 mg/dL were commonly identified, but levels ≥25 mg/dL were not.

scholarly journals Epidemiology of Injuries Sustained by Elite Under-18 Rugby Players

2019 ◽  
Vol 54 (11) ◽  
pp. 1187-1191
Author(s):  
Cristian Solis-Mencia ◽  
Juan José Ramos-Álvarez ◽  
Roberto Murias-Lozano ◽  
Mikel Aramberri ◽  
José Carlos Saló
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Outcome Measure ◽  
Injury Rate ◽  
Physical Nature ◽  
Main Outcome Measure ◽  
The Third ◽  
High Incidence ◽  
The World ◽  
Rugby Players

Context The physical nature of rugby is responsible for the high incidence of injuries, but no researchers have examined the epidemiology of injuries sustained by elite under-18 rugby players. Objective To investigate the incidence of injuries sustained by players on the Spanish national under-18 rugby team during their participation in 4 European championships (2014–2017) and the types of play in which they occurred. Design Cohort study. Setting European rugby championships. Patients or Other Participants Ninety-eight under-18 rugby players. Main Outcome Measure(s) All injuries sustained during the championship periods were recorded per the World Rugby protocol. Results A total of 40 injuries were logged over the 4 championships. The incidence of injury was higher during matches than during training (P < .05), with 138.0 (95% confidence interval [CI] = 136.5, 139.6) injuries per 1000 hours of play compared with 1.2 (95% CI = 1.2, 1.3) per 1000 hours of training. With only 2 days of rest between games, the injury rate was higher than with 3 days of rest (P < .05). More injuries were sustained during the third quarter of the game: 13 (44.8%) versus 6 (20.6%) in the last quarter, 5 (17.3%) in the second quarter, and 5 (17.3%) in the first quarter. Conclusions The most common injuries during matches were sprains and concussions, and these injuries were more likely to occur during matches than during training. Most injuries were caused by tackles and occurred during the third quarter of the game. These findings indicate that teams should focus on teaching players skills to reduce injuries caused by tackles and warming up properly before returning to the field after halftime. The injury rate was higher with only 2 versus 3 days' rest between games. These results suggest that young players' matches should be at least 72 hours apart.

RADIOIMMUNOASSAY FOR HUMAN CHORIONIC GONADOTROPHIN AND LUTEINISING HORMONE

The Lancet ◽  
1966 ◽  
Vol 287 (7447) ◽  
pp. 1118-1121 ◽  
Author(s):  
K.D. Bagshawe ◽  
C.E. Wilde ◽  
ANNHILARY Orr
Keyword(s):  
Luteinising Hormone ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin

scholarly journals Conjunctival colonisation and antibiotic resistance of coagulase-negativeStaphylococcusafter cataract surgery: a 6-month longitudinal study at a medical centre in Taiwan

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e027036
Author(s):  
Eugene Yu-Chuan Kang ◽  
Chiun-Ho Hou ◽  
Yhu-Chering Huang ◽  
Ching-Hsi Hsiao
Keyword(s):  
Antibiotic Resistance ◽  
Cohort Study ◽  
Cataract Surgery ◽  
Outcome Measure ◽  
Medical Centre ◽  
Main Outcome Measure ◽  
Colonisation Rate ◽  
Significant Difference ◽  
Increasing Trend

ObjectiveTo explored 6-month longitudinal changes in conjunctival colonisation and antibiotic resistance profiles of coagulase-negativeStaphylococcus(CNS) after cataract surgery with 1 month tobramycin treatment.DesignProspective cohort study between 1 August 2012, and 31 July 2013.SettingA single medical centre in Taiwan.ParticipantsA total of 128 Taiwanese patients with 46.9% of male participants.InterventionsSamples from the conjunctival sacs of both operation (OP) and non-OP eyes were obtained separately before cataract surgery and at 1, 3 and 6 months after surgery. Tobramycin (0.3%) treatment was applied four times daily for 1 month postoperatively.Main outcome measureIdentification of CNS isolates and their antibiotic susceptibility by using disk diffusion or E-test.ResultsCNS was detected in 24.2% of patients at baseline. During postoperative follow-up, the CNS colonisation rate did not decrease in either eye but showed an increasing trend in the OP eyes at 1 month (p=0.06). The colonisation rate showed no significant difference between the OP and non-OP eyes from baseline to a specific follow-up. We observed a significant increase (p<0.05) in resistance to tobramycin at 1 month and to ciprofloxacin at 3 months in the OP eyes and to trimethoprim/sulfamethoxazole at 1 month and 3 months and to oxacillin at 6 months in the non-OP eyes.ConclusionsDuring the 6-month postoperative follow-up, 0.3% tobramycin administration failed to reduce CNS colonisation but increased resistance to several antibiotics. Postoperative antibiotic treatment may be replaced by other evidence-endorsed prophylactic routines.

Sign in / Sign up

Export Citation Format

Share Document