scholarly journals Transcranial DC Stimulation in Patients with Migraine: a study protocol for a randomized clinical trial

2021 ◽  
Author(s):  
Luana Dias Santiago Pimenta ◽  
Elidianne Layanne Medeiros de Araújo ◽  
Joyce Poláine dos Santos Silva ◽  
Jamyson Júnior França ◽  
Pedro Nascimento Araújo Brito ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Mindfulness Practice ◽  
Controlled Clinical Trial ◽  
Five Facet Mindfulness Questionnaire ◽  
Brain Wave ◽  
Parallel Group ◽  
Before And After ◽  
Mindfulness Practices ◽  
Midas Questionnaire ◽  
The Individual

Abstract BackgroundChronic migraine is a disease with a difficult diagnosis and an as yet undefined pathophysiology. Its symptoms affect the quality of life and the daily activities of the individual, leading to momentary disability. This study is a controlled clinical trial of a randomized parallel group that will select patients aged between 18–65 years who are diagnosed with chronic migraine.Methods / DesignThis study will be held at the Aging Studies Laboratory and Neuroscience of the Federal University of Paraíba, where twelve sessions of transcranial direct current stimulation (tDCS) and associated with mindfulness practices will be applied over four weeks (one per week). Muse, a portable electroencephalogram (EEG), will be used to measure brain wave biomarkers before and after the intervention. We will use, at the beginning and end of treatment and one month after the completion of any intervention, the score on the Migraine Disability Assessment (MIDAS) questionnaire as the primary outcome and the scores on the HIT-6 (Headache Impact Test) questionnaire and on the Five Facet Mindfulness Questionnaire (FFMQ-BR) as the secondary outcomes.DiscussionBased on the use of tDCS in patients with chronic pain, and in benefits of Mindfulness practice in these patients, the objective is to evaluate if the mindfulness-associated tD provides satisfactory results in the painful prophylaxis of patients with chronic migraine.Trial registrationClinicaltrials.gov, NCT04219345. Registered 16 September 2019. Retrospectively registered.

scholarly journals Efficacy of Sphincter Control Training and medical device in the treatment of premature ejaculation: A multicenter randomized controlled clinical trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257284
Author(s):  
Jesús E. Rodríguez ◽  
Jose A. Picazo ◽  
Juan C. Marzo ◽  
José A. Piqueras ◽  
Leandro Reina ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Medical Device ◽  
Premature Ejaculation ◽  
Electronic Device ◽  
Fold Increase ◽  
Controlled Clinical Trial ◽  
Treatment Groups ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Partner Involvement

A new line of treatment for premature ejaculation (PE) based on the use of masturbation aid device in combination with behavioral techniques has emerged in recent years. We report a multicenter randomized clinical trial with a parallel group design to determine the effectiveness of an electronic device called Myhixel I© in the treatment of PE. Forty patients who met the criteria for the diagnosis of lifelong PE, were assigned to two treatment groups completed the Sphincter control training (SCT) program in eight weeks. The only difference between groups was the use of the device. The main measure was the “fold increase” (FI) of the intravaginal ejaculatory latency time (IELT). The geometric means of IELT show, at the end of the treatment at week 8, a superiority of the device group. The mean FI 4.27 (SD 2.59) at the end of treatment for the device group was clearly higher than obtained in the previous clinical trial, in which a specific medical device was not used. No side effects were observed and it required little therapeutic input and no partner involvement. The SCT program in combination with the Myhixel I© is an effective treatment for PE.

scholarly journals Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250501
Author(s):  
Danielle da Silva Pompeu ◽  
Brennda Lucy Freitas de Paula ◽  
Antônia Patricia Oliveira Barros ◽  
Samir Costa Nunes ◽  
Alexandra Melo Pingarilho Carneiro ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Near Infrared ◽  
Laser System ◽  
Tooth Bleaching ◽  
Infrared Light ◽  
Controlled Clinical Trial ◽  
Strontium Chloride ◽  
Tooth Sensitivity ◽  
The Individual

Objective This split-mouth randomized controlled clinical trial assessed the effect of 10% strontium chloride in combination with photobiomodulation (PBM) for the control of tooth sensitivity (TS) post-bleaching. Methods The upper/lower, right and left quadrants of fifty volunteers were randomized and allocated to four groups (n = 25): PLACEBO—placebo gel + simulation of PBM; Placebo + PBM; STRONTIUM—10% strontium chloride + simulation of PBM; and PBM + STRONTIUM—10% strontium chloride + PBM. All groups received tooth bleaching treatment with 35% hydrogen peroxide. For the PBM treatment, the laser tip was positioned in the apical and cervical regions of the teeth bleached in the respective hemi-arch. The laser system was operated in continuous mode, using 1.7 J of energy. A dose of 60 J/cm2 was applied to each point for 16 seconds under 808 nm near-infrared light (100mW of power), with a point area of 0.028 cm2. TS was assessed during a 21-day follow-up, using the modified visual analogue scale. Results In the intragroup assessment, the Friedman test indicated that PBM + STRONTIUM promoted the greatest reduction in TS after the second week of treatment (p ≤ 0.05). The Wilcoxon-Mann-Whitney test indicated that the groups Placebo + PBM, STRONTIUM, and STRONTIUM + PBM did not differ statistically (p ≥ 0.05) in the first and third weeks of treatment The group PLACEBO exhibited the greatest TS in the first three days after each bleaching session. Conclusion The combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, the combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, it did not differ from the individual use of Placebo + PBM or STRONTIUM groups assessed after 21 days of follow-up.

scholarly journals Transcranial magnetic stimulation associated with manual therapy in patients with knee osteoarthritis: a randomized controlled clinical trial protocol

2020 ◽  
pp. 1-4
Author(s):  
Mannaly Mendonça ◽  
Maria das Graças Araújo ◽  
Camilla Fonseca ◽  
Maíra Lima, Luiz Mèlo ◽  
Sérgio Rocha ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Transcranial Magnetic Stimulation ◽  
Knee Osteoarthritis ◽  
Manual Therapy ◽  
Magnetic Stimulation ◽  
Treatment Protocol ◽  
Controlled Clinical Trial ◽  
Knee Oa ◽  
Before And After ◽  
Registration Number

Background: Persistent pain in knee osteoarthritis (KOA) may generate sensitization of the afferent and central nervous system (CNS) pathways over time. Therefore, for patients with chronic pain derived from KOA, to associate therapies that address peripheral impairment, such as central and manual therapy and transcranial magnetic stimulation seems to be a promising strategy for pain reduction. Objectives: The purpose of this study is to unite rTMS and TM to control the pain of patients with knee OA and to examine the efficacy of this treatment protocol, assuming that this union would be more beneficial than the formally applied therapies isolated. Methods: This clinical trial with three arms interventions, controlled, triple blind and randomized, will allocate patients with KOA in groups (i) transcranial magnetic stimulation; (ii) sham transcranial magnetic stimulation + manual therapy and (iii) transcranial magnetic stimulation + manual therapy. Pain assessment will be performed using the visual analog scale of pain of 100 points, before and after the interventions, and for a maximum of 30 days after the single session. This session will involve the application of real or fictitious transcranial magnetic stimulation followed by manual or home therapy. Discussion: The study is in the recruitment stage and it is expected that after the application of the therapeutic protocol the group that performed the association has a more significant improvement in comparison to the others. Study registry: The protocol of this study was published on the Clinical Trials (www.clinicaltrials.org), with the registration number NCT03076294.

Image-guided versus palpation-guided injections for the treatment of chronic lateral epicondylopathy: a randomized controlled clinical trial

2018 ◽  
Vol 50 (05) ◽  
pp. 348-352 ◽  
Author(s):  
Michael-Alexander Malahias ◽  
Maria-Kyriaki Kaseta ◽  
Sotirios-Tsambikos Kazas ◽  
Panayiotis D Megaloikonomos ◽  
Andreas F Mavrogenis ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Statistical Difference ◽  
Lateral Epicondylitis ◽  
T Test ◽  
Controlled Clinical Trial ◽  
Ultrasound Guided ◽  
Chi Square ◽  
Before And After ◽  
Group A ◽  
Group B

Abstract Background There have been several studies published comparing the ultrasound-guided with the “blind” infiltrations in the shoulder’s area. On the contrary, there is only very limited data regarding the necessity of ultrasound guidance in lateral epicondylitis. Materials and Methods A prospective, randomized, blinded at initial and follow-up evaluation, comparative clinical trial was conducted, involving 44 patients with a history of chronic persistent epicondylopathy. The patients were randomly divided into 2 groups of 22 people each. Group A patients underwent three ultrasound-guided betamethazone injections, while group B included those who underwent three “blind” injections, centered at the palpable point of maximum pain. The evaluation was done before and after (4 and 12 weeks) the injections using the Visual Analogue Scale for pain (VAS, 0–10) and the Roles & Maudsley score. Results There was not any significant statistical difference between the two groups as for mean VAS at 4 weeks (p = 0.150, t-test) and mean VAS at 12 weeks (p = 0.286, t-test). Furthermore, the final success rate, as measured by the Roles & Maudsley score, was slightly superior in group B (67 % of the patients with excellent or good results) when compared with group A (46 % of the patients), but without any statistical difference (p = 0.161, chi-square). Conclusion Our trial proved that an ultrasound-guided injection is not superior than a palpation-guided injection of corticosteroids in the treatment of lateral epicondylopathy.

scholarly journals Effects of Mindfulness practice on work stress: a study with professionals in Primary Health Care

2021 ◽  
Vol 10 (4) ◽  
pp. e23210414002
Author(s):  
Mariana Fernandes ◽  
João Paulo Souza ◽  
Edilaine Cristina da Silva Gherardi-Donato ◽  
Hayala Cristina Cavenague de Souza ◽  
Ana Carolina Arruda Franzon ◽  
...  
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Quantitative Methods ◽  
Job Strain ◽  
Mindfulness Practice ◽  
Five Facet Mindfulness Questionnaire ◽  
Inner Experience ◽  
Primary Health ◽  
Before And After ◽  
Quasi Experimental

The objective of this study is to evaluate the effect of a Mindfulness-based program on mindfulness levels and in the risk of illness associated with stress at work in primary health care (PHC) professionals in Ribeirão Preto, Brazil. This is a quasi-experimental study, with 26 PHC professionals, using quantitative methods and an analytical before and after approach of an 8-week Mindfulness Program. The intervention was evaluated applying the instruments: Five Facet Mindfulness Questionnaire and Job Stress Scale. There were significant differences in six Mindfulness facets after the intervention: Observe (p = 0.002); Describe (p = 0.01); Act with awareness - autopilot (p = 0.01) and distraction (p = 0.05); Non-reactivity to inner experience (p = 0.0005); Non-judgement of inner experience (p = 0.01); and in total Mindfulness scores (p = 0.0000018). Regarding the stress levels at work, the reduction of the organizational mode in high job strain was observed (before: 35%, after: 19%).  It is concluded that interventions based on Mindfulness applied to PHC professionals can improve the levels of mindfulness and modify the modes of organization at work, reducing the risk of illness associated with stress in these professionals.

scholarly journals Impact of adding mindfulness practices to a bachelor of social work direct practice course

2021 ◽  
Vol 11 (2) ◽  
pp. 29-42
Author(s):  
Lea Tufford
Keyword(s):  
Community College ◽  
Social Work ◽  
Secondary School ◽  
Mindfulness Practice ◽  
Future Research ◽  
Five Facet Mindfulness Questionnaire ◽  
Direct Practice ◽  
Bachelor Of Social Work ◽  
Post Test ◽  
Mindfulness Practices

This study sought to determine whether mindfulness increased or decreased for Year 4 Bachelor of Social Work (BSW) students. Twenty-four participants received a brief mindfulness practice each week at the start of class and completed the Five Facet Mindfulness Questionnaire in the first and last class. Results showed a decrease from pre-test to post-test on the non-reactivity to inner experience facet of the scale. In addition, in a post-test, those participants who came to the BSW programme from secondary school had an overall higher score than those participants who came to the programme from community college. Moreover, participants who had no prior practice in mindfulness and those who did not practice mindfulness during their practicum saw an increase in scores. These findings are discussed and recommendations for future research are offered.   Keywords: Mindfulness, BSW students, practices, social work, course.

scholarly journals Randomized, Double-masked, Placebo-controlled Clinical Trial on the Effects of Propolis and Chlorhexidine Mouthrinses on Gingivitis

2014 ◽  
Vol 17 (1) ◽  
pp. 11 ◽  
Author(s):  
Camilo Anauate-Netto ◽  
Andréa Anido-Anido ◽  
Hugo Roberto Lewgoy ◽  
Ricardo Matsumoto ◽  
Roberta Caroline Bruschi Alonso ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Group Analysis ◽  
Study Groups ◽  
Controlled Clinical Trial ◽  
Gingival Inflammation ◽  
Treatment Protocols ◽  
Study Protocols ◽  
Gingival Health ◽  
Before And After ◽  
Bleeding Score

<p><strong>Objective:</strong> The aim of this study was to compare the effects of typified propolis and chlorhexidine mouthrinses on gingival health in a randomized double-masked placebo-controlled clinical trial.</p><p><strong>Methods:</strong> Sixty participants were randomized to 3 mouthrinse study groups: 1) 2% typified propolis (n=20); 2) 0.12% chlorhexidine (n=20), and 3) placebo (n=20). Participants rinsed unsupervised twice a day for 28 days. The Papillary Bleeding Score (PBS) was measured on the mesio-buccal surfaces of all teeth at baseline and 28 days thereafter. Co-variance analysis was employed to compare PBS average values and the number of sites with PBS ≥2 among study groups. Sub-group analysis was further applied to participants who were &lt;40 years-old.</p><p><strong>Results:</strong> The results show efficacy of propolis mouthrinse when comparing before and after treatment protocols significantly for a reduction of mean PBS scores. When looking at younger participants after 28 days, propolis mouthrinse was superior to all groups in reducing mean PBS scores and significantly so when compared to 0.12% chlorhexidine mouthrinse.</p><p><strong>Conclusion:</strong> The efficacy of 2% typified propolis mouthrinse was demonstrated in reducing the levels of gingival inflammation. These results need to be duplicated by other investigators by employing similar study protocols.</p><p><strong>Descriptors:</strong> Randomized Clinical Trial, Propolis, Chlorhexidine, Gingivitis<strong><em></em></strong></p>

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