scholarly journals Relationship Between Hyperuricemia and Apolipoprotein AI in Chinese Healthy People: a Cohort Study

2021 ◽  
Author(s):  
Yan Duan ◽  
Xiaona Chang ◽  
Xiaoyu Ding ◽  
Yu An ◽  
Guang Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Healthy Subjects ◽  
Independent Risk Factor ◽  
Healthy People ◽  
Apolipoprotein Ai ◽  
Apo B ◽  
Blood Uric Acid ◽  
The Relationship ◽  
Plasma Apolipoprotein ◽  
Apo Ai

Abstract Background: Hyperuricemia is an independent risk factor for various cardiovascular diseases. However the association of plasma uric acid and Apolipoprotein AI among Chinese healthy people is still unclear.Aims: To evaluate the relationship between blood uric acid and Apolipoprotein AI level in Chinese healthy people. Method; A total of 3501 normal healthy subjects who were undergone physical examination were divided into hyperuricemia (HUA) group and normouricemia (NUA) group.Result: Apo AI (1.33±0.21 vs. 1.47±0.26) and HDL-c (1.12±0.27 vs. 1.36±0.33)decreased significantly in HUA group than NUA group. LDL-C(2.81±0.77 vs. 2.69±0.73),Apo B(0.96±0.20 vs. 0.89±0.20), FBG(5.48±0.48 vs. 5.36±0.48) and HOMA-IR(2.75（1.92-3.91）vs. 2.18（1.50-3.12）) was significantly higher in HAU group than NUA group. Increased plasma UA was correlated with decreased HDL-c(r=-0.289, P<0.01 ) and Apo AI(r=-0.236, p<0.01) .Conclusion: Hyperuricemia was associated with decreased plasma Apolipoprotein AI and HDL-c. Inhibiting Apolipoprotein AI may be one of the mechanisms of UA involved in the progression of cardiovascular disease.

scholarly journals U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects

2017 ◽  
Vol 312 (6) ◽  
pp. F992-F997 ◽  
Author(s):  
Hideki Uedono ◽  
Akihiro Tsuda ◽  
Eiji Ishimura ◽  
Shinya Nakatani ◽  
Masafumi Kurajoh ◽  
...  
Keyword(s):  
Uric Acid ◽  
Regression Analysis ◽  
Serum Uric Acid ◽  
Healthy Subjects ◽  
Hemodynamic Parameters ◽  
Quadratic Regression ◽  
Dummy Variables ◽  
Arteriolar Resistance ◽  
Glomerular Hemodynamics ◽  
The Relationship

Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found to be associated with loss of kidney function. The goal of this study was to evaluate the relationship between SUA levels and intrarenal hemodynamic parameters in healthy subjects, using plasma clearance of para-aminohippurate (CPAH) and inulin (Cin). Renal and glomerular hemodynamics were evaluated by simultaneous measurements of CPAH and Cin in 48 healthy subjects (54.6 ± 13.4 yr). Intrarenal hemodynamic parameters, including efferent and afferent (Ra) arteriolar resistance, were calculated using Gómez’s formulas. Relationships of SUA levels with these intrarenal hemodynamic parameters were examined. In quadratic regression analysis, SUA levels had a significant inverse U-shaped relationship with Cin ( P < 0.0001, R2 = 0.350) and CPAH ( P = 0.0093, R2 = 0.188) and a U-shaped relationship with Ra ( P = 0.0011, R2 = 0.262). In multiple regression analysis with normal (3.5–6.0 mg/dl) and mildly low or high (<3.5 or >6.0 mg/dl) SUA levels entered as dummy variables of zero and one, respectively, mildly low or high SUA levels were significantly and independently associated with Ra (β = 0.230, P = 0.0403) after adjustment for several factors ( R2 = 0.597, P < 0.0001). Both mild hyperuricemia and mild hypouricemia are significantly associated with increased Ra, although weakly. The increase in Ra in subjects with mild hyperuricemia or hypouricemia may be related to renal hemodynamic abnormalities, possibly leading to a decline in renal function.

scholarly journals Prognostic Value of Serum Uric Acid in Patients on the Waiting List before and after Renal Transplantation

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Henrique Cotchi Simbo Muela ◽  
Jose Jayme Galvão De Lima ◽  
Luis Henrique W. Gowdak ◽  
Flávio J. de Paula ◽  
Luiz Aparecido Bortolotto
Keyword(s):  
Uric Acid ◽  
Renal Transplantation ◽  
Serum Uric Acid ◽  
Prognostic Value ◽  
Independent Risk Factor ◽  
High Serum ◽  
Increased Risk ◽  
Before And After ◽  
The Impact ◽  
The Relationship

Background.High serum uric acid (UA) is associated with increased cardiovascular (CV) risk in the general population. The impact of UA on CV events and mortality in CKD is unclear.Objective.To assess the relationship between UA and prognosis in hemodialysis (HD) patients before and after renal transplantation (TX).Methods.1020 HD patients assessed for CV risk and followed from the time of inception until CV event, death, or TX (HD) or date of TX, CV event, death, or return to dialysis (TX).Results.821 patients remained on HD while 199 underwent TX. High UA (≥428 mmol/L) was not associated with either composite CV events or mortality in HD patients. In TX patients high UA predicted an increased risk of events (P=0.03, HR 1.6, and 95% CI 1.03–2.54) but not with death. In the Cox proportional model UA was no longer significantly associated with CV events. Instead, a reduced GFR (<50 mL/min) emerged as the independent risk factor for events (P=0.02, HR 1.79, and % CI 1.07–3.21).Conclusion.In recipients of TX an increased posttransplant UA is related to higher probability of major CV events but this association probably caused concurrent reduction in GFR.

scholarly journals Time Averaged Uric Acid Is Associated With the Prognosis of IgAN in Females

2021 ◽  
Author(s):  
Quan Zhang ◽  
Luyao Dong ◽  
Hongling Han
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
General Hospital ◽  
Independent Risk Factor ◽  
Glomerular Diseases ◽  
Progression Of Disease ◽  
Medical University ◽  
The Relationship ◽  
Worse Prognosis

Abstract Background IgA Nephropathy (IgAN) is one of the most common glomerular diseases. However, the effect of uric acid on the prognosis of IgAN is still unclear, especially between males and females. Therefore, the present study aimed to explore the role of hyperuricemia in IgAN patients and the differences in gender. Consequently, the study conducted a retrospective analysis of the prognosis of IgAN in patients from the General Hospital of Tianjin Medical University. Methods: A total of 1,022 patients with primary IgAN, diagnosed through renal biopsy were enrolled from the Department of Nephrology, General Hospital of Tianjin Medical University. However, after applying the exclusion criteria, only 463 patients remained and were regularly followed up in the hospital. In addition, the relationship between Time Average Uric Acid (TA-UA) and prognosis of IgAN was analyzed. Results: The findings showed that TA-UA was an independent risk factor for the prognosis of IgAN in the 463 patients studied (OR=1.752，95%CI=1.348-2.277，p＜0.001). Additionally, higher TA-UA values were associated with a faster progression of disease and worse prognosis (p < 0.05). Elevated TA-UA was also shown to be an independent risk factor for the progression of disease in female patients but not in their male counterparts (women: HR=1.998，95%CI=1.398-2.854，p＜0.001，men: HR=1.405，95%CI=0.869-2.274, p=0.166). Conclusion: Increased TA-UA is an independent risk factor for the progression of IgAN, especially in women.

Relationship Between Blood Uric Acid Level and Personality Traits

1990 ◽  
Vol 39 (1) ◽  
pp. 117-122 ◽  
Author(s):  
S. Ooki ◽  
K. Yamada ◽  
A. Asaka
Keyword(s):  
Uric Acid ◽  
Personality Traits ◽  
Uric Acid Level ◽  
Acid Level ◽  
Intraclass Correlation ◽  
Blood Uric Acid ◽  
Males And Females ◽  
Mz Twins ◽  
The Relationship ◽  
High Uric Acid

AbstractThe present study deals with the relationship between blood uric acid level and human behavior. Subjects were 37 MZ and 7 DZ twins aged from 18 to 45 years. In males, blood uric acid level increased with age, while it decreased with age in females. Blood uric acid level was corrected and standardized using regression lines separately for males and females. The distribution of standardized uric acid level corresponded well with the theoretical curve of normal distribution. The intraclass correlation coefficient for standardized uric acid level was r = 0.370 (P < 0.05) for the 37 MZ twins, but not significant for the 7 DZ twins. These findings suggest that blood uric acid level is genetically controlled. By the analysis of 12 personality traits in YG (Yatabe-Guilford) character test, it was revealed that “General activity” was more controlled by genetically than environmentally. In the evaluation of the correlation between standardized uric acid level and the YG 12 personality traits, significant correlation was observed in “Lack of agreeableness” and “Rhathymia”. Since these two personality traits include the factor of “activity”, it is concluded that the plasma uric acid level and activity in a broader sense are under genetic control. This conclusion is consistent with the generally accepted view that persons with high uric acid level are more active and energetic than those with low level.

scholarly journals GAMBARAN ASAM URAT PADA REMAJA OBES DI KABUPATEN MINAHASA

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Vindy G. N. Wurangian
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Random Sampling ◽  
Sampling Technique ◽  
Male Students ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Blood Uric Acid ◽  
Cross Sectional Design ◽  
The Relationship

Abstract: Uric acid is an end product of purine metabolism and is also associated with obesity. Most people with this condition are overweight and have a tendency of hyperuricemia which is associated with insulin resistance. Insulin resistance is the basis of metabolic abnormalities that could explain the relationship between the various components of the metabolic syndrome. This study aimed to determine the profile of uric acid in obese adolescent.This was a descriptive study with cross sectional design. Sampling technique used was random sampling method. Samples consisted of obese students determined by measuring their waist circumferences. The students had to fast for at least 8 hours, and then their blood was taken for examination of blood uric acid level. The results showed that there were 54 obese students as samples, and 8 students (14.28%) with hyperuricemia. Of those with hyperuricemia, there were 3 male students (5.56%) and 5 female students (9.26%). Conclusion: Although a large part of obese students in Minahasa had normal blood uric acid levels, some of them showed hyperuricemia.Keywords: uric acid, hyperuricemia, obeseAbstrak: Asam urat merupakan hasil akhir metabolisme purin. Asam urat sering dikaitkan dengan obesitas. Orang dengan kegemukan mempunyai kecenderungan mengalami peningkatan kadar asam urat dalam darah. Asam urat berhubungan dengan resistensi insulin. Resistensi insulin merupakan dasar kelainan metabolik yang dapat menjelaskan hubungan antara berbagai komponen sindrom metabolik. Penelitian ini bertujuan untuk mengetahui gambaran asam urat pada remaja obes. Penelitian ini bersifat deskriptif dengan desain potong lintang. Sampel diperoleh dengan tekhnik random sampling. Sebagai sampel penelitian diambil siswa-siswi SMK Negeri Tondano yang obes yang ditentukan berdasarkan lingkar pinggang. Siswa yang bersedia dijadikan sampel diminta untuk berpuasa minimal 8 jam, kemudian diambil darahnya untuk pemeriksaan kadar asam urat. Hasil penelitian memperlihatkan dari 54 siswa obes diperoleh prevalensi siswa obes yang mengalami hiperurisemia di Kabupaten Minahasa 8 orang (14,82%), yang terdiri dari 3 siswa laki-laki (5,56%) dan 5 siswa perempuan (9,26%). Simpulan: Walaupun sebagian besar siswa obes mempunyai kadar asam urat darah yang normal, beberapa di antaranya memperlihatkan hiperurisemia.Kata kunci: asam urat, hiperurisemia, obesitas

scholarly journals Hubungan antara kadar asam urat dengan tekanan darah pada anak obes di Kecamatan Talawaan Kabupaten Minahasa Utara

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Herlin S. Sarundaitan ◽  
Sarah M. Warouw ◽  
Ari L. Runtunuwu
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Acid Level ◽  
Pearson Correlation ◽  
P Value ◽  
Obese Children ◽  
Consecutive Sampling ◽  
Blood Uric Acid ◽  
The Mean ◽  
The Relationship

Abstract: Obesity is an increasing global health problem in many countries. The most common causes are genetic factor, lack of physical activity as well as combinations of these factors. Uric acid is an end product of purine metabolism. Elevated uric acid level is influenced by various factors such as alcohol, genetic, hypothyroidism, obesity, and high-purine diet. In children all over the world, the increased prevalence of overweight and obesity influences the prevalence of hypertension, especially primary hypertension. This study aimed to determine the relationship between the level of blood uric acid and blood pressure among obese children. This was an observational analytical study. Samples were obtained by using consecutive sampling method. This study was conducted at Talawaan North Minahasa during October 2015-January 2016. There were 38 obese children aged 13-15 years as samples, consisted of 14 males and 24 females. The results showed that the majority of samples were in the age categories 13 and 14 years; each category consisted of 17 samples (44.7%). The lowest was age category of 15 years, consisted of 4 samples (10.5%). The mean systolic blood pressure was 123.16 mmHg (SD ± 12.967) and the mean diastolic blood pressure was 81.58 mmHg (SD ± 11.514). The mean level of blood uric acid was 4.858 mg/dL (SD ± .9328). The Pearson correlation statistical test for the relationship between uric acid level and systolic blood pressure showed a P value of 0.306 (r<0.02) and for the relationship between uric acid levels and diastolic blood pressure showed a P value of 0.152 (r <0.02). Conclusion: There was a positive relationship between the level of blood uric acid and blood pressure among obese children but not statistically significant. Keywords: uric acid, blood pressure, obesity Abstrak: Obesitas merupakan masalah kesehatan dunia yang semakin meningkat di berbagai negara. Penyebab yang paling sering menyebabkan obesitas ialah faktor genetik, kurangnya aktifitas fisik, serta kombinasi dari kedua faktor ini. Asam urat merupakan produk akhir metabolisme purin. Penyebab meningkatnya kadar asam urat dipengaruhi oleh berbagai macam faktor antara lain alkohol, genetik, hipotiroid, obesitas, dan diet tinggi purin. Pada populasi anak di seluruh dunia, peningkatan prevalensi kegemukan dan obesitas turut meningkatkan prevalensi hipertensi, terutama hipertensi primer. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dengan tekanan darah pada anak obes. Jenis penelitian ini analitik observasional dengan desain potong lintang. Sampel diperoleh dengan metode consecutive sampling. Penelitian ini dilakukan di Kecamatan Talawaan Kabupaten Minahasa Utara selama bulan Oktober 2015 – Januari 2016. Terdapat 38 anak obes berusia 13-15 tahun sebagai sampel, yang terdiri dari 14 anak laki-laki dan 24 anak perempuan. Hasil penelitian memperlihatkan bahwa sebagian besar responden berada pada kategori umur 13 dan 14 tahun masing-masing berjumlah 17 orang (44,7%), dan terendah umur 15 tahun sebanyak 4 orang (10,5%).Rerata tekanan darah sistol 123,16 mmHg (SD ± 12,967) dan rerata tekanan darah diastol 81,58 mmHg (SD ± 11,514). Rerata kadar asam urat responden 4,858 mg/dL (SD ± 0,9328). Uji statistik Pearson Correlation untuk hubungan antara kadar asam urat dengan tekanan darah sistol menunjukkan nilai P = 0,306 (r<0,02) dan untuk hubungan antara kadar asam urat dengan tekanan darah diastol menunjukkan nilai P = 0,152 (r <0,02). Simpulan: Terdapat hubungan positif antara kadar asam urat darah dengan tekanan darah pada anak obes namun secara statistik tidak bermakna.Kata kunci: asam urat, tekanan darah, obesitas

scholarly journals Study on the association SLC2A9 RS12510549 with uric acid and gout in Vietnamese population

2020 ◽  
Vol 18 (1) ◽  
pp. 49-57
Author(s):  
Nguyen Tran Minh Thang ◽  
Nguyen Doan Tinh ◽  
Nong Van Hai ◽  
Nguyen Thuy Duong
Keyword(s):  
Uric Acid ◽  
Genotype Distribution ◽  
Genotype Frequencies ◽  
Pcr Rflp ◽  
Blood Uric Acid ◽  
Vietnamese Population ◽  
Study Population ◽  
The Relationship ◽  
Protein Channels ◽  
Larger Sample

Gout is the most common form of arthritis in Vietnam and around the world, caused by an excess of blood uric acid levels. The occurrence of gout is influenced by many risk factors such as diet, living and genetic factors. Studies showed gout is associated with polymorphisms located on genes that encode transport protein channels, including SLC2A9 rs12510549. To evaluate the association of polymorphism SLC2A9 rs12510549 to uric acid levels and gout in the Vietnamese population, we genotyped rs12510549 of 519 subjects (168 gout patients and 351 healthy people) by the PCR–RFLP method. The relationship between genotype distribution, the allele frequency of polymorphism with uric acid levels and gout was assessed through statistical methods. The results show that SLC2A9rs12510549 was in accordance with HWE (p> 0.05) and the genotype frequencies of TT, TC and CC were 0.73, 0.25 and 0.02, respectively, confirming the randomness and representation of the study population. The genotype distribution and frequency of the rs12510549 allele were determined unrelated to uric acid levels and gout in the Vietnamese population (p>0.05). Further study with a larger sample size should be implemented to confirm our results on the association of SLC2A9rs12510549 and gout in the Vietnamese population.

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