scholarly journals Demographic and Clinical Characteristics of Patients With Pancreatic Cancer, A Study in Kerman, Iran

2021 ◽  
Author(s):  
Mohammad Shafiee ◽  
Maryam Kouhestani Parizi ◽  
Akram Arabi ◽  
Mohammad Reza Lashkarizadeh ◽  
Mehran Ebrahimi Shah-abadi ◽  
...  
Keyword(s):  
Population Aging ◽  
Tumor Resection ◽  
Pancreatic Head ◽  
Tumor Location ◽  
Palliative Surgery ◽  
Common Type ◽  
Teaching Hospitals ◽  
Cross Sectional ◽  
Statistical Population ◽  
Kerman City

Abstract PurposePancreatic cancer (PC) has the worst prognosis among cancers and is the only cancer whose annual incidence is higher than its prevalence. Considering that many PC cases are annually diagnosed in the world, and the fact that the disease has the worst prognosis among cancers, and the prevalence of its risk factors such as diabetes, high-fat diets, smoking, population aging, etc. has been on the rise, the incidence of PC is expected to increase in the future. So, our aim was to assess the demographic features of PC patients in an Iranian population.MethodsThe present study was a descriptive cross-sectional research conducted in 2018 in the teaching hospitals affiliated with Kerman University of Medical Sciences (i.e., Afzalipour and Bahonar hospitals). The statistical population of this study was all the patients with PC, referring to these hospitals. The files of all the patients diagnosed with PC (confirmed clinically and pathologically) from the beginning of 2009 to the end of 2019 were assessed. Treatments (i.e., surgical tumor resection or other alternative treatments) were recorded into a data collection sheet. Finally, the data was entered into SPSS version 20 for performing statistical analyses. ResultsIn this study, 380 patients with PC were studied, of whom 60.5% were male, and 39.5% female. Most of the patients were in the age range of 61-70 years (26.1%), and most of them were residents of Kerman city (62.9%), followed by Jiroft (5.5%) and Bam and Iranshahr (each 4.7%). A history of alcohol consumption was noted in 9.3%, and 33.7% were exposed to cigarette smoke. The most common symptoms of the patients were jaundice (65.3%), abdominal pain (54.7%), and anorexia (50.7%). The most common tumor location was the head of the pancreas (62.4%), and the most common type of the tumors was adenocarcinoma (71%). Overall, 23.7% and 76.3% of the patients underwent chemotherapy and surgery, respectively. Of those who had surgeries, 63.8% underwent palliative surgery. Of all 380 patients, 30 (7.8%) individuals were still alive, and 350 (91.4%) had died.ConclusionThe results of this study showed that most of the PC patients were male, had an age between 61 and 70 years, and lived in Kerman and Jiroft cities. The most common tumor site was the pancreatic head, and the most common type of the tumors among both sexes was adenocarcinoma. Surgery, mostly palliative surgery, was the most frequent treatment of choice among all patients.

scholarly journals A case of 18 years disease-free survival after combined pancreatoduodenectomy and hemicolectomy for carcinosarcoma of the transverse colon

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Susumu Ohwada ◽  
Amika Moro ◽  
Nair Amit ◽  
Kazunari Sasaki ◽  
Shinji Sakurai ◽  
...  
Keyword(s):  
Transverse Colon ◽  
Malignant Tumors ◽  
Submucosal Tumor ◽  
Tumor Resection ◽  
Pancreatic Head ◽  
Disease Free Survival ◽  
En Bloc ◽  
Abdominal Ultrasonography ◽  
Cross Sectional ◽  
Pancreas Head

Abstract Background Ascertaining the origin of large tumors located in the region of the pancreas head and adjacent mesocolon can pose a challenge preoperatively. En bloc pancreatoduodenectomy with hemicolectomy is often required towards curative tumor resection (R0) of malignant tumors in this region. Case presentation Herein we report a case of a 48-year-old man with two contiguous masses each 5 cm in size, located in the pancreatic head. The masses were detected incidentally by abdominal ultrasonography at an annual health check. Endoscopic biopsies revealed inflammation with no malignancy. Cross-sectional imaging showed the tumor direct invasion of the uncinate process of the pancreas, and the third portion of the duodenum. Based on imaging, a malignant submucosal tumor originating from mesenchymal cells in the mesentery of the transverse colon was made preoperatively. The mass required en bloc pancreatoduodenectomy, right hemicolectomy, and resection of the superior mesenteric vein. The final pathology was carcinosarcoma of the transverse colon. The patient survived 18 years after surgery without recurrence. Conclusions Malignant tumors located in the region of the pancreas head should be considered for an en bloc curative tumor resection and adjuvant chemotherapy treatments offered that might be beneficial for carcinosarcoma.

scholarly journals Identifying Factors Affecting of Cooperation Management between Charities and the Teaching Hospitals of Shahid Beheshti University of Medical Sciences

2021 ◽  
Vol 16 (3) ◽  
pp. 249-259
Author(s):  
Seyed Mahmud Nayeri ◽  
Somayeh Hessam ◽  
Amir Ashkan Nasiripour ◽  
Katayoun Jahangiri
Keyword(s):  
Public Hospitals ◽  
Teaching Hospitals ◽  
Path Coefficient ◽  
Medical Sciences ◽  
University Hospitals ◽  
Treatment Area ◽  
Cross Sectional ◽  
Statistical Population ◽  
Factors Affecting ◽  
The University

Objectives: One of the most important issues in the provision of health services in every country is providing the necessary resources for presenting these services. Cooperation between charity organizations and public hospitals is especially important as it can increase charity participation, facilitate public participation in the treatment area and develop hospital units. This study aimed was to identify factors affecting cooperation Management and designing a model of cooperation management between charities and the university hospitals of Shahid Beheshti University of Medical Sciences. Methods: This descriptive-analytical, cross-sectional and applied study was conducted in hospitals of Shahid Beheshti University of Medical Sciences in 2019. The statistical population consisted of 411 people including managers, chiefs and deputies, contracting hospital experts and social workers, managers and lawyers of the university, trustees and managers and charity experts. The research sample consisted of 330 people who were selected through the stratified random sampling method. Data was collected using a researcher-made questionnaire. The SPSS 18 and AMOS software were used to analyze the data. Results: The most effective contract pattern determinant had a path coefficient of 1.177, while the least effective current consumption expenditure determinant had a path coefficient of 0.530. Conclusion: The following steps are ways in which costs related to an inpatient department are guaranteed to be covered by a charity during the term of the contract: defining the criteria for selecting a charity to operate in a hospital, choosing a cooperative method and a contract template, determining the share of capital and current costs, and selecting the department type in the contract.  

Palliative surgery for pancreatic head malignancies

2007 ◽  
Vol 45 (05) ◽  
Author(s):  
Z Csapó ◽  
P Nagy ◽  
L Harsányi ◽  
G Bodoky ◽  
P Kupcsulik
Keyword(s):  
Pancreatic Head ◽  
Palliative Surgery

Hubungan ekspresi p53, Bcl-2, c-Myc dan MMP-9 dengan gambaran klinikopatologi karsinoma sel skuamosa kepala-leher

2016 ◽  
Vol 46 (1) ◽  
pp. 53
Author(s):  
Azwar Azwar ◽  
Sofia Mubarika ◽  
Agus Surono
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Location ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Cross Sectional ◽  
P53 Expression ◽  
Local Metastasis

Latar belakang: Karsinoma sel skuamosa kepala dan leher merupakan salah satu kanker terseringdi seluruh dunia. Pendekatan pengobatan agresif dan multidisiplin telah dilakukan, namun belum adapeningkatan yang signifikan dalam kelangsungan hidup 5 tahun, selama 20 tahun terakhir. Kegagalanpengobatan terjadi dalam bentuk kekambuhan lokoregional, metastasis jauh, dan/atau tumor primer kedua.Berbagai penanda molekular tumor telah diteliti untuk mengetahui potensinya dalam memprediksi hasilpenyakit atau respon terhadap terapi.Tujuan: Mengetahui hubungan ekspresi protein p53, Bcl-2, c-Myc,dan MMP-9 berdasarkan gambaran klinikopatologis karsinoma sel skuamosa kepala dan leher di RumahSakit dr. Zainoel Abidin.Metode: Studi menggunakan desain cross sectional. Sampel terdiri dari 60blok parafin karsinoma sel skuamosa kepala dan leher. Prosedur pewarnaan imunohistokimia dilakukandengan menggunakan antibodi monoklonal terhadap p53, Bcl-2, c-Myc, dan MMP-9. Ekspresi proteinp53, Bcl-2, c-Myc, dan MMP-9 dianalisis secara imunohistokimia pada karsinoma sel skuamosa kepaladan leher kemudian hasilnya dihubungkan dengan parameter klinikopatologis seperti usia, jenis kelamin,lokasi tumor, diferensiasi tumor, metastasis kelenjar getah bening dan stadium tumor, kemudian dianalisisstatistik dengan Chi square.Hasil: Hasil penelitian menunjukkan terdapat hubungan bermakna tingkatekspresi p53 dengan metastasis lokal (p=0,021) dan ada hubungan bermakna tingkat ekspresi MMP-9dengan lokasi tumor (p=0,026). Tidak terdapat hubungan ekspresi p53, Bcl-2, cMyc, dan MMP-9 terhadapusia, jenis kelamin, stadium tumor, diferensiasi histologi, tingkat T, N, dan metastasis jauh.Kesimpulan:Ada hubungan ekpresi p53 dengan metastasis kelenjar limfe regional dan ekspresi MMP-9 dengan lokasitumor pada karsinoma sel skuamosa kepala dan leher. Kata kunci: Karsinoma sel skuamosa kepala dan leher, p53, Bcl-2, c-Myc, MMP-9 ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most commoncancers world wide. Although aggressive and multidisciplinary approach to the treatment has been done,there is no significant improvement in 5-year survival in the last 20 years. Treatment failure occurredin the form of locoregional recurrence, distant metastasis, and/or a second primary tumor. A variety oftumor molecular markers have been studied to determine their potential in predicting disease outcome orresponse to the therapy. Purpose: To investigate correlation p53, Bcl-2, c-Myc, and MMP-9 expressionto clinicopathologic parameter in head and neck squamous cell carcinoma patient in dr. Zainoel Abidinhospital. Methods: Cross sectional design study. The sample was consisted of 60 paraffin blocks ofhead and neck squamous cell carcinoma. Procedure of immunohistochemical staining used monoclonalantibodies against p53, Bcl-2, c-Myc, and MMP-9. Expression of p53 protein, Bcl-2, c-Myc, and MMP-9were analyzed by immunohistochemistry in head and neck squamous cell carcinoma. Then, the results were linked to clinicopathologic parameters such as age, sex, tumor location, tumor differentiation,lymph node metastasis and tumor stage, and statistically analyzed with Chi square. Results: The resultsshowed there were significant correlation between p53 expression level with local metastasis (p=0,021)and significant correlation of MMP-9 expression levels with tumor location (p=0,026). There were norelationship of p53, Bcl-2, cMyc and MMP-9 expressions based on age, sex, stage tumor, histologicdifferentiation, level of T, N, and distant metastases. Conclusion: There were relationships between p53expression with local metastasis and MMP-9 expression with tumor location in head and neck squamouscell carcinoma. Keywords: Head and neck squamous cell carcinoma, p53, Bcl-2, c-Myc, MMP-9

scholarly journals Preservation of nasal turbinates in endoscopic, anterior skull base surgery—yes, we can!

2021 ◽  
Author(s):  
Axel Wolf ◽  
Alexandros Andrianakis ◽  
Peter Valentin Tomazic ◽  
Michael Mokry ◽  
Georg Clarici ◽  
...  
Keyword(s):  
Skull Base ◽  
Skull Base Surgery ◽  
Tumor Resection ◽  
Tumor Location ◽  
Anterior Skull Base ◽  
Tumor Diameter ◽  
Tumor Type ◽  
Preoperative Information ◽  
Medical University ◽  
Significant Factors

Abstract Objective To evaluate the frequency, type and indications of nasal turbinate (NT) resection during endoscopic, anterior skull base surgery and to analyze factors that may have an impact on the need of NT removal. Methods In this retrospective cohort study, 306 subjects (150 males and 156 females, mean age 55.4 ± 15.3 years) who underwent multidisciplinary, transnasal, endoscopic tumor surgery of the anterior skull base using 4-handed techniques between 2011 and 2019 at the Department of Otorhinolaryngology, Medical University of Graz, were included. Results In the majority of interventions (n = 281/306; 91.8%), all NT were preserved. Significant factors influencing the need of NT resections turned out to be type of endoscopic approach (p < 0.001; V = 0.304), sagittal (p = 0.003; d = 0.481) and transversal (p = 0.017; d = 0.533) tumor diameter, tumor type (p < 0.001; V = 0.355) and tumor location (p < 0.001; V = 0.324). Conclusions NT can be preserved in the majority of patients undergoing tumor resection in anterior, transnasal, skullbase surgery and routine resection of NT should be avoided. Variables that have an impact on the need of NT resections are types of endoscopic approaches, sagittal and transversal tumor extension and tumor type. These factors should be considered in planning of surgery and preoperative information of patients.

EXPERIENCE OF EVALUATION OF PATIENTS OF OBSTRUCTIVE JAUNDICE BY SONOGRAPHY AND MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY AT A TERTIARY CARE CENTRE IN EASTERN INDIA

2021 ◽  
pp. 61-64
Author(s):  
Santosh Kumar Prasad ◽  
Nupur Nupur ◽  
Akshit Pathak ◽  
Indra Shekhar Thakur ◽  
Vijay Shankar Prasad
Keyword(s):  
Magnetic Resonance ◽  
Obstructive Jaundice ◽  
Hepatic Duct ◽  
Tertiary Care ◽  
Pancreatic Head ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Stricture Formation ◽  
Tertiary Care Centre ◽  
Left Hepatic Duct ◽  
Cross Sectional

INTRODUCTION: Jaundice means yellow due to the yellowish discolouration of skin, sclera, and mucous membrane seen in jaundice caused by bilirubin pigment. It is divided in to two forms obstructive(surgical) and non- obstructive (non-surgical). AIM AND OBJECTIVE: To evaluate patients of obstructive jaundice by sonography and magnetic resonance cholangiopancreatography and compare the reporting and ndings by both the modalities. MATERIALS AND METHODS: Cross sectional observational study done from November 2018 to October 2020 and consists of 32 patients who had clinical jaundice and consented to being subjected to both ultrasound and MRCP. OBSERVATIONS:Both USG and MRCP were able to detect extrahepatic CBD dilatation equally in 25 patients. In 5(15.6%) patients USG and MRI both demonstrated intrahepatic mass causing obstruction at the level of conuence of right and left hepatic duct or CHD. Ultrasonography was able to detect the intrinsic mass of the extrahepatic common bile duct in 2(6.2%) patients out of 32 patients in our study population. MRCP could detect the same in 6(18.7%) patients. In our study narrowing of CBD with stricture formation and upstream dilatation of biliary tree was identied in 10(31.2%) patients on MRCP. Ultrasound could diagnose the same in one patient. Both USG and MRCP were able to detect pancreatic head mass as well as pseudocyst. CONCLUSION: The accuracy of MRCP was found to be comparable to that of ERCP for diagnosis of etiology for obstructive jaundice. MRCP allows better lesion characterization and assessment. However, the patchy availability of MR machines become the main achilles heel for the surgeons as well as the radiologists. Hence the valuable role of the omnipresent ultrasonography become immense.

scholarly journals Respiratory Protection Program Compliance in Iranian Hospitals: Application of Fuzzy Analytical Hierarchy Process

2017 ◽  
Vol 66 (4) ◽  
pp. 173-182 ◽  
Author(s):  
Marzieh Honarbakhsh ◽  
Mehdi Jahangiri ◽  
Haleh Ghaem ◽  
Payam Farhadi
Keyword(s):  
Analytical Hierarchy Process ◽  
Weight Coefficient ◽  
Teaching Hospitals ◽  
Fars Province ◽  
Respiratory Protection ◽  
Fuzzy Analytical Hierarchy Process ◽  
Cross Sectional ◽  
Wide Range ◽  
Fit Testing ◽  
Hierarchy Process

In hospitals, health care workers (HCWs) are exposed to a wide range of respiratory hazards, which requires using respiratory protective equipment and implementing Respiratory Protection Programs (RPPs). The aim of this cross-sectional study was to investigate RPP implementation in 36 teaching hospitals located in the Fars province of Iran. A researcher-developed checklist, including nine components of the RPP standard, was completed by industrial hygienists in the study hospitals. The Fuzzy Analytical Hierarchy Process (FAHP) was used to determine the weight coefficient of RPP components. Finally, a Respiratory Protection Program Index (RPPI) was developed to calculate hospital compliance with RPP. The results showed that RPP were not fully implemented in the studied hospitals, and the highest and lowest RPPI scores were related to training and fit testing, respectively. To promote the implementation of RPP, significant efforts are required for all components, especially fit testing and worker evaluation.

scholarly journals Prevalence of injury and its associated factors in a rural area of eastern Nepal

2017 ◽  
Vol 6 (4) ◽  
pp. 7-13 ◽  
Author(s):  
V K Khanal ◽  
R Upreti ◽  
U Oli ◽  
A K Sunny ◽  
A Ghimire ◽  
...  
Keyword(s):  
Rural Area ◽  
Associated Factors ◽  
Population Based ◽  
Cross Sectional Study ◽  
Common Type ◽  
Injury Pattern ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pattern Of Injury ◽  
Public Health Threat

Injury is a serious public health threat as it is one of the leading cause of death globally. This study aims to assess the prevalence of injury, pattern of injury and its associated factors among people residing in a rural area of Aurabani VDC of Eastern Nepal. A population based cross sectional study was carried out among 552 people residing in selected wards with door to door visit. The prevalence of minor injury was 3.1% and major was 0.4% per year in the study.Most common mode of injury was fall and most common type was incised wound. Injuries mostly occurred in extremities, in morning time, autumn season and in roads while most of the injuries were accidental in nature. 

scholarly journals Phosphatase Regenerating Liver3 and ECadherin Expression in Epithelial Ovarian Cancer

2017 ◽  
pp. 170-175
Author(s):  
Risma Maharani ◽  
Syahrul Rauf ◽  
Rina Masadah
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
Advanced Stage ◽  
Cross Sectional ◽  
Exact Test ◽  
Significant Difference ◽  
E Cadherin

Objective: To determine the expression of Phosphatase Regenerating Liver-3 (PRL-3) and E-Cadherin in the epithelial ovarian cancer on various stages and differentiation grades. Method: This was a cross-sectional study design conducted at Obstetrics and Gynecology Department of several teaching hospitals, Faculty of Medicine Universitas Hasanuddin from January to June 2015. The expression of PRL-3 and E-cadherin was assessed immunohistochemically in 40 patients with epithelial ovarian cancer including 15 patients in early stage and 25 patients in advanced stage. We used the Fisher’s exact test with the significance of p0.05). The significant difference was found in the expression of E-cadherin whereas the high expression was shown at early stage than advanced stage (p0.05). This study also pointed out no correlation between the expression of PRL-3 and E-cadherin in epithelial ovarian cancer (p>0.05). Conclusion: PRL-3 overexpression does not decrease E-cadherin expression in epithelial ovarian cancer. Keywords: E-cadherin, epithelial ovarian cancer, PRL-3

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