scholarly journals Texture Analysis of Myometrium-Derived T2WI in the Evaluation of Placenta Increta: An Observational Retrospective Study

2021 ◽  
Author(s):  
Lishan Dong ◽  
Zhiyi Lei ◽  
Jiangong Zhang ◽  
Zongqiong Sun ◽  
Yonggang Li
Keyword(s):  
Multivariate Analysis ◽  
Texture Analysis ◽  
Placenta Accreta ◽  
Profile Analysis ◽  
Statistical Significance ◽  
Histopathological Diagnosis ◽  
Placenta Increta ◽  
Fisher Discriminant ◽  
Registration Number ◽  
Two Parameters

Abstract Background: To develop an objective and quantitative measurement based on texture analysis of myometrium-derived T2WI to differentiate placenta accreta from increta.Methods: Participants with MRI and clinical or histopathological diagnosis of placenta increta were included. Texture analysis of T2WI was implemented on normal myometrium and placenta increta by MaZda software. Parameter selection and reduction was automatically done with Fisher discriminant method. Multivariate analysis was used for the comparison of response variables between two groups. Profile analysis was used to compare the contours of multivariable average vectors. Two-step clustering was performed to evaluate the importance of parameters.Results: Multivariate analysis showed that nine second-order parameters between normal myometrium and placenta increta were statistically significant(P﹤0.05). The t-test showed that there were two parameters (Skew and Kurtosis) that had no statistical significance. Profile analysis showed that the profiles of seven parameters were neither parallel(P﹤0.05) nor coincident(P﹤0.05). The results of two-step cluster indicated that Mean, Percentile 90% and Percentile 99% were important (predictor importance﹥0.8).Conclusion: The study showed statistically significant differences for Mean, Percentile 90% and Percentile 99% between normal myometrium and placenta increta. Texture analysis of myometrium-derived T2WI may be a useful add-on to MRI in diagnosing placenta increta.Trial registration: Registration number: ChiCTR2000038604 and name of registry: Evaluation of diagnostic accuracy of MRI multi-parameter imaging combined with texture analysis for placenta accreta spectrum disorders (PAD).

scholarly journals Texture analysis of dark intraplacental bands on T2WI in the evaluation of placenta accreta spectrum disorders: a feasibility study

2021 ◽  
Author(s):  
Lishan Dong ◽  
Hailin Shen ◽  
Sheng Wang ◽  
Zhiyi Lei ◽  
Jiangong Zhang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Model ◽  
Texture Analysis ◽  
Logistic Regression Model ◽  
Placenta Accreta ◽  
Objective Assessment ◽  
Registration Number ◽  
Placenta Accreta Spectrum ◽  
Spectrum Disorders

Abstract Background: To evaluate whether texture analysis of dark intraplacental bands on T2WI can provide a novel methodological viewpoint valuable in assessing the classification of placenta accreta spectrum disorders (PAS disorders).Methods: 174 participants with suspected PAS disorders were consecutively included in the study. Texture analysis was implemented on dark intraplacental bands on T2WI by MaZda software. The two steps of parameter selection and reduction led to a decrease of the parameter space dimensionality. The logistics regression models were constructed with texture parameters to evaluate the classification of PAS disorders.Results: Both run length nonuniformity (RLN) and grey level nonuniformity (Gle) of four directions showed significant differences between participants with placenta accreta, increta and percreta (P﹤0.05). The AUC and cut-off for logistic regression model of accreta vs increta were 0.75 (95% CI: 0.54, 0.90) and 6.72, respectively; corresponding values for logistic regression model of increta vs percreta were 0.81 (95% CI: 0.61, 0.93) and 10.92. The sensitivity and specificity for cut-off of 6.72 were 88.46% and 84.62%, respectively; corresponding values for cut-off of 10.92 were 92.59% and 85.71%.Conclusion: Texture analysis offered promise for more quantitative and objective assessment of PAS disorders than other image modalities. It may be a useful add-on to MRI in evaluating the classification of PAS disorders. Trial registration: Registration number: ChiCTR2000038604 and name of registry: Evaluation of diagnostic accuracy of MRI multi-parameter imaging combined with texture analysis for placenta accreta spectrum disorders (PAD).

scholarly journals Methods for the Quantification of Resistance of Apple Genotypes to European Fruit Tree Canker Caused by Neonectria ditissima

Plant Disease ◽  
2017 ◽  
Vol 101 (12) ◽  
pp. 2012-2019 ◽  
Author(s):  
M. Wenneker ◽  
P. W. Goedhart ◽  
P. van der Steeg ◽  
W. E. van de Weg ◽  
H. J. Schouten
Keyword(s):  
Statistical Significance ◽  
Lesion Size ◽  
Fruit Tree ◽  
Infection Frequency ◽  
Pome Fruit ◽  
Start Date ◽  
Apple Cultivars ◽  
Lesion Growth ◽  
Two Parameters ◽  
Parallel Tests

European fruit tree canker, caused by Neonectria ditissima, is an important disease of pome fruit worldwide. Apple cultivars differ in their levels of susceptibility to N. ditissima. In order to design an effective plant resistance test, we examined the effectiveness of two resistance parameters: infection frequency and lesion growth. Both parameters were evaluated in parallel tests using 10 apple cultivars in three experimental years, applying seminatural infection of leaf scars (infection frequency) or inoculation of artificial wounds (lesion growth). We compared six parameters for lesion growth, of which a new parameter, lesion growth rate (LGR), appeared to be the best with respect to reproducibility and statistical significance. LGR is defined as the slope of the regression of lesion size versus time. The slope was estimated for each lesion, employing a common start date and a lesion-specific end date determined by the girdling of the lesion. The two parameters (infection frequency and LGR) were examined in separate experiments and in three successive years, and provided complementary information and resulted in reproducible conclusions on the relative resistance levels to N. ditissima of the tested cultivars. The presented methods can be used to develop strategies for the control of European fruit tree canker (e.g., in the breeding of new apple cultivars with high levels of resistance to N. ditissima).

scholarly journals Radiomic Profiling of Head and Neck Cancer: 18F-FDG PET Texture Analysis as Predictor of Patient Survival

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
G. Feliciani ◽  
F. Fioroni ◽  
E. Grassi ◽  
M. Bertolini ◽  
A. Rosca ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Head And Neck ◽  
Texture Analysis ◽  
Local Control ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Local Failure ◽  
Clinical Variables ◽  
Pet Ct ◽  
Fdg Pet Ct

Background and Purpose. The accurate prediction of prognosis and pattern of failure is crucial for optimizing treatment strategies for patients with cancer, and early evidence suggests that image texture analysis has great potential in predicting outcome both in terms of local control and treatment toxicity. The aim of this study was to assess the value of pretreatment 18F-FDG PET texture analysis for the prediction of treatment failure in primary head and neck squamous cell carcinoma (HNSCC) treated with concurrent chemoradiation therapy. Methods. We performed a retrospective analysis of 90 patients diagnosed with primary HNSCC treated between January 2010 and June 2017 with concurrent chemo-radiotherapy. All patients underwent 18F-FDG PET/CT before treatment. 18F-FDG PET/CT texture features of the whole primary tumor were measured using an open-source texture analysis package. Least absolute shrinkage and selection operator (LASSO) was employed to select the features that are associated the most with clinical outcome, as progression-free survival and overall survival. We performed a univariate and multivariate analysis between all the relevant texture parameters and local failure, adjusting for age, sex, smoking, primary tumor site, and primary tumor stage. Harrell c-index was employed to score the predictive power of the multivariate cox regression models. Results. Twenty patients (22.2%) developed local failure, whereas the remaining 70 (77.8%) achieved durable local control. Multivariate analysis revealed that one feature, defined as low-intensity long-run emphasis (LILRE), was a significant predictor of outcome regardless of clinical variables (hazard ratio < 0.001, P=0.001).The multivariate model based on imaging biomarkers resulted superior in predicting local failure with a c-index of 0.76 against 0.65 of the model based on clinical variables alone. Conclusion. LILRE, evaluated on pretreatment 18F-FDG PET/CT, is associated with higher local failure in patients with HNSCC treated with chemoradiotherapy. Using texture analysis in addition to clinical variables may be useful in predicting local control.

scholarly journals Clowns Benefit Children Hospitalized for Respiratory Pathologies

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Mario Bertini ◽  
Elena Isola ◽  
Giuseppe Paolone ◽  
Giuseppe Curcio
Keyword(s):  
Statistical Significance ◽  
Systolic Pressure ◽  
Therapeutic Modality ◽  
Control Group ◽  
Self Evaluation ◽  
Positive Effects ◽  
Before And After ◽  
Two Parameters ◽  
Therapeutic Settings ◽  
Experimental Group

The study aims at evaluating health-generating function of humor therapy in a hospital ward hosting children suffering from respiratory pathologies. The main scope of this study is to investigate possible positive effects of the presence of a clown on both the clinical evolution of the on-going disease, and on some physiological and pain parameters. Forty-three children with respiratory pathologies participated in the study: 21 of them belonged to the experimental group (EG) and 22 children to the control group (CG). During their hospitalization, the children of the EG interacted with two clowns who were experienced in the field of pediatric intervention. All participants were evaluated with respect to clinical progress and to a series of physiological and pain measures both before and after the clown interaction. When compared with the CG, EG children showed an earlier disappearance of the pathological symptoms. Moreover, the interaction of the clown with the children led to a statistically significant lowering of diastolic blood pressure, respiratory frequency and temperature in the EG as compared with the control group. The other two parameters of systolic pressure and heart frequency yielded results in the same direction, without reaching statistical significance. A similar health-inducing effect of clown presence was observed on pain parameters, both by self evaluation and assessment by nurses. Taken together, our data indicate that the presence of clowns in the ward has a possible health-inducing effect. Thus, humor can be seen as an easy-to-use, inexpensive and natural therapeutic modality to be used within different therapeutic settings.

Immunocytochemical markers in stage I lung cancer: relevance to prognosis.

1997 ◽  
Vol 15 (8) ◽  
pp. 2858-2865 ◽  
Author(s):  
U Pastorino ◽  
S Andreola ◽  
E Tagliabue ◽  
F Pezzella ◽  
M Incarbone ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multivariate Analysis ◽  
Cox Model ◽  
Statistical Significance ◽  
Prognostic Significance ◽  
Stage I ◽  
Laminin Receptor ◽  
Independent Predictive Factor ◽  
Time To Recurrence ◽  
Egfr Expression

PURPOSE This study investigated the frequency of the expression and prognostic significance of a panel of immunocytochemical markers in resected non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS A total of 515 cases of pathologic stage I NSCLC were analyzed. The median follow-up time of surviving patients was 102 months. The following immunocytochemical markers were tested: blood group A and precursors of blood antigens; laminin receptor; c-erbB1/epidermal growth factor receptor (EGFR) and c-erbB2/Neu; BCl2; p53; and angiogenesis. Kaplan-Meier estimates of survival and time to recurrence were calculated for clinical variables and biologic markers using the Cox model for multivariate analysis. RESULTS The pathologic tumor extension (pT) represented the most powerful prognostic factor for survival (P = .0008) and time to recurrence (P = .0007). None of the immunocytochemical markers emerged as an independent predictive factor for survival. Bcl2-positive tumors showed a better time to recurrence (P = .03), but the difference lost statistical significance in the multivariate analysis. Of interest, in the group of 137 patients classified as pT1N0, both EGFR expression and nonangiogenic type of vascular pattern were associated with a poorer survival (P = .02). However, data derived from subset analysis must be interpreted cautiously. CONCLUSION Our findings do not support a relevant prognostic role of immunocytochemical markers in NSCLC. The evidence is not sufficient to alter clinical practice or even to restrict clinical trials of adjuvant treatments to predefined biologic subsets of patients.

Ultrasound and magnetic resonance imaging in the diagnosis of clinically significant placenta accreta spectrum disorders

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Cecilia Cavalli ◽  
Claudia Maggi ◽  
Sebastiana Gambarini ◽  
Anna Fichera ◽  
Amerigo Santoro ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Placenta Accreta ◽  
Placenta Previa ◽  
Color Doppler ◽  
Histopathological Diagnosis ◽  
Resonance Imaging ◽  
Placenta Accreta Spectrum ◽  
Clinically Significant ◽  
Placental Lacunae

Abstract Objectives We aimed to assess the performance of ultrasound (US) and magnetic resonance imaging (MRI) signs for antenatal detection of placenta accreta spectrum (PAS) disorders in women with placenta previa (placental edge ≤2 cm from the internal uterine orifice, ≥260/7 weeks’ gestation) with and without a history of previous Caesarean section. Methods Single center prospective observational study. US suspicion of PAS was raised in the presence of obliteration of the hypoechoic space between uterus and placenta, interruption of the hyperechoic uterine-bladder interface and/or turbulent placental lacunae on color Doppler. All MRI studies were blindly evaluated by a single operator. PAS was defined as clinically significant when histopathological diagnosis was associated with at least one of: intrauterine balloon placement, compressive uterine sutures, peripartum hysterectomy, uterine or hypogastric artery ligature, uterine artery embolization. Results A total of 39 women were included: 7/39 had clinically significant PAS. There were 6/18 cases of PAS with anterior placenta: hypoechoic space interruption and placental lacunae were the most sensitive sonographic signs (83%), while abnormal hyperechoic interface was the most specific (83%). On MRI, focal myometrial interruption and T2 intraplacental dark bands showed the best sensitivity (83%), bladder tenting had the best specificity (100%). 1/21 women with posterior placenta had PAS. There was substantial agreement between US and MRI in patients with anterior placenta (κ=0.78). Conclusions US and MRI agreement in antenatal diagnosis of clinically significant PAS was maximal in high-risk women. Placental lacunae on ultrasound scan and T2 intraplacental hypointense bands on MRI should trigger the suspicion of PAS.

Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review

2020 ◽  
Author(s):  
Elisa T. Bushman ◽  
Gabriella Cozzi ◽  
Rachel G. Sinkey ◽  
Catherine H. Smith ◽  
Michael W. Varner ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
English Language ◽  
Statistical Significance ◽  
Cochrane Library ◽  
Control Group ◽  
Inclusion Criteria ◽  
Headache Diagnosis ◽  
Registration Number ◽  
In Pregnancy

Abstract Objective Headaches affect 88% of reproductive-aged women. Yet data are limited addressing treatment of headache in pregnancy. While many women experience improvement in pregnancy, primary and secondary headaches can develop. Consequently, pregnancy is a time when headache diagnosis can influence maternal and fetal interventions. This study was aimed to summarize existing randomized control trials (RCTs) addressing headache treatment in pregnancy. Study Design We searched PubMed, CINAHL, EMBASE, ClinicalTrials.gov, Cochrane Library, CINAHL, and SCOPUS from January 1, 1970 through June 31, 2019. Studies were eligible if they were English-language RCTs addressing treatment of headache in pregnancy. Conference abstracts and studies investigating postpartum headache were excluded. Three authors reviewed English-language RCTs addressing treatment of antepartum headache. To be included, all authors agreed each article to meet the following criteria: predefined control group, participants underwent randomization, and treatment of headache occurred in the antepartum period. If inclusion criteria were met no exclusions were made. Our systematic review registration number was CRD42019135874. Results A total of 193 studies were reviewed. Of the three that met inclusion criteria all were small, with follow-up designed to measure pain reduction and showed statistical significance. Conclusion Our systematic review of RCTs evaluating treatment of headache in pregnancy revealed only three studies. This paucity of data limits treatment, puts women at risk for worsening headache disorders, and delays diagnosis placing both the mother and fetus at risk for complications.

P6200Effect of LPA gene on CAD risk among diabetic patients

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Borges ◽  
R Palma Dos Reis ◽  
A Pereira ◽  
F Mendonca ◽  
J Sousa ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
General Population ◽  
Independent Predictor ◽  
Statistical Significance ◽  
Diabetic Patients ◽  
Diabetes Status ◽  
Chi Squared ◽  
Coronary Patients ◽  
Diabetic Population ◽  
Cad Risk

Abstract Introduction Previous research reported that LPA gene is a strong and independent predictor of CAD in non-diabetic patients but not in patients with type 2 diabetes. These results suggest that LPA gene might contribute less to CAD risk in patients with T2DM than in general population. Objective Investigate, in our population, the association between LPA gene CT variant and CAD risk among diabetic patients. Methods 3050 individuals (1619 coronary patients and 1431 controls) were genotyped for LPA rs3798220 TT/CT. Pearson's chi-squared test was applied to evaluate the association between LPA variants and CAD, firstly, in the general population and, secondly, in the group of patients with T2DM (n=735). Multivariate logistic regression was performed with LPA CT variant and 6 traditional risk factors (TRF) (smoking, dyslipidemia, diabetes, hypertension, family history of CAD and physical inactivity) in both general and diabetic population. Results In total population, LPA CT variant was found to be strongly and significantly associated with CAD with an OR of 2.32 (95% CI: 1.56–3.45; p<0.0001). However, this association was less pronounced in the diabetic population with a CAD risk of 1.38 (95% CI: 0.56–3.43) without statistical significance (p=0.485). In the presence of 6 major TRF, multivariate analysis showed that LPA CT remained a strong and independent predictor of CAD risk (OR= 2.34; 95% CI: 1.52–3.62; p<0.0001). In diabetic population, LPA was no longer an independent predictor for CAD by multivariate analysis. Conclusions Our results show that the effect of LPA gene on CAD risk among diabetic patients might be different from that in the general population. Diabetes status is such a strong risk factor that may attenuate the genetic effects of LPA on CAD risk. This may indicate a complex role of Lp (a) and diabetes interaction in cardiometabolic diseases.

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