scholarly journals RFA Lowers IDO Activity and Slows Non-Ablated Lesion Growth in Multifocal Hepatic Carcinoma

2021 ◽  
Author(s):  
Kailin Wang ◽  
Jun Mao ◽  
Siyue Mao ◽  
Xicheng Wang ◽  
Wanlin Tan ◽  
...  
Keyword(s):  
Growth Rate ◽  
Treatment Group ◽  
High Performance ◽  
Controlled Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Hepatic Carcinoma ◽  
Before And After ◽  
Lesion Growth ◽  
The Mean

Abstract Background: The aim of this study was to determine whether radiofrequency ablation (RFA) could activate immunity and slow non-ablated lesion growth in multifocal hepatic carcinoma.Methods: We performed a retrospective study on patients with multifocal hepatic carcinoma and assessed the non-ablated lesion growth rate between patients who received RFA and those who did not. In self-controlled study, before and three weeks after RFA, blood samples were collected from patients who received RFA to allow for comparisons of the alpha-fetoprotein (AFP) level, indoleamine 2,3-dioxygenase (IDO) concentration as assessed by enzyme-linked immunosorbent assay (ELISA) and IDO activity as assessed by high-performance liquid chromatography (HPLC).Results: A total of 66 patients were included in the retrospective analysis: there were 46 (69.7%) patients in the treatment group and 20 (30.3%) patients in the control group. The mean growth rate of non-ablated tumors was 0.0291 ± 0.0965 mm/d in the treatment group and 0.0947 ± 0.0754 mm/d in the control group (P = 0.001). The mean concentrations of IDO before and after RFA were 15.57±4.06 ng/ml and 7.53±1.56 ng/ml in 45 eligible patients, and this difference was significant (P = 0.034). The mean IDO activity values were 29.7±22.03 and 25.25±1.75 before and after RFA, respectively (P = 0.031). AFP decreased significantly after RFA, but there was no significant correlation between the decrease in AFP and the decrease in IDO concentration and activity.Conclusions: RFA may induce abscopal effects in hepatic carcinoma patients, manifested by a decrease in IDO concentration and activity and a slowed growth rate in non-ablated lesions.

scholarly journals Increasing drug compliance to hypertension patients through android applications in Wonosobo regency province of Central Java Indonesia

2019 ◽  
Vol 7 (1) ◽  
pp. 16
Author(s):  
Suyoto . ◽  
Farid Agushybana ◽  
Antono Suryoputro
Keyword(s):  
Treatment Group ◽  
Control Group ◽  
Android Application ◽  
Control Group Design ◽  
Central Java ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental ◽  
Android Applications ◽  
The Mean

Background: Based on data from WHO, it is estimated that 70% of the 57 million deaths that occurred in the world in 2008 were caused by non-communicable diseases. The prevalence of cases of hypertension primary in the District of Wonosobo in the year 2016 as many as 43.30%. Hypertension patients must take medication during their lifetime to prevent rising blood pressure and complications. This research aims to find out the effect of hypertension management through an android application on the practice of adherence to taking medication in hypertensive patients in Wonosobo regency.Methods: This research is a quasi-experimental with a non-randomized pre-post-test control group design. The study is conducted in patients prolanis hypertension as much as 105 respondents were divided into a treatment group 53 respondents and group control of 52 respondents.Results: Results of the study showed the significant influence of the use of android application to practice obedience to drink medicine. Results of Mann Whitney U analysis showed the treatment group experienced a rise in the mean is higher than the group of control. Likewise, the results of the test Wilcoxon which compares the level of compliance before and after treatment obtained value significantly for both groups with a mean group of treatment is higher.Conclusions: The management of hypertension through an android application has proven to be more effective in improving the practice of adherence to taking medication hypertension patients who take part in the prolanis program in Wonosobo regency.

scholarly journals Effectiveness of Radial Shock-Wave Therapy for Calcific Tendinitis of the Shoulder: Single-Blind, Randomized Clinical Study

2006 ◽  
Vol 86 (5) ◽  
pp. 672-682 ◽  
Author(s):  
Angelo Cacchio ◽  
Marco Paoloni ◽  
Antonio Barile ◽  
Romildo Don ◽  
Fosco de Paulis ◽  
...  
Keyword(s):  
Shock Wave ◽  
Treatment Group ◽  
Calcific Tendinitis ◽  
Controlled Study ◽  
Control Group ◽  
Shock Wave Therapy ◽  
Randomized Clinical Study ◽  
Before And After ◽  
Single Blind

Abstract Background and Purpose. Radial shock-wave therapy (RSWT) is a pneumatically generated, low- to medium-energy type of shock-wave therapy. This single-blind, randomized, “less active similar therapy”-controlled study was performed to evaluate the effectiveness of RSWT for the management of calcific tendinitis of the shoulder. Subjects. Ninety patients with radiographically verified calcific tendinitis of the shoulder were tested. Methods. Subjects were randomly assigned to either a treatment group (n=45) or a control group (n=45). Pain and functional level were evaluated before and after treatment and at a 6-month follow-up. Radiographic modifications in calcifications were evaluated before and after treatment. Results. The treatment group displayed improvement in all of the parameters analyzed after treatment and at the 6-month follow-up. Calcifications disappeared completely in 86.6% of the subjects in the treatment group and partially in 13.4% of subjects; only 8.8% of the subjects in the control group displayed partially reduced calcifications, and none displayed a total disappearance. Discussion and Conclusion. The results suggest that the use of RSWT for the management of calcific tendinitis of the shoulder is safe and effective, leading to a significant reduction in pain and improvement of shoulder function after 4 weeks, without adverse effects.

scholarly journals High-dose levocetirizine for the treatment of refractory chronic spontaneous urticaria and the effect on the serum inositol triphosphate level

2019 ◽  
Vol 47 (9) ◽  
pp. 4374-4379 ◽  
Author(s):  
Xianqiong Huang ◽  
Zhaoyang Li ◽  
Renshan Sun
Keyword(s):  
Serum Concentration ◽  
Cell Types ◽  
Chronic Spontaneous Urticaria ◽  
Inositol Triphosphate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
High Dose ◽  
Before And After ◽  
The Mean ◽  
Urticaria Activity Score

Objective The second messenger inositol triphosphate (IP3) is involved in signal transduction in multiple cell types. We evaluated the effects of high-dose levocetirizine on chronic spontaneous urticaria (CSU) and examined the significance of serum IP3 level in the pathogenesis of CSU. Methods Fifteen patients with refractory CSU were given oral levocetirizine at a dose of 15 mg once daily for 7 days, and treatment efficacy was determined using the Urticaria Activity Score and by evaluating wheal-and-erythema reactions and itching. The serum concentration of IP3 at specific time points was determined by enzyme-linked immunosorbent assay. Results The mean serum concentration of IP3 was 43.54 ± 41.97 pg/mL prior to treatment, 18.40 ± 17.53 pg/mL after treatment, and 1.31 ± 0.92 pg/mL in a healthy control group. The mean concentration of IP3 was significantly higher before treatment than after treatment, and the level of IP3 in the patient group before and after treatment was significantly higher than that in the control group. Conclusion High-dose levocetirizine was shown to be effective in the treatment of CSU. The level of serum IP3 was positively correlated with CSU activity, indicating that IP3 may play an important role in the pathogenesis of this condition.

scholarly journals Effectiveness of Rinsing Black Tea Compared to Green Tea in Decreasing Streptococcus mutans

2019 ◽  
Vol 7 (22) ◽  
pp. 3799-3802 ◽  
Author(s):  
Ranu Putra Armidin ◽  
Gema Nazri Yanti
Keyword(s):  
Treatment Group ◽  
Streptococcus Mutans ◽  
Green Tea ◽  
Black Tea ◽  
Plate Count ◽  
Control Group ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
The Difference

BACKGROUND: Herbal mouthwash is considered as an alternative regimen in maintaining oral hygiene. Tea contains compounds such as catechin and tannin which possess bactericidal and bacteriostatic effect which helps to prevent dental caries. AIM: This study was conducted to determine the effectiveness between rinsing with steeping black tea and green tea solution in decreasing the amount of Streptococcus mutans. METHODS: This is an experimental study with pre and post-test controlled group design. The sample were 60 college students from North Sumatera University which were then divided into three groups: oral rinsing with steeping black tea (treatment group), oral rinsing with steeping green tea (treatment group) and oral rinsing with listerine (control group). Saliva collection was carried out before treatment (pre-test/baseline) and after treatment (post-test). Treatment group was instructed to rinse 15 ml of steeping black and green tea solution whereas control group were instructed to rinse 15 ml listerine for 30 seconds and get rid of it. The saliva samples before and after treatment were brought to the microbiology laboratorium for Streptococcus mutans amount calculation using Total Plate Count (TPC) method. A T-test were used to determine the difference between rinsing with black tea and green tea and Kruskalwalis used to determine the difference between rinsing with steeping black tea, steeping green tea and aquadest towards the mean amount of bacteria before and after treatment. RESULT: The results showed significant reduction in amount of Streptococcus mutans in both treatment group where black tea group before treatment 28.90 x 103 ± 7.152 x 103 CFU/ml and after treatment 21.60 x 103 ± 6.295 x 103 CFU/ml (p < 0.05) and green tea group before treatment 70.15 x 103 ± 34.814 x 103 CFU/ml and after treatment 54.85 x 103 ± 31.451 x 103 CFUml (p < 0.05). The results in control group also showed reduction in amount of Streptococcus mutans where before treatment 25.80 x 103 ± 12.190 x 103 CFU/ml and after treatment 11.30 x 103 ± 8.228 x 103 CFU/ml (p > 0.000). Statistical analysis revealed that significant difference was found in the mean reduction of total Streptococcus mutans before and after in black tea group 7.30 x 103 ± 3.062 x 103 CFU/ml and green tea group 15.30 x 103 ± 11.045 x 103 CFU/ml (p < 0.05). CONCLUSION: It can be concluded that rinsing with steeping green tea solution has more effectiveness in decreasing the total Streptococcus mutans as compared to black tea solution.

scholarly journals Huanglong Antitussive Granule Relieves Acute Asthma Through Regulating Pulmonary Lipid Homeostasis

2021 ◽  
Vol 12 ◽  
Author(s):  
Hua Yan ◽  
Guiying Qian ◽  
Rui Yang ◽  
Zichen Luo ◽  
Xianzheng Wang ◽  
...  
Keyword(s):  
Treatment Group ◽  
High Performance ◽  
Acute Asthma ◽  
Enrichment Analysis ◽  
Negative Ion ◽  
Lipid Homeostasis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Asthma Model ◽  
Negative Ion Mode

Background: Asthma is a respiratory disease with chronic airway inflammatory, and individuals with asthma exacerbations is one of the most frequent causes of hospitalization. Huanglong antitussive granule (HL Granule), a Chinese proprietary herbal medicine, has been proved to be effective in the clinical treatment of pulmonary disease. This study is devoted to the pharmacodynamics of HL Granule in acute asthma and the possible mechanism from the perspective of lipidomics.Methods: Mice were divided into four groups, control group, acute asthma model group, HL Granule treatment and montelukast sodium treatment group. Acute asthma was induced by ovalbumin (OVA). Histopathology, pulmonary function and enzyme linked immunosorbent assay (ELISA) were used to validated model and effect of HL Granule. Lipids were detected by ultra-high-performance liquid chromatography coupled to hybrid Quadrupole-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive Orbitrap MS) and identified by MS-DAIL and built-in Lipidblast database. Differentially expressed lipids recalled in HL Granule treatment group were extracted for heatmap, enrichment analysis and correlation analysis.Results: HL Granule was effective in decreasing airway hyperresponsiveness (AHR), airway inflammatory and the levels of IL-4 and IL-5. A total of 304 and 167 lipids were identified in positive and negative ion mode, respectively. Among these, 104 and 73 lipids were reserved in HL Granule group (FDR &lt; 0.05), including acylcarnitine (ACar), fatty acid (FA), lysophosphatidylcholine (LPC), phosphatidylcholine (PC), lysophosphatidylethanolamine (LPE), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine (PS), diglyceride (DG), triglyceride (TG), sphingomyelin (SM) and ceramide (Cer). Furthermore, 118 and 273 correlations among 47 and 96 lipids in the positive and negative were observed, with ether-linked phosphatidylethanolamine (PEe) and phosphatidylcholine (PCe) (FDR &lt; 0.001, Spearman correlation coefficient r2 &gt; 0.75).Conclusion: HL Granule might improve pulmonary lipid homeostasis and could be used as an alternative or supplementary therapy in clinical for the treatment of asthma.

Clinical Study of Qingpeng Ointment Treatment of Shoulder-Hand Syndrome After Cerebral Hemorrhage During the Rehabilitation Period

2020 ◽  
Vol 23 ◽  
Author(s):  
Ruihuan Pan ◽  
Shanshan Ling ◽  
Haodong Yang ◽  
Yan Huang ◽  
Lechang Zhan ◽  
...  
Keyword(s):  
Treatment Group ◽  
Cerebral Hemorrhage ◽  
Clinical Medicine ◽  
External Rotation ◽  
Statistical Significance ◽  
Hand Function ◽  
Tibetan Medicine ◽  
Controlled Study ◽  
Control Group ◽  
The Difference

Background: Shoulder-hand syndrome (SHS) refers to a syndrome causing sudden edema, shoulder pain and limited hand function. Qingpeng ointment, a kind of Tibetan medicine, can reduce swelling, relieve pain, tonify stagnation and clear the meridians, which is consistent with the pathological mechanism of SHS after stroke. Therefore, if clinical trials can be used to explore the effectiveness of Qingpeng ointment for treatment of poststroke SHS and promote its application in clinical medicine, this is of specific significance for the treatment of poststroke SHS. Objective: To investigate the clinical efficacy and safety of Qingpeng ointment in the treatment of poststroke SHS. To provide an objective basis for a better therapeutic treatment for poststroke SHS． Method: A prospective, randomized, controlled study was conducted. This study recruited 120 patients with poststroke SHS who met the inclusion criteria. They were randomized into the treatment group and the control group, with 60 patients allocated to each group. The treatment group received routine medical treatment and rehabilitative care after using the Qingpeng ointment, while the patients in the control group received only routine treatment without the ointment. All patients received clinical assessment with the Visual Analogue Scale (VAS), measurement of the range of motion (ROM) of the upper-limb joints, the Fugl-Meyer Assessment of Upper Extremity (FMA-U) and the Modified Barthel Index Score (MBI) before and after the whole treatment. Results: After 4 weeks of treatment, the VAS scores of both groups were decreased significantly (P＜0.05), and the difference between the two groups was statistically significant (P < 0.05). There is no statistical significance for the difference between the treatment group and control group in terms of the FMA-U and MBI scores and the forward bend, backward, outstretch, external rotation and pronation angles after treatment. The increases in the values of VAS, FMA-M and MBI in the treatment group were greater than those in the control group, and the difference was statistically significant (P < 0.05). The increases in the values of the forward bend, outreach and external rotation angles in the treatment group were greater than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The treatment group showed better results than the control group in terms of the relief of pain symptoms, the improvement of motor function and the improvement of the activities of daily living for patients with shoulder-hand syndrome after cerebral hemorrhage. Qingpeng ointment is effective and safe in treating poststroke SHS.

Effect of High Plane of Nutrition on Blood Biochemical Profile and Onset of Puberty in Prepubertal HF X Kankrej Crossbred Heifers

2019 ◽  
Vol 15 (02) ◽  
pp. 14-17
Author(s):  
K K Hadiya ◽  
A J Dhami ◽  
D V Chaudhari ◽  
P M Lunagariya
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Plasma Levels ◽  
Age Of Onset ◽  
The Body ◽  
Monthly Interval ◽  
Control Group ◽  
Blood Biochemical ◽  
Lower Protein ◽  
The Mean

This study was initiated on 24 prepubertal Holstein x Kankrej crossbred heifers of nearly identical age (7-9 months) and body weight (130-140 kg) at University farm to evaluate the effect of high plane of nutrition on blood biochemical and minerals profile and the age at puberty. Twelve heifers were managed under routine farm feeding (control) and the rest 12 under ideal optimum feeding regime (treatment) that included extra 1 kg concentrate, 30 g min mix and ad-lib dry fodder. The body weight and ovarian ultrasonography together with blood sampling was carried out at monthly interval from 10 to 18 months of age to study the ovarian dynamics and blood biochemical changes. High plane of nutrition to growing heifers was beneficial in reducing the age of onset of puberty (by 2-3 months) compared to routine farm fed group. The mean plasma total protein and cholesterol concentrations showed a rising trend with significant variations from 10 to 16 months of age, where it got mostly stabilized indicating adult profile. The activity of enzymes GOT and GPT also rose gradually and significantly from 10 months till 14-15 months of age, and thereafter it remained more or less static till 18 months of age. The levels of both these enzymes were higher, with lower protein and cholesterol, in control than the treatment group from 15-16 months of age onwards. The mean plasma levels of both calcium and phosphorus increased gradually and significantly with advancing age till 16-17 months of age, with little higher values in supplemented than a control group. The plasma levels of zinc, iron, copper, and cobalt also showed rising trend with significant differences between 10th and 12th-14th months of age, and from 15th to 18th months of age the levels were statistically the same in all the groups with slightly higher values in the treatment group.

The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Asieh Mehdipour ◽  
Parvin Abedi ◽  
Somayeh Ansari ◽  
Maryam Dastoorpoor
Keyword(s):  
Randomized Controlled Trial ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled ◽  
Moderate Depression ◽  
Before And After ◽  
The Mean ◽  
And Control

Abstract Objectives Postmenopausal women are at greater risk of depression. Depression may negatively affect the quality of life of women. An emotional freedom technique (EFT) is an evidence-based therapy combining cognitive and exposure components with acupressure. This study aimed to evaluate the effect of EFT on depression in postmenopausal women. Methods This was a randomized controlled trial in which 88 women with mild to moderate depression recruited from a menopausal clinic in Ahvaz, Iran, and randomly assigned into two groups of EFT (n=44) and control for sham therapy (n=44). Women in the EFT group received two sessions of training and asked to continue EFT for 8 weeks, one time per day. The Beck Depression Inventory (BDI2) completed by women before and after the intervention. The control group received training on sham acupressure points similar to the intervention group. Data collected using a demographic and BDI2. Women requested to complete the BDI2 before and after the intervention. The independent t-test, chi-square, and ANCOVA were used to analyze data. Results The mean depression score in the intervention group reduced from 20.93 ± 4.6 to 10.96 ± 4.38 in comparison to the control group that reduced from 19.18 ± 2.79 to 17.01 ± 6.05 after intervention (p=0.001). After the 8 week intervention, the frequency of moderate depression decreased from 56.8 to 9.35% in the intervention and from 50 to 29.5% in the control group. In total, 63.4 and 34.15% in the intervention and control groups were free of depression respectively after the intervention (p<0.001). Conclusions The results of this study showed that using EFT for 8 weeks could significantly reduce the mean score of depression in postmenopausal women. Using this method in public health centers for postmenopausal women is recommended.

Effects of an Off-Site Walking Program on Energy Expenditure, Serum Lipids, and Glucose Metabolism in Middle-Aged Women

2003 ◽  
Vol 4 (3) ◽  
pp. 181-192 ◽  
Author(s):  
Fumiko Furukawa ◽  
Keiko Kazuma ◽  
Masako Kawa ◽  
Mitsunori Miyashita ◽  
Kyohko Niiro ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Nurse Managers ◽  
Intervention Group ◽  
Density Lipoprotein ◽  
Control Group ◽  
Middle Aged ◽  
Walking Program ◽  
Before And After ◽  
The Mean ◽  
Blood Profiles

The present study aims to identify the effects of systematic walking on exercise energy expenditure (EEE) and blood profiles in middle-aged women. Fifty-two female nurse managers, aged 32 to 57 years (42.0 ± 6.2), were randomly assigned to an intervention group (IG) and a control group (CG) for a 12-week study of the walking program. EEE was measured using a microelectronic device. Blood profiles were assessed before and after the walking program. The mean EEE (kcal/kg/d) in the IG and CG was 4.73 ± 1.02 and 3.88 ± 0.81 ( P = 0.01), indicating an increase of 1.17 ± 0.98 and 0.46 ± 0.68 from baseline ( P = 0.01), respectively. The mean change in high-density lipoprotein cholesterol in the IG and CG was 1.8 ± 8.3 mg/dL and −2.9 ± 7.0 mg/dL ( P = 0.051); that in insulin was −4.5 ± 7.5 μU/dL and −0.6 ± 4.3 μU/dL ( P = 0.046), respectively. These results show that systematic walking increases EEE and improves blood profiles.

THE EFFECT OF DHIKR ON ANXIETY AND DEPRESSION LEVEL IN HEMODIALYSIS PATIENTS AT PURWOKERTO ISLAMIC HOSPITAL

2021 ◽  
Vol 2 (1) ◽  
pp. 15-25
Author(s):  
Muhammad Anggun ◽  
Titik Kusumawinakhyu ◽  
Irma Finurina Mustikawati ◽  
Wiharto Wiharto
Keyword(s):  
Intervention Group ◽  
Depression Scale ◽  
Sampling Technique ◽  
Hemodialysis Patients ◽  
Anxiety And Depression ◽  
Control Group ◽  
Control Group Design ◽  
Hemodialysis Unit ◽  
Before And After ◽  
The Mean

Hemodialysis is a routinely performed therapy on chronic kidney patients, leading to psychological problems among subjects who undergo hemodialysis, such as anxiety and depression. One of the efforts to overcome anxiety and depression is with the dhikr intervention. Dhikr presents hearts to remember and be obedient to Allah followed by the words and actions in various conditions.  Discover dhikr's influence on the level of anxiety and depression in patients on hemodialysis in  Purwokerto Islamic Hospital. It was a quantitative study using quasi experiment with a non-quivalent control group design. The number of samples was 12 subjects consisting of 6 subjects in the control group and six subjects in the intervention group with the purposive sampling technique. Instruments were used to measure anxiety and depression are the HADS ( Hospital Anxiety and Depression Scale ) before and after dhikr intervention as much as 12 times. Research is carried out in Hemodialysis Unit of  Purwokerto Islamic Hospital. Test statistics on research are used paired t-test and independent t-tests. This study showed a decrease in the mean level of anxiety from 5, 83 to 1.67 in the experimental group ( p = 0.003). The mean level of depression experienced a decline of 9, 67 becomes 4.67 on a group experiment ( p = 0.003). Dhikr reduces the level of anxiety and depression in hemodialysis patients at the Purwokerto Islamic Hospital.

Sign in / Sign up

Export Citation Format

Share Document